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Biodegradable Oxamide-Phenylene-Based Mesoporous Organosilica Nanoparticles with Unprecedented Drug Payloads for Delivery in Cells.
- Source :
-
Chemistry - A European Journal . 10/10/2016, Vol. 22 Issue 42, p14806-14811. 6p. - Publication Year :
- 2016
-
Abstract
- We describe biodegradable mesoporous hybrid nanoparticles (NPs) in the presence of proteins and their applications for drug delivery. We synthesized oxamide phenylene-based mesoporous organosilica nanoparticles (MON) in the absence of a silica source which had remarkably high organic content and high surface areas. Oxamide functions provided biodegradability in the presence of trypsin model proteins. MON displayed exceptionally high payloads of hydrophilic and hydrophobic drugs (up to 84 wt %), and a unique zero premature leakage without the pore capping, unlike mesoporous silica. MON were biocompatible and internalized into cancer cells for drug delivery. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BIODEGRADABLE materials
*SILICONES
*DRUG delivery systems
*ENZYMES
*NANOPARTICLES
Subjects
Details
- Language :
- English
- ISSN :
- 09476539
- Volume :
- 22
- Issue :
- 42
- Database :
- Academic Search Index
- Journal :
- Chemistry - A European Journal
- Publication Type :
- Academic Journal
- Accession number :
- 118514361
- Full Text :
- https://doi.org/10.1002/chem.201601714