25 results on '"Perera F"'
Search Results
2. Co-Benefits to Children's Health of the U.S. Regional Greenhouse Gas Initiative.
- Author
-
Perera F, Cooley D, Berberian A, Mills D, and Kinney P
- Subjects
- Air Pollution prevention & control, Child, Conservation of Natural Resources, Humans, Particulate Matter, Air Pollutants, Air Pollution statistics & numerical data, Child Health, Environmental Exposure statistics & numerical data, Environmental Policy, Greenhouse Gases
- Abstract
Background: While various policies have been implemented globally to mitigate climate change and reduce exposure to toxic air pollutants, policy assessments have considered few if any of the benefits to children., Objective: To comprehensively assess the co-benefits of climate change mitigation to children, we expanded the suite of adverse health outcomes in the U.S. Environmental Protection Agency's Benefits Mapping and Analysis Program (BenMAP) to include additional outcomes associated with prenatal and childhood exposure to ambient fine particulate matter ( PM 2.5 ). We applied this newly expanded program to an assessment of the U.S. Regional Greenhouse Gas Initiative (RGGI), the United States' first regional market-based regulatory program designed to reduce greenhouse gas emissions from the electric power sector within the Northeast., Methods: We used calculated changes in ambient PM 2.5 concentrations for the period 2009-2014, with newly incorporated concentration-response (C-R) functions to quantify changes in the incidence of preterm birth (PTB), term low birth weight (TLBW), autism spectrum disorder (ASD), and asthma. These outcomes are causally or likely to be causally related to PM 2.5 exposure. Cost per case estimates were incorporated to monetize those changes in incidence., Results: The estimated avoided cases of adverse child health outcomes included 537 asthma cases, 112 preterm births, 98 cases of ASD, and 56 cases of TLBW, with an associated avoided cost estimate ranging from $191 to $350 million. In a previous analysis of health benefits of RGGI, the only benefits accruing to children were limited to prevented cases of infant mortality and respiratory illnesses, with a monetized impact of $8.1 million-only 2-4% of the new results attributable to RGGI., Conclusion: The results of this innovative analysis indicate that RGGI has provided substantial child health benefits beyond those initially considered. Moreover, those health benefits had significant estimated economic value. https://doi.org/10.1289/EHP6706.
- Published
- 2020
- Full Text
- View/download PDF
3. Characterizing peak exposure of secondhand smoke using a real-time PM 2.5 monitor.
- Author
-
Zhang T, Chillrud SN, Yang Q, Pitiranggon M, Ross J, Perera F, Ji J, Spira A, Breysse PN, Rodes CE, Miller R, and Yan B
- Subjects
- Air Pollutants analysis, Child, Environmental Monitoring, Humans, New York City, Environmental Exposure statistics & numerical data, Particulate Matter analysis, Tobacco Smoke Pollution statistics & numerical data
- Abstract
Although short-duration elevated exposures (peak exposures) to pollutants may trigger adverse acute effects, epidemiological studies to understand their influence on different health effects are hampered by lack of methods for objectively identifying peaks. Secondhand smoke from cigarettes (SHS) in the residential environment can lead to peak exposures. The aim of this study was to explore whether peaks in continuous PM
2.5 data can indicate SHS exposure. A total of 41 children (21 with and 20 without SHS exposure based on self-report) from 28 families in New York City (NY, USA) were recruited. Both personal and residential continuous PM2.5 monitoring were performed for five consecutive days using MicroPEM sensors (RTI International, USA). A threshold detection method based on cumulative distribution function was developed to identify peaks. When children were home, the mean accumulated peak area (APA) for peak exposures was 297 ± 325 hour*µg/m3 for children from smoking families and six times that of the APA from non-smoking families (~50 ± 54 hour*µg/m3 ). Average PM2.5 mass concentrations for SHS exposed and unexposed children were 24 ± 15 µg/m3 and 15 ± 9 µg/m3 , respectively. The average SHS exposure duration represents ~5% of total exposure time, but ~13% of children's total PM2.5 exposure dose, equivalent to an additional 2.6 µg/m3 per day. This study demonstrated the feasibility of peak analysis for quantifying SHS exposure. The developed method can be adopted more widely to support epidemiology studies on impacts of short-term exposures., (© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)- Published
- 2020
- Full Text
- View/download PDF
4. Prenatal exposure to airborne polycyclic aromatic hydrocarbons and childhood growth trajectories from age 5-14 years.
- Author
-
Rundle AG, Gallagher D, Herbstman JB, Goldsmith J, Holmes D, Hassoun A, Oberfield S, Miller RL, Andrews H, Widen EM, Hoepner LA, and Perera F
- Subjects
- Adolescent, Body Mass Index, Child, Child, Preschool, Female, Humans, New York, Pregnancy, Air Pollution, Environmental Exposure statistics & numerical data, Growth and Development drug effects, Polycyclic Aromatic Hydrocarbons, Prenatal Exposure Delayed Effects
- Abstract
There is evidence that exposures to polycyclic aromatic hydrocarbons (PAH) and fine particles in air pollution are associated with higher childhood body mass index (BMI). Birth cohort analyses of prenatal exposures to PAH and child BMI Z-scores from age 5-14 years were conducted. African-American and Hispanic children born in the Bronx or Northern Manhattan, New York (1998-2006), whose mothers underwent personal air monitoring for airborne PAH exposure during pregnancy, were followed up with measurements of height and weight at approximate ages 5, 7, 9, 10, 11, 12.5 and 13.5 years. Multivariable generalized estimating equation analyses were used to relate prenatal airborne PAH exposures to child BMI Z-scores through time. The analyses adjusted for many known risk factors for childhood obesity and included interactions terms between age and exposure tertiles and age squared and exposure tertiles. In total, 535 children had at least one height and weight measure during follow-up. The prevalence of obesity was 20.6% at age 5 and increased across follow-ups until age 11 when it was 33.0%. At age 5, BMI Z-scores were significantly greater for children in the third tertile of exposure relative to the first tertile (0.35 Z-score units, 95% CI 0.09, 0.61, p = 0.007) and were non-significantly higher for the second tertile of exposure compared to the first tertile (0.25 Z-score units, 95% CI -0.02, 0.52, P = 0.075). The trajectories of BMI Z-scores by tertiles of exposure converged as the children aged, such that by age 11 years the estimated mean BMI Z-scores associated with each tertile of exposure were not different. Prenatal exposures to airborne PAH were associated with higher childhood BMI Z-scores at a young age, but growth trajectories converged by age 11 years. Accordingly, highly exposed children spend a greater proportion of their childhood with higher BMI Z-scores., (Copyright © 2019 Elsevier Inc. All rights reserved.)
- Published
- 2019
- Full Text
- View/download PDF
5. Healthy Air, Healthy Brains: Advancing Air Pollution Policy to Protect Children's Health.
- Author
-
Payne-Sturges DC, Marty MA, Perera F, Miller MD, Swanson M, Ellickson K, Cory-Slechta DA, Ritz B, Balmes J, Anderko L, Talbott EO, Gould R, and Hertz-Picciotto I
- Subjects
- Air Pollution legislation & jurisprudence, Child, Child Development physiology, Environmental Exposure legislation & jurisprudence, Humans, Particulate Matter adverse effects, Polycyclic Aromatic Hydrocarbons adverse effects, Air Pollutants adverse effects, Air Pollution adverse effects, Child Health, Environmental Exposure adverse effects
- Abstract
Evidence is growing on the adverse neurodevelopmental effects of exposure to combustion-related air pollution. Project TENDR (Targeting Environmental Neurodevelopmental Risks), a unique collaboration of leading scientists, health professionals, and children's and environmental health advocates, has identified combustion-related air pollutants as critical targets for action to protect healthy brain development. We present policy recommendations for maintaining and strengthening federal environmental health protections, advancing state and local actions, and supporting scientific research to inform effective strategies for reducing children's exposures to combustion-related air pollution. Such actions not only would improve children's neurological development but also would have the important co-benefit of climate change mitigation and further improvements in other health conditions.
- Published
- 2019
- Full Text
- View/download PDF
6. Assessment of exposure to air pollution in children: Determining whether wearing a personal monitor affects physical activity.
- Author
-
Lovinsky-Desir S, Lawrence J, Jung KH, Rundle AG, Hoepner LA, Yan B, Perera F, Perzanowski MS, Miller RL, and Chillrud SN
- Subjects
- Accelerometry, Adolescent, Child, Cohort Studies, Female, Humans, Male, Air Pollution analysis, Environmental Exposure analysis, Environmental Monitoring instrumentation, Exercise
- Abstract
Personal air pollution monitoring in research studies should not interfere with usual patterns of behavior and bias results. In an urban pediatric cohort study we tested whether wearing an air monitor impacted activity time based on continuous watch-based accelerometry. The majority (71%) reported that activity while wearing the monitor mimicked normal activity. Correspondingly, variation in activity while wearing versus not wearing the monitor did not differ greatly from baseline variation in activity (P = 0.84)., (Copyright © 2018 Elsevier Inc. All rights reserved.)
- Published
- 2018
- Full Text
- View/download PDF
7. Associations between prenatal and childhood PBDE exposure and early adolescent visual, verbal and working memory.
- Author
-
Cowell WJ, Margolis A, Rauh VA, Sjödin A, Jones R, Wang Y, Garcia W, Perera F, Wang S, and Herbstman JB
- Subjects
- Adolescent, Child, Child, Preschool, Female, Fetal Blood chemistry, Halogenated Diphenyl Ethers toxicity, Humans, Infant, Newborn, Male, Pregnancy, Task Performance and Analysis, Environmental Exposure analysis, Environmental Exposure statistics & numerical data, Halogenated Diphenyl Ethers blood, Maternal Exposure, Memory physiology
- Abstract
Background: Prenatal and childhood exposure to polybrominated diphenyl ether (PBDE) flame retardants has been inversely associated with cognitive performance, however, few studies have measured PBDE concentrations in samples collected during both prenatal and postnatal periods., Methods: We examined prenatal (cord) and childhood (ages 2, 3, 5, 7 and 9 years) plasma PBDE concentrations in relation to memory outcomes assessed between the ages of 9 and 14 years. The study sample includes a subset (n = 212) of the African American and Dominican children enrolled in the Columbia Center for Children's Environmental Health Mothers and Newborns birth cohort. We used multivariable linear regression to examine associations between continuous log
10 -transformed PBDE concentrations and performance on tests of visual, verbal and working memory in age-stratified models. We additionally used latent class growth analysis to estimate trajectories of exposure across early life, which we analyzed as a categorical variable in relation to memory outcomes. We examined interactions between PBDE exposure and sex using cross-product terms., Results: Associations between prenatal exposure and working memory significantly varied by sex (p-interaction = 0.02), with inverse relations observed only among girls (i.e. βBDE-47 = -7.55, 95% CI: -13.84, -1.24). Children with sustained high concentrations of BDEs-47, 99 or 100 across childhood scored approximately 5-8 standard score points lower on tests of visual memory. Children with PBDE plasma concentrations that peaked during toddler years performed better on verbal domains, however, these associations were not statistically significant., Conclusions: Exposure to PBDEs during both prenatal and postnatal periods may disrupt memory domains in early adolescence. These findings contribute to a substantial body of evidence supporting the developmental neurotoxicity of PBDEs and underscore the need to reduce exposure among pregnant women and children., (Copyright © 2018 Elsevier Ltd. All rights reserved.)- Published
- 2018
- Full Text
- View/download PDF
8. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group.
- Author
-
Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, and Murphy SK
- Subjects
- Child, Child Health, Child Welfare, DNA Methylation, Epigenesis, Genetic, Female, Group Processes, Humans, Longitudinal Studies, Pregnancy, Research, Environmental Exposure, Environmental Health, Epigenomics
- Abstract
Background: Characterization of the epigenome is a primary interest for children's environmental health researchers studying the environmental influences on human populations, particularly those studying the role of pregnancy and early-life exposures on later-in-life health outcomes., Objectives: Our objective was to consider the state of the science in environmental epigenetics research and to focus on DNA methylation and the collective observations of many studies being conducted within the Children's Environmental Health and Disease Prevention Research Centers, as they relate to the Developmental Origins of Health and Disease (DOHaD) hypothesis., Methods: We address the current laboratory and statistical tools available for epigenetic analyses, discuss methods for validation and interpretation of findings, particularly when magnitudes of effect are small, question the functional relevance of findings, and discuss the future for environmental epigenetics research., Discussion: A common finding in environmental epigenetic studies is the small-magnitude epigenetic effect sizes that result from such exposures. Although it is reasonable and necessary that we question the relevance of such small effects, we present examples in which small effects persist and have been replicated across populations and across time. We encourage a critical discourse on the interpretation of such small changes and further research on their functional relevance for children's health., Conclusion: The dynamic nature of the epigenome will require an emphasis on future longitudinal studies in which the epigenome is profiled over time, over changing environmental exposures, and over generations to better understand the multiple ways in which the epigenome may respond to environmental stimuli.
- Published
- 2017
- Full Text
- View/download PDF
9. Significant interactions between maternal PAH exposure and single nucleotide polymorphisms in candidate genes on B[ a ]P-DNA adducts in a cohort of non-smoking Polish mothers and newborns.
- Author
-
Iyer S, Wang Y, Xiong W, Tang D, Jedrychowski W, Chanock S, Wang S, Stigter L, Mróz E, and Perera F
- Subjects
- Adult, Cytochrome P-450 CYP1A1 genetics, DNA Adducts, Female, Gene Frequency, Gene-Environment Interaction, Humans, Infant, Newborn, Maternal-Fetal Exchange, Poland, Polymorphism, Single Nucleotide, Pregnancy, Air Pollutants toxicity, Environmental Exposure, Polycyclic Aromatic Hydrocarbons toxicity
- Abstract
Polycyclic aromatic hydrocarbons (PAH) are a class of chemicals common in the environment. Certain PAH are carcinogenic, although the degree to which genetic variation influences susceptibility to carcinogenic PAH remains unclear. Also unknown is the influence of genetic variation on the procarcinogenic effect of in utero exposures to PAH. Benzo[ a ]pyrene (B[ a ]P) is a well-studied PAH that is classified as a known human carcinogen. Within our Polish cohort, we explored interactions between maternal exposure to airborne PAH during pregnancy and maternal and newborn single nucleotide polymorphisms (SNPs) in plausible B[ a ]P metabolism genes on B[ a ]P-DNA adducts in paired cord blood samples. The study subjects included non-smoking women ( n = 368) with available data on maternal PAH exposure, paired cord adducts, and genetic data who resided in Krakow, Poland. We selected eight common variants in maternal and newborn candidate genes related to B[ a ]P metabolism, detoxification, and repair for our analyses: CYP1A1 , CYP1A2 , CYP1B1 , GSTM1 , GSTT2 , NQO1 , and XRCC1 . We observed significant interactions between maternal PAH exposure and SNPs on cord B[ a ]P-DNA adducts in the following genes: maternal CYP1A1 and GSTT2 , and newborn CYP1A1 and CYP1B1 . These novel findings highlight differences in maternal and newborn genetic contributions to B[ a ]P-DNA adduct formation and have the potential to identify at-risk subpopulations who are susceptible to the carcinogenic potential of B[ a ]P., (© The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Published
- 2016
- Full Text
- View/download PDF
10. Estimation of chronic personal exposure to airborne polycyclic aromatic hydrocarbons.
- Author
-
Choi H, Zdeb M, Perera F, and Spengler J
- Subjects
- Environmental Exposure analysis, Humans, Models, Chemical, Poland, Regression Analysis, Seasons, Air Pollutants analysis, Air Pollution statistics & numerical data, Environmental Exposure statistics & numerical data, Polycyclic Aromatic Hydrocarbons analysis
- Abstract
Background: Polycyclic aromatic hydrocarbons (PAH) exposure from solid fuel burning represents an important public health issue for the majority of the global population. Yet, understanding of individual-level exposures remains limited., Objectives: To develop regionally adaptable chronic personal exposure model to pro-carcinogenic PAH (c-PAH) for the population in Kraków, Poland., Methods: We checked the assumption of spatial uniformity in eight c-PAH using the coefficients of divergence (COD), a marker of absolute concentration differences. Upon successful validation, we developed personal exposure models for eight pro-carcinogenic PAH by integrating individual-level data with area-level meteorological or pollutant data. We checked the resulting model for accuracy and precision against home outdoor monitoring data., Results: During winter, COD of 0.1 for Kraków suggest overall spatial uniformity in the ambient concentration of the eight c-PAH. The three models that we developed were associated with index of agreement approximately equal to 0.9, root mean square error < 2.6 ng/m(3), and 90th percentile of absolute difference ≤ 4 ng/m(3) for the predicted and the observed concentrations for eight pro-carcinogenic PAH., Conclusions: Inexpensive and logistically feasible information could be used to estimate chronic personal exposure to PAH profiles, in lieu of costly and labor-intensive personal air monitoring at wide scale. At the same time, thorough validation through direct personal monitoring and assumption checking are critical for successful model development., (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Published
- 2015
- Full Text
- View/download PDF
11. Science as an early driver of policy: child labor reform in the early Progressive Era, 1870-1900.
- Author
-
Perera F
- Subjects
- Child, Employment ethics, Employment legislation & jurisprudence, Environmental Exposure legislation & jurisprudence, Family, History, 19th Century, History, 20th Century, Humans, Morals, New York, Occupational Exposure history, Occupational Exposure legislation & jurisprudence, Social Change, Socioeconomic Factors, Employment history, Environmental Exposure history, Research history
- Abstract
Scientific evidence is an increasingly important driver of social and environmental policy concerning child health. This trend began earlier than generally recognized. The child labor reform movement of the Gilded Age and early Progressive Era reflected not only moral and economic forces but also the dramatic advances during the later decades of the 19th century in scientific knowledge concerning children's biological and psychological vulnerability to environmental and psychosocial stressors. The growing importance of scientific information in shaping policy concerning children's health between 1870 and 1900 is illustrated by the events leading up to and following the New York State Child Labor Law of 1886. Child labor reform during this period was a critical step in the development of a science-based as well as a value-driven movement to protect children's environmental health and well-being that continues today.
- Published
- 2014
- Full Text
- View/download PDF
12. Air pollution effects on fetal and child development: a cohort comparison in China.
- Author
-
Tang D, Li TY, Chow JC, Kulkarni SU, Watson JG, Ho SS, Quan ZY, Qu LR, and Perera F
- Subjects
- Adult, Air Pollutants analysis, Air Pollutants blood, Biomarkers blood, Child Development drug effects, China, Coal, DNA Adducts metabolism, Environmental Exposure statistics & numerical data, Female, Fetal Blood metabolism, Humans, Infant, Newborn, Male, Nervous System drug effects, Nervous System growth & development, Polycyclic Aromatic Hydrocarbons analysis, Polycyclic Aromatic Hydrocarbons blood, Polycyclic Aromatic Hydrocarbons metabolism, Power Plants, Young Adult, Air Pollutants toxicity, Air Pollution statistics & numerical data, Environmental Exposure analysis, Polycyclic Aromatic Hydrocarbons toxicity
- Abstract
In Tongliang, China, a coal-fired power plant was the major pollution source until its shutdown in 2004. We enrolled two cohorts of nonsmoking women and their newborns before and after the shutdown to examine the relationship between prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) and fetal and child growth and development. PAHs were used to measure exposure to air pollution generated by the power plant. Using PAH-DNA adduct levels as biomarkers for the biologically effective dose of PAH exposure, we examined whether PAH-DNA adduct levels were associated with birth outcome, growth rate, and neurodevelopment. Head circumference was greater in children of the second cohort, compared with the first (p = 0.001), consistent with significantly reduced levels of cord blood PAH-DNA adducts in cohort II (p < 0.001) and reduced levels of ambient PAHs (p = 0.01)., (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Published
- 2014
- Full Text
- View/download PDF
13. Molecular Epidemiology, prenatal exposure and prevention of cancer.
- Author
-
Perera F
- Subjects
- DNA drug effects, DNA Damage, Female, Fetus pathology, Gene Expression Regulation, Neoplastic, Humans, Molecular Epidemiology, Neoplasms epidemiology, Pregnancy, Prenatal Exposure Delayed Effects, Risk Factors, Carcinogens, Environmental toxicity, Environmental Exposure, Neoplasms chemically induced, Neoplasms prevention & control
- Abstract
Molecular Epidemiology was originally conceived as a preventive approach, providing a valuable tool for investigating risk factors for cancer in vulnerable populations. Biomarkers can be used as early indicators of risk for preventative purposes and risk assessment. The present contribution mainly refers to in utero exposures to carcinogens, since humans are especially vulnerable during fetal development. Environmental exposures in utero can increase risks for both childhood and adult cancers; their interactions with genetic and nutritional susceptibility factors may further increase risk. Thus, the early developmental period represents an important window for cancer prevention., (© 2011 Perera; licensee BioMed Central Ltd.)
- Published
- 2011
- Full Text
- View/download PDF
14. Prenatal environmental exposures, epigenetics, and disease.
- Author
-
Perera F and Herbstman J
- Subjects
- Animals, DNA Methylation drug effects, DNA Methylation genetics, Disease genetics, Epigenesis, Genetic genetics, Female, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects genetics, Risk Assessment, Disease etiology, Environmental Exposure adverse effects, Environmental Pollutants toxicity, Epigenesis, Genetic drug effects, Prenatal Exposure Delayed Effects chemically induced, Xenobiotics toxicity
- Abstract
This review summarizes recent evidence that prenatal exposure to diverse environmental chemicals dysregulates the fetal epigenome, with potential consequences for subsequent developmental disorders and disease manifesting in childhood, over the lifecourse, or even transgenerationally. The primordial germ cells, embryo, and fetus are highly susceptible to epigenetic dysregulation by environmental chemicals, which can thereby exert multiple adverse effects. The data reviewed here on environmental contaminants have potential implications for risk assessment although more data are needed on individual susceptibility to epigenetic alterations and their persistence before this information can be used in formal risk assessments. The findings discussed indicate that identification of environmental chemicals that dysregulate the prenatal epigenome should be a priority in health research and disease prevention., (Copyright © 2011 Elsevier Inc. All rights reserved.)
- Published
- 2011
- Full Text
- View/download PDF
15. Biomarkers in assessing residential insecticide exposures during pregnancy and effects on fetal growth.
- Author
-
Whyatt RM, Camann D, Perera FP, Rauh VA, Tang D, Kinney PL, Garfinkel R, Andrews H, Hoepner L, and Barr DB
- Subjects
- Adolescent, Adult, Biomarkers, Birth Weight drug effects, Body Height drug effects, Environmental Monitoring, Female, Fetal Blood chemistry, Humans, Infant, Newborn, Insecticides blood, Pregnancy, Environmental Exposure, Fetus drug effects, Insecticides toxicity
- Abstract
The Columbia Center for Children's Environmental Health is using a combination of environmental and biologic measures to evaluate the effects of prenatal insecticide exposures among urban minorities in New York City. Of the 571 women enrolled, 85% report using some form of pest control during pregnancy and 46% report using exterminators, can sprays, and/or pest bombs. Chlorpyrifos, diazinon, and propoxur were detected in 99.7-100% of 48-h personal air samples collected from the mothers during pregnancy (n = 394) and in 39-70% of blood samples collected from the mothers (n = 326) and/or newborns (n = 341) at delivery. Maternal and newborn blood levels are similar and highly correlated (r = 0.4-08, P < 0.001). Levels of insecticides in blood samples and/or personal air samples decreased significantly following the 2000-2001 U.S. Environmental Protection Agency's regulatory actions to phase out residential use of chlorpyrifos and diazinon. Among infants born prior to 1/1/01, birth weight decreased by 67.3 g (95% confidence interval (CI) -116.6 to -17.8, P = 0.008) and birth length decreased by 0.43 centimeters (95% CI, -0.73 to -0.14, P = 0.004) for each unit increase in log-transformed cord plasma chlorpyrifos levels. Combined measures of (ln)cord plasma chlorpyrifos and diazinon (adjusted for relative potency) were also inversely associated with birth weight and length (P = 0.007). Birth weight averaged 215.1 g less (95% CI -384.7 to -45.5) among those with the highest exposures compared to those without detectable levels. No association was seen between birth weight and length and cord plasma chlorpyrifos or diazinon among newborns born after 1/1/01 (P > 0.8). Results support recent regulatory action to phase out residential uses of these insecticides.
- Published
- 2005
- Full Text
- View/download PDF
16. DNA damage from polycyclic aromatic hydrocarbons measured by benzo[a]pyrene-DNA adducts in mothers and newborns from Northern Manhattan, the World Trade Center Area, Poland, and China.
- Author
-
Perera F, Tang D, Whyatt R, Lederman SA, and Jedrychowski W
- Subjects
- Adult, Benzo(a)pyrene analysis, China, Cohort Studies, Female, Humans, Infant, Newborn, Neoplasms epidemiology, New York City, Poland, Pregnancy, Risk Assessment, Benzo(a)pyrene chemistry, Biomarkers analysis, Carcinogens analysis, DNA Adducts, DNA Damage, Environmental Exposure, Maternal-Fetal Exchange, Polycyclic Aromatic Hydrocarbons adverse effects, September 11 Terrorist Attacks
- Abstract
Polycyclic aromatic hydrocarbons (PAH), of which benzo[a]pyrene is a representative member, are combustion-related environmental pollutants and include known carcinogens. Laboratory animal studies indicate that the dose of PAHs to the fetus is on the order of a 10th that to the mother and that there is heightened susceptibility to PAH-induced carcinogenesis during the fetal and infancy periods. Carcinogen-DNA adducts, a measure of procarcinogenic genetic damage, are considered a biomarker of increased cancer risk. Here we compare the levels of benzo[a]pyrene-DNA adducts as a proxy for PAH-DNA damage measured in maternal blood and newborn cord blood obtained at delivery in four different populations of mothers (total of 867) and newborns (total of 822), representing a 30-fold range of exposure to ambient PAHs. The populations include residents in Northern Manhattan, participants in a study of the effects of the World Trade Center disaster, residents in Krakow, Poland, and residents in Tongliang, China. Mean adduct concentrations in both maternal and cord blood and the proportion of samples with detectable adducts, increased across the populations [Northern Manhattan < World Trade Center (WTC) < Krakow < Tongliang], consistent with the trend in estimated ambient exposure to PAHs (P < 0.001). For mothers, the means in the respective populations were Northern Manhattan (0.21 adducts per 10(8) nucleotides), WTC (0.23 adducts per 10(8) nucleotides), Krakow (0.28 adducts per 10(8) nucleotides), Tongliang (0.31 adducts per 10(8) nucleotides); the corresponding means in the newborns were Northern Manhattan (0.23), WTC (0.24), Krakow (0.29), Tongliang (0.31). The percentage of mothers with detectable levels of adducts in the respective populations were Northern Manhattan (36.8%), WTC (57.5%), Krakow (72.9%), Tongliang (73.4%); the corresponding percentages among the newborns were Northern Manhattan (42.4%), WTC (60.6%), Krakow (71.1%), Tongliang (79.5%). Despite the estimated 10-fold lower PAH dose to the fetus based on laboratory animal experiments, the adduct levels in the newborns were similar to or higher than in the mothers. This study suggests that the fetus may be 10-fold more susceptible to DNA damage than the mother and that in utero exposure to polycyclic aromatic hydrocarbons may disproportionately increase carcinogenic risk. The data support preventive policies to limit PAH exposure to pregnant women and children.
- Published
- 2005
- Full Text
- View/download PDF
17. Developmental effects of exposure to environmental tobacco smoke and material hardship among inner-city children.
- Author
-
Rauh VA, Whyatt RM, Garfinkel R, Andrews H, Hoepner L, Reyes A, Diaz D, Camann D, and Perera FP
- Subjects
- Child, Child, Preschool, Cohort Studies, Cotinine blood, Female, Follow-Up Studies, Humans, Lead analysis, Lead blood, Male, Models, Statistical, Pregnancy, Prospective Studies, Reproducibility of Results, Time Factors, Environmental Exposure, Prenatal Exposure Delayed Effects, Social Environment, Tobacco Smoke Pollution adverse effects, Urban Health, Vulnerable Populations psychology
- Abstract
Because of the growing concern that exposures to airborne pollutants have adverse effects on fetal growth and early childhood neurodevelopment, and the knowledge that such exposures are more prevalent in disadvantaged populations, we assessed the joint impact of prenatal exposure to environmental tobacco smoke (ETS) and material hardship on the 2-year cognitive development of inner-city children, adjusted for other sociodemographic risks and chemical exposures. The purpose was to evaluate the neurotoxicant effects of ETS among children experiencing different degrees of socioeconomic disadvantage, within a minority population. The sample did not include children exposed to active maternal smoking in the prenatal period. Results showed significant adverse effects of prenatal residential ETS exposure and the level of material hardship on 2-year cognitive development, as well as a significant interaction between material hardship and ETS, such that children with both ETS exposure and material hardship exhibited the greatest cognitive deficit. In addition, children with prenatal ETS exposure were twice as likely to be classified as significantly delayed, as compared with nonexposed children. Postnatal ETS exposure in the first 2 years of life did not contribute independently to the risk of developmental delay, over and above the risk posed by prenatal ETS exposure. The study concluded that prenatal exposure to ETS in the home has a negative impact on 2-year cognitive development, and this effect is exacerbated under conditions of material hardship in this urban minority sample.
- Published
- 2004
- Full Text
- View/download PDF
18. Health and environmental consequences of the world trade center disaster.
- Author
-
Landrigan PJ, Lioy PJ, Thurston G, Berkowitz G, Chen LC, Chillrud SN, Gavett SH, Georgopoulos PG, Geyh AS, Levin S, Perera F, Rappaport SM, and Small C
- Subjects
- Adult, Animals, Female, Humans, Hydrogen-Ion Concentration, Incidence, Infant, Newborn, Infant, Small for Gestational Age, Lung immunology, Lung pathology, Male, Mice, Middle Aged, New York City, Polycyclic Aromatic Hydrocarbons analysis, Polycyclic Aromatic Hydrocarbons poisoning, Pregnancy, Prevalence, Respiratory Tract Diseases epidemiology, Risk Assessment, Aircraft, Construction Materials, Environmental Exposure, Occupational Exposure, Respiratory Tract Diseases etiology, Terrorism
- Abstract
The attack on the World Trade Center (WTC) created an acute environmental disaster of enormous magnitude. This study characterizes the environmental exposures resulting from destruction of the WTC and assesses their effects on health. Methods include ambient air sampling; analyses of outdoor and indoor settled dust; high-altitude imaging and modeling of the atmospheric plume; inhalation studies of WTC dust in mice; and clinical examinations, community surveys, and prospective epidemiologic studies of exposed populations. WTC dust was found to consist predominantly (95%) of coarse particles and contained pulverized cement, glass fibers, asbestos, lead, polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), and polychlorinated furans and dioxins. Airborne particulate levels were highest immediately after the attack and declined thereafter. Particulate levels decreased sharply with distance from the WTC. Dust pH was highly alkaline (pH 9.0-11.0). Mice exposed to WTC dust showed only moderate pulmonary inflammation but marked bronchial hyperreactivity. Evaluation of 10,116 firefighters showed exposure-related increases in cough and bronchial hyperreactivity. Evaluation of 183 cleanup workers showed new-onset cough (33%), wheeze (18%), and phlegm production (24%). Increased frequency of new-onset cough, wheeze, and shortness of breath were also observed in community residents. Follow-up of 182 pregnant women who were either inside or near the WTC on 11 September showed a 2-fold increase in small-for-gestational-age (SGA) infants. In summary, environmental exposures after the WTC disaster were associated with significant adverse effects on health. The high alkalinity of WTC dust produced bronchial hyperreactivity, persistent cough, and increased risk of asthma. Plausible causes of the observed increase in SGA infants include maternal exposures to PAH and particulates. Future risk of mesothelioma may be increased, particularly among workers and volunteers exposed occupationally to asbestos. Continuing follow-up of all exposed populations is required to document the long-term consequences of the disaster.
- Published
- 2004
- Full Text
- View/download PDF
19. Correspondence re: Gammon et al, Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. 11, 677-685, 2002.
- Author
-
Perera F and Rundle A
- Subjects
- Breast Neoplasms blood, DNA Adducts analysis, DNA Adducts blood, DNA Damage, Female, Humans, New York City epidemiology, Risk Factors, Breast Neoplasms etiology, Environmental Exposure adverse effects, Polycyclic Aromatic Hydrocarbons adverse effects
- Published
- 2003
20. In utero DNA damage from environmental pollution is associated with somatic gene mutation in newborns.
- Author
-
Perera F, Hemminki K, Jedrychowski W, Whyatt R, Campbell U, Hsu Y, Santella R, Albertini R, and O'Neill JP
- Subjects
- Adult, Cross-Sectional Studies, DNA Mutational Analysis, Female, Humans, Infant, Newborn, Male, Poland, Pregnancy, Umbilical Cord, DNA Adducts, DNA Damage, Embryonic and Fetal Development, Environmental Exposure, Environmental Pollutants adverse effects, Hypoxanthine Phosphoribosyltransferase genetics, Maternal-Fetal Exchange
- Abstract
Transplacental exposure to carcinogenic air pollutants from the combustion of fossil fuels is a growing health concern, given evidence of the heightened susceptibility of the fetus. These mutagenic/carcinogenic pollutants include aromatic compounds such as polycyclic aromatic hydrocarbons that bind to DNA, forming chemical-DNA adducts. We have investigated the genotoxic effects of transplacental exposure in humans by analyzing aromatic-DNA adducts and the frequency of gene mutations at the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus in umbilical cord and maternal blood samples. Here we show, in a cross-sectional study of 67 mothers and 64 newborns from the Krakow Region of Poland, that aromatic-DNA adducts measured by (32)P-postlabeling are positively associated with HPRT mutant frequency in the newborns (beta = 0.56, P = 0.03) after controlling for exposure to tobacco smoke, diet, and socioeconomic status. In contrast to the fetus, HPRT mutations and DNA adducts do not reflect similar exposure periods in the mother, and the maternal biomarkers were not correlated. Adducts were higher in the newborn than the mother, indicating differential susceptibility of the fetus to DNA damage; but HPRT mutation frequency was 4-fold lower, consistent with the long lifetime of the biomarker. These results provide the first demonstration of a molecular link between somatic mutation in the newborn and transplacental exposure to common air pollutants, a finding that is relevant to cancer risk assessment.
- Published
- 2002
21. Molecular epidemiology: on the path to prevention?
- Author
-
Perera FP
- Subjects
- Chromosome Aberrations, Health Policy, Humans, Neoplasms genetics, Neoplasms prevention & control, Research Design, Risk, Risk Assessment, Environmental Exposure, Molecular Epidemiology, Neoplasms etiology
- Abstract
Cancer prevention has been the stated goal of molecular cancer epidemiology for the past 17 years. In this review, progress toward that goal is evaluated by using as examples well-studied environmental exposures-i.e., tobacco smoke, polycyclic aromatic hydrocarbons, aflatoxin B(1), benzene, and hepatitis B virus-and their roles in lung, breast, and liver cancers and leukemia. The contributions of molecular epidemiology discussed here include providing evidence that environmental agents pose carcinogenic risks, helping establish the causal roles of environmental factors in cancer, identifying environment-susceptibility interactions and populations at greatest risk, and developing new intervention strategies. Molecular epidemiologic and other data indicate that assessment of carcinogenic risks should address both the range of risk across the population and the risk to subgroups who may be at high risk because of genetic or acquired susceptibilities, including young children. However, for the most part, research results have not yet been effectively translated into risk assessments and preventive health policies. An infrastructure linking scientists, policy makers, and other constituencies is needed to facilitate this process. To extend our knowledge, the second generation of molecular epidemiologic research should include large-scale, collaborative studies incorporating validated biomarkers and automated technologies. An incentive to make the necessary investment is the recognition that prevention of only 20% of cancer in the United States would result in 200000 fewer new cases diagnosed each year and an annual savings of $21.4 billion in direct costs alone.
- Published
- 2000
- Full Text
- View/download PDF
22. Molecular and genetic damage from environmental tobacco smoke in young children.
- Author
-
Tang D, Warburton D, Tannenbaum SR, Skipper P, Santella RM, Cereijido GS, Crawford FG, and Perera FP
- Subjects
- Aminobiphenyl Compounds blood, Black People genetics, Child, Child, Preschool, Cotinine blood, Female, Hispanic or Latino genetics, Humans, Infant, Male, New York City epidemiology, Polycyclic Aromatic Hydrocarbons blood, Sister Chromatid Exchange, White People genetics, Black or African American, Biomarkers blood, Environmental Exposure adverse effects, Neoplasms ethnology, Neoplasms etiology, Tobacco Smoke Pollution adverse effects
- Abstract
To assess the risks of early life exposure to environmental tobacco smoke (ETS), we tested whether four biomarkers in peripheral blood were associated with home ETS exposure in Hispanic and African-American children. The biomarkers included cotinine (a metabolite of nicotine) and three indicators of molecular and genetic damage from mutagens/carcinogens, protein adducts formed by the carcinogens 4-aminobiphenyl (4-ABP) and polycyclic aromatic hydrocarbons (PAHs), and sister chromatid exchanges (SCEs). We also explored possible ethnic differences in biomarkers. The study cohort comprised 109 Hispanic and African-American preschool children (1-6 years of age). Plasma cotinine was analyzed by gas chromatography, 4-ABP-hemoglobin adducts by gas chromatography-mass spectroscopy, PAH-albumin adducts by ELISA, and SCEs by cytogenetic techniques. Data on the amount of smoking by mothers (average 10.5 cigarettes per day) and other household members and regular visitors (average 6.5 cigarettes per day) were obtained by interview-administered questionnaires. Cotinine, 4-ABP-hemoglobin adducts, and PAH-albumin were significantly higher (P < 0.05) in the ETS-exposed children compared with the unexposed. SCEs were marginally higher (P = 0.076). African-American children had higher levels of cotinine (P = 0.059) and PAH-albumin (P = 0.02) than Hispanic children, after controlling for exposure to ETS. These results indicate molecular and genetic damage in minority children with
- Published
- 1999
23. Relationship between ambient air pollution and DNA damage in Polish mothers and newborns.
- Author
-
Whyatt RM, Santella RM, Jedrychowski W, Garte SJ, Bell DA, Ottman R, Gladek-Yarborough A, Cosma G, Young TL, Cooper TB, Randall MC, Manchester DK, and Perera FP
- Subjects
- Adult, Air Pollutants analysis, Biomarkers blood, Cytochrome P-450 CYP1A1 genetics, DNA Adducts blood, Environmental Exposure analysis, Environmental Exposure classification, Enzyme-Linked Immunosorbent Assay, Female, Genotype, Glutathione Transferase genetics, Humans, Infant, Newborn, Linear Models, Matched-Pair Analysis, Maternal Exposure adverse effects, Poland, Polycyclic Aromatic Hydrocarbons analysis, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Pregnancy, Prenatal Exposure Delayed Effects, Retrospective Studies, Smoking adverse effects, Urban Health, Air Pollutants adverse effects, DNA Damage, Environmental Exposure adverse effects
- Abstract
Industrialized regions in Poland are characterized by high ambient pollution, including polycyclic aromatic hydrocarbons (PAHs) from coal burning for industry and home heating. In experimental bioassays, certain PAHs are transplacental carcinogens and developmental toxicants. Biologic markers can facilitate evaluation of effects of environmental PAHs on the developing infant. We measured the amount of PAHs bound to DNA (PAH-DNA adducts) in maternal and umbilical white blood cells. The cohort consisted of 70 mothers and newborns from Krakow, Poland, an industrialized city with elevated air pollution. Modulation of adduct levels by genotypes previously linked to risk of lung cancer, specifically glutathione S-transferase MI (GSTM1) and cytochrome P4501A1 (CYP1A1) Msp restriction fragment length polymorphism (RFLP), was also investigated. There was a dose-related increase in maternal and newborn adduct levels with ambient pollution at the women's place of residence among subjects who were not employed away from home (p < or = 0.05). Maternal smoking (active and passive) significantly increased maternal (p < or = 0.01) but not newborn adduct levels. Neither CYP1A1 Msp nor GSTM1 polymorphisms was associated with maternal adducts. However, adducts were significantly higher in newborns heterozygous or homozygous for the CYP1A1 Msp RFLP compared to newborns without the RFLP (p = 0.04). Results indicate that PAH-induced DNA damage in mothers and newborns is increased by ambient air pollution. In the fetus, this damage appears to be enhanced by the CYP1A1 Mspl polymorphism.
- Published
- 1998
- Full Text
- View/download PDF
24. Children's health and the environment: a new agenda for prevention research.
- Author
-
Landrigan PJ, Carlson JE, Bearer CF, Cranmer JS, Bullard RD, Etzel RA, Groopman J, McLachlan JA, Perera FP, Reigart JR, Robison L, Schell L, and Suk WA
- Subjects
- Child, Environmental Exposure adverse effects, Environmental Exposure statistics & numerical data, Health Policy, Health Transition, Humans, Primary Prevention methods, Research trends, United States, Child Welfare statistics & numerical data, Environmental Exposure prevention & control, Environmental Health standards, Health Promotion methods
- Abstract
Patterns of illness in American children have changed dramatically in this century. The ancient infectious diseases have largely been controlled. The major diseases confronting children now are chronic and disabling conditions termed the "new pediatric morbidity"--asthma mortality has doubled; leukemia and brain cancer have increased in incidence; neurodevelopmental dysfunction is widespread; hypospadias incidence has doubled. Chemical toxicants in the environment as well as poverty, racism, and inequitable access to medical care are factors known and suspected to contribute to causation of these pediatric diseases. Children are at risk of exposure to over 15,000 high-production-volume synthetic chemicals, nearly all of them developed in the past 50 years. These chemicals are used widely in consumer products and are dispersed in the environment. More than half are untested for toxicity. Children appear uniquely vulnerable to chemical toxicants because of their disproportionately heavy exposures and their inherent biological susceptibility. To prevent disease of environmental origin in America's children, the Children's Environmental Health Network (CEHN) calls for a comprehensive, national, child-centered agenda. This agenda must recognize children's vulnerabilities to environmental toxicants. It must encompass a) a new prevention-oriented research focus; b) a new child-centered paradigm for health risk assessment and policy formulation; and c) a campaign to educate the public, health professionals, and policy makers that environmental disease is caused by preventable exposures and is therefore avoidable. To anchor the agenda, CEHN calls for long-term, stable investment and for creation of a national network of pediatric environmental health research and prevention centers.
- Published
- 1998
- Full Text
- View/download PDF
25. Recent developments in molecular epidemiology: A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland.
- Author
-
Perera FP, Whyatt RM, Jedrychowski W, Rauh V, Manchester D, Santella RM, and Ottman R
- Subjects
- Adult, Biomarkers blood, Cotinine blood, DNA Adducts analysis, Female, Humans, Infant, Newborn, Male, Molecular Epidemiology, Poland, Pregnancy, Retrospective Studies, Carcinogens adverse effects, Embryonic and Fetal Development drug effects, Environmental Exposure adverse effects, Polycyclic Aromatic Hydrocarbons adverse effects, Pregnancy Outcome, Prenatal Exposure Delayed Effects
- Abstract
The authors briefly review the current potential and limitations of molecular epidemiology. This approach uses biomarkers to measure the internal and bioeffective dose of toxicants, early biologic effects likely to be predictive of cancer, and variations in individual susceptibility. The most frequent application of biomarkers has been in assessment of exposure/dose and susceptibility due to genetic and nongenetic factors. More research is needed to establish the predictive significance of biomarkers in terms of disease risk. To illustrate that molecular epidemiology has potential in identifying etiologic factors in disease, this article presents data from a recent study of the developmental effects of fetal exposure to polycyclic aromatic hydrocarbons (PAH) via ambient pollution. The study was carried out in an industrialized area of Poland with relatively high levels of PAH pollution from coal burning. PAH-DNA adducts in leukocytes and plasma cotinine were measured in umbilical cord blood as dosimeters of transplacental PAH and cigarette smoke, respectively. The study subjects were 70 newborns from the industrialized city of Krakow and 90 newborns from Limanowa, a rural town with far greater use of coal for home heating. Newborns whose levels of PAH-DNA adducts were above the median (3.85/10[8] nucleotides) had a significantly decreased birth length, weight, and head circumference. Cotinine was significantly inversely associated with birth weight and length. Although preliminary, these results provide a new molecular link between PAH exposure and developmental effects, generating initial data and hypotheses for further study.
- Published
- 1998
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.