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Air pollution effects on fetal and child development: a cohort comparison in China.
- Source :
-
Environmental pollution (Barking, Essex : 1987) [Environ Pollut] 2014 Feb; Vol. 185, pp. 90-6. Date of Electronic Publication: 2013 Nov 13. - Publication Year :
- 2014
-
Abstract
- In Tongliang, China, a coal-fired power plant was the major pollution source until its shutdown in 2004. We enrolled two cohorts of nonsmoking women and their newborns before and after the shutdown to examine the relationship between prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) and fetal and child growth and development. PAHs were used to measure exposure to air pollution generated by the power plant. Using PAH-DNA adduct levels as biomarkers for the biologically effective dose of PAH exposure, we examined whether PAH-DNA adduct levels were associated with birth outcome, growth rate, and neurodevelopment. Head circumference was greater in children of the second cohort, compared with the first (p = 0.001), consistent with significantly reduced levels of cord blood PAH-DNA adducts in cohort II (p < 0.001) and reduced levels of ambient PAHs (p = 0.01).<br /> (Copyright © 2013 Elsevier Ltd. All rights reserved.)
- Subjects :
- Adult
Air Pollutants analysis
Air Pollutants blood
Biomarkers blood
Child Development drug effects
China
Coal
DNA Adducts metabolism
Environmental Exposure statistics & numerical data
Female
Fetal Blood metabolism
Humans
Infant, Newborn
Male
Nervous System drug effects
Nervous System growth & development
Polycyclic Aromatic Hydrocarbons analysis
Polycyclic Aromatic Hydrocarbons blood
Polycyclic Aromatic Hydrocarbons metabolism
Power Plants
Young Adult
Air Pollutants toxicity
Air Pollution statistics & numerical data
Environmental Exposure analysis
Polycyclic Aromatic Hydrocarbons toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1873-6424
- Volume :
- 185
- Database :
- MEDLINE
- Journal :
- Environmental pollution (Barking, Essex : 1987)
- Publication Type :
- Academic Journal
- Accession number :
- 24239591
- Full Text :
- https://doi.org/10.1016/j.envpol.2013.10.019