1. Serum bile acid response to oral glucose is attenuated in patients with early type 2 diabetes and correlates with 2‐hour plasma glucose in individuals without diabetes
- Author
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Xuyi Wang, Chang Chen, Cong Xie, Weikun Huang, Richard L. Young, Karen L. Jones, Michael Horowitz, Christopher K. Rayner, Zilin Sun, Tongzhi Wu, Wang, Xuyi, Chen, Chang, Xie, Cong, Huang, Weikun, Young, Richard L, Jones, Karen L, Horowitz, Michael, Rayner, Christopher K, Sun, Zilin, and Wu, Tongzhi
- Subjects
bile acids ,Blood Glucose ,postprandial glycaemia ,Endocrinology, Diabetes and Metabolism ,Bile Acids and Salts ,Fibroblast Growth Factors ,Glucose ,Endocrinology ,fibroblast growth factor-19 ,glucagon-like peptide-1 ,Diabetes Mellitus, Type 2 ,Glucagon-Like Peptide 1 ,Internal Medicine ,Humans ,Insulin ,type 2 diabetes - Abstract
usc Aim: To determine the serum bile acid (BA) response to 75-g oral glucose in individuals without diabetes, and whether this is attenuated in patients with ‘early’ type 2 diabetes (T2D) and related to the glycaemic response at 2 hours in either group. Methods: Forty newly diagnosed, treatment-naïve Han Chinese T2D subjects and 40 age-, gender-, and body mass index-matched controls without T2D ingested a 75-g glucose drink after an overnight fast. Plasma glucose and serum concentrations of total and individual BAs, fibroblast growth factor-19 (FGF-19), total glucagon-like peptide-1 (GLP-1), and insulin, were measured before and 2 hours after oral glucose. Results: Fasting total BA levels were higher in T2D than control subjects (P
- Published
- 2022