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Summary 1.Arterial hypertension induces changes in the mesenchymal metabolism of rat aortic wall. This can be demonstrated by high increases of [ 35 S]sulfate incorporation into aortic sulfomucopolysaccharides. 2.Arterial hypertension is also accompanied by changes in lipid concentration of the vessel wall. This was shown for cholesterol, palmitic, oleic and linoleic acid, which all show definite increases in concentration. 3.The increase of lipid concentration in the vessel wall is almost entirely due to lipid material penetrating the wall from the blood stream, however it cannot be decided whether this is due to increased inflow or decreased outflow of lipids in the vessel wall. 4.Increased lipid concentration in the vessel wall is not an immediate consequence of arterial hypertension, since it begins developing after intensive changes in the mesenchymal metabolism and in experiments with acute hypertension of short duration even hours after blood pressure has returned to normal values.

Experiments in animals concerning the influence of oestrogens on the metabolism of the mesenchym have shown the stimulating effect of 17β-oestradiol whereas the effect of conjugated oestrogens may result in an inhibition as well as an increase of the metabolic rate of the mesenchym, depending on the different conditions of the performed experiments.

Bei gesunden Mannern sowie bei Patienten mit uberstandenem Myokardinfarkt und mit peripheren Durchblutungsstorungen wurde der 17-β-Oestradiolspiegel uberpruft.

A series of experiments with alloxan-diabetic and control rats was done in order to investigate growth of cotton-pellet granulomas and incorporation rate of35S-sulphate into sulphated mucopolysaccharides of the granulation tissue. — It could be demonstrated that in the alloxan-diabetic animals there was not only markedly less formation of granulation tissue, but a pronounced blocking of synthesis of sulphated mucopolysaccharides in the granulation tissue as well. — These findings are assumed to be caused by the lack of insulin in alloxan diabetes, and to be related to the delayed wound-healing in patients with badly controlled diabetes mellitus.