Tierexperimenteller Beitrag zur gest�rten Wundheilung bei Diabetes mellitus

A series of experiments with alloxan-diabetic and control rats was done in order to investigate growth of cotton-pellet granulomas and incorporation rate of35S-sulphate into sulphated mucopolysaccharides of the granulation tissue. — It could be demonstrated that in the alloxan-diabetic animals there was not only markedly less formation of granulation tissue, but a pronounced blocking of synthesis of sulphated mucopolysaccharides in the granulation tissue as well. — These findings are assumed to be caused by the lack of insulin in alloxan diabetes, and to be related to the delayed wound-healing in patients with badly controlled diabetes mellitus.