1. Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles
- Author
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Hani Manssor Albetran, Mohsen G. Al-Mutary, It Meng Low, Mohammad Kaleem Ahmad, and Gasem Mohammad Abu-Taweel
- Subjects
Sexual behavior ,inorganic chemicals ,medicine.medical_specialty ,Health, Toxicology and Mutagenesis ,Motility ,Apoptosis ,Oxidative phosphorylation ,010501 environmental sciences ,Toxicology ,01 natural sciences ,Silver nanoparticle ,03 medical and health sciences ,0302 clinical medicine ,RA1190-1270 ,Internal medicine ,Spermatotoxicity ,mental disorders ,TBARS ,medicine ,Testosterone ,health care economics and organizations ,0105 earth and related environmental sciences ,Chemistry ,technology, industry, and agriculture ,Regular Article ,respiratory system ,Sperm ,Endocrinology ,Toxicology. Poisons ,Toxicity ,Nanoparticles ,030217 neurology & neurosurgery - Abstract
Graphical abstract Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles. Gasem Mohammad Abu-Taweel, Hani Manssor Albetran, Mohsen Ghaleb Al-Mutary, Mohammad Ahmad, It Meng Low., Highlights • Exposure to silver nanoparticles decreased the weight of the reproductive organs, sexual behavior, oxidative defense parameters, sperm count and their motility in male mice. • In addition, serum testosterone, apoptotic germ cells and testicular histology were also disrupted due to silver nanoparticles. • Yttrium oxide nanoparticles have protective effects on sexual behavior and spermatotoxicity induced by silver nanoparticles in male mice. • The toxicity of silver nanoparticles altered testicular functions that were effectively ameliorated by yttrium oxide nanoparticles., Silver nanoparticles (Ag-NPs) can easily cross through the blood-testis barrier and encourage reproductive dysfunction. This study investigated the protective effects of yttrium oxide nanoparticles (YO-NPs) on sexual behavior and spermatotoxicity induced by Ag-NPs in male mice. Twenty-four male mice were separated into four groups and injected intraperitoneally once a week as the following: group I (Ag-NPs at the dose of 40 mg/kg), group II (YO-NPs at the dose of 40 mg/kg), group III (Ag + YO NPs at the doses of 40 mg/kg, each) and group IV (control; distilled water). After 35 days of the injections, the sexual behavior, oxidative parameters in testis, sperm parameters, serum testosterone, apoptotic germ cells and testicular histology were evaluated. Our findings showed that Ag-NPs decreased the weight of the reproductive organs, sexual behavior, oxidative defense parameters, sperm count and motility of male mice. In addition, the apoptotic cells in testicular cross-sections and TBARS level increased after Ag-NPs exposure when compared to other groups. However, the YO-NPs had protective effects in the studied parameters of testicles and minimized the Ag-NPs toxicity in male mice. In conclusion, the results revealed that the toxicity of Ag-NPS altered testicular functions in male mice that were effectively ameliorated by YO-NPs.
- Published
- 2021