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Effect of monosodium glutamate and aspartame on behavioral and biochemical parameters of male albino mice
- Source :
- African Journal of Biotechnology; Vol 15, No 15 (2016); 601-612
- Publication Year :
- 2016
- Publisher :
- Academic Journals, 2016.
-
Abstract
- The present study aimed to investigate the individual and combined effect of mono-sodium glutamate (MSG) and aspartame (ASM) on biochemical, blood parameters and neuro-behavioral aspects of mice. The results indicated that exposure induced many changes in fear and anxiety behavior. The non-social and social behavior of the exposed mice was significantly affected, showing an increase in the former and a decrease in the later stages, respectively. The elements of social behavior including attack, numbers of fights and bites, naso-nasal and naso-genital contacts were decreased significantly. The latencies to threat and attack and first bite were increased significantly. Locomotor activity and neuromuscular coordination (grip strength) were decreased in treated animals as compared to the control group. There was a significant decrease in the red blood cell count, packed cell volume, hemoglobin concentration, white blood cell count platelets count and testosterone hormone in the treated males. The activity of acetylcholinesterase enzyme decreased as compared to the control. In conclusion, the current study indicated that exposure to food additives MSA and ASM was dangerous to mice in relation to behavior and biochemical analysis. In addition, these food additives need more scientific researches to investigate their effect on other parameters. Key words: Mono-sodium glutamate, mono-sodium aspartame, fear and anxiety, locomotory behavior, grip strength, acetylcholinesterase.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Monosodium glutamate
Mono-sodium glutamate, mono-sodium aspartame, fear and anxiety, locomotory behavior, grip strength, acetylcholinesterase
Applied Microbiology and Biotechnology
03 medical and health sciences
chemistry.chemical_compound
Grip strength
0302 clinical medicine
Internal medicine
White blood cell
Genetics
medicine
Molecular Biology
Testosterone
Aspartame
business.industry
Glutamate receptor
Acetylcholinesterase
030104 developmental biology
Endocrinology
medicine.anatomical_structure
chemistry
Hemoglobin
business
Agronomy and Crop Science
030217 neurology & neurosurgery
Biotechnology
Subjects
Details
- ISSN :
- 16845315
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- African Journal of Biotechnology
- Accession number :
- edsair.doi.dedup.....571aa546117eb166b978bcef9e02bc61