1. Higher ANGPTL3, apoC-III, and apoB48 dyslipidemia, and lower lipoprotein lipase concentrations are associated with dysfunctional visceral fat in adolescents with obesity
- Author
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Reyna Rodríguez-Mortera, Ma. Eugenia Garay-Sevilla, Alejandro Gugliucci, and Russell Caccavello
- Subjects
0301 basic medicine ,medicine.medical_specialty ,Very low-density lipoprotein ,Adolescent ,Clinical Biochemistry ,Intra-Abdominal Fat ,Biochemistry ,03 medical and health sciences ,0302 clinical medicine ,Chylomicron remnant ,Insulin resistance ,Internal medicine ,medicine ,Humans ,Obesity ,Triglycerides ,Angiopoietin-Like Protein 3 ,Dyslipidemias ,Apolipoprotein C-III ,Lipoprotein lipase ,Adiponectin ,business.industry ,Biochemistry (medical) ,General Medicine ,medicine.disease ,Lipoprotein Lipase ,Angiopoietin-like Proteins ,Cross-Sectional Studies ,030104 developmental biology ,Endocrinology ,030220 oncology & carcinogenesis ,lipids (amino acids, peptides, and proteins) ,Metabolic syndrome ,Apolipoprotein B-48 ,business ,Dyslipidemia ,Chylomicron - Abstract
Background We hypothesized that adolescents with obesity have higher remnant B48 concentrations associated with lipoprotein lipase dysregulation. Methods Cross-sectional study of 32 adolescents with obesity and 27 control subjects. Results As compared to lean controls, obese participants showed 35% higher concentrations of apoB48: 3.60 (2.93–4.30) vs 2.65 (1.64–3.68) ng/ml; 28% of apoC-III: (72.7 (58.6–89.7) vs 56.9 (44.8–79.8 ug/ml and 17% ANGPTL 3: (72.2 ± 20.2 vs 61.2 ± 19.2 ng/ml). This was accompanied by a 33% reduction in LPL: 13.1 ± 5.1 vs 18.9 ± 4.7 ng/ml. Obese participants had 25% lower adiponectin 2.9 (1.9–3.8) vs 4.4 (3.2.-5.2) μg/ml; 260% higher leptin 25.7 (11.2–44.8) vs 9.3 (2.8–20.7) ng/ml c and 83% higher Il-6: 2.2 (1.3–5.4) vs 1.2 (0.8–1.4) pg/ml. ApoC-III and ANGPTL3 correlated positively with VAI; ANGPTL3 negatively with HDL-C; LDL size and VLDL-C. ApoB48 correlated negatively with LDL-C. Conclusions Adolescents with obesity show higher ANGPTL3 compounded with increased apoC-III associated with increased CR and lower LPL mass. This is associated with inflammation and visceral fat. The significance of these findings resides in that they shed light on a mechanism for TRL dyslipidemia in adolescents: increased LPL inhibition impairs VLDL and chylomicron catabolism leading to atherogenic remnants.
- Published
- 2020