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Start Over Descriptor "tickborne encephalitis virus" Topic encephalitis, tick-borne
8 results on '"tickborne encephalitis virus"'

1. Virus RNA Load in Patients with Tick-Borne Encephalitis, Slovenia.

Author

Saksida A, Jakopin N, Jelovšek M, Knap N, Fajs L, Lusa L, Lotrič-Furlan S, Bogovič P, Arnež M, Strle F, and Avšič-Županc T

Subjects
Adult, Antibodies, Viral immunology, Female, Humans, Immunoglobulin G immunology, Male, Middle Aged, Phylogeny, Slovenia epidemiology, Encephalitis Viruses, Tick-Borne genetics, Encephalitis Viruses, Tick-Borne immunology, Encephalitis, Tick-Borne epidemiology, Encephalitis, Tick-Borne virology, RNA, Viral, Viral Load
Abstract

We determined levels of tick-borne encephalitis (TBE) virus (TBEV) RNA in serum samples obtained from 80 patients during the initial phase of TBE in Slovenia. For most samples, levels were within the range of 3-6 log 10 copies RNA/mL. Levels were higher in female patients than in male patients, but we found no association between virus load and several laboratory and clinical parameters, including severity of TBE. However, a weak humoral immune response was associated with a more severe disease course, suggesting that inefficient clearance of virus results in a more serious illness. To determine whether a certain genetic lineage of TBEV had a higher virulence potential, we obtained 56 partial envelope protein gene sequences by directly sequencing reverse transcription PCR products from clinical samples of patients. This method provided a large set of patient-derived TBEV sequences. We observed no association between phylogenetic clades and virus load or disease severity.

Published
2018
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2. Tick-Borne Encephalitis in Auvergne-Rhône-Alpes Region, France, 2017–2018

Author

Gilda Grard, Paul O. Verhoeven, Sylvie Pillet, Elisabeth Botelho-Nevers, Claire Bretagne, M. Guerbois-Galla, Sylvie Gonzalo, Alexandra Mailles, Samira Fafi-Kremer, Isabelle Leparc-Goffart, Aurélie Velay, Bruno Pozzetto, Amandine Gagneux-Brunon, Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes (URMITE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR48, INSB-INSB-Centre National de la Recherche Scientifique (CNRS), Université de Saint-Etienne, Virology Laboratory, General Hospital Papageorgiou, Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA), Unité des Virus Emergents (UVE), Aix Marseille Université (AMU)-Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence des Arbovirus [Marseille], Institut de Recherche Biomédicale des Armées [Antenne Marseille] (IRBA)-Unité d'Arbovirologie [Marseille], Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées-Service de Santé des Armées-Hôpital d'Instruction des Armées Laveran, Service de Santé des Armées-Service de Santé des Armées, Université de Picardie Jules Verne (UPJV), Département des maladies infectieuses, Institut de Veille Sanitaire (INVS), Groupe Immunité des Muqueuses et Agents Pathogènes (GIMAP), Université Jean Monnet [Saint-Étienne] (UJM), CHU Saint-Etienne, Interaction virus-hôte et maladies du foie, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne (CHU de Saint-Etienne), Institut des sciences biologiques (INSB-CNRS)-Institut des sciences biologiques (INSB-CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Jean Monnet - Saint-Étienne (UJM), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne] (CHU ST-E), and BUISINE, Soline

Subjects
Male, tickborne encephalitis, Epidemiology, vector-borne infections, lcsh:Medicine, TBE, 0302 clinical medicine, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, 030212 general & internal medicine, tickborne encephalitis virus, Child, ComputingMilieux_MISCELLANEOUS, [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, biology, Lyme borreliosis, Tick-Borne Encephalitis in Auvergne-Rhône-Alpes Region, France, 2017–2018, tick-borne encephalitis, Dispatch, 3. Good health, Tick-borne encephalitis virus, Infectious Diseases, Geography, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Female, France, Encephalitis, Tick-Borne, Encephalitis, Microbiology (medical), tick-borne encephalitis virus, 030231 tropical medicine, Tbe virus, Encephalitis Viruses, Tick-Borne, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, medicine, Animals, Humans, emergence, Serologic Tests, viruses, lcsh:RC109-216, Aged, Ixodes, lcsh:R, Tick-borne encephalitis, medicine.disease, biology.organism_classification, bacterial infections and mycoses, Virology
Abstract

Three autochthonous cases of tick-borne encephalitis (TBE) acquired in rural areas of France where Lyme borreliosis, but not TBE, is endemic highlight the emergence of TBE in new areas. For patients with neurologic involvement who have been in regions where Ixodes ticks circulate, clinicians should test for TBE virus and other tickborne viruses.

Published
2019

3. Virus RNA Load in Patients with Tick-Borne Encephalitis, Slovenia

Author

Petra Bogovič, Lara Lusa, Maja Arnež, Tatjana Avšič-Županc, Stanka Lotric-Furlan, Franc Strle, Luka Fajs, Ana Saksida, Mateja Jelovšek, Nina Jakopin, and Nataša Knap

Subjects
Male, 0301 basic medicine, Epidemiology, Slovenia, vector-borne infections, lcsh:Medicine, Antibodies, Viral, flavivirus, tickborne encephalitis virus, (TBEV), Phylogeny, arbovirus infections, tick-borne encephalitis, Virus RNA Load in Patients with Tick-Borne Encephalitis, Slovenia, Middle Aged, Viral Load, 3. Good health, Flavivirus, Infectious Diseases, arboviruses, RNA, Viral, Female, meningitis/encephalitis, Viral load, Encephalitis, Tick-Borne, Encephalitis, Adult, Microbiology (medical), Virulence, Biology, Virus, Encephalitis Viruses, Tick-Borne, ticks, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, virus RNA, medicine, Humans, viruses, lcsh:RC109-216, tickborne diseases, Gene, Research, lcsh:R, Tick-borne encephalitis, RNA, virus load, medicine.disease, biology.organism_classification, Virology, 030104 developmental biology, Immunoglobulin G
Abstract

We determined levels of tick-borne encephalitis (TBE) virus (TBEV) RNA in serum samples obtained from 80 patients during the initial phase of TBE in Slovenia. For most samples, levels were within the range of 3–6 log10 copies RNA/mL. Levels were higher in female patients than in male patients, but we found no association between virus load and several laboratory and clinical parameters, including severity of TBE. However, a weak humoral immune response was associated with a more severe disease course, suggesting that inefficient clearance of virus results in a more serious illness. To determine whether a certain genetic lineage of TBEV had a higher virulence potential, we obtained 56 partial envelope protein gene sequences by directly sequencing reverse transcription PCR products from clinical samples of patients. This method provided a large set of patient-derived TBEV sequences. We observed no association between phylogenetic clades and virus load or disease severity.

Published
2018

4. Novel Variant of Tickborne Encephalitis Virus, Russia

Author

Valery B. Loktev, E. V. Chausov, Sergey V. Netesov, Vladimir A. Ternovoi, Elena V. Protopopova, Galina N. Leonova, and Dmitry V. Novikov

Subjects
Male, Microbiology (medical), Fatal outcome, Adolescent, Genotype, Epidemiology, Tickborne encephalitis virus, lcsh:Medicine, Biology, polyprotein sequence, Virus, Encephalitis Viruses, Tick-Borne, Russia, lcsh:Infectious and parasitic diseases, TBEV, Fatal Outcome, flavivirus, Phylogenetics, Humans, lcsh:RC109-216, Base sequence, Amino Acid Sequence, Peptide sequence, Phylogeny, Genetics, Base Sequence, lcsh:R, Dispatch, human lethal cases, Virology, Infectious Diseases, genotyping, Tickborne encephalitis, Encephalitis, Tick-Borne
Abstract

We isolated a novel strain of tickborne encephalitis virus (TBEV), Glubinnoe/2004, from a patient with a fatal case in Russia. We sequenced the strain, whose landmark features included 57 amino acid substitutions and 5 modified cleavage sites. Phylogenetically, Glubinnoe/2004 is a novel variant that belongs to the Eastern type of TBEV.

Published
2007

5. Migrating Birds and Tickborne Encephalitis Virus

Author

Jonas Waldenström, Kerstin I. Falk, Gunnel Lindegren, Åke Lundkvist, Bjorn R. Olsen, Ulf Garpmo, Paul D. Haemig, Hans Mejlon, Thord Fransson, Anders Sjöstedt, and Sven Bergström

Subjects
Microbiology (medical), Veterinary medicine, Ixodes ricinus, Epidemiology, Biogeography, long-distance dispersal, lcsh:Medicine, TBE, Virus, lcsh:Infectious and parasitic diseases, ticks, Encephalitis Viruses, Tick-Borne, Birds, TBEV, Zoonoses, biology.animal, parasitic diseases, Animals, lcsh:RC109-216, tickborne encephalitis virus, biogeography, Sweden, Bird Diseases, Ixodes, biology, lcsh:R, Dispatch, biology.organism_classification, Passerine, Infectious Diseases, Arachnid Vectors, Migratory birds, Biological dispersal, Animal Migration, Encephalitis, Tick-Borne
Abstract

During spring and autumn 2001, we screened 13,260 migrating birds at Ottenby Bird Observatory, Sweden, and found 3.4% were infested with ticks. Four birds, each a different passerine species, carried tickborne encephalitis virus (TBEV)–infected ticks (Ixodes ricinus). Migrating birds may play a role in the geographic dispersal of TBEV-infected ticks.

Published
2007

6. Siberian Subtype Tickborne Encephalitis Virus, Finland

Author

Andrey N. Alekseev, Antti Vaheri, Tapani Tikkakoski, Nathalie Y. Uzcátegui, Anu Jääskeläinen, and Olli Vapalahti

Subjects
Adult, Male, Endemic Diseases, Tickborne encephalitis virus, 030231 tropical medicine, Ixodes ricinus, lcsh:Medicine, Ixodes persulcatus, Virus, Encephalitis Viruses, Tick-Borne, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, 0302 clinical medicine, Encephalitis Viruses, medicine, Animals, Humans, lcsh:RC109-216, Child, Finland, Aged, 030304 developmental biology, 0303 health sciences, Ixodes, biology, Reverse Transcriptase Polymerase Chain Reaction, lcsh:R, Arthropod Vectors, dispatch, Middle Aged, medicine.disease, biology.organism_classification, Virology, Siberian subtype TBEV, Female, Tickborne encephalitis, Endemic diseases, Encephalitis, Tick-Borne, Encephalitis
Abstract

We isolated 11 Siberian subtype tickborne encephalitis virus (TBEV) strains from Ixodes persulcatus ticks from a TBEV-endemic focus in the Kokkola Archipelago, western Finland. Thus I. persulcatus and the Siberian TBEV are reported in a focus considerably northwest of their previously known range in eastern Europe and Siberia.

Published
2006

7. Tickborne Encephalitis Virus, Norway and Denmark

Author

Haakon Sjursen, Unn Ljøstad, Sirkka Vene, Irina Golovljova, Åke Lundkvist, Alexander Plyusnin, and Tone Skarpaas

Subjects
Microbiology (medical), tickborne encephalitis, Epidemiology, Denmark, 030231 tropical medicine, Tbe virus, lcsh:Medicine, Norwegian, Biology, Virus, Encephalitis Viruses, Tick-Borne, lcsh:Infectious and parasitic diseases, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Animals, lcsh:RC109-216, tickborne encephalitis virus, Phylogeny, 0303 health sciences, Ixodes, Norway, 030306 microbiology, lcsh:R, Dispatch, biology.organism_classification, Virology, language.human_language, 3. Good health, Denmark, dispatch, Infectious Diseases, language, RNA, Viral, Tickborne encephalitis, Encephalitis, Tick-Borne
Abstract

Serum from 2 Norwegians with tickborne encephalitis (TBE) (1 of whom was infected in Denmark) and 810 Norwegian ticks were tested for TBE virus (TBEV) RNA by reverse transcription-polymerase chain reaction. Sequencing and phylogenetic analysis were performed. This is the first genome detection of TBEV in serum from Norwegian patients.

Published
2006

8. Tickborne Encephalitis in Naturally Exposed Monkey (Macaca sylvanus)

Author

Jochen Süss, Ellen Gelpi, Audrey Bagon, Helmut Hotzel, Werner E. G. Müller, Elisabeth M. Liebler-Tenorio, Bernhard Stark, Herbert Budka, and Christine Klaus

Subjects
Microbiology (medical), tickborne encephalitis, Fatal outcome, Endemic Diseases, Animals zoo, Epidemiology, Tbe virus, lcsh:Medicine, Encephalitis Viruses, Tick-Borne, lcsh:Infectious and parasitic diseases, Area at risk, Fatal Outcome, flavivirus, Germany, Animals, lcsh:RC109-216, tickborne encephalitis virus, biology, Macaca sylvanus, lcsh:R, Dispatch, Brain, European subtype, biology.organism_classification, Virology, natural infection, Flavivirus, Infectious Diseases, Macaca, Animals, Zoo, Female, Tickborne encephalitis, monkey, Encephalitis, Tick-Borne
Abstract

We describe tickborne encephalitis (TBE) in a monkey (Macaca sylvanus) after natural exposure in an area at risk for TBE. TBE virus was present in the brain and could be identifi ed as closely related to the European subtype, strain Neudoerfl .

Published
2007

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