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Start Over Author "Gay, Robert D." Topic electric fields
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1. Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down" (Adv. Sci. 30/2024).

Author

Pinyon, Jeremy L., von Jonquieres, Georg, Crawford, Edward N., Abed, Amr Al, Power, John M., Klugmann, Matthias, Browne, Cherylea J., Housley, David M., Wise, Andrew K., Fallon, James B., Shepherd, Robert K., Lin, John Y., McMahon, Catherine, McAlpine, David, Birman, Catherine S., Lai, Waikong, Enke, Ya Lang, Carter, Paul M., Patrick, James F., and Gay, Robert D.

Subjects
NUCLEIC acids, PARKINSON'S disease, NERVOUS system regeneration, ELECTRIC fields, COCHLEA, ION channels
Abstract

The article titled "Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: 'A Spoonful of Sugar Helps the Medicine Go Down'" discusses a new technique called conductivity-clamped gene electrotransfer (CC-GET) that allows for the delivery of nucleic acid therapeutics without the need for vectors. The authors conducted preclinical studies and found that CC-GET was effective in delivering neurotrophin-encoding plasmid DNA to the cochlea, leading to auditory nerve regeneration in deafened individuals. Additionally, CC-GET enabled targeted expression of photo-activated ion channels in the brain, which could be relevant for the treatment of Parkinson's Disease. The article is authored by a team of researchers and scientists. [Extracted from the article]

Published
2024
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