Gene Electrotransfer via Conductivity‐Clamped Electric Field Focusing Pivots Sensori‐Motor DNA Therapeutics: "A Spoonful of Sugar Helps the Medicine Go Down" (Adv. Sci. 30/2024).

The article titled "Gene Electrotransfer via Conductivity-Clamped Electric Field Focusing Pivots Sensori-Motor DNA Therapeutics: 'A Spoonful of Sugar Helps the Medicine Go Down'" discusses a new technique called conductivity-clamped gene electrotransfer (CC-GET) that allows for the delivery of nucleic acid therapeutics without the need for vectors. The authors conducted preclinical studies and found that CC-GET was effective in delivering neurotrophin-encoding plasmid DNA to the cochlea, leading to auditory nerve regeneration in deafened individuals. Additionally, CC-GET enabled targeted expression of photo-activated ion channels in the brain, which could be relevant for the treatment of Parkinson's Disease. The article is authored by a team of researchers and scientists. [Extracted from the article]