1. A clinically and genomically annotated nerve sheath tumor biospecimen repository
- Author
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Xengie Doan, Christine A. Pratilas, Fausto J. Rodriguez, Kai Pollard, Allan J. Belzberg, Carol D. Morris, Christian F. Meyer, Bronwyn Slobogean, Xindi Guo, Robert J. Allaway, Jineta Banerjee, David M. Loeb, Sara J. C. Gosline, Jaishri O. Blakeley, Shannon Langmead, Justin Guinney, and Jiawan Wang
- Subjects
Statistics and Probability ,Data Descriptor ,Neurofibromatosis 1 ,Biospecimen ,Nerve sheath ,Library and Information Sciences ,Bioinformatics ,Nerve Sheath Neoplasms ,Education ,Unmet needs ,Transcriptome ,03 medical and health sciences ,Gene expression analysis ,0302 clinical medicine ,Cell Line, Tumor ,medicine ,Sequencing ,Humans ,In patient ,Neurofibromatosis ,lcsh:Science ,030304 developmental biology ,0303 health sciences ,Heterogeneous group ,business.industry ,High-Throughput Nucleotide Sequencing ,Genomics ,medicine.disease ,Standardization ,Paediatric neurological disorders ,Computer Science Applications ,Nerve sheath tumor ,030220 oncology & carcinogenesis ,Cohort ,lcsh:Q ,Statistics, Probability and Uncertainty ,business ,Information Systems - Abstract
Nerve sheath tumors occur as a heterogeneous group of neoplasms in patients with neurofibromatosis type 1 (NF1). The malignant form represents the most common cause of death in people with NF1, and even when benign, these tumors can result in significant disfigurement, neurologic dysfunction, and a range of profound symptoms. Lack of human tissue across the peripheral nerve tumors common in NF1 has been a major limitation in the development of new therapies. To address this unmet need, we have created an annotated collection of patient tumor samples, patient-derived cell lines, and patient-derived xenografts, and carried out high-throughput genomic and transcriptomic characterization to serve as a resource for further biologic and preclinical therapeutic studies. In this work, we release genomic and transcriptomic datasets comprised of 55 tumor samples derived from 23 individuals, complete with clinical annotation. All data are publicly available through the NF Data Portal and at http://synapse.org/jhubiobank., Measurement(s)gene expression • gene_variantTechnology Type(s)RNA sequencing • exome sequencing • DNA sequencingFactor Type(s)tumor typeSample Characteristic - OrganismHomo sapiens • Homo sapiens/Mus musculus xenograft Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.12037599
- Published
- 2019