Back to Search
Start Over
A clinically and genomically annotated nerve sheath tumor biospecimen repository
- Source :
- Scientific Data, Vol 7, Iss 1, Pp 1-9 (2020), Scientific Data
- Publication Year :
- 2019
- Publisher :
- Cold Spring Harbor Laboratory, 2019.
-
Abstract
- Nerve sheath tumors occur as a heterogeneous group of neoplasms in patients with neurofibromatosis type 1 (NF1). The malignant form represents the most common cause of death in people with NF1, and even when benign, these tumors can result in significant disfigurement, neurologic dysfunction, and a range of profound symptoms. Lack of human tissue across the peripheral nerve tumors common in NF1 has been a major limitation in the development of new therapies. To address this unmet need, we have created an annotated collection of patient tumor samples, patient-derived cell lines, and patient-derived xenografts, and carried out high-throughput genomic and transcriptomic characterization to serve as a resource for further biologic and preclinical therapeutic studies. In this work, we release genomic and transcriptomic datasets comprised of 55 tumor samples derived from 23 individuals, complete with clinical annotation. All data are publicly available through the NF Data Portal and at http://synapse.org/jhubiobank.<br />Measurement(s)gene expression • gene_variantTechnology Type(s)RNA sequencing • exome sequencing • DNA sequencingFactor Type(s)tumor typeSample Characteristic - OrganismHomo sapiens • Homo sapiens/Mus musculus xenograft Machine-accessible metadata file describing the reported data: 10.6084/m9.figshare.12037599
- Subjects :
- Statistics and Probability
Data Descriptor
Neurofibromatosis 1
Biospecimen
Nerve sheath
Library and Information Sciences
Bioinformatics
Nerve Sheath Neoplasms
Education
Unmet needs
Transcriptome
03 medical and health sciences
Gene expression analysis
0302 clinical medicine
Cell Line, Tumor
medicine
Sequencing
Humans
In patient
Neurofibromatosis
lcsh:Science
030304 developmental biology
0303 health sciences
Heterogeneous group
business.industry
High-Throughput Nucleotide Sequencing
Genomics
medicine.disease
Standardization
Paediatric neurological disorders
Computer Science Applications
Nerve sheath tumor
030220 oncology & carcinogenesis
Cohort
lcsh:Q
Statistics, Probability and Uncertainty
business
Information Systems
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Scientific Data, Vol 7, Iss 1, Pp 1-9 (2020), Scientific Data
- Accession number :
- edsair.doi.dedup.....eaa041c8701768f27ddf7d57f7535dd8