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A study conducted at QILU University of Technology in Jinan, People's Republic of China, explores the use of Human Serum Albumin (HSA) as a carrier for photodynamic and photothermal therapy in tumor treatment. The research highlights the advantages of HSA delivery in targeted therapy with less trauma, but also notes limitations such as the dependence on dosage and tissue penetration. The study aims to enhance photosensitizers and photothermal converting agents for improved cancer diagnosis and treatment. [Extracted from the article]

A recent report from QILU University of Technology in Jinan, People's Republic of China, discusses the advancements in noble metal-based single-atom nanozymes for biomedical applications. Nanozymes are nanomaterials designed to mimic enzyme activities with durability, low cost, and tunable catalytic properties. Single-atom nanozymes have shown excellent catalytic performance in biosensing, antibacterial, and tumor therapy, offering promising applications in various fields. The study highlights the potential of noble metal-based single-atom nanozymes in biomedicine and addresses the challenges and future prospects in this area. [Extracted from the article]

Researchers from Shandong University in Jinan, China, conducted a study on Fusobacterium nucleatum, a bacterium associated with dental plaques. They evaluated the effectiveness of bioactive compounds from Salvadora persica (chewing stick) against this bacterium using in-silico methods. The study found promising results, suggesting that these compounds could be used as an alternative therapy for managing Fusobacterium nucleatum-related oral diseases. Financial support for the research came from Princess Nourah bint Abdulrahman University. [Extracted from the article]

A recent study from Shandong Jianzhu University in Jinan, People's Republic of China, focused on the application of activated carbon-immobilized laccase for degrading tetracycline in wastewater. The research highlighted the effectiveness of this enzymatic degradation method, showcasing high removal rates of tetracycline using the Laccase@AC system. The study emphasized the potential of immobilized laccase as a biocatalyzer for treating antibiotic-contaminated wastewater, offering a cost-effective and eco-friendly solution. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China, have isolated new secondary metabolites from Penicillium christenseniae SD.84, including two quinolone alkaloid enantiomers. These compounds showed antimicrobial activity against Staphylococcus aureus and methicillin-resistant S. aureus. The study highlights the potential of Penicillium sp. as a source of new antimicrobial agents, contributing to the fight against drug-resistant bacteria. The research has been peer-reviewed and published in Natural Product Research. [Extracted from the article]

Researchers at Shandong Cancer Hospital and Institute in Jinan, China, have found that the combination of fluconazole with natural compounds shows promise in managing resistant Candida albicans infections. Candida albicans is a pathogenic fungus responsible for many invasive fungal infections, and its resistance to fluconazole poses a significant challenge. The study identified 48 natural antifungal compounds that, when combined with fluconazole, exhibit synergistic effects against Candida albicans, offering new therapeutic options and insights into reversing resistance. This research has been peer-reviewed and provides valuable information for combating fungal infections. [Extracted from the article]

A recent report from Shandong Normal University in Jinan, People's Republic of China, discusses the development of quasi-intrinsic photosensitizers for dual-function fluorescence imaging and photodynamic therapy. The study focuses on enhancing two-photon absorption and fluorescence emission for tumor localization, as well as improving the generation of superoxide anions and singlet oxygen. This research, supported by various foundations, highlights the potential of these new photosensitizers in advancing phototherapy techniques. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, People's Republic of China, focused on addressing challenges in treating oral squamous cell carcinoma (OSCC) by utilizing spatial dimension conversion drug delivery systems. The research introduced an innovative approach combining photodynamic therapy and tumor immunotherapy to enhance drug penetration and induce significant therapeutic outcomes. The study concluded that this approach shows promise for future OSCC therapeutic interventions. The findings were published in Chinese Chemical Letters and have been peer-reviewed. [Extracted from the article]

A study conducted at Shandong University in Jinan, People's Republic of China, explored the impact of probiotic supplementation combined with bismuth-containing quadruple therapy on gut microbiota during Helicobacter pylori eradication. The research involved 100 H. pylori-positive patients who were randomly assigned to receive either the probiotic or a placebo. The study found that probiotic supplementation helped mitigate antibiotic-induced alterations in gut microbiota and alleviated gastrointestinal symptoms, showcasing the potential benefits of probiotics in such treatments. [Extracted from the article]

Researchers at Shandong University in Jinan, China, have developed a novel sodium alginate composite hydrogel with a dual cross-linking mechanism for creating adhesive microneedle patches. This new technology addresses issues with conventional microneedle patches by improving surface morphology and mechanical properties, resulting in better drug delivery efficacy and mechanical robustness. The microneedle patch demonstrated excellent water adhesion and efficient drug release within 15 minutes, showing promise for transdermal drug delivery and reducing the workload of healthcare professionals. The study has been peer-reviewed and published in Colloids and Surfaces A Physicochemical and Engineering Aspects. [Extracted from the article]

Researchers from Shandong Normal University in Jinan, People's Republic of China, have developed a new hydrophobic surface-enhanced Raman scattering (SERS) strategy using superhydrophobic ZnO/Ag nanowires to monitor trace antibiotics in harsh water environments. This innovative approach concentrates dispersed molecules in water and enhances the electric field, improving detection sensitivity and anti-interference capabilities. The study demonstrates the potential application of this platform in various real-time detection scenarios, such as monitoring antibiotics in corrosive urine and flowing wastewater. The research, published in ENERGY & ENVIRONMENTAL MATERIALS, highlights the synergistic enhancement of in situ SERS performance under aqueous conditions and offers insights for improving analytical techniques. [Extracted from the article]

Researchers at Shandong University in Jinan, China, have found that the level of nicotinamide adenine dinucleotide (NAD+) is decreased in the plasma and CD4+ T cells of patients with immune thrombocytopenia (ITP). By supplementing with NAD+ precursor nicotinamide (NAM), Treg frequency increased, ameliorating thrombocytopenia in an ITP murine model. NAM promoted Foxp3 acetylation and stability in induced Tregs, suggesting it as a potential therapeutic strategy for restoring immune balance in ITP. [Extracted from the article]

A study conducted at the School of Stomatology in Jinan, People's Republic of China, explored the effects of Y27632 on tongue squamous cell carcinoma (TSCC) cells. The research found that Y27632 effectively inhibited the proliferation of TSCC cells in vitro and in vivo, inducing apoptosis through the MAPK-ERK/JNK signaling pathway. This study suggests that Y27632 could be a potential therapeutic drug for TSCC treatment in the future. [Extracted from the article]

A study conducted at QILU University of Technology in Jinan, People's Republic of China, focused on the degradation of high-concentration tetracycline (TC) in the environment. The research introduced a method using Fe/N-doped biochar activated by peroxymonosulfate (PMS) to achieve a 90.56% removal efficiency of TC within 60 minutes. The study highlighted the catalytic mechanism of PMS activation through both radical and non-radical pathways, offering a cost-effective and efficient approach to treating high-concentration TC. This research was funded by the National Natural Science Foundation of China and the Talent Research Project of Qilu University of Technology. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, People's Republic of China, focused on the use of biocompatible carbon nanozymes to regulate reactive oxygen species (ROS) balance for treating wounds infected with drug-resistant bacteria. The research demonstrated that the carbon nanozymes could effectively balance ROS generation based on changes in pH at the wound site, leading to successful antimicrobial efficiency against drug-resistant bacteria while minimizing oxidative damage to normal tissues. This study, published in the Chemical Engineering Journal, highlights a promising approach for developing adaptive therapeutic platforms for treating bacterial infections in wounds. [Extracted from the article]

A case report from Jinan, People's Republic of China, discusses the successful treatment of the first recorded case of pulmonary mixed infection in a diabetic girl involving Aspergillus and Mucor. The patient initially underwent treatment with voriconazole, but the infection worsened, leading to a combined treatment regimen of AmB liposomes and isavuconazole that effectively eradicated the fungal infection. The research emphasizes the importance of early and precise identification of fungal pathogens, determination of effective antifungal medications, and timely implementation of well-planned therapeutic strategies. [Extracted from the article]

Researchers from QILU University of Technology in Jinan, China, have conducted a study on nanosuspension for improved transdermal targeted drug delivery systems. The research highlights the benefits of nanosuspension, such as high drug loading and improved skin penetration, in enhancing drug absorption and bioavailability. The study emphasizes the potential of nanosuspension technology in transdermal drug delivery and provides insights into future challenges and prospects in this field. This peer-reviewed research offers valuable information for those interested in nanosuspension technology for drug delivery. [Extracted from the article]

Research conducted at Shandong Provincial Hospital in Jinan, China, has explored the protective effects of gastrodin against gentamicin-induced vestibular damage through the Notch signaling pathway. Gentamicin, a commonly used antibiotic, can lead to ototoxicity and balance issues, but gastrodin showed promise in alleviating these impairments in mice. The study highlights the potential of gastrodin as a therapeutic agent for preventing vestibular injuries caused by gentamicin. This research has been peer-reviewed and provides valuable insights into the modulation of the Notch signaling pathway in protecting against drug-induced vestibular dysfunction. [Extracted from the article]

A study conducted at Shandong University in Jinan, China, has found that 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a safe and effective treatment for women with intractable vulvar lichen sclerosus (VLS). VLS is a chronic inflammatory skin disease of the vulva that causes symptoms such as itching, burning, and dyspareunia. The study analyzed the data of 36 patients with VLS who received ALA-PDT treatment and found that the therapy significantly improved symptoms and quality of life for the majority of patients. The main side effects of the treatment were transient and tolerable. [Extracted from the article]

A study conducted by researchers at the University of Jinan in China explores the use of nanoengineered biomaterials for stem cell therapy in regenerative medicine. Stem cells have the potential for tissue repair and regeneration, but their limited spontaneous differentiation makes it difficult to harness their full potential without external intervention. Nanoengineered biomaterials offer a solution by solidifying and nanosizing regulating molecules and ions, facilitating their uptake by stem cells. This approach has shown promising results and has the potential to enhance clinical stem cell therapy. The study provides an overview of the design principles, categories, and characteristics of nanoparticles, as well as their application in tissue repair and regeneration. The researchers also discuss the prospects and challenges of using nanoengineered biomaterials in clinical practice. [Extracted from the article]

Researchers at the Shandong Academy of Agricultural Sciences in Jinan, China have conducted a study on the immunomodulatory effects of Lactarius deliciosus, a mushroom known for its taste and texture. The study focused on the polysaccharide extracted from the mushroom and its impact on tumor-bearing mice. The results showed that the polysaccharide had a positive effect on the immune organs of the mice, suppressed tumor growth, and improved intestinal lactobacillus contents. The findings suggest potential applications of Lactarius deliciosus polysaccharide in the food and drug industries. [Extracted from the article]

A report from QILU University of Technology in Jinan, China discusses the efficient removal of non-steroidal anti-inflammatory drugs (NSAIDs) from water systems. The researchers synthesized a magnetic LDH with a three-dimensional hollow structure to remove carprofen and flurbiprofen from water environments. The study found that the adsorption capacity of the synthesized material for the two NSAIDs was high, making it a promising adsorbent for NSAIDs. The research provides valuable insights into the removal of emerging pollutants from aquatic environments. [Extracted from the article]

Researchers at Shandong University in Jinan, China have conducted a study on the impact of miR-137-3p on the pathogenesis of Alzheimer's disease (AD) and developed a novel drug delivery system for its therapeutic potential. The study found that miR-137-3p deficiency is present in both AD cells and animal models. The researchers engineered lipid nanoparticles (LNPs) functionalized with rabies virus glycoprotein to deliver miR-137-3p across the blood-brain barrier and target neurons, resulting in increased miR-137-3p levels in the hippocampus of AD mice. The study suggests that miR-137-3p could be a key factor in AD pathogenesis and a potential avenue for treatment. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, explored the role of autophagy and immunity in Wilms' tumor (WT), a type of malignant tumor. The study aimed to identify differentially expressed immune genes related to autophagy in WT and analyze their correlation with disease prognosis. The researchers found that the plasminogen activator urokinase (PLAU) gene was associated with survival and prognosis in WT patients and could serve as an independent prognostic biomarker. The study also provided insights into the pathways associated with PLAU gene expression, which could be valuable for the development of new therapies for WT. [Extracted from the article]

A recent study conducted at Shandong University in Jinan, China, has explored the use of endoplasmic reticulum (ER)-targeted photosensitizers for photodynamic immunotherapy. The researchers aimed to address the limitations of current agents, such as the slow intersystem crossing process and insufficient production of reactive oxygen species (ROS). By modifying the excited state characteristics of xanthene-based cyanine photosensitizers, the researchers were able to optimize ROS generation and activate the immunogenic cell death pathway. The results showed significant inhibition of both primary and distant tumors, highlighting the potential efficacy of this strategy for developing photodynamic immunotherapy drugs. This research provides a pioneering pathway for the design of such drugs. [Extracted from the article]

A systematic review and meta-analysis conducted by researchers at Shandong University of Traditional Chinese Medicine in Jinan, China, examined the efficacy of acupuncture combined with medication in the treatment of sciatica. The review analyzed relevant literature from various databases and found that acupuncture combined with medication reduced pain and improved the overall effectiveness and cure rate of sciatica treatment. However, the researchers concluded that larger-scale and multi-center randomized controlled trials are needed to confirm these findings. This study provides valuable insights into the potential benefits of acupuncture in managing sciatica. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, has developed a new class of drugs for the treatment of cancer. The study focused on the development of a dual inhibitor that targets two enzymes involved in epigenetic regulation, DNMT1 and HDAC. The compound (R)-23a showed promising results in inhibiting these enzymes and reactivating tumor suppressor genes, leading to significant tumor growth inhibition in mouse models. The researchers believe that (R)-23a has the potential to be further developed as a cancer therapeutic agent. [Extracted from the article]

A recent report from Shandong University of Traditional Chinese Medicine in Jinan, China discusses the challenges of delivering drugs to the brain due to the blood-brain barrier (BBB). The researchers review various strategies for crossing the BBB, including receptor/transporter-mediated crossing, focused ultrasound, adenosine agonist reversible opening, aromatic resuscitation, transnasal administration, cell-mediated crossing, and viral vector system-mediated delivery. The potential applications, advantages, and disadvantages of these strategies are analyzed, and the researchers conclude that these strategies hold promise for treating brain diseases. This research has been peer-reviewed and provides valuable insights into gene therapy and drug delivery for brain diseases. [Extracted from the article]

Researchers at the University of Jinan in China have developed a method for precisely manipulating steric hindrance in DNA walkers to detect microRNA-21 (miR-21) with tunable dynamic range and sensitivity. By adjusting the length of empty bases and the volumetric dimensions of the hairpin structure, the researchers achieved a tunable limit of detection for miR-21 ranging from 3.6 aM to 35.6 nM, with successful identification of cancer cells and clinical serum samples. This novel strategy has potential applications in personalized medicine, early disease detection, and drug development. The research has been peer-reviewed and published in Analytical Chemistry. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China have conducted a study on the solubility properties of the antiviral drug Molnupiravir (MPV). The researchers measured the solubility of MPV in 15 different solvents and found that it was highest in cyclohexanone and lowest in ethyl formate. They also used thermodynamic models and molecular simulation techniques to analyze the solubility data and determine the interactions between MPV and the solvents. The results of this study can provide guidance for optimizing the crystallization process of MPV. [Extracted from the article]

A report from the University of Jinan in China discusses the synthesis and evaluation of novel 1,2,3,4-tetrahydrofi-carboline (THfiC) derivatives as potential antibacterial agents. The study aimed to find new antibacterial drugs due to the increasing problem of antibiotic resistance. The researchers synthesized a series of THfiC derivatives and tested their antibacterial activity against both gram-positive and gram-negative bacteria. Some of the compounds showed promising efficacy against methicillin-resistant Staphylococcus aureus (MRSA) and demonstrated rapid bactericidal action. However, one of the compounds also showed significant cytotoxicity towards human cells. The study suggests that THfiC derivatives have potential applications in the development of antibacterial drugs. [Extracted from the article]

A study conducted by Shandong First Medical University in Jinan, China, examined the association between global longitudinal strain (GLS) and cardiovascular events in pediatric patients undergoing high-dose cyclophosphamide chemotherapy. The study found that GLS after chemotherapy may be a reliable indicator for predicting cardiovascular events in these patients. The research suggests that this information could be crucial in optimizing treatment strategies for this high-risk patient group. The study was published in Translational Pediatrics and has been peer-reviewed. [Extracted from the article]

Researchers at Shandong University in Jinan, China have developed a novel class of SHP2 allosteric inhibitors with a furanyl amide-based scaffold, which show promising potential as antitumor therapies. SHP2 plays a critical role in tumor growth and the PD-1-related signaling pathway, making it an attractive target for cancer treatment. The newly developed inhibitor, SDUY038, demonstrated potent binding affinity and enzymatic activity, as well as pan-antitumor activity in cellular and animal models. This research offers new lead compounds for the development of antitumor drugs targeting SHP2. [Extracted from the article]

A recent study conducted by researchers at Shandong University in Jinan, China, explores the immunomodulatory mechanism involved in chronic rhinosinusitis with nasal polyps (CRSwNP). The study focuses on the regulatory role of dendritic cells (DCs) and the impact of microRNA-124 (miR-124) on DCs in this context. The researchers used primary cultures of nasal mucosa from CRSwNP patients and normal nasal mucosa from non-rhinitis patients to examine the interaction between miR-124 and the target gene Rab27a. The findings suggest potential therapeutic targets for the treatment of CRSwNP. [Extracted from the article]

A recent study conducted in Jinan, People's Republic of China, has revealed new findings on hernia repair. The study focused on the development of a gel-modified mesh that can effectively address issues such as bacterial infection, postoperative adhesion, and foreign body reaction. The gel-modified mesh, known as the Janus mesh, demonstrated asymmetric performances, with one side maintaining intact gel structures to hinder the stick of proteins and cells, while the other side accelerated degradation to combat bacterial infection. In vivo experiments showed promising results, with no detectable adhesions on the Janus mesh treated group and lower levels of inflammatory response compared to commercial mesh. This research provides a new approach for soft tissue repair biomaterials. [Extracted from the article]

Researchers at QILU University of Technology in Jinan, China have developed bio-based films for potential use as wound dressings. These films incorporate silver nanoparticles (AgNPs) and have high antibacterial properties and low drug resistance. The films also exhibit high UV blocking and antioxidant properties, increased tensile strength, and good biocompatibility. They have shown antibacterial activity against E. coli and S. aureus, making them promising candidates for wound dressings. The research was supported by the Foundation of State Key Laboratory of Biobased Material and Green Papermaking. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital in Jinan, People's Republic of China, examined the effectiveness of piperacillin/tazobactam (PIP/TAZ) in treating lower respiratory tract bacterial infections in children. The study found that the current dosing regimen of PIP/TAZ resulted in subtherapeutic drug concentrations in most children. The researchers concluded that alternative therapies or optimized dosing regimens should be explored. This research was supported by various funding sources, including the National Key R&D Program of China and the National Natural Science Foundation of China. [Extracted from the article]

Researchers from Shandong University in Jinan, People's Republic of China, have conducted a study on anti-infectives. They have developed a bioinspired skeletal reconstruction approach that allows for the synthesis of platensilin, platensimycin, and platencin, which are potential inhibitors of beta-ketoacyl-acyl carrier protein synthase (FabF) in the bacterial and mammalian fatty acid synthesis system. These compounds show promise as drug leads for antibacterial and antidiabetic therapies. The researchers have also prepared analogs with different polycyclic scaffolds, and one of these analogs has demonstrated improved antibacterial activity against S. aureus compared to platensimycin. The study has been published in the Journal of the American Chemical Society. [Extracted from the article]