Search

Four compounds isolated from the rhizomes of Drynaria propinqua collected in Sichuan have been identified. One of them was a new natural product, namely propinqualin, whose structure was established as (-)-epiafzelechin-3-O-beta-D-allopyranoside. The other three were 4-O-beta-D-glucopyranosyl caffeic acid, beta-sitosterol-3-O-beta-D-glucopyranoside and sucrose.

A new highly oxygenated iridoid, lamiophlomiol C isolated from the alcohol soluble fraction of the roots of Lamiophlomis rotata (Labiatae), was shown to have the molecular formula C11H14O7. On the basis of UV, IR, MS and NMR spectroscopic data, particularly X-ray crystallographlic analysis, structure I has been assigned to this iridoid.

Two new highly oxygenated iridoids, named lamiophlomiol A and B, were isolated from an alcohol extract of the roots of Lamiophlomis rotata (Labiatea) by silica gel G column chromatography. Lamiophlomiol A and B are two epimers. Their structures were elucidated to be Ia and Ib with spectroscopic and chemical analysis.

Two new oleanane type triterpene glycosides, named yiyeliangwanoside I and yiyeliangwanoside II, were isolated from Nothopanax davidii (Franch) Harms (Araliaceae). Their chemical structures were elucidated by means of chemical and spectrometric analysis. Yiyeliangwanoside I: C57H88O25, a white powder, mp 203-205 degrees C (dec.), [alpha]D20-3.47(c 0.1, CH3OH). Its structure was determined as 3-O-alpha-(3',4'-O-dioic-acetyl)-L-arabinopyranosyl-3 beta-hydroxyolean-12-ene-28,29-dioic acid-28-O-[alpha-L-rhamnopyranosyl-(1----6)-beta-D-glycopyranosyl- (1----4)-beta-D-glycopyranosyl] ester. Yiyeliangwanoside II: C37H56O10, a white powder, mp 240-244 degrees C (dec.), [alpha]D20+36.5(c 0.1, CH3OH). Its structure was determined as 3-O-alpha-(3'-O-acetyl)-L-arabinopyranosyl-3 beta-hydroxyolean-12-ene-28,29-dioic acid.

The arrhythmias induced by chloroform-epinephine, BaCl2, and aconitine were prevented and antagonized by Ophiopogon total saponins (OTS) which were extracted from the root of Ophiopogon japonicus (Thunb) Ker-Gawl. The incidence of ventricular arrhythmia produced by ligation of the left anterior descending coronary artery was effectively decreased without any changes in the hemodynamic indices of dogs. The electrophysiological effects of OTS in vivo and in vitro were studied by means of contact electrode and intracellular microelectrode techniques. The results showed that OTS shortened APD10, APD50, APD90; decreased APA and Vmax of both monophasic and transmembrane action potentials. OTS also increased the ERP/APD ratio and prevented or abolished the arrhythmikinesis provoked by ouabain and aconitine. The anti-arrhythmic properties of OTS lead us to draw an inference that the anti-arrhythmic mechanism may be related to the blocking of sodium and calcium channels.

Five compounds were isolated from the seeds of Momordica charantia. This paper reports their structure determination by spectral (IR, UV, HNMR, CNMR, and MS) and chemical methods. The structures of I, II, III, IV and V were elucidated as vacine, mycose, 3-O-(beta-D-glucopyranosyl)-24 beta-ethyl-5 alpha-cholesta-7, trans-22E, 25 (27)-trien-3 beta-ol, momorcharaside A and momorcharaside B respectively. Mycose was the first time found in this plant and compound III was the first time found in the genus Momordica. IV and V were new compounds. IV exhibited obvious inhibition of DNA and RNA syntheses in S 180 tumor cells in preliminary pharmacological studies.