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1. The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release.

Author

Liang, Yan, Sun, Yalin, Fu, Xiaoheng, Lin, Yang, Meng, Zhu, Meng, Yanan, Niu, Jiping, Lai, Yusi, and Sun, Yong

Subjects
*MICELLES, *MOIETIES (Chemistry), *STACKING interactions, *NANOSATELLITES
Abstract

Here we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL and the efficient intracellular delivery process was monitored. This research provided a way to fabricate stable polymeric micelles and develop a practical nanocarrier for therapeutics delivery. [ABSTRACT FROM AUTHOR]

Published
2020
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