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The effect of π-Conjugation on the self-assembly of micelles and controlled cargo release.
- Source :
-
Artificial Cells, Nanomedicine & Biotechnology . Dec2020, Vol. 48 Issue 1, p525-532. 8p. - Publication Year :
- 2020
-
Abstract
- Here we presented a novel micelle self-assembled from amphiphiles with π-conjugated moieties (OEG-DPH). The π-conjugated structural integrity of the micelles enabled stable encapsulation of Nile Red (NR, model drug). The self-assembly behaviour of the amphiphiles and the release profile of NR loaded micelles were investigated. Spherical core-shell structured NR loaded micelles with low CMC of 57 μg/mL and the efficient intracellular delivery process was monitored. This research provided a way to fabricate stable polymeric micelles and develop a practical nanocarrier for therapeutics delivery. [ABSTRACT FROM AUTHOR]
- Subjects :
- *MICELLES
*MOIETIES (Chemistry)
*STACKING interactions
*NANOSATELLITES
Subjects
Details
- Language :
- English
- ISSN :
- 21691401
- Volume :
- 48
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Artificial Cells, Nanomedicine & Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 148164712
- Full Text :
- https://doi.org/10.1080/21691401.2020.1725028