8 results on '"Devorah M. Stowe"'
Search Results
2. Hematologic and clinical characteristics of dogs with circulating macrophage‐like cells
- Author
-
Devorah M. Stowe and Hiroyuki Mochizuki
- Subjects
medicine.medical_specialty ,General Veterinary ,medicine.diagnostic_test ,Clinical pathology ,business.industry ,Anemia ,Macrophages ,Monocyte ,Complete blood count ,Histiocytic sarcoma ,medicine.disease ,Gastroenterology ,Pancytopenia ,Blood Cell Count ,Dogs ,medicine.anatomical_structure ,Internal medicine ,medicine ,Animals ,Macrophage ,Dog Diseases ,Histiocytic Sarcoma ,business ,Histiocyte ,Retrospective Studies - Abstract
BACKGROUND Macrophage-like (ML) cells are rarely observed on blood smear examinations, and the significance of these cells has been poorly described. OBJECTIVE The objective of this study was to retrospectively describe selected hematologic and clinical characteristics of dogs with ML cells in peripheral blood. MATERIALS AND METHODS Complete blood count (CBC) reports with blood smear evaluations from the clinical pathology laboratory records at North Carolina University College of Veterinary Medicine were retrospectively reviewed. Data were collected over a 10-year-period. Dogs were defined as having circulating ML cells if three or more ML cells were present on a single blood smear. Hematologic and clinical data of dogs with circulating ML cells were compared with age-matched hospital-derived control dogs. RESULTS Of 61,631 CBC records, 87 reports (0.14%) described the presence of ML cells. Thirty-nine dogs met the inclusion criteria. The hemogram of dogs with circulating ML cells was characterized by a pronounced inflammatory and stress leukogram, anemia, and thrombocytopenia. Of the 39 dogs, 19 (49%) had systemic or severe localized inflammatory/necrotic diseases. Eighteen (46%) dogs were diagnosed with neoplasia of histiocytic (5) and non-histiocytic origins (13). Dogs with circulating ML cells had a shorter median survival time (34 days) than the control dogs (595 days, P
- Published
- 2021
3. Factors associated with clinical interpretation of tracheal wash fluid from dogs with respiratory disease: 281 cases (2012‐2017)
- Author
-
James B Robertson, Amber M. Graham, Eleanor C. Hawkins, Megan E. Jacob, Devorah M. Stowe, and Karen M Tefft
- Subjects
medicine.medical_specialty ,040301 veterinary sciences ,medicine.drug_class ,Respiratory Tract Diseases ,Antibiotics ,endotracheal ,Standard Article ,030204 cardiovascular system & hematology ,Bacterial growth ,Gastroenterology ,antibiotics ,0403 veterinary science ,03 medical and health sciences ,Dogs ,0302 clinical medicine ,Internal medicine ,Cytology ,medicine ,Animals ,Dog Diseases ,Retrospective Studies ,transtracheal ,lcsh:Veterinary medicine ,Bacteria ,General Veterinary ,business.industry ,Respiratory disease ,Retrospective cohort study ,04 agricultural and veterinary sciences ,medicine.disease ,Mucus ,Standard Articles ,Anti-Bacterial Agents ,Trachea ,Hypocellularity ,aerobic culture ,Respiratory ,lcsh:SF600-1100 ,SMALL ANIMAL ,Culture negative ,business - Abstract
Background Clinicians face several dilemmas regarding tracheal washes (TWs) for the diagnosis of respiratory disease, including method and prediction of bacterial growth from cytology results. Objective To compare cytology and culture of endotracheal and transtracheal washes and identify factors associated with discordancy and bacterial growth. Animals Two hundred forty‐five dogs with respiratory disease. Methods Retrospective study. Tracheal wash submissions were included if cellularity was sufficient for cytologic interpretation and aerobic cultures were performed. Collection technique, cytology, bacterial growth, and antibiotic history were analyzed. Results Fewer transtracheal specimens (9/144, 6.3%) were excluded for hypocellularity than endotracheal (28/174, 16.1%); otherwise, results were similar and were combined. Of 281 specimens with cellularity sufficient for interpretation, 97 (34.5%) had bacteria on cytology and 191 (68.0%) had bacterial growth. Cytology positive/culture negative discordancy was uncommon (8/97, 8%). Cytology negative/culture positive discordancy was frequent (102/184, 55.4%), but occurred less often (28/184, 14.2%) when only 1+ growth or greater was considered positive. Oropharyngeal contamination was associated with bacterial growth, but not discordancy. No association was found between antibiotic administration and bacterial growth. Conclusions and Clinical Importance Endotracheal wash fluid, in particular, should be screened for gross mucus or turbidity to maximize the likelihood of an adequate specimen. Otherwise, endotracheal and transtracheal specimens were similar. Presence of bacteria on cytology was a good predictor of any growth, while their absence was a good predictor of the absence of growth of 1+ or more. Recent antibiotic usage should not discourage TW culture if there is compelling reason to avoid delay.
- Published
- 2021
4. Incidental immitis; a microfilaria medley
- Author
-
Meagan A. Wheatley and Devorah M. Stowe
- Subjects
Dogs ,General Veterinary ,Dirofilaria immitis ,Animals ,Dirofilariasis ,Dog Diseases ,Microfilariae - Published
- 2022
5. Multicenter flow cytometry proficiency testing of canine blood and lymph node samples
- Author
-
Mary Jo Burkhard, Barbara C. Rütgen, William Vernau, Dorothee Bienzle, Stefano Comazzi, Adi Wasserkrug-Naor, Davis M. Seelig, Kristina Meichner, Jaime L. Tarigo, Anne C. Avery, Devorah M. Stowe, Jonathan E. Fogle, and Tracy Stokol
- Subjects
030213 general clinical medicine ,medicine.medical_specialty ,Laboratory Proficiency Testing ,040301 veterinary sciences ,Concordance ,Transit time ,Sample (statistics) ,Flow cytometry ,Immunophenotyping ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Cohen's kappa ,Dogs ,Internal medicine ,medicine ,Proficiency testing ,Animals ,Dog Diseases ,Lymph node ,General Veterinary ,medicine.diagnostic_test ,business.industry ,04 agricultural and veterinary sciences ,Flow Cytometry ,Lymphoproliferative Disorders ,medicine.anatomical_structure ,Cross-Sectional Studies ,Hematologic Neoplasms ,Lymph Nodes ,business ,Cytometry - Abstract
BACKGROUND Flow cytometry (FC) is used increasingly in veterinary medicine for further characterization of hematolymphoid cells. Guidelines for optimizing assay performance and interpretation of results are limited, and concordance of results across laboratories is unknown. OBJECTIVES This study aimed to determine inter-investigator agreement on the interpretation of FC results from split samples analyzed in different laboratories using various protocols, cytometers, and software; and on the interpretation of archived FC standard (FCS) data files contributed by the different investigators. METHODS This was a multicenter observational cross-sectional study. Anticoagulated blood or lymph node aspirate samples from nine client-owned dogs were aliquoted and shipped to participating laboratories. Samples were analyzed with individual laboratory-developed protocols. In addition, FCS files from a set of separate samples from 11 client-owned dogs were analyzed by participating investigators. A person not associated with the study tabulated the results and interpretations. Agreement of interpretations was assessed with Fleiss' kappa statistic. RESULTS Prolonged transit times affected sample quality for some laboratories. Overall agreement among investigators regarding the FC sample interpretation was strong (κ = 0.86 ± 0.19, P
- Published
- 2019
6. What is your diagnosis? Abdominal fluid from a dog
- Author
-
Amy E. DiDomenico, Devorah M. Stowe, and Alex M. Lynch
- Subjects
Epididymis ,Inflammation ,Lethargy ,Male ,Photomicrography ,medicine.medical_specialty ,General Veterinary ,Abdominal Fluid ,business.industry ,Vasectomy ,Sperm ,Peritoneal Effusion ,Spermatozoa ,Surgery ,Dogs ,Cytology ,Testis ,Medicine ,Animals ,Ascitic Fluid ,Spermatocele ,Dog Diseases ,business ,Ultrasonography - Published
- 2019
7. Cancer-testis antigens in canine histiocytic sarcoma and other malignancies
- Author
-
Jennifer C. Holmes, Alexander Kapatos, Paul R. Hess, Paige S. Nemec, and Devorah M. Stowe
- Subjects
Male ,040301 veterinary sciences ,Biology ,Histiocytic sarcoma ,Epitope ,0403 veterinary science ,03 medical and health sciences ,0302 clinical medicine ,Dogs ,Antigen ,Antigens, Neoplasm ,HLA Antigens ,Tandem Mass Spectrometry ,Canine Histiocytic Sarcoma ,Cell Line, Tumor ,MHC class I ,Testis ,medicine ,Animals ,Humans ,Dog Diseases ,RNA, Messenger ,General Veterinary ,Dog leukocyte antigen ,04 agricultural and veterinary sciences ,medicine.disease ,Lymphoma ,Gene Expression Regulation, Neoplastic ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Cancer/testis antigens ,Histiocytic Sarcoma ,Chromatography, Liquid - Abstract
Cancer-testis antigens (CTAs) are a category of self proteins aberrantly expressed in diverse malignancies, mostly solid tumours, due to epigenetic de-repression. Normally expressed only in fetal or gametogenic tissues, CTAs are tantalizing immunotherapy targets, since autoimmunity risks appear minimal. Few prevalent CTAs have been identified in human hematologic cancers, and just two in their veterinary counterparts. We sought to discover new CTAs in canine hematologic cancers such as histiocytic sarcoma (HS) and lymphoma to foster immunotherapy development. To accomplish this, the ligandome binding the dog leukocyte antigen (DLA)-88*508:01 class I allele overexpressed in an HS line was searched by mass spectrometry to identify possible CTA-derived peptides, which could serve as CD8+ T-cell epitopes. Twenty-two peptides mapped to 5 human CTAs and 12 additional proteins with CTA characteristics. Expression of five promising candidates was then evaluated in tumour and normal tissue by quantitative and end-point RT-PCR. The ortholog of an established CTA, IGF2BP3, had unexpectedly high expression in peripheral blood mononuclear cells (PBMCs). Four other testis-enhanced proteins were also assessed. AKR1E2, SPECC1 and TPX2 were expressed variably in HS and T-cell lymphoma biopsies, but also at high levels in critical tissues, including kidney, brain and marrow, diminishing their utility. A more tissue-restricted candidate, NT5C1B, was detected in T-cell lymphomas, but also at low levels in some normal dog tissues. These results illustrate the feasibility of discovering canine CTAs by a reverse approach, proceeding from identification of MHC class I-presented peptides to a comparative RNA expression survey of tumours and normal tissues.
- Published
- 2018
8. What is your diagnosis? Cerebrospinal fluid from a dog
- Author
-
Devorah M. Stowe, Jennifer A. Neel, and Carolina Escobar
- Subjects
Male ,Pathology ,medicine.medical_specialty ,General Veterinary ,business.industry ,Immunocytochemistry ,Dendritic cell ,Dendritic Cells ,Histiocytic sarcoma ,medicine.disease ,Prognosis ,Magnetic Resonance Imaging ,CD11c Antigen ,Immunophenotyping ,Diagnosis, Differential ,Cerebrospinal fluid ,Dogs ,Medicine ,Animals ,Dog Diseases ,Histiocytic Sarcoma ,business - Published
- 2012
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.