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DNA origami enables the manipulation of objects at nanoscale, and demonstrates unprecedented versatility for fabricating both static and dynamic nanostructures. In this work, we introduce a new strategy for transferring modular reconfigurable DNA nanostructures from two‐dimensional to three‐dimensional. A 2D DNA sheet could be modularized into connected parts (e.g. two, three, and four parts in this work), which can be independently transformed between two conformations with a few DNA "trigger" strands. More interestingly, the transformation of the connected 2D modules can lead to the controlled, resettable structural conversion of a 2D sheet to a 3D architecture, due to the constraints induced by the connections between the 2D modules. This new approach can provide an efficient mean for constructing programmable, higher‐order, and complex DNA objects, as well as sophisticated dynamic substrates for various applications. [ABSTRACT FROM AUTHOR]

In a parallel universe: DNA origami structures based on modified parallel double‐crossover tiles (see scheme) were constructed and a unidirectional (parallel) arrangement of the scaffold strand (gray lines) was used in the assembly of a variety of 2D and 3D DNA origami structures. This will greatly expand the diversity of DNA origami and enable their assembly into larger structures. [ABSTRACT FROM AUTHOR]