3 results on '"Muzzammil Ahmadzada"'
Search Results
2. Factors Associated with Disease Severity and Mortality among Patients with Coronavirus Disease 2019: A Systematic Review and Meta-Analysis
- Author
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Muhammad A. Saeed, Marie Gilbert Majella, Izza A. Ishak, Kuang-Heng Wang, Eman F. Haque, Panagis Galiatsatos, Samuel K. Ayeh, Vignesh Chidambaram, Muhammad Asharib Arshad, Sheriza N. Baksh, Lin Wang, Bhavna Seth, Ayu P. B. Sarena, Syed Mh Ali, Muzzammil Ahmadzada, Waqas Haque, Ahsan Zil-E-Ali, Aqsha A. Nur, Tzu-Miao Pu, Angela Ting-Wei Hsu, Emmanuella L. Salia, Nyan Lynn Tun, Petros C. Karakousis, Ranjith Kumar Sivakumar, Amudha Kumar, and Pranita Neupane
- Subjects
medicine.medical_specialty ,business.industry ,Disease ,medicine.disease ,Triage ,Heart failure ,Meta-analysis ,Internal medicine ,Diabetes mellitus ,medicine ,Risk of mortality ,Observational study ,Leukocytosis ,medicine.symptom ,business - Abstract
BackgroundUnderstanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19.MethodsWe searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently.ResultsAmong 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45, 95%CI 1.23–1.71), dyspnea (RR 2.55, 95%CI 1.88–2.46), diabetes (RR 1.59, 95%CI 1.41–1.78), hypertension (RR 1.90, 95%CI 1.69–2.15). Congestive heart failure (OR 4.76, 95%CI 1.34–16.97), hilar lymphadenopathy (OR 8.34, 95%CI 2.57–27.08), bilateral lung involvement (OR 4.86, 95%CI 3.19–7.39) and reticular pattern (OR 5.54, 95%CI 1.24–24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis(>10.0 ×109/L), lymphopenia(< 1.1 ×109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality.ConclusionKnowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.Primary Funding SourceNone.
- Published
- 2020
3. Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis
- Author
-
Panagis Galiatsatos, Muhammad Asharib Arshad, Eman F. Haque, Sheriza N. Baksh, Waqas Haque, Vignesh Chidambaram, Lin Wang, Muhammad A. Saeed, Marie Gilbert Majella, Izza A. Ishak, Syed Muhammad Hammad Ali, Ranjith Kumar Sivakumar, Muzzammil Ahmadzada, Ayu P. B. Sarena, Aqsha A. Nur, Angela Ting-Wei Hsu, Amudha Kumar, Bhavna Seth, Kuang Heng Wang, Pranita Neupane, Nyan Lynn Tun, Petros C. Karakousis, Ahsan Zil-E-Ali, Samuel K. Ayeh, Tzu Miao Pu, and Emmanuella L. Salia
- Subjects
Thin-Layer Chromatography ,Viral Diseases ,Pulmonology ,Epidemiology ,Disease ,Cardiovascular Medicine ,Severity of Illness Index ,Biochemistry ,White Blood Cells ,Medical Conditions ,Endocrinology ,Animal Cells ,Risk of mortality ,Medicine and Health Sciences ,Leukocytosis ,Lymphocytes ,Multidisciplinary ,Chromatographic Techniques ,Infectious Diseases ,Cardiovascular Diseases ,Meta-analysis ,Creatinine ,Medicine ,medicine.symptom ,Cellular Types ,Research Article ,medicine.medical_specialty ,Endocrine Disorders ,Chronic Obstructive Pulmonary Disease ,Immune Cells ,Science ,Immunology ,Cardiology ,Research and Analysis Methods ,Internal medicine ,Diabetes mellitus ,Severity of illness ,medicine ,Diabetes Mellitus ,Humans ,Blood Cells ,business.industry ,COVID-19 ,Biology and Life Sciences ,Covid 19 ,Cell Biology ,medicine.disease ,Planar Chromatography ,Heart failure ,Medical Risk Factors ,Metabolic Disorders ,Observational study ,business ,Biomarkers - Abstract
Background Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45, 95%CI 1.23–1.71), dyspnea (RR 2.55, 95%CI 1.88–2.46), diabetes (RR 1.59, 95%CI 1.41–1.78), hypertension (RR 1.90, 95%CI 1.69–2.15). Congestive heart failure (OR 4.76, 95%CI 1.34–16.97), hilar lymphadenopathy (OR 8.34, 95%CI 2.57–27.08), bilateral lung involvement (OR 4.86, 95%CI 3.19–7.39) and reticular pattern (OR 5.54, 95%CI 1.24–24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis(>10.0 x109/L), lymphopenia(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.
- Published
- 2020
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