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Factors associated with disease severity and mortality among patients with COVID-19: A systematic review and meta-analysis
- Source :
- PLoS ONE, Vol 15, Iss 11, p e0241541 (2020), PLoS ONE
- Publication Year :
- 2020
- Publisher :
- Public Library of Science (PLoS), 2020.
-
Abstract
- Background Understanding the factors associated with disease severity and mortality in Coronavirus disease (COVID-19) is imperative to effectively triage patients. We performed a systematic review to determine the demographic, clinical, laboratory and radiological factors associated with severity and mortality in COVID-19. Methods We searched PubMed, Embase and WHO database for English language articles from inception until May 8, 2020. We included Observational studies with direct comparison of clinical characteristics between a) patients who died and those who survived or b) patients with severe disease and those without severe disease. Data extraction and quality assessment were performed by two authors independently. Results Among 15680 articles from the literature search, 109 articles were included in the analysis. The risk of mortality was higher in patients with increasing age, male gender (RR 1.45, 95%CI 1.23–1.71), dyspnea (RR 2.55, 95%CI 1.88–2.46), diabetes (RR 1.59, 95%CI 1.41–1.78), hypertension (RR 1.90, 95%CI 1.69–2.15). Congestive heart failure (OR 4.76, 95%CI 1.34–16.97), hilar lymphadenopathy (OR 8.34, 95%CI 2.57–27.08), bilateral lung involvement (OR 4.86, 95%CI 3.19–7.39) and reticular pattern (OR 5.54, 95%CI 1.24–24.67) were associated with severe disease. Clinically relevant cut-offs for leukocytosis(>10.0 x109/L), lymphopenia(< 1.1 x109/L), elevated C-reactive protein(>100mg/L), LDH(>250U/L) and D-dimer(>1mg/L) had higher odds of severe disease and greater risk of mortality. Conclusion Knowledge of the factors associated of disease severity and mortality identified in our study may assist in clinical decision-making and critical-care resource allocation for patients with COVID-19.
- Subjects :
- Thin-Layer Chromatography
Viral Diseases
Pulmonology
Epidemiology
Disease
Cardiovascular Medicine
Severity of Illness Index
Biochemistry
White Blood Cells
Medical Conditions
Endocrinology
Animal Cells
Risk of mortality
Medicine and Health Sciences
Leukocytosis
Lymphocytes
Multidisciplinary
Chromatographic Techniques
Infectious Diseases
Cardiovascular Diseases
Meta-analysis
Creatinine
Medicine
medicine.symptom
Cellular Types
Research Article
medicine.medical_specialty
Endocrine Disorders
Chronic Obstructive Pulmonary Disease
Immune Cells
Science
Immunology
Cardiology
Research and Analysis Methods
Internal medicine
Diabetes mellitus
Severity of illness
medicine
Diabetes Mellitus
Humans
Blood Cells
business.industry
COVID-19
Biology and Life Sciences
Covid 19
Cell Biology
medicine.disease
Planar Chromatography
Heart failure
Medical Risk Factors
Metabolic Disorders
Observational study
business
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 15
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....0f7707fa734656d5e46fd1f4fef84c17