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4 results on '"Christine Mac Nab"'

1. Occupational Exposures to Ebola Virus in Ebola Treatment Center, Conakry, Guinea

Author

Hélène Savini, Frédéric Janvier, Ludovic Karkowski, Magali Billhot, Marc Aletti, Julien Bordes, Fassou Koulibaly, Pierre-Yves Cordier, Jean-Marie Cournac, Nancy Maugey, Nicolas Gagnon, Jean Cotte, Audrey Cambon, Christine Mac Nab, Sophie Moroge, Claire Rousseau, Vincent Foissaud, Thierry De Greslan, Hervé Granier, Gilles Cellarier, Eric Valade, Philippe Kraemer, Philippe Alla, Audrey Mérens, Emmanuel Sagui, Thierry Carmoi, and Christophe Rapp

Subjects
Ebola virus, disease, viruses, occupational exposure, healthcare workers, Conakry, Medicine, Infectious and parasitic diseases, RC109-216
Abstract

We report 77 cases of occupational exposures for 57 healthcare workers at the Ebola Treatment Center in Conakry, Guinea, during the Ebola virus disease outbreak in 2014−2015. Despite the high incidence of 3.5 occupational exposures/healthcare worker/year, only 18% of workers were at high risk for transmission, and no infections occurred.

Published
2017
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2. Rhabdomyolysis in Ebola Virus Disease. Results of an Observational Study in a Treatment Center in Guinea

Author

Benoit Quentin, Hervé Granier, Thierry de Greslan, Philippe Dubrous, Ludovic Karkowski, M. Aletti, Vincent Foissaud, Nancy Maugey, Christophe Rapp, Magali Billhot, Nicolas Gagnon, Thierry Carmoi, Jean Marie Cournac, Christine Mac Nab, Audrey Mérens, Hélène Savini, Emmanuel Sagui, Helene Broto, Claire Rousseau, Pierre-Yves Cordier, Sophie Moroge, S. Duron, Jean Cotte, Gilles Cellarier, Julien Bordes, and Frédéric Janvier

Subjects
Adult, Male, 0301 basic medicine, Microbiology (medical), myalgia, medicine.medical_specialty, 030106 microbiology, Disease, medicine.disease_cause, Rhabdomyolysis, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Humans, Renal Insufficiency, 030212 general & internal medicine, Young adult, Creatine Kinase, Creatinine, Ebola virus, biology, business.industry, Myalgia, Hemorrhagic Fever, Ebola, medicine.disease, Surgery, Infectious Diseases, chemistry, biology.protein, Female, Guinea, Creatine kinase, medicine.symptom, business, Viral load
Abstract

BACKGROUND The pathogenesis of Ebola virus disease (EVD) remains unclear. The sporadic nature of Ebola outbreaks and their occurrence in resource-limited settings have precluded the acquisition of extensive clinical and laboratory data. Rhabdomyolysis during EVD has been suggested to occur in previous studies showing increased aspartate aminotransferase-alanine aminotransferase ratios, but, to date, has not been confirmed with creatine kinase (CK) assays. METHODS We performed an observational study of 38 patients admitted to an Ebola treatment center from January to April 2015. CK values from patients with confirmed EVD were compared with those in patients without confirmed EVD. A panel of other analyses were also performed. In patients with EVD, characteristics were compared between survivors and nonsurvivors. RESULTS High levels of CK were more frequent in patients with EVD than in those without (P = .002), and rhabdomyolysis was more frequent (59% vs 19%, respectively; P = .03). CK levels >5000 U/L were observed in 36% of patients with EVD. Also in patients with EVD, fatal outcome was significantly associated with higher creatinine and bilirubin levels, international normalized ratio, and viral load. CONCLUSIONS Rhabdomyolysis is a frequent disorder in EVD and seems to be more common than in other viral infections. It may contribute to the renal failure observed in nonsurviving patients. More studies are needed to determine the impact of rhabdomyolysis on EVD outcome.

Published
2015

3. Ebola Virus–Related Encephalitis: Table 1

Author

Philippe Dubrous, Benoit Quentin, Christine Mac Nab, Fassou Koulibaly, Thierry De Greslan, Julien Bordes, Magali Billhot, Sophie Moroge, S. Duron, Gilles Cellarier, Flavie Bompaire, Nicolas Gagnon, Jean-Luc Renard, Jean-Marie Cournac, Ludovic Karkowski, and Claire Rousseau

Subjects
0301 basic medicine, Microbiology (medical), Ebola virus, business.industry, viruses, virus diseases, Disease, Ideation, medicine.disease, medicine.disease_cause, Virology, Diagnostic spinal puncture, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Infectious Diseases, Cerebrospinal fluid, Medicine, 030212 general & internal medicine, business, Encephalitis
Abstract

Ebola patients frequently exhibit behavioral modifications with ideation slowing and aggressiveness, sometimes contrasting with mild severity of Ebola disease. We performed lumbar punctures in 3 patients with this presentation and found Ebola virus in all cerebrospinal fluid samples. This discovery helps to discuss the concept of a specific Ebola virus encephalitis.

Published
2016

4. Occupational Exposures to Ebola Virus in Ebola Treatment Center, Conakry, Guinea

Author

Nancy Maugey, Marc Aletti, Jean-Marie Cournac, Pierre-Yves Cordier, Sophie Moroge, Christophe Rapp, Hélène Savini, Magali Billhot, Hervé Granier, Christine Mac Nab, Audrey Mérens, Vincent Foissaud, Julien Bordes, Thierry De Greslan, Fassou Koulibaly, Eric Valade, P. Alla, Ludovic Karkowski, Audrey Cambon, Frédéric Janvier, Gilles Cellarier, Claire Rousseau, Philippe Kraemer, Emmanuel Sagui, Jean Cotte, Nicolas Gagnon, and Thierry Carmoi

Subjects
0301 basic medicine, Microbiology (medical), medicine.medical_specialty, Epidemiology, viruses, Health Personnel, 030106 microbiology, lcsh:Medicine, Ebola virus disease, occupational exposures, treatment center, medicine.disease_cause, lcsh:Infectious and parasitic diseases, 03 medical and health sciences, Ebola virus, 0302 clinical medicine, Conakry, Occupational Exposure, medicine, Humans, lcsh:RC109-216, 030212 general & internal medicine, Prospective Studies, Ebolavirus, disease, Transmission (medicine), business.industry, healthcare workers, Incidence, lcsh:R, Dispatch, Outbreak, Healthcare worker, virus diseases, Hemorrhagic Fever, Ebola, Virology, Treatment center, Infectious Diseases, Occupational Exposures to Ebola Virus in Ebola Treatment Center, Conakry, Guinea, Emergency medicine, Guinea, Occupational exposure, High incidence, business
Abstract

We report 77 cases of occupational exposures for 57 healthcare workers at the Ebola Treatment Center in Conakry, Guinea, during the Ebola virus disease outbreak in 2014-2015. Despite the high incidence of 3.5 occupational exposures/healthcare worker/year, only 18% of workers were at high risk for transmission, and no infections occurred.

Published
2017

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