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Rhabdomyolysis in Ebola Virus Disease. Results of an Observational Study in a Treatment Center in Guinea
- Source :
- Clinical Infectious Diseases. 62:19-23
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- BACKGROUND The pathogenesis of Ebola virus disease (EVD) remains unclear. The sporadic nature of Ebola outbreaks and their occurrence in resource-limited settings have precluded the acquisition of extensive clinical and laboratory data. Rhabdomyolysis during EVD has been suggested to occur in previous studies showing increased aspartate aminotransferase-alanine aminotransferase ratios, but, to date, has not been confirmed with creatine kinase (CK) assays. METHODS We performed an observational study of 38 patients admitted to an Ebola treatment center from January to April 2015. CK values from patients with confirmed EVD were compared with those in patients without confirmed EVD. A panel of other analyses were also performed. In patients with EVD, characteristics were compared between survivors and nonsurvivors. RESULTS High levels of CK were more frequent in patients with EVD than in those without (P = .002), and rhabdomyolysis was more frequent (59% vs 19%, respectively; P = .03). CK levels >5000 U/L were observed in 36% of patients with EVD. Also in patients with EVD, fatal outcome was significantly associated with higher creatinine and bilirubin levels, international normalized ratio, and viral load. CONCLUSIONS Rhabdomyolysis is a frequent disorder in EVD and seems to be more common than in other viral infections. It may contribute to the renal failure observed in nonsurviving patients. More studies are needed to determine the impact of rhabdomyolysis on EVD outcome.
- Subjects :
- Adult
Male
0301 basic medicine
Microbiology (medical)
myalgia
medicine.medical_specialty
030106 microbiology
Disease
medicine.disease_cause
Rhabdomyolysis
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
medicine
Humans
Renal Insufficiency
030212 general & internal medicine
Young adult
Creatine Kinase
Creatinine
Ebola virus
biology
business.industry
Myalgia
Hemorrhagic Fever, Ebola
medicine.disease
Surgery
Infectious Diseases
chemistry
biology.protein
Female
Guinea
Creatine kinase
medicine.symptom
business
Viral load
Subjects
Details
- ISSN :
- 15376591 and 10584838
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Clinical Infectious Diseases
- Accession number :
- edsair.doi.dedup.....16ba808034574a2d80fd37e3d422c978