1. Effect of body weight on fixed dose of diclofenac for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis.
- Author
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Leerhøy B, Nordholm-Carstensen A, Novovic S, Hansen MB, and Jørgensen LN
- Subjects
- Acute Disease, Aged, Diclofenac administration & dosage, Female, Humans, Logistic Models, Male, Pancreatitis etiology, Body Weight, Cholangiopancreatography, Endoscopic Retrograde adverse effects, Diclofenac therapeutic use, Pancreatitis prevention & control
- Abstract
Objective: The aim of this study was to assess the influence of patient body weight on the clinical effect of 100 mg diclofenac administered as a single dose for the prevention of post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP)., Materials and Methods: All patients subjected to endoscopic retrograde cholangiopancreatography (ERCP) from 2009 to 2014 were evaluated for inclusion. In total, 772 patients were included of whom 378 (49%) received diclofenac prophylaxis., Results: In the diclofenac prophylaxis group, body weight was higher in patients with PEP (mean ± SD: 82 ± 18 kg) than in patients without PEP (74 ± 18 kg) (p = 0.029). In patients not receiving prophylaxis, body weight was not associated with the occurrence of PEP (mean ± SD: 77 ± 18 vs 75 ± 18 kg, respectively, p = 0.450). In an adjusted analysis, higher patient body weight was inversely associated with the clinical effect of 100 mg diclofenac for the prophylaxis of PEP., Conclusions: High patient body weight was associated with a reduced effect of 100 mg diclofenac for prophylaxis of PEP.
- Published
- 2016
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