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Diclofenac is associated with a reduced incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis: results from a Danish cohort study.
- Source :
-
Pancreas [Pancreas] 2014 Nov; Vol. 43 (8), pp. 1286-90. - Publication Year :
- 2014
-
Abstract
- Objective: The aim of this study was to assess the clinical effect of diclofenac administered as a single dose for the prevention of postprocedure pancreatitis in a consecutive series of patients who had undergone endoscopic retrograde cholangiopancreatography (ERCP).<br />Methods: Patients with a native papilla Vateri subjected to ERCP during 2010 (control group, n = 218) and 2012 (diclofenac group, n = 182) were included. Patients with a history of chronic pancreatitis or recent acute pancreatitis were excluded. From January 2012, a rectal suppository containing 100 mg of diclofenac was administered immediately after endoscopy in all patients. The primary outcome of post-ERCP pancreatitis was assessed retrospectively by reviewing the patients' charts.<br />Results: The overall incidence of post-ERCP pancreatitis was 32 (14.7%) of the 218 patients in the control group and 9 (4.9%) of the 182 patients in the diclofenac group (P = 0.002). Moderate to severe pancreatitis occurred in 22 (10.1%) of the 218 patients in the control group versus 8 (4.4%) of the 182 patients in the diclofenac group (P = 0.036).<br />Conclusions: This controlled cohort study suggests that the implementation of a single dose of 100 mg of diclofenac rectally administered significantly reduces the incidence of post-ERCP pancreatitis in an unselected material of patients with native papilla.
- Subjects :
- Acute Disease
Administration, Rectal
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal administration & dosage
Cohort Studies
Denmark
Diclofenac administration & dosage
Drug Evaluation
Female
Humans
Incidence
Length of Stay statistics & numerical data
Male
Middle Aged
Pancreatitis epidemiology
Pancreatitis etiology
Retrospective Studies
Anti-Inflammatory Agents, Non-Steroidal therapeutic use
Cholangiopancreatography, Endoscopic Retrograde adverse effects
Diclofenac therapeutic use
Pancreatitis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1536-4828
- Volume :
- 43
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Pancreas
- Publication Type :
- Academic Journal
- Accession number :
- 25003219
- Full Text :
- https://doi.org/10.1097/MPA.0000000000000169