Search

Laugier-Hunziker syndrome (LHS) is a sporadic, acquired, and infrequent condition characterized by the onset of brown macules on the lips, the oral mucosa, and the acral glabrous skin (mainly fingers and toes) in middle-aged patients. In several cases melanonychia of fingernails and toenails coexists. No other systemic involvement is observed. A case of LHS in a 50-year-old woman is described, with particular attention to dermoscopic features. No dermoscopic specific findings of mucosal/cutaneous maculae have been to date described in the literature. Accumulation of dermoscopic observations of pigmented lesions in LHS is needed and if found to be distinct, it may contribute to a more accurate diagnosis in the future. [ABSTRACT FROM AUTHOR]

The lack of consensus among clinicians and pathologists, owing to the mixture of clinical and histopathologic features used to define the various melanocytic nevi, underscores the need for a better classification system for these benign lesions. Most dermoscopic patterns of melanocytic nevi correspond to specific histopathologic correlates and, based on this, we recently introduced a new classification system of melanocytic nevi that is directed at clinicians dealing with early diagnosis of melanoma, as well at pathologists, in order to promote better communication between these different specialists. [ABSTRACT FROM AUTHOR]

Dermoscopy improves the diagnostic accuracy in the clinical evaluation of pigmented skin lesions, but it is also useful for the assessment of vascular structures that are not visible to the naked eye. As a consequence, dermoscopy has been employed more and more for the differential diagnosis of nonpigmented skin disorders, including tumors but also inflammatory and infectious diseases. This article provides a review of the dermoscopic features seen in various nonpigmented tumoral and nontumoral skin lesions as well as the dermoscopic criteria used for monitoring skin reactions to various treatments. Copyright © 2006 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]

Objective To achieve a clinicopathologic classification of Spitz nevi by comparing their clinical, dermoscopic, and histopathologic features. Design Eighty-three cases were independently reviewed by 3 histopathologists and preliminarily classified into classic or desmoplastic Spitz nevus (CDSN, n = 11), pigmented Spitz nevus (PSN, n = 14), Reed nevus (RN, n = 16), or atypical Spitz nevus (ASN, n = 14); the remaining 28 cases were then placed into an intermediate category (pigmented Spitz-Reed nevus, PSRN) because a unanimous diagnosis of either PSN or RN was not reached. Setting University dermatology and pathology departments and general hospital pathology departments. Patients A sample of subjects with excised melanocytic lesions. Main Outcome Measure Frequency of dermoscopic patterns within the different histopathologic subtypes of Spitz nevi. Results Overlapping clinical, dermoscopic, and histopathologic findings were observed among PSN, RN, and PSRN, thereby justifying their inclusion into the single PSRN diagnostic category. Asymmetry was the most frequent indicator of histopathologic ASN (79%; n = 11); in only 4 cases did dermoscopic asymmetry show no histopathologic counterpart, and in those cases the discrepancy was probably the result of an artifact of the gross sampling technique carried out with no attention to the dermoscopic features. Conclusions Among Spitz nevi, histopathologic distinction between PSN and RN is difficult, not reproducible, and may be clinically useless. A simple clinicopathologic classification of these neoplasms might therefore be structured as CDSN, PSRN, and ASN. Asymmetry should be assessed using both dermoscopic and histopathologic analysis, and reliability in histopathologic diagnosis may be enhanced by the simultaneous evaluation of the corresponding dermoscopic images. [ABSTRACT FROM AUTHOR]

We examined a combined (dermoscopic–pathological) approach to the telediagnosis of melanocytic skin lesions. A store-and-forward teleconsultation was simulated. Dermoscopic and histopathology images from 12 melanocytic lesions were stored in a telepathology workstation. A dermoscopy consultant, a histopathology consultant and an expert in dermoscopic–pathological correlation gave their diagnoses and comments on the images. The consensus diagnosis between two teleconsultants on the original histological slides was regarded as the gold standard. The diagnostic accuracy was 83% (including one false negative diagnosis of malignancy) for teledermoscopy and 100% for teledermatopathology. The combined approach detected one case that showed a much greater atypia on dermoscopy than on histopathology. In this case step-sections of the sample were deemed to be required for definite diagnosis. The combined approach was helpful in detecting macroscopic and microscope sampling errors of melanocytic lesions during teleconsultation. [ABSTRACT FROM AUTHOR]

Discusses the case of a 77-year-old female patient diagnosed with porokeratosis using dermoscopy technique. Size of lesion; Cell characteristics; Characteristics of lesions.

Lauds the work of S.H. Hirata and colleagues for their report on the dermoscopic features of two cases of clonal seborrheic keratosis. Observation of large areas of a bluish pigmentation composed of multiple, blue-gray roundish structures; Differential diagnosis of pigmented basal cell carcinoma.

Presents several dermatologic images. Recognition of patterns in dermatologic disease processes that may enhance both diagnostic and research capabilities; Interaction of specific gene defects with local environmental factors; Demonstration of the normal photographic and dermatologic appearance of the lesions.

The article reports on the case of a 30-year-old woman who developed two primary melanomas on her left lower extremity where atypical melanocytic skin lesions were seen in a quadrant or segmented distribution. She was diagnosed with a quadrant or segmental atypical nevus syndrome. Surgical excision of the nevi is impractical because it may not save the patient from the development of de novo melanoma within the affected site. Patients benefit from digital dermoscopic follow-up.