Author: "Francesco Prisco" / Topic: diabetes mellitus - Searchworks@Jio Institute Digital Library Search Results

29 results on '"Francesco Prisco"'

1. Erratum to: Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy

Author: A. Scaramazza, Maurizio Delvecchio, F. Mammì, G. Santoro, E. De Nitto, Silvia Pietrosanti, E. Montani, F. Cardella, V. De Donno, Chiara Giorgetti, Federica Ortolani, L. Beccaria, G. Fichera, A. Francese, Annalisa Pedini, Dario Iafusco, Santino Confetto, Sonia Toni, Barbara Predieri, C. Arnaldi, L. Tomaselli, M. Frongia, Fortunato Lombardo, F. De Berardinis, Gianluca Tornese, C. Ripoli, E. Piccino, Riccardo Schiaffini, Antonio Iannilli, Maria Luisa Manca Bitti, G. Ignaccolo, B. Pasquino, Giovanni Federico, A. Marsciani, Angela Zanfardino, Anna Maria Marinaro, N. Lazzaro, Federica Zallocco, A. La Loggia, Ippolita Patrizia Patera, Stefano Zucchini, M. Trada, P. Pusceddu, G. Zanette, A. Gaiero, Lorenzo Iughetti, G. Cardinale, C. Monciotti, F. Citriniti, R. Cardani, G. Piredda, V. Rapisarda, Claudio Maffeis, M. Bruzzese, T. Soprani, Marco Marigliano, B. Kienberger, L. Guerraggio, L. De Luna, Elena Faleschini, Vittoria Cauvin, E. Prandi, Maria Ferrari, G. Morganti, Lorenzo Lenzi, Roberta Lidano, Giuseppe d'Annunzio, U. Marongiu, G. Meloni, A. Correddu, Nicola Minuto, Alessandro Salvatoni, Valentino Cherubini, A. Milia, A. Gualtieri, R. Maccioni, A. Pipia, Ivana Rabbone, Riccardo Bonfanti, Claudia Ventrici, Giulio Maltoni, V. Zattoni, F. Cadario, G. Ponzi, D. Pardi, Mohamad Maghnie, M. Soro, P. Scanu, F. Gallo, Francesco Prisco, P. Reinstadler, P. Bulciolu, R. Lera, M. G. Berioli, Stefano Tumini, L. Mereu, Andrea Rigamonti, M. S. Coccioli, C. Zecchino, B. Mainetti, Roberto Franceschi, P. Banin, Giovanni Chiari, I. Rabbone, A. Sabbion, and L. Ferrito
Subjects: Male, Gerontology, Adolescent, Distribution (economics), Regional Medical Programs, 03 medical and health sciences, 0302 clinical medicine, Surveys and Questionnaires, 030225 pediatrics, Diabetes mellitus, Prevalence, Humans, Medicine, 030212 general & internal medicine, Practice Patterns, Physicians', Child, business.industry, Incidence, Disease Management, medicine.disease, Diabetes Mellitus, Type 1, Italy, Female, Erratum, business, Delivery of Health Care
Abstract: The incidence of type 1 diabetes in childhood is increasing by 3 % per year, placing growing demands on healthcare professionals and medical expenditures. Aim of this study wars to assess the organization of care to children with diabetes in Italy.During 2012 a structured questionnaire was sent to all of the members of Italian Society of Paediatric Endocrinology and Diabetology (ISPED). Questions examined organizational structure of Centers, personnel dedicated to the care of children with diabetes, number of subjects followed, local legal legislation supporting centres.A total of 68 centers taking care to 15,563 children and adolescents with diabetes under 18 years of age were identified with a prevalence of 1.4 per 1,000 people. A wide variation in the organizational background was also reported. Fourty-four centers were organized as outpatient departments, 17 as simple units, 5 as complex units and 2 as simple departmental structures. Most centers had a multidisciplinary team. Ten out of twenty Italian regions had introduced supportive regional legislation, but it was fully applied only in six of them.Great differences between regions were found in organizational structures, staffing levels and supportive legislation. The national legislation on diabetes was broadly implemented throughout the country regions. Further efforts are needed to improve standards and consistency of pediatric diabetes care in Italy.
Published: 2016
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2. Chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus

Author: Dario Iafusco, Francesco Prisco, Rossella Paolillo, Antonietta Rizzo, Caterina Romano Carratelli, Rizzo, Antonietta, Paolillo, R, Iafusco, Dario, Prisco, F, and Romano Carratelli, C.
Subjects: Blood Glucose, Male, Microbiology (medical), medicine.medical_specialty, Adolescent, endocrine system diseases, Disease, Biology, Real-Time Polymerase Chain Reaction, Microbiology, Serology, Risk Factors, Internal medicine, Diabetes mellitus, Epidemiology, medicine, Humans, Child, Chlamydophila Infections, Glycated Hemoglobin, Type 1 diabetes, Chlamydia, nutritional and metabolic diseases, General Medicine, Chlamydophila pneumoniae, medicine.disease, Antibodies, Bacterial, Immunoglobulin A, Diabetes Mellitus, Type 1, Immunoglobulin M, Immunoglobulin G, Metabolic control analysis, Immunology, Etiology, Female
Abstract: Chlamydia pneumoniae, an intracellular bacterium, is associated with respiratory diseases, reinfectivity and chronic diseases such as cardiovascular disease, hypertension and stroke. The risk of infection is higher and infections are a serious clinical problem in patients with type 1 (insulin-dependent) diabetes mellitus (T1DM). Although diabetes mellitus and hyperglycaemia are considered possible risk factors for various types of aetiological agents, the epidemiological evidence concerning C. pneumoniae infection is scanty. The aim of the present study was to evaluate the impact of glycosylated haemoglobin (HbA1c) levels, an indicator of a hyperglycaemic state, on C. pneumoniae infection and disease chronicity; in addition we compared the duration of diabetes with the occurrence of C. pneumoniae infection. C. pneumoniae blood real time PCR and serology (IgG, IgA and IgM) assays by an ELISA method were performed. C. pneumoniae DNA was detected in 46.5 % [95 % confidence interval (CI) = 35.1-57.9 %] of the patients with T1DM; this prevalence is higher (P0.05) than in non-diabetic paediatric controls, 10.5 % (95 % CI = 3.6-17.4 %). IgG/IgA C. pneumoniae antibody positivity was significantly (P≤0.05) more common in patients in poor metabolic control (HbA1c9 %) versus patients in good metabolic control (HbA1c7 %), suggesting that the metabolic control of the disease is compromised in the patients with T1DM. In conclusion, adolescents with T1DM were more likely to show signs of infection with C. pneumoniae compared with healthy adolescents and the results suggest an increased risk of progressing from an acute C. pneumoniae infection to a chronic form.
Published: 2012
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3. A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes

Author: F. De Berardinis, Fortunato Lombardo, G. Zanette, R. Cardani, Ivana Rabbone, C. Zecchino, Barbara Predieri, C. Arnaldi, Barbara Piccini, B. Felappi, Riccardo Bonfanti, D. Lo Presti, B. Mainetti, G. Ignaccolo, F. Stamati, Roberto Franceschi, G. Ponzi, M. S. Coccioli, F. Citriniti, C. Ripoli, F. Chiarelli, Valeria Calcaterra, M. Trada, Giovanni Federico, A. Sabbion, D. Cirillo, Enza Mozzillo, C. Salvo, Francesco Prisco, G. Piredda, Alessandro Salvatoni, Maurizio Delvecchio, R. A. Taccardi, Valentino Cherubini, Gianluca Tornese, G. Morganti, Giulio Maltoni, Nicola Minuto, Giovanni Chiari, S. Zonca, M. Bensa, Franco Meschi, V. De Donno, Martina Biagioni, Silvia Savastio, L. Guerraggio, A. Gualtieri, T. Suprani, A. Franzese, M. G. Berioli, D. Iafusco, Francesco Cadario, Andrea Scaramuzza, A. Favia, Luciano Beccaria, Gian Vincenzo Zuccotti, Sonia Toni, Riccardo Schiaffini, F. Cerutti, N. Lazzaro, Lorenzo Iughetti, B. Pasquino, Francesco Fontana, P. Banin, G. Cardinale, A. Marsciani, Anna Paola Frongia, S. Lucchesi, E. Schieven, R. Lera, R. De Marco, F. Cardella, F. Gallo, Vittoria Cauvin, P. Sogno Valin, E. Prandi, L. Tomaselli, Vanna Graziani, M Bruzzese, Lorenzo Lenzi, F. Mammì, Giuseppe d'Annunzio, Ippolita Patrizia Patera, Stefano Zucchini, C. Maffeis, A. Bobbio, A. Gaiero, V. Castaldo, Alfonso Galderisi, Stefano Tumini, P Buono, C. Monciotti, Elvira Piccinno, D. Pardi, Marco Cappa, Renata Lorini, Marco Marigliano, Zucchini, Stefano, Scaramuzza, Andrea E, Bonfanti, Riccardo, Buono, Pietro, Cardella, Francesca, Cauvin, Vittoria, Cherubini, Valentino, Chiari, Giovanni, D'Annunzio, Giuseppe, Frongia, Anna Paola, Iafusco, Dario, Maltoni, Giulio, Patera, Ippolita Patrizia, Toni, Sonia, Tumini, Stefano, Tornese, Gianluca, Rabbone, Ivana, Lera, R., Bobbio, A., Gualtieri, A., Piccinno, E., Zecchino, C., Pasquino, B., Felappi, B., Prandi, E., Gallo, F., Morganti, G., Ripoli, C., Cardinale, G., Ponzi, G., Castaldo, V., Stamati, F., Lo Presti, D., Tomaselli, L., Citriniti, F., Suprani, T., Bensa, M., Graziani, V., De Berardinis, F., Chiarelli, F., De Marco, R., Lazzaro, N., De Donno, V., Banin, P., Piccini, B., Lenzi, L., Mainetti, B., Coccioli, M. S., Minuto, N., Lorini, R., Trada, M., Sogno Valin, P., Beccaria, L., Lucchesi, S., Bruzzese, M., Mammì, F., Cirillo, D., Pardi, D., Taccardi, R. A., Lombardo, F., Zuccotti, G. V., Meschi, F., Iughetti, L., Predieri, B., Franzese, A., Mozzillo, Enza., Prisco, F., Cadario, F., Savastio, S., Piredda, G., Monciotti, C., Galderisi, A., Salvo, C., Calcaterra, V., Berioli, M. G., Federico, G., Favia, A., Zanette, G., Marsciani, A., Schiaffini, R., Cappa, M., Delvecchio, M., Gaiero, A., Ignaccolo, G., Cerutti, F., Fontana, F., Guerraggio, L., Zonca, S., Franceschi, R., Tornese, G., Biagioni, M., Salvatoni, A., Cardani, R., Marigliano, M., Sabbion, A., Maffeis, C., Schieven, E., Arnaldi, C., Zucchini, S., Scaramuzza, A. E., Bonfanti, R., Buono, P., Cardella, F., Cauvin, V., Cherubini, V., Chiari, G., D'Annunzio, G., Frongia, A. P., Iafusco, D., Maltoni, G., Patera, I. P., Toni, S., Tumini, S., Rabbone, I., Mammi, F., Mozzillo, E., and Prisco, Francesco
Subjects: 0301 basic medicine, Male, Pediatrics, Endocrinology, Diabetes and Metabolism, Endocrinology, endocrine system diseases, type 1 diabetes, Adolescent, Child, Child, Preschool, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Female, Health Care Surveys, Humans, Infant, Infant, Newborn, Insulin, Italy, Rehydration Solutions, Retrospective Studies, Treatment Outcome, lcsh:Diseases of the endocrine glands. Clinical endocrinology, ketoacidosis, Retrospective Studie, Medicine, Diabetology, Diabetes and Metabolism, Newly diagnosed diabetes, Research Article, Type 1, Human, medicine.medical_specialty, Article Subject, Referral, Diabetic ketoacidosis, Diabetic Ketoacidosi, 03 medical and health sciences, children, Retrospective survey, Diabetes mellitus, Diabetes Mellitus, Preschool, Type 1 diabetes, lcsh:RC648-665, business.industry, Rehydration Solution, nutritional and metabolic diseases, Retrospective cohort study, Newborn, medicine.disease, 030104 developmental biology, Health Care Survey, business
Abstract: We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected for all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe DKA (pH < 7.1), DKA in preschool children, DKA treatment according to ISPAD protocol, type of rehydrating solution used, bicarbonates use, and amount of insulin infused. Records(n=2453)of children with newly diagnosed diabetes were collected from 68/77 centers (87%), 39 of which are tertiary referral centers, the majority of whom (n=1536, 89.4%) were diagnosed in the tertiary referral centers. DKA was observed in 38.5% and severe DKA in 10.3%. Considering preschool children, DKA was observed in 72%, and severe DKA in 16.7%. Cerebral edema following DKA treatment was observed in 5 (0.5%). DKA treatment according to ISPAD guidelines was adopted in 68% of the centers. In the first 2 hours, rehydration was started with normal saline in all centers, but with different amount. Bicarbonate was quite never been used. Insulin was infused starting from third hour at the rate of 0.05–0.1 U/kg/h in 72% of centers. Despite prevention campaign, DKA is still observed in Italian children at onset, with significant variability in DKA treatment, underlying the need to share guidelines among centers.
Published: 2016

4. Lower limbs edema by insulin glargine treatment: two other cases in pediatrics

Author: Pasquale Villano, Giulia Pezzino, Dario Iafusco, Santino Confetto, Francesco Prisco, Alessandra Cocca, Loredana Russo, Alessia Piscopo, Angela Zanfardino, Elisabetta Caredda, Francesca Casaburo, Iafusco, Dario, Piscopo, Alessia, Confetto, Santino, Cocca, Alessandra, Pezzino, Giulia, Caredda, Elisabetta, Casaburo, Francesca, Villano, Pasquale, Russo, Loredana, Zanfardino, Angela, and Prisco, Francesco
Subjects: medicine.medical_specialty, medicine.medical_treatment, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Inferior vena cava, Thoracic duct, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Internal medicine, Edema, Diabetes mellitus, medicine, Internal Medicine, Type 1 diabetes, Insulin glargine, business.industry, Insulin, General Medicine, medicine.disease, Surgery, medicine.anatomical_structure, medicine.vein, Abdomen, medicine.symptom, business, 030217 neurology & neurosurgery, medicine.drug
Abstract: Marta, 13 years aged, suffered from type 1 diabetes from the age of 9 years. She was admitted in our clinic for a progressive appearance of edema in both legs (Fig. 1). The edema was located in the pretibial and ankle region, bilaterally, mainly on the left; the skin was normal, not hot and not erythematous. Femoral and popliteal pulses were normal. Left and right ankle diameters were, respectively, 29.5 and 28 cm. The family history was negative for diseases associated with edema. The metabolic control has always been good (yearly mean HbA1c 7.5 % 58 mmol/mol). She was on multi-daily injections (MDI) therapy, and the need of insulin was 0.7 U/kg/day. Up to 3 months before the occurrence of edema, she had been treated with human insulin (Humulin R and Humulin I ). During the adolescence, as the lifestyle was changing, we decided to start basal bolus therapy. Boluses of fast analogues were administered on the arms and in abdomen, while insulin glargine was administered exclusively on both thighs, alternating the right and the left thigh every day. All the most common causes of edema have been ruled out with specific investigations: Color Doppler ultrasound of the arteries and veins of the limbs excluded vascular diseases; ECG and transthoracic echocardiography excluded cardiac failure. Blood count, C-reactive protein (CRP) and VES, serum electrolytes, protein electrophoresis and the liver, thyroid and kidney function tests were within the normal range. Moreover, we rejected other causes of edema due to infection diseases. To exclude obstruction of the inferior vena cava or the thoracic duct, the patient underwent, respectively, abdominal ultrasound and chest X-rays, which did not show pathognomonic features. In addition, we also ruled out the Turner syndrome with the high-definition karyotype study. Medical history, clinical examination and laboratory findings excluded the involvement of systemic diseases. No other medicaments except for insulin had been assumed so, suspecting that the cause of the edema could have been the local mechanism of absorption of basal insulin, we replaced insulin glargine with rapid and intermediate human insulin. After 1-month edema was still present, but significantly reduced (diameter 25 cm in both legs). The complete resolution occurred after 3 months from the suspension of glargine even if a slight worsening of metabolic control (HbA1c 8.5 % 69 mmol/mol) was observed. Managed by Antonio Secchi.
Published: 2016

5. Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study)

Author: Paolo Pozzilli, Sonia Toni, Antonio Picardi, A. Crinò, M E Martinucci, Laura Minicucci, Raffaella Buzzetti, Dario Iafusco, F. Cerutti, Ivana Rabbone, Francesco Prisco, Renata Lorini, Prisco, F., Picardi, A., Iafusco, Dario, Lorini, R., Minicucci, L., Martinucci, M., Toni, S., Cerutti, F., Rabbone, I., Buzzetti, R., Crino, A., and Pozzilli, P.
Subjects: Blood Glucose, Male, medicine.medical_specialty, Adolescent, Diabetic ketoacidosis, type 1 diabetes, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Ketone Bodies, Urine, Glucagon, Acetoacetates, Diabetic Ketoacidosis, Excretion, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, Humans, Child, blood ketone bodies, insulin theraphy, insulin therapy, Type 1 diabetes, 3-Hydroxybutyric Acid, business.industry, Insulin, Infant, Hydrogen-Ion Concentration, medicine.disease, Diabetes Mellitus, Type 1, Endocrinology, Child, Preschool, blood ketone bodie, Pediatrics, Perinatology and Child Health, Ketone bodies, Female, business
Abstract: Background: Insulin deficiency with glucagon excess leads to the release of ketone bodies (KBs) by the liver and excretion in the urine. So far, only KB monitoring in urine has been used during assessment of children with diabetes. Currently used nitroprusside strips for urine KB detection react only with acetoacetate (AcAc) and not with the most prevalent KB moiety – 3β-hydroxybutyrate (3HB) – that is in equilibrium with AcAc (up to 10:1 ratio). Aim: To verify the significance of 3HB in the blood compared to that of AcAc in the urine in recently diagnosed type 1 diabetic subjects independent of the presence of diabetic ketoacidosis (DKA). Methods: A total of 118 consecutive newly diagnosed subjects with type 1 diabetes from different centers in Italy underwent intensive insulin therapy and hydration when necessary (38/118 = 32% with DKA). Hourly urine and capillary blood samples were used to monitor KBs until metabolic control was achieved. Results: Although DKA was present in 32% of patients, blood 3HB was significantly increased (3.56 ± 1.7 mmol/L) in 83% of the patients and correlated with blood glucose (r = 0.39; p < 0.01) according to a bimodal model. The strongest association was found between 3HB and venous pH (r =−0.56; p < 0.0001). Time required for blood 3HB normalization depended strongly on the starting blood KB values (r = 0.44; p < 0.0001) and was significantly lower than that required for disappearance of KB from urine (17.4 ± 13.6 h, range 1–69 h vs. 19.7 ± 17.8 h, range 1–120 h; p = 0.004). However, urine KBs disappeared before blood 3HB normalization in 23% of the patients. Conclusions: Blood 3HB evaluation is a better indicator of metabolic control compared to urine KB detection and is useful to predict the time required for blood KB clearing. Further studies are needed to assess its use in the early detection and management of DKA.
Published: 2006
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6. Diabetes Incidence in 0- to 14-Year Age-Group in Italy

Author: Francesco Prisco, Paolo Pozzilli, Flavia Carle, Renata Lorini, Rosaria Gesuita, Alberto Falorni, Valentino Cherubini, Marco Songini, Giovanni V. Coppa, M E Martinucci, M. T. Tenconi, and Graziella Bruno
Subjects: Advanced and Specialized Nursing, Research design, Type 1 diabetes, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Incidence (epidemiology), medicine.disease, symbols.namesake, El Niño, Diabetes mellitus, Epidemiology, Internal Medicine, medicine, symbols, Poisson regression, Prospective cohort study, business, Demography
Abstract: OBJECTIVE—The Registry for Type 1 Diabetes Mellitus in Italy (RIDI) Study Group was established to coordinate the registries of type 1 diabetes in Italy. This report is based on 3,606 children younger than 15 years diagnosed with type 1 diabetes and prospectively registered during 1990–1999 by nine centers, covering >35% of the Italian population. RESEARCH DESIGN AND METHODS—Registries were pooled in four geographic macro-areas: north, central, south, and insular. The completeness of registration was assessed by the capture-recapture method. Poisson regression analysis was used to evaluate temporal trend in incidence. RESULTS—Large variations in incidence were confirmed not only between Sardegna and the mainland but also among peninsular areas. In Sardegna, there was an excess of boys (the boy-to-girl incidence ratio was 1.4). The overall incidence showed average increases of 3.6% (P < 0.001) and 3.7% (P < 0.001) per year in peninsular Italy and in Sardegna, respectively. Significant increases in incidence rates were found in boys aged 10–14 years (6.7%, 95% CI 0.5–13.3) and in girls aged 5–9 years (6.6%, 0.5–13.1) living in the southern area. The incidence rate also increased in boys aged 10–14 years (5.0%, 0.3–10) and in girls aged 0–4 years (4.9%, 0.8–9.1) living in Sardegna. CONCLUSIONS—Italy is a country with large geographical variations in incidence rates of type 1 diabetes. However, the rates are evenly increasing both in the mainland and Sardegna, suggesting that similar environmental factors are operating over populations that have different genetic backgrounds.
Published: 2004
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7. Continuous subcutaneous insulin infusion in preschool children: butt or tummy, which is the best infusion set site?

Author: Elisabetta Caredda, Angela Zanfardino, Gian Vincenzo Zuccotti, Francesco Prisco, Alessandra Cocca, Pasquale Villano, Emilia Forgione, Santino Confetto, Andrea Scaramuzza, Stefania Picariello, Assunta S Rollato, Francesca Casaburo, Dario Iafusco, Loredana Russo, Alessia Piscopo, Zanfardino, A, Iafusco, Dario, Piscopo, A, Cocca, A, Villano, P, Confetto, S, Caredda, E, Picariello, S, Russo, L, Casaburo, F, Rollato, A, Forgione, E, Zuccotti, G, Prisco, F, and Scaramuzza, A. E.
Subjects: Insulin pump, Blood Glucose, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Injections, Subcutaneous, Skin Absorption, Infusion Site, Body Mass Index, chemistry.chemical_compound, Endocrinology, Diabetes mellitus, Abdomen, medicine, Humans, Hypoglycemic Agents, Insulin, Glycated Hemoglobin, Type 1 diabetes, Cross-Over Studies, business.industry, Area under the curve, medicine.disease, Crossover study, Surgery, Medical Laboratory Technology, Diabetes Mellitus, Type 1, Treatment Outcome, chemistry, Area Under Curve, Child, Preschool, Buttocks, Female, Glycated hemoglobin, business
Abstract: Choosing the right infusion set site can be an important factor in obtaining good glycemic control, especially in very young children. In an attempt to identify the best infusion site, we performed a crossover study in six preschool children with type 1 diabetes using insulin pump therapy.We enrolled six patients 5.2±0.7 years old (range, 4-6 years), with type 1 diabetes for more than 1.5 years, using insulin pump therapy for at least 6 months. For each patient, body mass index, glycated hemoglobin, and all data downloaded from the system were evaluated on two occasions: the first with the infusion set placed on the buttock and the second on the abdomen, each for 3 days. The order of infusion set placement was randomized. Mean capillary blood glucose, mean continuous glycemia, mean area under the curve (AUC) using the trapezoidal rule for both140 mg/dL and70 mg/dL, insulin daily dose, carbohydrate/insulin ratio, total basal insulin, total bolus insulin, and mean amplitude of glucose excursions (MAGE) were evaluated.Mean glycemic values, mean AUC140 mg/dL, and MAGE were significantly lower when the infusion set was placed on the buttock versus the abdomen (144.6±31.9 mg/dL vs. 166.0±34.8 mg/dL [P=0.000], 28.4±18.3% vs. 48.8±28.2% [P=0.000], and 32±10 vs. 60±15 mg/dL [P0.001], respectively), whereas mean AUC70 mg/dL was higher (1.47±2.77% vs. 0.87±1.03% [P0.001]).The present findings suggest that preschool children with type 1 diabetes using insulin pump therapy could benefit from inserting the infusion set in the buttock instead of the abdomen.
Published: 2014

8. Celiac Disease in Children and Adolescents with Type I Diabetes: Importance of Hypoglycemia

Author: Marina Cerruto, Stefano Tumini, Francesco Prisco, Dario Iafusco, Ornella Stoppoloni, Francesco Chiarelli, Angelika Mohn, A, Mohn, M., Cerruto, Iafusco, Dario, F., Prisco, S., Tumini, and O. STOPPOLONI AND F., Chiarelli
Subjects: Adult, Male, medicine.medical_specialty, Malabsorption, Adolescent, Glutens, medicine.medical_treatment, Disease, Hypoglycemia, Gastroenterology, Coeliac disease, Intestinal mucosa, Risk Factors, Internal medicine, Diabetes mellitus, medicine, Humans, Insulin, Child, Retrospective Studies, business.industry, Case-control study, Infant, nutritional and metabolic diseases, medicine.disease, Surgery, Celiac Disease, Kinetics, Diabetes Mellitus, Type 1, Case-Control Studies, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, business
Abstract: Background Symptomatic hypoglycemia is an unavoidable problem in the treatment of type I diabetes. Celiac disease is associated with malabsorption and may therefore represent an important risk factor. Methods The frequency of symptomatic hypoglycemia in patients with type I diabetes and celiac disease (cases) was compared with those of patients who had diabetes without celiac disease (controls). For this purpose, each case was matched for age, sex, and duration of disease with one to two control patients. Indices of metabolic control (hemoglobin [Hb]A1c, frequency of hypoglycemia, and total insulin requirement) were retrieved for the 18 months before and after diagnosis of celiac disease. Results Eighteen patients (6 males and 12 females) had diagnosed celiac disease and were matched with 26 control patients (10 males and 16 females). There was no difference in age (11.0 years; range, 1.8-21.9 vs. 13.1 years; range, 2.3-22; P = 0.3) and duration of disease (8.4 years; range, 1.2-19.3 vs. 8.3 years; range, 1.1-18.7; P = 0.3) between the two groups. During the 6 months before and after diagnosis of celiac disease the cases had significantly more hypoglycemic episodes than the controls (means +/- SD; 4.5+/-4 vs. 2.0+/-2.2 episodes/months, P = 0.01). This was reflected by a progressive reduction in insulin requirement over the 12 months before diagnosis reaching a nadir at time 0 (0.6+/-0.2 vs. 0.9+/-0.3, P = 0.05). Conclusion These data suggest that underlying celiac disease is associated with an increased risk of symptomatic hypoglycemia and that the introduction of a gluten-free diet with normalization of the intestinal mucosa may reduce its frequency.
Published: 2001
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9. Refractory rheumatoid factor positive polyarthritis in a female adolescent already suffering from type 1 diabetes mellitus and Hashimoto's thyroiditis successfully treated with etanercept

Author: Francesco Prisco, Alma Nunzia Olivieri, Carmela Granato, Angela Zanfardino, Laura Perrone, Maria Francesca Gicchino, Dario Iafusco, Antonio Mellos, Angela Mauro, Olivieri, Alma Nunzia, Iafusco, Dario, Mellos, A, Zanfardino, A, Mauro, A, Granato, C, Gicchino, MARIA FRANCESCA, Prisco, Francesco, and Perrone, Laura
Subjects: Arthritis, Case Report, Autoimmunity, Polyarthriti, medicine.disease_cause, Thyroiditis, Receptors, Tumor Necrosis Factor, Etanercept, Immunosuppressive Agent, Hashimoto Disease, Anti-TNF therapy, Autoimmune Hashimoto's thyroiditi, Treatment Outcome, Autoimmune Hashimoto's thyroiditis, Polyarthritis, Female, Immunotherapy, Immunosuppressive Agents, medicine.drug, Human, medicine.medical_specialty, Adolescent, Tumor necrosis factor, Injections, Subcutaneous, Type 1 diabetes mellitus, Injections, Subcutaneou, Autoimmune Disease, Risk Assessment, Drug Administration Schedule, Autoimmune Diseases, Follow-Up Studie, Juvenile idiopathic arthriti, Rheumatoid Factor, Diabetes mellitus, Internal medicine, medicine, Humans, Type 1 diabetes, Dose-Response Relationship, Drug, business.industry, Juvenile idiopathic arthritis, medicine.disease, Arthritis, Juvenile, Diabetes Mellitus, Type 1, Immunoglobulin G, Immunology, business, Follow-Up Studies, Type 1 diabetes mellitu
Abstract: Type 1 diabetes mellitus may be associated with many autoimmune diseases with the common autoimmune pathogenesis. We describe the case of a girl suffering from Type 1 diabetes mellitus and autoimmune Hashimoto's thyroiditis since the childhood and, due to the onset of Juvenile Idiopathic Arthritis during adolescence, for three years practiced therapy with an anti-TNF drug, etanercept . Currently her inflammatory markers are normal, arthritis is inactive and diabetes is well controlled. During the treatment with anti-TNF drug we observed a significative reduction of insulin dose, probably due to an increased tissue sensitivity secondary to the suppression of the activity of TNF-alpha. Several clinical trials that have evaluated the effect of immunomodulatory agents in diabetic patients, especially in those with recent onset of disease, were already performed but further studies of longer duration on a larger population are needed to assess the role of biologic drugs and immunotherapy in this group of patients.
Published: 2013

10. All classifications not built on pathogenesis become inadequate sooner or later

Author: Alfonso Galderisi, R. Giugliano, Andrea Scaramuzza, Dario Iafusco, Angela Napoli, B. Giugliano, F. Stoppoloni, Edoardo Tartaglia, Fortunato Lombardo, T. Sena, Pasquale Mastrantonio, Francesco Prisco, Alessandra Cocca, Iafusco, Dario, Galderisi, A, Lombardo, F, Scaramuzza, A, Tartaglia, E, Cocca, A, Giugliano, R, Giugliano, B, Sena, T, Napoli, A, Mastrantonio, P, Stoppoloni, F, and Prisco, F.
Subjects: Pediatrics, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Birth weight, MODY 2, MODY-2, Endocrinology, Pregnancy, Risk Factors, Diabetes mellitus, Glucokinase, medicine, Diabetes Mellitus, Prevalence, Internal Medicine, Birth Weight, Humans, Gestational diabetes, Type 1 diabetes, Diabetes Mellitus, Type 2, Diabetes, Gestational, Female, Hyperglycemia, Infant, Newborn, Pregnancy Outcome, business.industry, Diabetes, Infant, medicine.disease, Newborn, Obesity, Diabetes and Metabolism, gestational diabetes, glucokinase, mody-2, Gestational, Gestation, business, Type 2
Abstract: Keywords Gestational diabetes.Glucokinase.MODY-2AbbreviationsHAPO Hyperglycemia Adverse Pregnancy OutcomeLGA Large for gestational ageSGA Small for gestational ageTo the Editor: We read with interest the paper by E. A. Ryan[1] concerning the new criteria suggested by the Hypergly-cemia Adverse Pregnancy Outcome (HAPO) study for thediagnosis of gestational diabetes [2]. Ryan showed thatapplying these criteria would result in a doubling of thenumber of pregnant women diagnosed with gestationaldiabetes without a clear demonstration of the benefitsderived from this new classification. As he observes,maternal obesity represents a stronger predictor of large-for-gestational-age (LGA) babies than glucose levels in allexcept the highest glucose category [1, 3]. This suggeststhat not all gestational hyperglycaemia has the sameaetiology. As was the case in paediatrics, where for manydecades we wrongly diagnosed all children with hyper-glycaemia as having type 1 diabetes [4], we risk includingin this generic categorisation of gestational diabetes theundetected monogenic forms that are often underdiagnosed[5, 6]. For example, in those patients belonging to thelowest glucose categories of HAPO those with MODY-2obtain no benefit from the treatment of their hyperglycae-mia. In the 11 patients with MODY-2 that we followed up
Published: 2011

11. Acute juvenile cataract in newly diagnosed type 1 diabetic patients: A description of six cases

Author: Ciro Costagliola, Teodosio Libondi, Francesco Prisco, Roberto dell'Omo, Dario Iafusco, Mario R. Romano, Iafusco, Dario, Prisco, F, Romano, Mr, Dell'Omo, R, Libondi, Teodosio, Costagliola, C., Prisco, Francesco, Romano, Mario, Dell'Omo, Roberto, and Costagliola, Ciro
Subjects: Adult, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Cataract, chemistry.chemical_compound, Young Adult, Internal medicine, Diabetes mellitus, Internal Medicine, medicine, Prevalence, Humans, Risk factor, Child, Glycemic, Retrospective Studies, Type 1 diabetes, Juvenile cataract, business.industry, Len, medicine.disease, eye diseases, Surgery, Ketoacidosis, Diabetes Mellitus, Type 1, Logistic Models, chemistry, Italy, Pediatrics, Perinatology and Child Health, Base excess, Female, Glycated hemoglobin, business, Juvenile diabete
Abstract: Cataract represents one of the most frequent eye complications in type 1 and type 2 patients; contrarily, acute cataract in young diabetic patients occurs very rarely. The aim of this study was to describe six cases of acute cataract in adolescents at the onset of type 1 diabetes. Eight hundred and twenty-six patients with type 1 diabetes were retrospectively studied. A multivariate analysis was applied to verify the weight of the following laboratory findings taken on admission (independent variables): glycemia, glycated hemoglobin (HbA1c), pH, base excess (BE),and on the occurrence of cataract (dependent variable). Six patients (0.7%) presented with acute lens opacities. Cataract development was significantly correlated with HbA1c and glycemia. The relative risk increases about twice for each percentage point from 12.8 to 14.1% of HbA1c; glycemic blood levels represent a moderate risk factor for cataractogenesis. Ketoacidosis and BE were not significantly correlated. © 2011 John Wiley & Sons A/S.
Published: 2011

12. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study

Author: Andrea Scaramuzza, Alfonso Galderisi, Dario Iafusco, Gian Vincenzo Zuccotti, Francesco Prisco, Alessandra Cocca, Ida Nocerino, Iafusco, Dario, Galderisi, A, Nocerino, I, Cocca, A, Zuccotti, G, Prisco, F, and Scaramuzza, A.
Subjects: Male, Coping (psychology), Pediatrics, Endocrinology, Diabetes and Metabolism, Health Behavior, Child Behavior, chemistry.chemical_compound, Endocrinology, Surveys and Questionnaires, Adaptation, Psychological, Child, Hemoglobin A, Diabetes and Metabolism, Medical Laboratory Technology, Italy, Female, Attitude to Health, Type 1, medicine.medical_specialty, Adolescent, Glycosylated, Patient Education as Topic, Adolescent Behavior, Diabetes Mellitus, Type 1, Follow-Up Studies, Hemoglobin A, Glycosylated, Humans, Internet, Patient Compliance, Quality of Life, Reproducibility of Results, Self Care, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Adaptation, Socioeconomic status, Glycemic, Glycated Hemoglobin, Type 1 diabetes, business.industry, medicine.disease, chemistry, Metabolic control analysis, Psychological, Glycated hemoglobin, business, Body mass index
Abstract: We evaluated the impact of a 2-year chat line involving adolescents with type 1 diabetes regarding quality of life and metabolic control.We enrolled 193 children, 10-18 years of age (mean ± SD, 13.6 ± 2.7 years), with type 1 diabetes for 1.2-6 years (3.6 ± 2.4 years), body mass index of 23.2 ± 4.1 kg/m(2), insulin requirement of 0.7 ± 0.3 U/kg/day, and glycated hemoglobin (HbA1c) of 7.8 ± 1.1%, who participated in a weekly physician-moderated chat line for a 2-year follow-up period. Each patient completed the Diabetes Quality of Life for Youth Inventory (DQOLY) at baseline and after 1 and 2 years. A measure of glycemic control (HbA1c) was also collected. Data from 17 patients who discontinued using the chat line were not included in the analysis. As controls, 203 patients with type 1 diabetes, age- and sex-matched, with similar HbA1c at baseline and socioeconomic status, were randomly selected among 834 patients who refused to participate in the chat sessions.DQOLY responses from youth with type 1 diabetes showed a significant improvement (P = 0.0001) only in patients who participated in chat sessions. We observed a decrease of 0.4% in HbA1c in patients who participated in chat session (7.8 ± 1.1% vs. 7.4 ± 0.5%, P0.0001) compared with the 0.1% of the controls (7.9 ± 1.9% vs. 7.8 ± 1.8%, P = 0.668). No difference was observed in HbA1c between the two groups (P = 0.056).A chat line is also a cheap and effective tool that helps improve diabetes compliance. The chat line could help the diabetes team understand and treat their patients more comprehensively; moreover, it could help patients cope better with their daily life.
Published: 2011

13. Not every child with diabetes needs insulin

Author: Dario Iafusco, Roberto Giugliano, Andrea Scaramuzza, Gian Vincenzo Zuccotti, Francesco Prisco, Alessandra Cocca, Alfonso Galderisi, Iafusco, Dario, Scaramuzza, Ae, Galderisi, A, Cocca, A, Giugliano, R, Zuccotti, Gv, and Prisco, F.
Subjects: medicine.medical_specialty, medicine.medical_treatment, Blood sugar, Unnecessary Procedures, Diabetes mellitus, Internal medicine, medicine, Diabetes Mellitus, Humans, Hypoglycemic Agents, Insulin, Intensive care medicine, General Environmental Science, Type 1 diabetes, business.industry, General Engineering, General Medicine, medicine.disease, Endocrinology, Diabetes Mellitus, Type 2, Hyperglycemia, General Earth and Planetary Sciences, business, Type 2
Abstract: Insulin is miraculous,1 and, as happens with most good and effective drugs, it has tended to be used whenever doctors meet a child with high blood sugar values. This presupposes that hyperglycaemia in children always means type 1 diabetes, overlooking the existence of many …
Published: 2010

14. Use of real time continuous glucose monitoring and intravenous insulin in type 1 diabetic mothers to prevent respiratory distress and hypoglycaemia in infants

Author: Goran Petrovski, Gilberto Vernetti, Fabrizio Stoppoloni, Patrizia Passaro, Gennaro Salvia, Francesco Prisco, Dario Iafusco, Iafusco, Dario, Stoppoloni, F, Salvia, G, Vernetti, G, Passaro, P, Petrovski, G, and Prisco, F.
Subjects: Adult, Blood Glucose, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Pregnancy in Diabetics, Disease, Hypoglycemia, Betamethasone, lcsh:Gynecology and obstetrics, Infant, Newborn, Diseases, Pregnancy, Diabetes mellitus, Obstetrics and Gynaecology, medicine, Humans, Hypoglycemic Agents, Insulin, Infusions, Intravenous, Intensive care medicine, Glucocorticoids, lcsh:RG1-991, Monitoring, Physiologic, Respiratory Distress Syndrome, Newborn, Type 1 diabetes, Respiratory distress, business.industry, Infant, Newborn, Obstetrics and Gynecology, medicine.disease, Fetal Diseases, Diabetes Mellitus, Type 1, Treatment Outcome, Technical Advance, Female, business, medicine.drug
Abstract: Background Pregnancy in Type 1 diabetic patients is a precarious condition, both for mother and fetus with increased the risk of prematurity and, immediately after delivery with risk of respiratory distress syndrome and hypoglycaemia in newborns. A strict control and monitoring of diabetes throughout pregnancy is important in reducing the impact of the disease on the fetus and newborn. In recent years many new technologies have been introduced to ameliorate diabetes monitoring, where the last is the Real-time Continuous Glucose Monitoring System (RT-CGMS). Methods In the last three years, 72 h continuous glucose monitoring system (RT-CGMS) (Medtronic, CA) was performed in 18 pregnant women with Type 1 diabetes in two moments of pregnancy: during treatment with betamethasone to prevent respiratory distress and during delivery. In both cases insulin was administered intravenous and the dose was changed on the basis of glycaemia. Results The results present the use of this new technique during two topics moments of pregnancy of type 1 diabetes patients when is very important intensively to monitor diabetes and to obtain the well being of the fetus. No infant experimented hypoglycaemia or respiratory distress syndrome at the moment and in the first hours after the birth. Conclusion We wish to stress the importance reducing glycaemia during administration of betamethasone and during labor. It is conceivable that the scarce attention paid to monitoring glucose levels in diabetic mothers during labor in gynaecological world may be due to the difficulty in glucose monitoring with the devices until now available. Hopefully, our anecdotal account may prompt improvements with RT-CGMS, and may lead to a better approach to the problem, thereby changing the prognosis of infants born to diabetic mothers.
Published: 2008

15. Bilateral isolated acute cataracts in three newly diagnosed insulin dependent diabetes mellitus young patients

Author: Ciro Costagliola, Francesca Landolfo, Francesco Parmeggiani, Roberto dell'Omo, Francesco Prisco, Dario Iafusco, Costagliola, Ciro, Dell'Omo, Roberto, Prisco, F, Iafusco, D, Landolfo, F, Parmeggiani, F., Costagliola, C, Dell'Omo, R, Iafusco, Dario, Landolfo, F., Dell'Omo, R., Costagliola, C., and Prisco, F.
Subjects: medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, General Medicine, Newly diagnosed, medicine.disease, Cataract, Endocrinology, Cataracts, Internal medicine, Insulin dependent diabetes, Diabetes mellitus, diabetes mellitus, Internal Medicine, medicine, business
Abstract: Cataract is a very frequent finding in adults with diabetes mellitus. On the contrary, acutely developed cataract in young insulin dependent diabetes mellitus (IDDM) patients at the onset of the disease has been rarely reported. In this paper we describe three cases of acute cataract in young patients with Type 1 Diabetes.
Published: 2007

16. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives

Author: Deborah Kryszak, Rosanna Lampis, Romano Carratù, Debra Counts, Alessio Fasano, Amit Tripathi, Laura de Magistris, Francesca Laghi, Francesco Prisco, Francesco Cucca, Maria Cartenì, Gabriele Riegler, Maddalena Generoso, Dario Iafusco, Maria Grazia Clemente, Anna Sapone, Michelle Pietzak, Sapone, A., DE MAGISTRIS, Laura, Pietzak, M., Clemente, M., Tripathi, A., Cucca, F., Lampis, R., Kryszak, D., Cartenì, M., Generoso, M., Iafusco, Dario, Prisco, F., Laghi, F., Riegler, Gabriele, Carratu, R., Counts, D., and Fasano, A.
Subjects: medicine.medical_specialty, Cholera Toxin, Endocrinology, Diabetes and Metabolism, Biology, Diabete, medicine.disease_cause, Permeability, Autoimmunity, Autoimmune Diseases, Downregulation and upregulation, zonulin, Internal medicine, Diabetes mellitus, Occludin, Claudin-1, Internal Medicine, medicine, Humans, Family, Genetic Predisposition to Disease, Protein Precursors, Autoimmune disease, Type 1 diabetes, Intestinal permeability, Haptoglobins, intestinal permeability, Zonulin, Membrane Proteins, Environmental exposure, medicine.disease, Intestines, Endocrinology, Diabetes Mellitus, Type 1, Immunology, Claudins
Abstract: Zonulin, a protein that modulates intestinal permeability, is upregulated in several autoimmune diseases and is involved in the pathogenesis of autoimmune diabetes in the BB/Wor animal model of the disease. To verify the association between serum zonulin levels and in vivo intestinal permeability in patients with type 1 diabetes, both parameters were investigated in different stages of the autoimmune process. Forty-two percent (141 of 339) of the patients had abnormal serum zonulin levels, as compared with age-matched control subjects. The increased zonulin levels correlated with increased intestinal permeability in vivo and changes in claudin-1, claudin-2, and myosin IXB genes expression, while no changes were detected in ZO1 and occludin genes expression. When tested in serum samples collected during the pre‐type 1 diabetes phase, elevated serum zonulin was detected in 70% of subjects and preceded by 3.5 0.9 years the onset of the disease in those patients who went on to develop type 1 diabetes. Combined, these results suggest that zonulin upregulation is associated with increased intestinal permeability in a subgroup of type 1 diabetic patients. Zonulin upregulation seems to precede the onset of the disease, providing a possible link between increased intestinal permeability, environmental exposure to non‐self antigens, and the development of autoimmunity in genetically susceptible individuals. Diabetes 55:1443‐1449, 2006
Published: 2006

17. Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene

Author: Fabrizio Barbetti, Stefano Tumini, Riccardo Bonfanti, D. Iafusco, Franco Meschi, Carla Bizzarri, Marco Cappa, F. Cerutti, Francesco Prisco, E. Ciacco, C. Torelli, Maurizio Vanelli, E. Faleschini, V. Cauvin, G. Tonini, Tonini, G, Bizzarri, C, Bonfanti, R, Vanelli, M, Cerutti, F, Faleschini, E, Meschi, F, Prisco, F, Ciacco, E, Cappa, M, Torelli, C, Cauvin, V, Tumini, S, Iafusco, Dario, Barbetti, F, EARLY ONSET DIABETES STUDY GROUP OF THE ITALIAN SOCIETY OF, Paediatric, ENDOCRINOLOGY AND, Diabetology, and Iafusco, D
Subjects: Blood Glucose, Potassium Channels, diabetes control, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, diarrhea, antidiabetic agent, glibenclamide, glipizide, insulin, sulfonylurea, clinical article, clinical trial, diabetes mellitus, gene mutation, gestational age, human, letter, missense mutation, newborn, newborn period, priority journal, Amino Acid Substitution, Child, Diabetes Mellitus, Humans, Hypoglycemic Agents, Infant, Infant, Newborn, Infant, Newborn, Diseases, Insulin, Mutation, Potassium Channels, Inwardly Rectifying, Sulfonylurea Compounds, Treatment Outcome, Diseases, Settore MED/13 - Endocrinologia, Diabetes mellitus genetics, Neonatal diabetes mellitus, neonatal diabetes mellitus, KCNJ11, Kir6.2, Permanent neonatal diabetes mellitus, Inwardly Rectifying, endocrine system, medicine.medical_specialty, medicine.drug_class, Diabetes mellitus, Internal medicine, Internal Medicine, medicine, business.industry, nutritional and metabolic diseases, medicine.disease, Sulfonylurea, Endocrinology, Sulfonylurea receptor, business
Abstract: To the Editor, Activating missense mutations in the gene encoding potassium inwardly rectifying channel, subfamily J, member 11 (KCNJ11) represent the most common cause (40 to 64%, depending on populations) of permanent neonatal diabetes mellitus in patients diagnosed in the first 6 months of life [1, 2]. In addition, KCNJ11 activating mutations can lead to transient/relapsing neonatal diabetes [3, 4]. The KCNJ11 gene encodes the pore-forming subunit (also known as KIR6.2) of the pancreatic beta cell ATP-sensitive potassium channel (KATP), which exerts a pivotal role in glucose-regulated insulin release. In the beta cell, KIR6.2 forms a hetero-octameric complex (4:4) with the sulfonylurea receptor subtype 1 (SUR1); binding to SUR1 by sulfonylureas determines channel closure and insulin secretion [2]. In previously published cases, seven patients have been reported to respond well to the transfer from insulin to oral hypoglycaemic agents [4–8]. Here we report on the replacement of insulin with sulfonylureas in ten Italian children who have mutations in KCNJ11 (R50P, V59M [x4], K170R, R201C and R201H [x3]) and were followed in nine Diabetologia (2006) 49:2210–2213 DOI 10.1007/s00125-006-0329-x
Published: 2006

18. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

Author: S. Artigas, A V Dreval, Mark I. McCarthy, C Watson, Peter H. Bennett, M Quint, Y Ikeda, E Alpert, F Schiele, H Sekihara, Erik Gylfe, P Lowe, J Kuhlmann, Alain Golay, V Longo, Shahidul Alam Khan Akm., L G Mantovani, M Zawodniak-Szalapska, G Winkler, T Harrity, L Virág, U Johne, Kuo S-W., Linda C Tapsell, J Rodriguez, Michel Komajda, K Kankova, Carole A. Cull, M Sporna, E Estilles, U Ribel, M C Spruce, E Buzzigoli, T Prazak, J K McLaughlin, M K Lingohr, M Lim, F Calara, A Siebenhofer, G Meregalli, Roberto Anichini, A D Baron, R Kurashvili, P C Butler, G I Fantus, T. E. De Gooyer, Park Y-M., R. Walther, S Heinrich, Agnieszka Zawiejska, S Mukherjee, Nikolaos Papanas, G Wong, Ian D. Caterson, David M. Maahs, Shuichi Kaneko, Alexandra E. Butler, Francisco Javier Ampudia-Blasco, O N Kong, Attali J-R., C A Hedman, K Oshinyemi, Nicolle Müller, I C Cranston, N Okumus, M V Vlaiculescu, Balasubramanian Ravikumar, W W Cheatham, K Mukasa, K B Biswas, Annunziata Lapolla, Phil McEwan, G Mader, Gilles Chassot, Dragi Anevski, Werner A. Scherbaum, M Donath, C Hesselmann, R A Gandhi, David E. Moller, Ezio Bonifacio, C Garcia, V Ifandi, P Hornnes, Nieuwenhoven Fav., C Puech, S Pérez-Del-Pulgar, Kim S-R., G Hines, C Rubio Terrés, Michael Gaster, N. Hosszufalusi, A Scholze, Andrew A. Young, Stavros Liatis, F Hariri, S Tan, Paul Valensi, Allan E. Karlsen, J Kim, E. Moberg, J Kaiser, L Berman, G Nelson, A Altkrüger, P Kothare, D B Cook, S Doran, G. van Dijk, Shahnaz Shahinfar, Kim C-S., P Stahl, M Manousaki, S Sigrist, S K Lim, M. P. Stern, A Guberti, C Rezzani, J McKenney, Karl Thomaseth, Sofia Carlsson, M Julia, R Brillante, I Rubesova, T Darkow, E Matsumoto, Wendy M. Macfarlane, M Di Martino, G Bardini, Rossella Menghini, D Duhot, E Farcasiu, Annalisa Natalicchio, I Lindner, J Buvat, Christian L. Brand, Harry Dorchy, Iwona Pietrzak, Z T Luo, P Home, M Ekelund, Jesper Gromada, Kristine Færch, F Piarulli, H Kim, R Mentel, Zsuzsanna K. Zsengellér, Dullaart Rpf., Anton Luger, Thomas A. Pearson, V Manicardi, P Rösen, Feng Y-M., R Morganti, Lars Hansen, Demuth H-U., Haruo Kasai, A Shostak, Rudi Steffensen, G Taylor, Markolf Hanefeld, C Santini, E Hamaguchi, Roberto Miccoli, F Storms, M Cooper, Y Lee, Allison E. Aiello, P Smith, T Suehiro, K Treece, M Waluś, Timothy A Welborn, Simone Baltrusch, E Kontela, S Chai, J Crean, H Yokoyama, Johan G. Eriksson, Rafael Hernández Hernández, J Rodríguez-Saldaña, M P Tornero, G Formoso, D. Lovell, E Bingham, A Mylonakis, M Manteghetti, D Fedele, Antonio Martín-Duce, Ralph A. DeFronzo, D Salcedo, Kurt Højlund, Antonio Petrone, Sheu Whh., C Gutierrez, Flavia Pricci, S Kurita, Z G Abbas, M M Benedetti, Philippe A. Halban, Daniel J. Cox, O Ljungkvist, Justine Davies, J Palsgaard, Lars Sjöström, E Bosi, L Janin-Manificat, W. F. Kelly, M. Fernandez, E Colak, O V Mulyarchik, B Kronshage, F Lang, M Erfurth, Takashi Kadowaki, N Jendrike, U Walter, J Wishart, Y. Neye, D Kim, N Furuhashi, M Barsotti, D Florow, L Ke, L Borgquist, N C Jackson, Ffolliott M. Fisher, V Baskar, K Yoshioka, Bryan A. Wolf, G Chabrier, R Skoumal, Livio Luzi, H Kose, I Pharisien, B. Klein, H Winiarska, M C Johnson, L Griffiths, Nonna Kravchun, C Combe, Baptist Gallwitz, J Zdychova, L Skorda, Jorma Ilonen, W Gao, I N Steen, A Terrinoni, P D Ambery, W Kern, C M Kusminski, Cho M-H., Paolo Pozzilli, Louise G. Grunnet, E Schönle, David R Matthews, Robert W. Taylor, Y Cohen, Kim H-S., M P Eccles, N B Tutuncu, D McDowell, Richard M. Bergenstal, K Takamatsu, T Steiner, Jaan Palgi, Valdemar Grill, N Niculescu, G Federici, S Lehto, P. M. McKeigue, M Barone, Michael E. Trautmann, S Smirnov, J Mannion, M Eto, C Rousseau, M Conti, C S Ernest, Antonio Ceriello, D H Schweitzer, Jung E-D., Andreas Festa, Avijit Lahiri, A Shepelkevich, A Murro, A Kollmann, Jonathan R.S. Arch, R Landgraf, Son H-Y., I Engelsberger, E Agardh, S Rodríguez-Mulero, P J Kraml, K Lee, D. F. Du Toit, E Kim, G Fadini, Williams Ajk., Philip Home, M B Antcieferov, C Perlemoine, D Perrea, Song X-L., D Ruggieri, Krister Bokvist, Heidi Sørensen, Bilbao, G Yoshino, J P Taylor, Shen H-M., S M Furier, R Urquhart, J Wohlgelernter, Jianping Weng, T. Baba, Q Hong, C Silva, Castaigne J-P., M Felaco, X X Zhang, M Jaroň, Milla Rosengård-Bärlund, J G Papp, Toshio Miyata, Lervang H-H., Park M-K., I Kinalska, A Long, Oomen Phn., N Kogawa, Ippolita Patrizia Patera, S. Karadeniz, Dinesh Selvarajah, D S Chung, A Wensaas, Richard Imrich, M Recasens, J Ruxer, O Buchea, E Wilpart, S P Stepanenko, Le Ttd., H Ohgawara, Mariaconsuelo Valentini, A Mondok, M Peltonen, Marianne O. Larsen, K Chatzianagnostou, Agneta Ståhle, A L Ferrari, L Bordier, F Maingrette, A Matsuda, G Vukomanovic, Jakob D. Wikstrom, T Yamakita, E Gorostiaga, J Jin, B Gopalan, Heinz Drexel, S Hewitt, Rury R. Holman, C Dieterle, T L Ruchti, N Asatiani, M Sidira, A Iezzi, A J Sommerfield, D Châtenet, M L Olsen, R Bergemann, C Koehler, T L Kuraeva, B Balas, Christian Berne, E Santos-Mazo, G Smith, A Siejka, R Kožnarová, A Mattina, S Sheikh, A Adomeit, M Rasmussen, J. Fagerudd, N Busciantella Ricci, Nuria Vilarrasa, E Hammar, T L Thoms, L Aydın, Ron G. Rosenfeld, A Nikolajuk, R Gos, C L Morgan, H L Yu, D Dheelchand, S Ramrath, N Boudriga, Jerome I. Rotter, C Jahannault, W M Weston, Folke Lindgärde, M Hertlova, D Knight, A Monroy-Mayorga, E Pardini, A Chamson-Reig, B Franke, Janie McCluskey, Joseph Bryan, C Nikolopoulou, Christie M. Ballantyne, Fausto Santeusanio, L Pegoraro, M Lee, A Klimenko, S Jaiveer, K. Pettersson-Fernholm, Michael A. Nauck, A Ekbom-Schnell, G Deferrari, Riccardo Schiaffini, S. Pampanelli, Khan Aka., David Hopkins, Maija Wessman, M Kamarinos, Noh J-H., O Ebisui, K McCarroll, Jeppe Sturis, Peter Nowotny, N Gorbenko, Åke Sjöholm, David G. Maggs, A E Halseth, B Cresci, A A Ortiz-Gress, A Korakovouni, O Matejkova, C E Mogensen, C J Lin, Ramon Gomis, H Seaman, C Granier, Yang C-H., F Assah, O Sanchez, Fausto Machicao, Peter G. Morris, Alberto Ortiz, A Giardinelli, D Bracaglia, A Gonzalo, S Pavlatos, Andreas Lechner, F Canovic, L Sjolind, Allan Vaag, Birgitte Bruun Nielsen, David A. Ziegler, Vito Lampasona, R Gershoni-Baruch, A. Dei Cas, H Renz, E Mena, Matthew Waltham, Kim D-M., H Levanen, D D Mick, Valentina Alexandrovna Peterkova, E Meskhishvili, Sarah Nutland, R Bustani, John R. Lindsay, M Christoforidou, A Abicht, E Harno, K Cyganek, A Fitchet, S Neelotpol, P Nikishin, P Serradas, J Hinrichsen, M Halvorson, M Chovatia, B Voet, Jinny Willis, E Parretti, M Haslbeck, M Wellard, L Teng, Julio Wainstein, J S Fischer, K. Lalic, D Roggenland, I Gich, R Anwar, Maurizio Cassader, D Serota, X J Li, R J Schotzinger, Vilmundur Gudnason, Björn Zethelius, S A Wootton, W Andrzejewski, R Rezsohazy, R Gao, T Klimentova, T Mazurek, I Bruckner, C Dohrmann, R E James, G daSilva Xavier, Kim S-Y., A Dorca, Stuart J. Pocock, Terri J. Allen, I Giovos, P B Parab, N H Andersen, P Fotinakis, Miriam Cnop, H Lee, Norbert Tennagels, Omorodola I. Abatan, F Ailett, I. Lager, D Manzella, H Hut, Larry A. Distiller, G Lip, Lim S-K., Rong Zhang, T Tsuno, Steen Knudsen, M. Bajardi, Manuel Benito, Dai Sugimoto, Melvin J. Prince, D W Dunstan, D Rankins, K A Majali, G Ozansoy, Isabella Russo, S Uçak, G Annuzzi, R Talar-Wojnarowska, K Lange, S Neugebauer-Baba, Campbell H. Thompson, Eric Renard, P. D. Mountjoy, Z Morrison, Elizabeth A. Davis, Franco Cavallo, C Corvaja, R Antuña, Craig John Currie, H Linnebjerg, He Y-L., A J Palmer, Mariola R. Chacón, H Malinska, M. Jones, R Lichnovská, K Mandes, Paolo Tessari, T Mokhort, A Laina, H. L. Y. Chan, I Schmidt, R Banks, Richard G. IJzerman, L Ksinantova, G Setti, H Vaudry, A Gallo, V Spallone, Chen J-W., Thomas Danne, A Chong, M Hallschmid, S Aczel, S Hulme, N Islam, M Hosoi, P M Ternan, P Di Bartolo, N Bishara, T Shibasaki, Martin A. Osterhoff, Im S-S., M Jecht, T Hamaguchi, S Mattera, K Ways, Elizabeth Northam, U Rajala, Reinhard W. Holl, L Yang, S Panaiotopoulos, K Horvath, R Kluge, Thora B. Bodvarsdottir, Y Dong, Irene Alemanno, C McDougall, Reimar W. Thomsen, M Campbell, W Rabl, John Öhrvik, Yuichiro Yamada, Paola Ungaro, W Benzer, Mike Sampson, Roberto Trevisan, R G Radu, Aas A-M., P E Lobo, Ricardo Scott, S M Son, Josephine M. Forbes, T A Hillier, K L Wyne, Louis L. 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Chipchase, S, Treece, K, Pound, N, Hill, N, Cyganek, K, Mirkiewicz sieradzka, B, Malecki, M, Wolkow, P, Skupien, J, Naskalska, A, Sieradzki, J, Tapp, R, Tonkin, A, Harper, A, Mccarty, D, Söderberg, S, Taylor, H, Chitson, P, Alberti, G, Sheetz, M, Aiello, L, Davis, M, Milton, R, Arora, V, Hu, K, Girach, A, Vignati, L, Tyrberg, M, Melander, A, Lindblad, U, Giannarelli, R, Coppelli, A, Sartini, M, Aragona, M, Fletcher, E, Ninkovic, S, Foster, L, Jones, D, De Gooyer, T, Stitt, A, Vingrys, A, Wilkinson berka, J, Lewandowska, A, Randeva, H, Komorowski, J, Lewandowski, K, Jurowski, P, Sankar, S, Gos, R, Kowluru, R, Odenbach, S, Shinn, S, Agardh, C, Hultberg, B, Segura, R, Fonollosa, A, Berrone, E, Beltramo, E, Solimine, C, Ubertalli, A, Islam, N, Esteve, E, Fernandez, M, Recas, I, Mauri, S, Biarnes, F, Junca, E, Fernádez real, J, Rössner, S, Stenlof, K, Levy, B, Perry, B, Fitchet, M, Chrysos, G, Kamaratos, A, Lepeniotis, G, Kokkoris, S, Varytimiadis, K, Stasini, F, Mikros, S, Gianneli, D, 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S, Choi, D, Kim, N, Matsumoto, S, Suetsugu, M, Matsutomo, R, Pisarczyk wiza, D, Banaszak, A, Wysocki, H, Usui, H, Shikata, K, Okada, S, Ogawa, D, Yozai, K, Kido, Y, Nagase, R, Ohga, S, Tone, A, Sasaki, M, Wada, J, Unno, Y, Horiuchi, S, Mclennan, S, Kamarinos, M, Waltham, M, Dy, V, Yue, D, Zdychova, J, Komers, R, Cresci, B, Giannini, S, Manuelli, C, Giunti, S, Pinach, S, Ianni Palarchio, A, Arnaldi, L, Vittone, F, Camussi, G, Cavallo Perin, P, Gruden, G, Marshall, S, Jones, S, White, K, Brizzi, M, Dentelli, P, Rosso, A, Calvi, C, Gambino, R, Cassader, M, Salvidio, G, Deferrari, G, Pegoraro, L, Pagano, G, Cavallo perin, P, Oates, R, Ellery, C, Beebe, D, Coutcher, J, Qian, Y, Lowe, V, Appleton, T, Raunig, D, O'Neil, S, Mylari, B, Amazonas, R, Fujita, A, Doi, A, Matsuno, S, Okamoto, K, Matsumoto, E, Furuta, H, Nishi, M, Tsuno, T, Taniguchi, H, Bessho, H, Wasén, E, Isoaho, R, Mattila, K, Vahlberg, T, Kivelä, S, Irjala, K, Rigalleau, V, Lasseur, C, Perlemoine, C, Barthes, N, Raffaitin, C, Chauveau, P, Combe, C, Baillet blanco, L, Beauvieux, M, Gin, H, Heinrich, S, Steiner, T, Ott, U, Holdass, H, Fellström, B, Jardine, A, Staffler, B, Logan, J, Gimpelewicz, C, Stanciu, C, Pena, C, Serafinceanu, C, González posada, J, Hernández, D, Pérez tamajó, L, Ló, A, Herná Alarcó, M, Meneses, M, Barsotti, M, Rizzo, G, Schmauss, S, Havrdova, T, Saudek, F, Boucek, P, Adamec, M, Invitti, C, Gilardini, L, Parati, G, Mazzilli, G, Pontiggia, B, Sartorio, A, Lutgers, H, Groenier, K, Zasadzinska, G, Saryusz wolska, M, Kurktschiev, D, Majdrakova, I, Varbanova, T, Todorova, B, Bajo martinez, A, Bernal, E, Sanchez, O, Ugalde canitrot, A, Sanchez largo, E, Coca robinot, D, Fabregate, R, Calbacho, M, Marquez, J, Saban ruiz, J, Penesova, A, Cizmarova, E, Blazicek, P, De Jongh, R, Serné, E, Ijzerman, R, De Vries, G, Andersen, N, Knudsen, S, Helleberg, K, Mogensen, C, Waluś, M, Idzior waluś, B, Sztefko, K, Cieślik, G, Fedak, D, Wozniakiewicz, E, Lin, S, Guo, M, Lin, C, Liu, X, Francisco, M, Rodriguez rosas, H, Peiró martinez, I, Macías batista, A, Harte, A, Rodriguez cuenca, S, Valsamakis, G, Chetty, R, Anderson, L, Roca, P, Matyka, K, Lasalle, J, Hershon, K, Berman, L, Gibson, E, Gillen, D, Maroni, J, Simmons, D, Hiukka, A, Forder, P, Leinonen, E, Hilden, H, Fruchart, J, Keech, A, Farnier, M, Freeman, M, Macdonell, G, Perevozskaya, I, Mitchel, Y, Gumbiner, B, Didangelos, T, Athyros, V, Mikhailidis, D, Papageorgiou, A, Bouloukos, V, Pehlivanidis, A, Symeonidis, A, Elisaf, M, Mckenney, J, Insull, W, Lewin, A, Maccubbin, D, Kush, D, Schuster, H, Barter, P, Stender, S, Bonnet, J, Morrell, J, Watkins, C, Kallend, D, Stalenhoef, A, Ballantyne, C, Murin, J, Tonstad, S, Rose, H, Wilpshaar, W, Jenkins, A, Karschimkus, C, Dragicevic, G, Rowley, K, Wolthers, T, Best, J, Voet, B, Murdoch, S, Marcovina, S, Brunzell, J, Caparevic, Z, Kostic, N, Ilic, S, Sartore, G, Piarulli, F, Cantaro, S, Reitano, R, Fiore, C, Marin, R, Bassan, S, Manzato, E, Fedele, D, Solini, A, Santini, E, Thornalley, P, Babaei jadidi, R, Karachalias, N, Kupich, C, Ahmed, N, Fowler, A, Baker, A, Starczynski, J, O'Hare, P, Szepietowska, B, Szelachowska, M, Puch, U, Glebocka, A, Quinn, D, Mcternan, C, Bonser, R, Idzior walus, B, Woźniakiewicz, E, Dimitriou, K, Apostolou, O, Kontela, E, Devangelio, E, Gould, E, Serri, O, Roussin, A, Buithieu, J, Mamputu, J, Renier, G, Giordanetti, S, De Amici, E, Poggi, G, Turpini, C, Fratino, P, Garzaniti, A, Banu, I, Paries, J, Roman, G, Negrean, M, Bala, C, Nita, C, Kistorp, C, Gustafsson, F, Chong, A, Lip, G, Galatius, S, Ari, N, Sahilli, M, Ceylan isık, A, Ozansoy, G, Karasu yilmaz, C, Matteucci, E, Rosada, J, Pallini, M, Evangelista, I, Cassetti, G, Giusti, C, Giampietro, O, Capaldo, B, Galderisi, M, Cicala, S, Turco, A, Imbroinise, A, Nosso, G, D'Errico, A, De Divitiis, O, Klimontov, V, Korolyova, E, Jeltova, L, Bondar, I, Tarkun, I, Arslan, B, Canturk, Z, Tarkun, P, Agacdiken, A, Komsuoglu, B, Méneveau, N, Pierre justin, E, Alsayed, M, Sabbah, R, Paulin, S, Marcu, S, Tauveron, I, Zimmermann, C, Schiele, F, Seronde, M, Vautrin, P, Lusson, J, Thieblot, P, Bernard, Y, Mistry, A, Pye, M, Peovska, I, Maksimovic Pavlovic, J, Vavlukis, M, Pop Gorceva, D, Bosevski, M, Scognamiglio, R, Negut, C, De Kreutzenberg, S, Madonna, R, De Caterina, R, Willerson, J, Geng, Y, Vahsen, S, Ledwig, D, Ramrath, S, Frantz, S, Schmidt, I, Calvillo, L, Dienesch, C, Elbing, I, Bischoff, H, Ertl, G, Bauersachs, J, Davydov, A, Mkrtum'Yan, A, Baranova, L, Ikeda, Y, Suehiro, T, Osaki, F, Ota, K, Arii, K, Kumon, Y, Hashimoto, K, Doney, A, Morris, A, Palmer, C, Byun, S, Doo, H, Pagnin, E, Calo, L, Fadini, G, Kubaszek, A, Chai, S, Chai, Q, Rasmussen, L, Ledet, T, Wogensen, L, Lengyel, C, Varró, A, Virág, L, Magyar, J, Bíró, T, Jost, N, Skoumal, R, Nánási, P, Tóth, M, Horkay, F, Papp, J, Zacharopoulou, O, Athanaselis, S, Tsokos, N, Doupis, J, Psallas, M, Cokkinos, D, Pavlatos, S, Liatis, S, Akhobadze, T, Dzneladze, L, Samarguliani, I, Taskiran, M, Rasmussen, V, Jensen, G, Fisher, A, Petrovsky, N, Srikusalanukul, W, Budge, M, Trifunovic zamaklar, D, Zivkovic, M, Jelic, V, Vukomanovic, G, Ristic, A, Seferovic, P, Costa, J, Duarte, S, Manley, S, Sailesh, S, Venkataraman, A, Haider, Y, Groza, I, Oprean, M, Ardelean, A, Morosanu, A, Darkow, T, Vanderplas, A, Mamas, M, Mcelduff, P, Burns, J, Edwards, R, Fitchet, A, Young, R, Gibson, J, Lichiardopol, R, Niculescu, N, Totora, A, Pencea, C, Tomescu, I, Cinteza, M, Manicardi, V, Coscelli, C, Navazio, A, Catellani, E, Michelini, M, Dall'Asta, D, Guberti, A, Piazza, A, Gasparini, E, Pantaleoni, M, Guiducci, U, Manari, A, Sejil, S, Janand delenne, B, Avierinos, J, Habib, G, Labastie, N, Vague, P, Lassmann vague, V, Luźniak, P, Tatoń, J, Wojciechowska Luźniak, A, Zairis, M, Lyras, A, Patsourakos, N, Tsirimbis, V, Foussas, S, Lupón, J, Urrutia, A, Herreros, J, González, B, Coll, R, Altimir, S, Prats, M, Valle, V, Abreu padí, C, Rábago, G, Ivanova, L, Brasacchio, D, Harno, E, Keenan, A, Li, H, Lu, Z, Ke, L, Liu, H, Jeong, I, Chae, M, Choi, M, Yoo, H, Kim, C, Yun, M, Na, M, Kang, Y, Kong, O, Son, S, Kim, I, Tanaka, N, Hosoi, M, Matsuyama, Y, Fukumoto, M, Yamakita, T, Yoshioka, K, Ishii, T, Sato, T, Fujii, S, Aoki, T, Shibata, T, Mizutani, N, Suzuki, J, Fowelin, J, Samuelsson, P, Brandrup wogsen, G, Okumura, K, Tokmakova, A, Staroverova, D, Antcieferov, M, Shutichina, I, Kuntchevich, G, Vriesendorp, T, Morélis, Q, Legemate, D, Schaper, F, Mainas, E, Gkioulmpasanis, I, Panagiotou, I, Vassilikos, G, Skorda, L, Sidira, M, Christoforidou, M, Alaveras, A, Artikis, V, Evdemon, E, Lechleitner, M, Koch, T, Ebenbichler, C, Sturm, W, Moretti, L, Moruzzo, D, Boldrini, E, Pandolfo, C, Kameyama, M, Iwasa, R, Cho, M, Nam, J, Huh, K, Kaplar, M, Paragh, G, Erdei, A, Csongradi, E, Garai, I, Varga, J, Galuska, L, Udvardy, M, Higa, M, Kaneko, Y, Hiroi, N, Koziarska, D, Nowacki, P, Majkowska, L, Luzniak, P, Wojciechowska luźniak, A, Tushuizen, M, Nieuwland, R, Snoeck, D, Sturk, A, Diamant, M, Aguiar, L, Bahia, L, Villela, N, Laflor, C, Conde, C, Bottino, D, Dorigo, D, Bouskela, E, Pu, S, Luo, Z, Lam, K, Dan, Q, Xu, A, Shen, J, Cheng, K, Xu, J, Thamer, C, Stefan, N, Haap, M, Heller, E, Tschritter, O, De Prado, A, Ortiz, A, Ybarra, J, Gich, I, Pou, J, Ehren, M, Roggenland, D, Reinsen, B, Klein, H, Rittig, K, Stock, J, Kocher, B, Balletshofer, B, Shon, H, Chung, D, Nakatani, Y, Matsuhisa, M, Kaneto, H, Hatazaki, M, Yoshiuchi, K, Katakami, N, Kawamori, D, Ohtoshi, K, Sakamoto, K, Matsuoka, T, Ozawa, K, Ogawa, S, Hori, M, Yamasaki, Y, Zitouni, K, Harry, D, Nourooz zadeh, J, Earle, K, Olesen, P, Franco, L, Corvaja, C, Semplicini, A, Ceylan işık, A, Arı, N, Rösen, P, Lee, I, Park, K, Jung, E, Shin, D, Jo, S, Obuobie, K, Prakash, P, Hanna, F, Lazarus, J, Varadhan, L, Gurushankar, J, James, D, Sheikh, S, Gaede, P, Zou, D, Vilarrasa, N, Perez maraver, M, Mena, E, Perez, D, Setti, G, Buckingham, R, Urbančič, V, Stefanovska, A, Bernjak, A, Ažman juvan, K, Kocijančič, A, Glowania, A, Filters, T, Fosmark, D, Torjesen, P, Kilhovd, B, Berg, T, Sandvik, L, Hanssen, K, Mentink, C, Donchenko, G, Stepanenko, S, Maingrette, F, Deng, H, Lindenmair, A, Freudenthaler, A, Baumgartner parzer, S, Nizheradze, K, Khoruzhenko, A, Tronko, N, Sheu, W, Ou, H, Shen, H, Lin, T, Wu, H, Yang, C, Mogylnytska, L, Schmoelzer, I, Davies, J, Band, M, Struthers, A, Prázný, M, Škrha, J, Kasalová, Z, Neelotpol, S, Jahan, P, Kauschke, S, Harrop, C, Schäfer, A, Widder, J, Eigenthaler, M, Walter, U, Uchimura, I, Ikebukuro, M, Kaibara, M, Hirata, M, Helal, R, Pervin, F, Yang, X, Jansson, P, Nagaev, I, Jack, M, Carvalho, E, Sunnerhagen, K, Cam, M, Cushman, S, Smith, U, Creely, S, Farmer, J, Gustafson, B, Kusminski, C, Krusinova, E, Wohl, P, Klementova, M, Lanska, V, Mcdougall, C, Kelly, I, Abbas, Z, Lutale, J, Archibald, L, Karunajeewa, H, Stingemore, N, Stuccio, G, Mcgechie, D, Muller, L, Hak, E, Goudzwaard, W, Montorsi, F, Homering, M, Sprenger, K, Goldstein, I, Asnaghi, V, Ferrari, G, Rastaldi, M, Gabellini, D, Dell'Antonio, G, Maestroni, A, Ruggieri, D, Luzi, L, Piemonti, L, Zerbini, G, Anafaroglu, I, Tutuncu, N, Sultana, M, Siddiqua, N, Iwasaki, T, Nakajima, A, Yoneda, M, Mukasa, K, Tanaka, S, and Sekihara, H
Subjects: 0303 health sciences, medicine.medical_specialty, business.industry, EASD, Endocrinology, Diabetes and Metabolism, Human physiology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, Diabetes mellitus, Family medicine, Internal Medicine, Medicine, business, 030217 neurology & neurosurgery, 030304 developmental biology
Published: 2004

19. Alternative site blood glucose testing:a multicenter study

Author: A Corsi, Antonio Nicolucci, Monica Franciosi, Dario Iafusco, C Noacco, Francesco Prisco, David A. Fedele, E Torre, R Toniato, G. De Berardis, M K Errico, Lorenzo Neri, and S. Squatrito
Subjects: Adult, Blood Glucose, Male, medicine.medical_specialty, Adolescent, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Hypoglycemia, Fingers, Endocrinology, Forearm, Reference Values, Diabetes mellitus, Linear regression, Medicine, Humans, Age of Onset, Child, Type 1 diabetes, business.industry, Blood Glucose Self-Monitoring, Glucose Measurement, Reproducibility of Results, Glucose clamp technique, medicine.disease, Surgery, Medical Laboratory Technology, medicine.anatomical_structure, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Patient Satisfaction, Anesthesia, Glucose Clamp Technique, Regression Analysis, Female, business
Abstract: The aim of this study was to compare glucose measurements between fingertip and forearm using the blood glucose (BG) monitoring system One Touch Ultra (LifeScan), an electrochemical sensor that requires only a very small drop of blood (1 microL). Patients with type 1 or type 2 diabetes were identified in five outpatient diabetes clinics. Participants were requested to use the One Touch Ultra at home for 1 week for the measurement of BG levels from both sites. Patients filled in a questionnaire about their experience with testing blood samples from fingertip and forearm. The agreement between the measurements from the two sites was assessed using linear regression analysis, mean absolute relative error (MARE), the Bland-Altman method, and Error Grid Analysis (EGA). Overall, 112 patients were recruited, of whom 58% had type 1 diabetes. Linear regression analysis showed an intercept of 17.7, statistically different from 0 (p
Published: 2004

20. Usefulness or uselessness of GlucoWatch in monitoring hypoglycemia in children and adolescents

Author: Colomba Gemma, Richard C. Eastman, Francesco Prisco, Dario Iafusco, Maria Katrin Errico, Iafusco, Dario, Errico, Mk, Gemma, C, and Prisco, F.
Subjects: Type 1 diabetes, Pediatrics, medicine.medical_specialty, business.industry, Incidence (epidemiology), Behavioral therapy, Physical activity, Hypoglycemia, medicine.disease, Pediatric department, Diabetes mellitus, Pediatrics, Perinatology and Child Health, medicine, Young adult, business
Abstract: To the Editor. — The article of Chase et al1 was the first report of the routine use of the GlucoWatch biographer in children with diabetes mellitus. Since May 2002 in our pediatric department, 14 children and adolescents (7–17.8 years old) and 8 young adults (18–23 years old) with type 1 diabetes mellitus wore the biographer each one on an average of 12 different occasions for a mean period of 30 days. We agree with Chase et al1,2 about the good correlation between noninvasive readings of glucose levels by GlucoWatch and finger-stick glycemia. Our patients too showed a good compliance with extemporaneous changes of therapy, diet, and physical activity in response to alarms for hypo- or hyperglycemia confirmed by finger-stick determinations (“behavioral therapy”). But in our opinion the usefulness of this device for investigating the incidence of unrecognized hypoglycemias is not absolute. In our patients, during the night, the GlucoWatch biographer recorded 7 episodes of hypoglycemia (blood glucose from 30 to 70 mg/dL) lasting from 20 to 280 minutes and confirmed by monitoring blood glucose in 4 of the 6 verified cases (85%). However, the alarm failed to alert the patient in the majority of cases, probably because the reduced awareness consequent to hypoglycemia itself. In particular, …
Published: 2004

21. Effect of gluten-free diet on the metabolic control of type 1 diabetes in patients with diabetes and celiac disease

Author: Francesco Prisco, Angelika Mohn, Francesco Chiarelli, Dario Iafusco, F. Rea, Iafusco, Dario, Rea, F, Chiarelli, F, Mohn, A, and Prisco, F.
Subjects: Advanced and Specialized Nursing, medicine.medical_specialty, Type 1 diabetes, business.industry, Endocrinology, Diabetes and Metabolism, Disease, medicine.disease, Gastroenterology, Diabetes mellitus, Metabolic control analysis, Internal medicine, Internal Medicine, medicine, In patient, Gluten free, business
Published: 2000

22. Hypoglycemia and Reduction of the Insulin Requirement as a Sign of Celiac Disease in Children With IDDM

Author: Francesco Prisco, Francesco Rea, Dario Iafusco, Iafusco, Dario, Francesco, Rea, and Francesco, Prisco
Subjects: Advanced and Specialized Nursing, Pediatrics, medicine.medical_specialty, Dose-Response Relationship, Drug, Glutens, business.industry, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Insulin, Disease, Hypoglycemia, medicine.disease, Celiac Disease, Diabetes Mellitus, Type 1, Diabetes mellitus, Internal Medicine, medicine, Humans, Hypoglycemic Agents, Child, business, Reduction (orthopedic surgery), Sign (mathematics)
Published: 1998
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23. Altered Intestinal Permeability to Mannitol in Diabetes Mellitus Type I

Author: Maria Grazia Carbone, Mario Secondulfo, Dario Iafusco, Romano Carratù, Marilena Cartenì, Laura de Magistris, Gabriele Pontoni, Francesco Prisco, Anna Urio, R., Carratù, M., Secondulfo, DE MAGISTRIS, Laura, Iafusco, Dario, A. G., Carbone, A., Urio, G., Pontoni, M., Cartenì, and F., Prisco
Subjects: Adult, Male, medicine.medical_specialty, Cell Membrane Permeability, Cellobiose, Magnetic Resonance Spectroscopy, Adolescent, endocrine system diseases, Disease, Coeliac disease, Diabetes mellitus, Immunopathology, Internal medicine, medicine, Humans, Mannitol, Child, Autoimmune disease, Intestinal permeability, business.industry, Gastroenterology, nutritional and metabolic diseases, medicine.disease, Pathophysiology, Diabetes Mellitus, Type 1, Endocrinology, Intestinal Absorption, Pediatrics, Perinatology and Child Health, Female, business, medicine.drug
Abstract: Intestinal permeability has seldom been investigated in diabetes mellitus, even though patients frequently report gastrointestinal symptoms, and it has recently been shown that the prevalence of celiac disease associated with diabetes mellitus is higher than expected.Intestinal permeability to cellobiose and mannitol was investigated in 31 patients affected by type I uncomplicated diabetes mellitus. Values were compared with those obtained in 32 normal subjects.The percentage of mannitol recovery was far higher than normal in two thirds of the investigated patients and correlated with the length of disease, even though the probes' ratio (cellobiose/mannitol) was in the normal range.A not previously reported increase of intestinal permeability to mannitol, clear-cut and not associated with that of the larger probe, is found in type I uncomplicated diabetes mellitus. These results may describe a primary feature of type I diabetes mellitus and the initial steps of evolution to celiac disease.
Published: 1999

24. Diabetes, Sensorineural Deafness, and Mitochondrial DNA Mutation

Author: Francesco Prisco, Dario Iafusco, Prisco, F, and Iafusco, Dario
Subjects: Genetics, Mitochondrial DNA, Otorhinolaryngology, business.industry, Diabetes mellitus, Mutation (genetic algorithm), Medicine, Sensorineural deafness, business, medicine.disease, Human mitochondrial genetics
Published: 2006
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25. Mitochondrial Diabetes in Children: Seek and You Will Find It

Author: Cristina Mazzaccara, Francesca Simonelli, Francesco Prisco, Mariorosario Masullo, Lucia Sacchetti, Paolo Landolfo, Alfonso Galderisi, Dario Iafusco, Maddalena Ferrigno, Domenico Vitale, Rosario Liguori, Mazzaccara, Cristina, Iafusco, Dario, Liguori, R., Ferrigno, M., Galderisi, A., Vitale, DINO FRANCO, Simonelli, Francesca, Landolfo, P., Prisco, Francesco, Masullo, Mariorosario, Sacchetti, Lucia, Mazzaccara, C, Iafusco, D, Liguori, R, Ferrigno, M, Galderisi, A, Vitale, D, Simonelli, F, Landolfo, P, Prisco, F, Masullo, M, and Sacchetti, L
Subjects: Male, Genetics and Molecular Biology (all), Proband, Mitochondrial Diseases, Diabetes mellitus and deafness, Respiratory chain, Physiology, Deafness, Biochemistry, Molecular Cell Biology, Complex I and IV mutations, Child, Genetics, Genome, Multidisciplinary, Medicine (all), Mitochondrial, Mitochondria, Pedigree, Genes, Mitochondrial, Maternally Inherited Diabetes and Deafness (MIDD), Child, Preschool, Medicine, Female, medicine.symptom, Sequence Analysis, Type 2, Research Article, Mitochondrial DNA, Adolescent, Hearing loss, Science, Biology, Maternally Inherited Diabetes and Deafness, Molecular Genetics, Electron Transport Complex IV, Genetic Mutation, Diabetes mellitus, Diabetes Mellitus, medicine, Humans, Genetic Testing, Mitochondrial diabetes, Preschool, Genetic Association Studies, Clinical Genetics, pathogenetic mtDNA mutations, Type 1 diabetes, Electron Transport Complex I, Mutation Types, Human Genetics, Sequence Analysis, DNA, DNA, Case-Control Studies, Diabetes Mellitus, Type 2, Genome, Mitochondrial, Agricultural and Biological Sciences (all), Biochemistry, Genetics and Molecular Biology (all), medicine.disease, Impaired fasting glucose, Diabetes Mellitus and Deafness, Genes, mitochondrial genome
Abstract: Maternally Inherited Diabetes and Deafness (MIDD) is a rare form of diabetes due to defects in mitochondrial DNA (mtDNA). 3243 A>G is the mutation most frequently associated with this condition, but other mtDNA variants have been linked with a diabetic phenotype suggestive of MIDD. From 1989 to 2009, we clinically diagnosed mitochondrial diabetes in 11 diabetic children. Diagnosis was based on the presence of one or more of the following criteria: 1) maculopathy; 2) hearing impairment; 3) maternal heritability of diabetes/impaired fasting glucose and/or hearing impairment and/or maculopathy in three consecutive generations (or in two generations if 2 or 3 members of a family were affected). We sequenced the mtDNA in the 11 probands, in their mothers and in 80 controls. We identified 33 diabetes-suspected mutations, 1/33 was 3243A>G. Most patients (91%) and their mothers had mutations in complex I and/or IV of the respiratory chain. We measured the activity of these two enzymes and found that they were less active in mutated patients and their mothers than in the healthy control pool. The prevalence of hearing loss (36% vs 75-98%) and macular dystrophy (54% vs 86%) was lower in our mitochondrial diabetic adolescents than reported in adults. Moreover, we found a hitherto unknown association between mitochondrial diabetes and celiac disease. In conclusion, mitochondrial diabetes should be considered a complex syndrome with several phenotypic variants. Moreover, deafness is not an essential component of the disease in children. The whole mtDNA should be screened because the 3243A>G variant is not as frequent in children as in adults. In fact, 91% of our patients were mutated in the complex I and/or IV genes. The enzymatic assay may be a useful tool with which to confirm the pathogenic significance of detected variants.
Published: 2012
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26. Early Preprandial Hypoglycemia After Administration of Insulin Lispro

Author: Francesco Prisco, Efisio Angius, Dario Iafusco, Iafusco, Dario, E., Angiu, and F., Prisco
Subjects: Advanced and Specialized Nursing, Pediatrics, medicine.medical_specialty, business.industry, Endocrinology, Diabetes and Metabolism, Hypoglycemia, medicine.disease, Diabetes mellitus, Internal Medicine, medicine, Insulin lispro, business, Administration (government), medicine.drug
Published: 1998
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27. Prevalence of Eating Disorders in Young Patients With Type 1 Diabetes From Two Different Italian Cities

Author: Maurizio Vanelli, Maria Gugliotta, Francesco Prisco, Dario Iafusco, Brunella Iovane, Giovanni Chiari, Iafusco, Dario, Vanelli, M, Gugliotta, M, Iovane, B, Chiari, G, and Prisco, F.
Subjects: Advanced and Specialized Nursing, Pediatrics, medicine.medical_specialty, Type 1 diabetes, Adolescent, business.industry, Endocrinology, Diabetes and Metabolism, Diabetology, Disease, medicine.disease, Thyroiditis, Feeding and Eating Disorders, Eating disorders, Diabetes Mellitus, Type 1, Italy, Diabetes mellitus, Metabolic control analysis, Prevalence, Internal Medicine, medicine, Humans, Child, Psychiatry, business, Socioeconomic status
Abstract: The prevalence of eating disorders and behaviors was evaluated in two populations of adolescents with type 1 diabetes from two cities in Italy. In this report, we will establish the relationship of these disorders with sex, BMI, socioeconomic status, metabolic control, and compliance to therapy. A total of 193 patients with type 1 diabetes aged 8–18 years (mean 13.6 ± 2.7 years; 92 female and 101 male subjects) were recruited from the pediatric diabetology units at the Second University of Naples ( n = 118, 56 female and 62 male subjects) and at the University of Parma ( n = 75, 36 female and 39 male subjects). All patients were affected by type 1 diabetes without evidence or history of other autoimmune diseases (thyroiditis, celiac disease, etc.). The distribution of sex, age at the onset of diabetes, disease duration, and BMI was statistically similar in …
Published: 2004
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28. The diet in children with diabetes mellitus (DM)

Author: Francesco Prisco, Angela Zanfardino, Santino Confetto, Dario Iafusco, Iafusco, Dario, Zanfardino, Angela, Confetto, Santino, and Prisco, Francesco
Subjects: Pediatrics, medicine.medical_specialty, Type 1 diabetes, business.industry, Insulin, medicine.medical_treatment, Type 2 Diabetes Mellitus, Type 2 diabetes, medicine.disease, Glycemic index, Diabetes mellitus, Meeting Abstract, Pediatrics, Perinatology and Child Health, medicine, Metabolic syndrome, business, Insulin index
Abstract: A proper nutritional plan is important in the treatment of children and adolescents with diabetes. Its main functions are a) maintaining a good metabolic control, reducing the risk of hyperglycemia and hypoglycemic crisis (induced by prolonged fasting or errors in insulin dose) and b) sustaining the "long term health", allowing a good general state of health, normal growth and pubertal development and reducing the risk of micro and macro vascular complications. The common opinion is that the general characteristics of a diet for a child with diabetes do not differ from the recommended intakes for the general pediatric population (Italian term: LARN), However until a few years ago the adaptation to the recommendations was not entirely possible being necessary to modulate the intake of carbohydrates with the pharmacodynamics of the various types of insulins. The introduction of new insulins such as fast, slow analogs and, at the same time, the increased use of subcutaneous insulin infusion pumps have allowed a better adaptation of the dietary habits of the different ages of life not underestimating that the approach to food by children and adolescents contains emotional meanings (premium, punishment, gratification, a sense of homologation with peers, etc..) that may affect the compliance to the therapy. In the basal-bolus insulin regimen it can be very useful to apply the “rule of carbohydrates” (adapting the dose of insulin to the amount of carbohydrates in the meal) and the insulin index (a parameter which takes into account the effect of amino acids and proteins on postprandial blood glucose levels). The choice of analog rapid or human insulin as boluses in the treatment with multi injection therapy or the possibility to change the bolus type (square-wave, double-wave,etc.) in the case of the pump can take in consideration also the timing of absorption of carbohydrates delayed on the basis of the glycemic index of food.[1] However, in line with the global obesity epidemic, a raised weight gain has been described also in adolescents with type 1 diabetes mellitus (T1DM). We have recently shown high prevalence of abdominal adiposity (28,1%) as a sign of metabolic syndrome (MetSy) (9,5%) in adolescents with T1DM [2,3]. On the other hand, due to the prevalence of obesity in children, Type 2 diabetes mellitus (T2DM) in adolescents is becoming an increasingly important public health also in Italy. Diet and exercise are the therapy and prevention of Type 2 diabetes and obesity [4].
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29. A girl with Diabetes and severe Combined Immunodeficiency from Adenosine Deaminase Deficiency

Author: F Prisco, E De Felice, Corrado Betterle, Rs Accolla, G. Tosi, Bm Amodeo, Dario Iafusco, G Stoppoloni, Ld Notarangelo, R. Toraldo, Iafusco, D, Iafusco, Dario, BIANCA M., Amodeo, EUGENIO DE, Felice, Toraldo, Roberto, Corrado, Betterle, LUIGI D., Notarangelo, Giovanna, Tosi, and ROBERTO S., ACCOLLA AND FRANCESCO PRISCO
Subjects: endocrine system diseases, Adenosine Deaminase, Endocrinology, Diabetes and Metabolism, Human leukocyte antigen, HLA-DQ alpha-Chains, Pathogenesis, Endocrinology, Adenosine deaminase, immune system diseases, HLA-DQ Antigens, Diabetes mellitus, medicine, HLA-DQ beta-Chains, Humans, Allele, Child, Gene, Autoantibodies, Severe combined immunodeficiency, biology, business.industry, Histocompatibility Testing, Gene Transfer Techniques, nutritional and metabolic diseases, Genetic Therapy, medicine.disease, Adenosine deaminase deficiency, Diabetes Mellitus, Type 1, Pediatrics, Perinatology and Child Health, Immunology, biology.protein, Female, Severe Combined Immunodeficiency, business
Abstract: We present a girl with severe combined immunodeficiency (SCID) from adenosine deaminase (ADA) deficiency who developed insulin dependent diabetes mellitus (IDDM). This combination of features has not been previously reported. Because HLA typing (DQbeta-57 Asp/Asp and DQalpha-52 Ser/Ser) showed no alleles usually associated with IDDM, and ICA were repeatedly negative even after treatment with PEG-ADA and gene transplant, hypotheses on the pathogenesis of diabetes mellitus in this patient are discussed.
Published: 1997

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29 results on '"Francesco Prisco"'

1. Erratum to: Organization and regional distribution of centers for the management of children and adolescents with diabetes in Italy

2. Chlamydia pneumoniae infection in adolescents with type 1 diabetes mellitus

3. A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes

4. Lower limbs edema by insulin glargine treatment: two other cases in pediatrics

5. Blood ketone bodies in patients with recent-onset type 1 diabetes (a multicenter study)

6. Diabetes Incidence in 0- to 14-Year Age-Group in Italy

7. Continuous subcutaneous insulin infusion in preschool children: butt or tummy, which is the best infusion set site?

8. Celiac Disease in Children and Adolescents with Type I Diabetes: Importance of Hypoglycemia

9. Refractory rheumatoid factor positive polyarthritis in a female adolescent already suffering from type 1 diabetes mellitus and Hashimoto's thyroiditis successfully treated with etanercept

10. All classifications not built on pathogenesis become inadequate sooner or later

11. Acute juvenile cataract in newly diagnosed type 1 diabetic patients: A description of six cases

12. Chat Line for Adolescents with Type 1 Diabetes: A Useful Tool to Improve Coping with Diabetes: A 2-Year Follow-Up Study

13. Not every child with diabetes needs insulin

14. Use of real time continuous glucose monitoring and intravenous insulin in type 1 diabetic mothers to prevent respiratory distress and hypoglycaemia in infants

15. Bilateral isolated acute cataracts in three newly diagnosed insulin dependent diabetes mellitus young patients

16. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes and their relatives

17. Sulfonylurea treatment outweighs insulin therapy in short-term metabolic control of patients with permanent neonatal diabetes mellitus due to activating mutations of the KCNJ11 (KIR6.2) gene

18. 40(th) EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004

19. Alternative site blood glucose testing:a multicenter study

20. Usefulness or uselessness of GlucoWatch in monitoring hypoglycemia in children and adolescents

21. Effect of gluten-free diet on the metabolic control of type 1 diabetes in patients with diabetes and celiac disease

22. Hypoglycemia and Reduction of the Insulin Requirement as a Sign of Celiac Disease in Children With IDDM

23. Altered Intestinal Permeability to Mannitol in Diabetes Mellitus Type I

24. Diabetes, Sensorineural Deafness, and Mitochondrial DNA Mutation

25. Mitochondrial Diabetes in Children: Seek and You Will Find It

26. Early Preprandial Hypoglycemia After Administration of Insulin Lispro

27. Prevalence of Eating Disorders in Young Patients With Type 1 Diabetes From Two Different Italian Cities

28. The diet in children with diabetes mellitus (DM)

29. A girl with Diabetes and severe Combined Immunodeficiency from Adenosine Deaminase Deficiency

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