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A Multicenter Retrospective Survey regarding Diabetic Ketoacidosis Management in Italian Children with Type 1 Diabetes
- Source :
- Journal of Diabetes Research, Journal of Diabetes Research, Vol 2016 (2016)
- Publication Year :
- 2016
-
Abstract
- We conducted a retrospective survey in pediatric centers belonging to the Italian Society for Pediatric Diabetology and Endocrinology. The following data were collected for all new-onset diabetes patients aged 0–18 years: DKA (pH < 7.30), severe DKA (pH < 7.1), DKA in preschool children, DKA treatment according to ISPAD protocol, type of rehydrating solution used, bicarbonates use, and amount of insulin infused. Records(n=2453)of children with newly diagnosed diabetes were collected from 68/77 centers (87%), 39 of which are tertiary referral centers, the majority of whom (n=1536, 89.4%) were diagnosed in the tertiary referral centers. DKA was observed in 38.5% and severe DKA in 10.3%. Considering preschool children, DKA was observed in 72%, and severe DKA in 16.7%. Cerebral edema following DKA treatment was observed in 5 (0.5%). DKA treatment according to ISPAD guidelines was adopted in 68% of the centers. In the first 2 hours, rehydration was started with normal saline in all centers, but with different amount. Bicarbonate was quite never been used. Insulin was infused starting from third hour at the rate of 0.05–0.1 U/kg/h in 72% of centers. Despite prevention campaign, DKA is still observed in Italian children at onset, with significant variability in DKA treatment, underlying the need to share guidelines among centers.
- Subjects :
- 0301 basic medicine
Male
Pediatrics
Endocrinology, Diabetes and Metabolism
Endocrinology
endocrine system diseases
type 1 diabetes
Adolescent
Child
Child, Preschool
Diabetes Mellitus, Type 1
Diabetic Ketoacidosis
Female
Health Care Surveys
Humans
Infant
Infant, Newborn
Insulin
Italy
Rehydration Solutions
Retrospective Studies
Treatment Outcome
lcsh:Diseases of the endocrine glands. Clinical endocrinology
ketoacidosis
Retrospective Studie
Medicine
Diabetology
Diabetes and Metabolism
Newly diagnosed diabetes
Research Article
Type 1
Human
medicine.medical_specialty
Article Subject
Referral
Diabetic ketoacidosis
Diabetic Ketoacidosi
03 medical and health sciences
children
Retrospective survey
Diabetes mellitus
Diabetes Mellitus
Preschool
Type 1 diabetes
lcsh:RC648-665
business.industry
Rehydration Solution
nutritional and metabolic diseases
Retrospective cohort study
Newborn
medicine.disease
030104 developmental biology
Health Care Survey
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Journal of Diabetes Research, Journal of Diabetes Research, Vol 2016 (2016)
- Accession number :
- edsair.doi.dedup.....7a9c0f8b00b78e06c5b22cc58ac5a6c7