1. More Than Effects in Skin: Ultraviolet Radiation-Induced Changes in Immune Cells in Human Blood.
- Author
-
Hart PH and Norval M
- Subjects
- B-Lymphocytes immunology, B-Lymphocytes metabolism, B-Lymphocytes radiation effects, Dendritic Cells immunology, Dendritic Cells metabolism, Humans, Killer Cells, Natural immunology, Killer Cells, Natural metabolism, Killer Cells, Natural radiation effects, Leukocytes immunology, Leukocytes metabolism, Seasons, T-Lymphocytes immunology, T-Lymphocytes metabolism, T-Lymphocytes radiation effects, Ultraviolet Rays adverse effects, Ultraviolet Therapy adverse effects, Dendritic Cells radiation effects, Leukocytes radiation effects, Phototherapy adverse effects, Radiation Exposure adverse effects, Sunlight adverse effects
- Abstract
Cells of the skin and circulation are in constant two-way communication. Following exposure of humans to sunlight or to phototherapy, there are alterations in the number, phenotype and function of circulating blood cells. In this review, only data obtained from human studies are considered, with changes induced by UV radiation (UVR) exposure described for phagocytic leukocytes and peripheral blood mononuclear cells plus their component T and B cells, natural killer cells and dendritic cells. These immune modulations illustrate the potential of UVR to have therapeutic effects beyond the skin, and that sunlight exposure is an important environmental influence on human health., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2021 Hart and Norval.)
- Published
- 2021
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