1. Brain imaging correlates of mild cognitive impairment and early dementia in patients with type 2 diabetes mellitus.
- Author
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Groeneveld O, Reijmer Y, Heinen R, Kuijf H, Koekkoek P, Janssen J, Rutten G, Kappelle L, and Biessels G
- Subjects
- Aged, Aged, 80 and over, Atrophy, Brain pathology, Case-Control Studies, Cognitive Dysfunction etiology, Cognitive Dysfunction pathology, Cognitive Dysfunction psychology, Cross-Sectional Studies, Dementia etiology, Dementia pathology, Dementia psychology, Diabetes Mellitus, Type 2 diagnosis, Diffusion Tensor Imaging, Early Diagnosis, Female, Gray Matter diagnostic imaging, Gray Matter pathology, Humans, Male, Neuropsychological Tests, Predictive Value of Tests, Risk Factors, Brain diagnostic imaging, Cognition, Cognitive Dysfunction diagnostic imaging, Dementia diagnostic imaging, Diabetes Mellitus, Type 2 complications, Diffusion Magnetic Resonance Imaging
- Abstract
Background and Aims: The risk of mild cognitive impairment and dementia is increased in type 2 diabetes mellitus (T2DM). We aimed to identify the neuroanatomical correlates of mild cognitive impairment (MCI) and early dementia in patients with T2DM, using advanced multimodal MRI., Methods and Results: Twenty-five patients (≥70 years) with T2DM and MCI (n = 22) or early dementia (n = 3) were included. The reference group consisted of 23 patients with T2DM with intact cognition. All patients underwent a 3 T MRI. Brain volumes and white matter hyperintensity volumes were obtained with automated segmentation methods. White matter connectivity was assessed with diffusion tensor imaging and fiber tractography. Infarcts and microbleeds were rated visually. Compared to patients without cognitive impairment, those with impairment had a lower grey matter volume (effect size: -0.58, p=0.042), especially in the right temporal lobe and subcortical brain regions (effect sizes: -0.45 to -0.91, false discovery rate corrected p < 0.05). White matter volume (effect size: -0.47, p = 0.11) and white matter connectivity (effect size: 0.55, p = 0.054) were also reduced in patients with versus without cognitive impairment, albeit not statistically significant. White matter hyperintensity volumes and occurrence of other vascular lesions did not differ between the two patient groups., Conclusion: In patients with T2DM, grey matter atrophy rather than vascular brain injury appears to be the primary imaging correlate of MCI and early dementia., (Copyright © 2018 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.)
- Published
- 2018
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