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Albuminuria and Cognitive Functioning in an Older Population: The Hoorn Study
- Source :
- Heringa, S M, van den Berg, E, Dekker, J M, Nijpels, G, Kessels, R P C, Kappelle, L J, Stehouwer, C D A & Biessels, G J 2011, ' Albuminuria and Cognitive Functioning in an Older Population: The Hoorn Study ', Dementia and Geriatric Cognitive Disorders, vol. 32, no. 3, pp. 182-187 . https://doi.org/10.1159/000333076, Dementia and Geriatric Cognitive Disorders, 32(3), 182-187. S. Karger AG, Dementia and Geriatric Cognitive Disorders, 32(3), 182-187. Karger
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Background/Aims: Markers of vascular disease elsewhere in the body may reflect vascular abnormalities in the brain relevant to age-related cognitive decline and dementia. We examined the association between albuminuria, as a marker of microvascular damage, and cognition in older individuals. Methods: 380 individuals (age 73 ± 6 years), participating in the population-based Hoorn Study, underwent extensive neuropsychological examination in 2005–2008, and urinary albumin-to-creatinine ratios measurements in 2000–2001 (n = 378) and/or 2005–2008 (n = 346). Cognition was expressed in z-scores on 6 domains. Results: In 2000–2001, 42 participants were with and 336 without albuminuria, and in 2005–2008 51 were with and 295 were without. In age-, sex- and premorbid IQ-adjusted analyses, participants with albuminuria 5–7 years earlier had slightly lower z-scores for the domains attention and executive functioning [mean difference: –0.21 (95% CI –0.40 to –0.02)] and language [–0.36 (95% CI –0.63 to –0.09)]. No statistically significant differences in cognition were found between participants with and without albuminuria at the time of neuropsychological testing. Conclusion: Albuminuria predicts future modest cognitive decrements, but concurrent albuminuria is unrelated to cognitive functioning. The link between albuminuria and cognitive dysfunction may convey an etiological message, but because effect sizes were modest its value in prognostic models for cognitive decline may be limited.
- Subjects :
- Male
Gerontology
Cognitive Neuroscience
Disease
Neuropsychological Tests
Cognitive functioning
Vascular disease
DISEASE
Cohort Studies
Cognition
SDG 3 - Good Health and Well-being
Predictive Value of Tests
Risk Factors
Humans
Albuminuria
Medicine
Dementia
Longitudinal Studies
Cognitive skill
Cognitive decline
Aged
Netherlands
DECLINE
HYPERTENSION
business.industry
DEMENTIA
MICROALBUMINURIA
ADULTS
Middle Aged
medicine.disease
PREVALENCE
Psychiatry and Mental health
Socioeconomic Factors
Creatinine
Arterial stiffness
Female
ELDERLY PERSONS
Microalbuminuria
GLUCOSE-TOLERANCE
Geriatrics and Gerontology
medicine.symptom
Cognition Disorders
ARTERIAL STIFFNESS
business
Subjects
Details
- ISSN :
- 14219824 and 14208008
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Dementia and Geriatric Cognitive Disorders
- Accession number :
- edsair.doi.dedup.....13284e3eaa28d11cc76dffbfdd67ea4d