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Objective: The role of temozolomide monotherapy in IDH-mutant (IDHmut) astrocytomas after biopsy or tumor resection has not been conclusively determined. Methods: In this retrospective, single-center study, 151 patients with IDHmut WHO grade 2 or 3 according to WHO 2016 and seen between 2001 [for full text, please go to the a.m. URL]

Objective: Preoperative seizures are a common symptom in meningioma patients. Known risk factors include radiological features, localization but also WHO grading. Recently, brain invasion was added as an independent criterion for WHO II meningioma and its clinical importance was questioned in subsequent[for full text, please go to the a.m. URL], 71. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 9. Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie

Objective: Methylation of the O-6-methylguanine-DNA methyltransferase (MGMT) promotor causes gene silencing and has been associated with a favourable prognosis in patients with glioblastoma multiforme (GBM) receiving alkylating chemotherapy. However, analysis of MGMT promotor methylation is usually [for full text, please go to the a.m. URL], 70. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Skandinavischen Gesellschaft für Neurochirurgie

Contrast enhancement (CE) and anaplasia have been reported to indicate poor outcome in diffuse glioma. Recently, mutational status of the IDH1/2 gene and loss of heterozygosity on chromosome 1p/19q (LOH1p/19q) have gained relevance for the evaluation of clinical outcome. We therefore [for full text, please go to the a.m. URL], Joint-Meeting of the German Society for Neuropathology and Neuroanatomy (DGNN) and the Scandinavian Neuropathological Society (SNS)

Objective: Prognosis of adult patients with WHO grade II-III gliomas is not accurately assessed by conventional histological classification. Recently published studies suggest improved classification on the basis of three molecular markers, namely IDH- and TERT-mutational status, and 1p/19q co-deletion[for full text, please go to the a.m. URL], 67. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), 1. Joint Meeting mit der Koreanischen Gesellschaft für Neurochirurgie (KNS)

Objective: The tethered spinal cord syndrome (TCS) is characterized by an attachment of the spinal cord down toward the tail end of the spine, comprising the danger of myelopathic symptoms due to persisting traction on the spinal cord. We retrospectively analyzed the outcome of adult patients with TCS[for full text, please go to the a.m. URL], 63. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC), Joint Meeting mit der Japanischen Gesellschaft für Neurochirurgie (JNS)

Objective: To report ont stereotactic 125Iodine brachytherapy (SBT) for the treatment of singular cerebral metastases regarding feasibility, survival and cerebral disease control, in order to identify prognostic factors and to compare results with other local treatment methods. Methods: Complications,[for full text, please go to the a.m. URL], 61. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC) im Rahmen der Neurowoche 2010