1. Synthesis of New Organotin(IV) N-methyl-N-benzyl Dithiocarbamate Compounds and Cytotoxicity assessment on Human Lung Carcinoma Cell Line (A549).
- Author
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AZIZ, NURUL AMALINA ABD, JAMALUDIN, NUR ATIYAH NADHRAH, AWANG, NORMAH, KAMALUDIN, NURUL FARAHANA, KOK MENG CHAN, and ANUAR, NUR NAJMI MOHAMAD
- Subjects
CYTOTOXINS ,LUNGS ,CELL lines ,X-ray crystallography ,ELEMENTAL analysis ,CARCINOMA ,CHEMICAL shift (Nuclear magnetic resonance) ,ATOMS - Abstract
Using the in situ method, the successful synthesis of dibutyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 1) and tricyclohexyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 2) was achieved. Both compounds were characterized by the CHNS elemental analysis, FTIR, NMR spectroscopies and X-ray crystallography study. The experimental CHNS values demonstrated good congruence with the CHNS's theoretical values of the suggested formula structures. The key infrared absorbance peaks, v(C-N) and v(C-S), which were found between 1475-1481 cm-1 and 971-975 cm-1, respectively. The 13C chemical shift of carbon in the NCS2 group was observed in the range of 200.66-202.32 ppm. The crystal structure of Compound 1 shows the anisobidentate's coordination mode between the central metal of the Sn atom and the dithiocarbamate ligands. Compound 1 and Compound 2 have shown great toxicity effects against carcinoma cells in the human lung (A549) with lower IC50 values of 0.80 µM and 2.77 µM, respectively. [ABSTRACT FROM AUTHOR]
- Published
- 2023
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