Synthesis of New Organotin(IV) N-methyl-N-benzyl Dithiocarbamate Compounds and Cytotoxicity assessment on Human Lung Carcinoma Cell Line (A549).

Using the in situ method, the successful synthesis of dibutyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 1) and tricyclohexyltin(IV) N-methyl-N-benzyl dithiocarbamate (Compound 2) was achieved. Both compounds were characterized by the CHNS elemental analysis, FTIR, NMR spectroscopies and X-ray crystallography study. The experimental CHNS values demonstrated good congruence with the CHNS's theoretical values of the suggested formula structures. The key infrared absorbance peaks, v(C-N) and v(C-S), which were found between 1475-1481 cm-1 and 971-975 cm-1, respectively. The 13C chemical shift of carbon in the NCS2 group was observed in the range of 200.66-202.32 ppm. The crystal structure of Compound 1 shows the anisobidentate's coordination mode between the central metal of the Sn atom and the dithiocarbamate ligands. Compound 1 and Compound 2 have shown great toxicity effects against carcinoma cells in the human lung (A549) with lower IC50 values of 0.80 µM and 2.77 µM, respectively. [ABSTRACT FROM AUTHOR]