1. Fabricate, advancement, molecular docking and DNA reactivity of preferred divalent metal(II) complexes attributing ( E )- N '-((6-hydroxybenzo[ d ]oxazol-5-yl) methylene)isonicotinohydrazide.
- Author
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Pratiba P, Betageri VS, Latha MS, Vinay Kumar B, Ravindranath BS, and Vidyasagar CC
- Subjects
- DNA chemistry, Isoniazid, Ligands, Molecular Docking Simulation, Schiff Bases chemistry, Coordination Complexes chemistry
- Abstract
A series of metal(II) complexes ( M =Co (II), Ni(II) and Cu(II)) supported by Schiff base ligand ( L =( E )- N '-((6-hydroxybenzo[ d ]oxazol-5-yl)methylene)isonicotinohydrazide) has been designed and developed from condensation of 6-hydroxybenzo[ d ]oxazole-5-carbaldehyde and isoniazid. The ligand (H
2 L) and its metal(II) complexes were structurally characterized utilizing a variety of physicochemical and spectroscopic approaches. The study shows that Schiff bases (H2 L) act as monobasic tridentate ONO ligand and conform to octahedral geometry according to the general formula [M(HL)2 ]. Furthermore, the interaction of these complexes with CT-DNA was investigated at pH = 7.2, utilizing UV-visible absorption, and viscosity measurement. In order to determine the mechanism of binding of the metal(II) complexes to the B-DNA dodecamer, docking studies were conducted using an AutoDock Vina 1.2.0 tool. The photo induced cleavage reveals that the ligand ( H2 L ) and its complexes have UV-visible photo nuclease properties against pUC19 DNA by agarose gel electrophoresis technique. Studies showed that the complexes evaluated firmly bind to CT-DNA via intercalative mode and provides a distinctive pattern of DNA binding. more...- Published
- 2022
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