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Your search keyword '"Ganmore, Ithamar"' showing total 3 results
Start Over Author "Ganmore, Ithamar" Topic cognitive decline
3 results on '"Ganmore, Ithamar"'

2. Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk

Author

West, Rebecca K., Ravona‐Springer, Ramit, Sharvit‐Ginon, Inbal, Ganmore, Ithamar, Manzali, Sigalit, Tirosh, Amir, Golan, Sapir, Boccara, Ethel, Heymann, Anthony, and Beeri, Michal Schnaider

Subjects
cognition, adiposity, obesity, parental history of Alzheimer's disease, RC952-954.6, Alzheimer's disease, cognitive decline, Psychiatry and Mental health, Geriatrics, risk factors, Cognitive & Behavioral Assessment, Neurology (clinical), Neurology. Diseases of the nervous system, RC346-429, Research Article
Abstract

Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results Higher BMI was associated with worse language (P = .045). Interactions of BMI with parental history were significant for episodic memory (P = .023), language (p = .027), working memory (P = .006), global cognition (P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P = .017), language (P = .013), working memory (P = .001), global cognition (P = .005), with stronger associations for maternal history. Discussion Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.

Published
2021

3. Alzheimer's Disease Polygenic Risk Score Is Not Associated With Cognitive Decline Among Older Adults With Type 2 Diabetes.

Author

Manzali, Sigalit B., Yu, Eric, Ravona-Springer, Ramit, Livny, Abigail, Golan, Sapir, Ouyang, Yuxia, Lesman-Segev, Orit, Lang Liu, Ganmore, Ithamar, Alkelai, Anna, Gan-Or, Ziv, Hung-Mo Lin, Heymann, Anthony, Schnaider Beeri, Michal, and Greenbaum, Lior

Subjects
COGNITION disorder risk factors, ALZHEIMER'S disease risk factors, BRAIN, ALZHEIMER'S disease, NEURAL pathways, BRAIN mapping, TYPE 2 diabetes, RISK assessment, NEUROPSYCHOLOGICAL tests, MEDICAL genetics, AGE factors in disease, GENOTYPES, JEWS, SYMPTOMS, OLD age
Abstract

Objectives: Multiple risk loci for late-onset Alzheimer's disease (LOAD) have been identified. Type 2 diabetes (T2D) is a risk factor for cognitive decline, dementia and Alzheimer's disease (AD). We investigated the association of polygenic risk score (PRS) for LOAD with overall cognitive functioning and longitudinal decline, among older adults with T2D. Methods: The study included 1046 Jewish participants from the Israel Diabetes and Cognitive Decline (IDCD) study, aged ≥ 65 years, diagnosed with T2D, and cognitively normal at baseline. The PRS included variants from 26 LOAD associated loci (at genome-wide significance level), and was calculated with and without APOE. Outcome measures, assessed in 18 months intervals, were global cognition and the specific domains of episodic memory, attention/working memory, executive functions, and language/semantic categorization. Random coefficient models were used for analysis, adjusting for demographic variables, T2D-related characteristics, and cardiovascular factors. Additionally, in a subsample of 202 individuals, we analyzed the association of PRS with the volumes of total gray matter, frontal lobe, hippocampus, amygdala, and white matter hyperintensities. Last, the association of PRS with amyloid beta (Ab) burden was examined in 44 participants who underwent an 18F-flutemetamol PET scan. Results: The PRS was not significantly associated with overall functioning or decline in global cognition or any of the specific cognitive domains. Similarly, following correction for multiple testing, there was no association with Ab burden and other brain imaging phenotypes. Conclusion: Our results suggest that the cumulative effect of LOAD susceptibility loci is not associated with a greater rate of cognitive decline in older adults with T2D, and other pathways may underlie this link. [ABSTRACT FROM AUTHOR]

Published
2022
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