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Long‐term trajectories and current BMI are associated with poorer cognitive functioning in middle‐aged adults at high Alzheimer's disease risk
- Source :
- Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 13, Iss 1, Pp n/a-n/a (2021), Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Introduction We examined relationships of body mass index (BMI) with cognition in middle‐aged adults at Alzheimer's disease (AD) risk due to parental family history. Methods Participants are offspring of AD patients from the Israel Registry of Alzheimer's Prevention (N = 271). Linear regressions assessed associations of BMI and cognition, and whether associations differed by maternal/paternal history. Analyses of covariance examined associations of long‐term trajectories of BMI with cognition. Results Higher BMI was associated with worse language (P = .045). Interactions of BMI with parental history were significant for episodic memory (P = .023), language (p = .027), working memory (P = .006), global cognition (P = .008); associations were stronger among participants with maternal history. Interactions of BMI trajectories with parental history were significant for episodic memory (P = .017), language (P = .013), working memory (P = .001), global cognition (P = .005), with stronger associations for maternal history. Discussion Higher BMI and overweight/obese trajectories were associated with poorer cognition in adults with maternal history of AD, but not those with paternal history.
- Subjects :
- cognition
adiposity
obesity
parental history of Alzheimer's disease
RC952-954.6
Alzheimer's disease
cognitive decline
Psychiatry and Mental health
Geriatrics
risk factors
Cognitive & Behavioral Assessment
Neurology (clinical)
Neurology. Diseases of the nervous system
RC346-429
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 23528729
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
- Accession number :
- edsair.doi.dedup.....a9456542686155facb779995fd523437