1. A new model for coenzyme B12 based on a Costa-type ligand
- Author
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M. W. G. De Bolster, R. Altink, R. J. van Delft, Y. Van Den Winkel, H. de Koning, Sijbe Balt, B. van Arkel, J. L. Van Der Baan, and Gerhard W. Klumpp
- Subjects
chemistry.chemical_classification ,Ligand ,Stereochemistry ,chemistry.chemical_element ,General Chemistry ,Nuclear magnetic resonance spectroscopy ,Methylenedioxy ,chemistry.chemical_compound ,Deprotonation ,chemistry ,Reagent ,Polymer chemistry ,Molecule ,Cobalt ,Alkyl - Abstract
The synthesis of a new Costa-type ligand (H2mdo), in which the propylene bridge has been replaced by a methylenedioxy bridge has been accomplished: two molecules of butanedione monoxime are coupled via a CH2 group by reaction with CH2Cl2 and 50% aqueous NaOH in the presence of a phase-transfer reagent. Dihalidocobalt and alkyl(halido)cobalt complexes of the deprotonated ligand have been prepared and structurally characterized by NMR spectroscopy.
- Published
- 2010
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