1. Activity of selected penicillins in vitro and in experimental bacterial infections in mice.
- Author
-
Miraglia GJ and Basch HI
- Subjects
- Animals, Dicloxacillin pharmacology, Escherichia coli drug effects, Escherichia coli Infections drug therapy, Mice, Proteus drug effects, Proteus Infections drug therapy, Salmonella Infections, Animal drug therapy, Salmonella paratyphi A drug effects, Staphylococcal Infections drug therapy, Staphylococcus drug effects, Streptococcal Infections drug therapy, Streptococcus pneumoniae drug effects, Streptococcus pyogenes drug effects, Ampicillin pharmacology, Cloxacillin pharmacology, Methicillin pharmacology, Oxacillin pharmacology, Penicillin G pharmacology, Penicillins therapeutic use
- Abstract
The minimal inhibitory concentration and the 50% mouse protective dose for five key penicillins are presented. Such data provide a useful guide in evaluating the activity of new penicillins, in comparison with those already commercially available, and establishes the amounts of antibiotic necessary to obtain a PD(50) for several experimental model infections in mice.
- Published
- 1967
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