22 results on '"Clavel, Jacqueline"'
Search Results
2. Family Cancer History and Risk of Childhood Acute Leukemia (France)
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Perrillat, Florence, Clavel, Jacqueline, Jaussent, Isabelle, Baruchel, André, Leverger, Guy, Nelken, Brigitte, Philippe, Noël, Schaison, Gérard, Sommelet, Danièle, Vilmer, Etienne, Bonaïti-Pellié, Catherine, and Hémon, Denis
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- 2001
3. Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013.
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Mancini, Matthieu, Hémon, Denis, de Crouy-Chanel, Perrine, Guldner, Laurence, Faure, Laure, Clavel, Jacqueline, and Goujon, Stéphanie
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GEOGRAPHIC information systems ,CONFIDENCE intervals ,LYMPHOBLASTIC leukemia ,PESTICIDES ,GRAPES ,RISK assessment ,MAPS ,PEARSON correlation (Statistics) ,WINES ,DESCRIPTIVE statistics ,RESEARCH funding ,DEMOGRAPHIC characteristics ,LOGISTIC regression analysis ,ODDS ratio ,SENSITIVITY & specificity (Statistics) ,HORTICULTURE ,ENVIRONMENTAL exposure ,DISEASE risk factors ,CHILDREN - Abstract
BACKGROUND: Pesticide exposures are suspected of being a risk factor for several childhood cancers, particularly acute leukemia (AL). Most of the evidence is based on self-reported parental domestic use of pesticides, but some studies have also addressed associations with agricultural use of pesticides near the place of residence. OBJECTIVES: The objective of the study was to evaluate the risk of AL in children living close to vines, a crop subject to intensive pesticide use. METHODS: Data were drawn from the national registry-based GEOCAP study. We included all of the AL cases under the age of 15 years diagnosed in 2006–2013 (푛 = 3,711) and 40,196 contemporary controls representative of the childhood population in France. The proximity of the vines (probability of presence within 200, 500, and 1,000 m) and the viticulture density (area devoted to vines within 1,000 m) were evaluated around the geocoded addresses in a geographic information system combining three national land use maps. Logistic regression models were used to estimate odds ratios (ORs) for all AL and for the lymphoblastic (ALL) and myeloid (AML) subtypes. Heterogeneity between regions was studied by stratified analyses. Sensitivity analyses were carried out to take into account, in particular, geocoding uncertainty, density of other crops and potential demographic and environmental confounders. RESULTS: In all, about 10% of the controls lived within 1 km of vines. While no evidence of association between proximity to vines and AL was found, viticulture density was positively associated with ALL [OR=1.05 (1.00–1.09) for a 10% increase in density], with a statistically significant heterogeneity across regions. No association with AML was observed. The results remained stable in all the sensitivity analyses. CONCLUSION: We evidenced a slight increase in the risk of ALL in children living in areas with high viticulture density. This finding supports the hypothesis that environmental exposure to pesticides may be associated with childhood ALL. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Residential exposure to ultraviolet light and risk of precursor B-cell acute lymphoblastic leukemia: assessing the role of individual risk factors, the ESCALE and ESTELLE studies
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Coste, Astrid, Hémon, Denis, Orsi, Laurent, Boniol, Mathieu, Doré, Jean-François, Faure, Laure, Clavel, Jacqueline, and Goujon, Stéphanie
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- 2017
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5. Parental occupational paint exposure and risk of childhood leukemia in the offspring: findings from the Childhood Leukemia International Consortium
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Bailey, Helen D., Fritschi, Lin, Metayer, Catherine, Infante-Rivard, Claire, Magnani, Corrado, Petridou, Eleni, Roman, Eve, Spector, Logan G., Kaatsch, Peter, Clavel, Jacqueline, Milne, Elizabeth, Dockerty, John D., Glass, Deborah C., Lightfoot, Tracy, Miligi, Lucia, Rudant, Jérémie, Baka, Margarita, Rondelli, Roberto, Amigou, Alicia, Simpson, Jill, Kang, Alice Y., Moschovi, Maria, and Schüz, Joachim
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- 2014
6. Residential exposure to solar ultraviolet radiation and incidence of childhood hematological malignancies in France
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Coste, Astrid, Goujon, Stéphanie, Boniol, Mathieu, Marquant, Fabienne, Faure, Laure, Doré, Jean-François, Hémon, Denis, and Clavel, Jacqueline
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- 2015
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7. Childhood Hematopoietic Malignancies and Parental Use of Tobacco and Alcohol: The ESCALE Study (SFCE)
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Rudant, Jérémie, Menegaux, Florence, Leverger, Guy, Baruchel, André, Lambilliotte, Anne, Bertrand, Yves, Patte, Catherine, Pacquement, Hélène, Vérité, Cécile, Robert, Alain, Michel, Gérard, Margueritte, Geneviève, Gandemer, Virginie, Hémon, Denis, and Clavel, Jacqueline
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- 2008
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8. Leukaemia near La Hague Nuclear Plant
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Clavel, Jacqueline, Hémon, Denis, Law, Graham, Roman, Eve, Wakeford, Richard, Barton, Carol, Ryder, Hilary, Hesse-Honegger, Cornelia, and Viel, Jean-François
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- 1997
9. Response to "Comment on 'Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013'".
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Goujon, Stéphanie, Mancini, Matthieu, and Clavel, Jacqueline
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LYMPHOBLASTIC leukemia ,PESTICIDES ,POPULATION geography ,GRAPES ,RISK assessment ,HORTICULTURE ,ENVIRONMENTAL exposure ,DISEASE risk factors ,CHILDREN - Abstract
The authors offer a response to a commentary made by Catherine Hill on their study on the association between residential proximity to virticultural areas and childhood acute leukemia risk in mainland France. Topics include Hill's conclusion that the results of the study do not justify the alarming information disseminated by the media in France and strengths of the study.
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- 2024
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10. ARID5B, IKZF1 and non-genetic factors in the etiology of childhood acute lymphoblastic leukemia: the ESCALE study
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Rudant, Jérémie, Orsi, Laurent, Bonaventure, Audrey, Goujon-Bellec, Stéphanie, Baruchel, André, Petit, Arnaud, Bertrand, Yves, Nelken, Brigitte, Pasquet, Marlène, Michel, Gérard, Saumet, Laure, Chastagner, Pascal, Ducassou, Stéphane, Réguerre, Yves, Hémon, Denis, Clavel, Jacqueline, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Institut d’Hémato-Oncologie Pédiatrique, Université Lille Nord de France (COMUE), Pôle Enfant, Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Sercice Hématologie, immunologie et oncologie pédiatrique [CHU Toulouse], Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Aix Marseille Université (AMU), Service d'hématologie et oncologie pédiatrique, Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Arnaud de Villeneuve [CHRU Montpellier], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Pellegrin Tripode, Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Registre National des Hémopathies malignes de l'Enfant (RNHE), Institut de Veille Sanitaire (INVS) - Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de recherche épidémiologies et biostatistique Sorbonne Paris Cité (CRESS), Université Paris Descartes - Paris 5 (UPD5) - Conservatoire National des Arts et Métiers [CNAM] - Université Paris Diderot - Paris 7 (UP7) - Institut National de la Santé et de la Recherche Médicale (INSERM) - Institut National de la Recherche Agronomique (INRA) - Université Paris 13, AP-HP Hôpital universitaire Robert-Debré [Paris], Université Paris Diderot - Paris 7 (UP7), Centre de Recherche Saint-Antoine (CR Saint-Antoine), Université Pierre et Marie Curie - Paris 6 (UPMC) - Institut National de la Santé et de la Recherche Médicale (INSERM), Institut d'Hématologie et d'Oncologie Pédiatrique de Lyon, PRES Université Lille Nord de France, Hématologie pédiatrique U1037 CHU Toulouse, Pédiatrie et oncologie pédiatrique [Hôpital de la Timone - APHM], Aix Marseille Université (AMU) - Assistance Publique - Hôpitaux de Marseille (APHM) - Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Arnaud de Villeneuve, Centre hospitalier de Nancy (CHU Nancy), CHU Nancy, CHU de Bordeaux Pellegrin [Bordeaux], CHU Félix Guyon, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS), Institut National de la Recherche Agronomique (INRA) - Université Paris Diderot - Paris 7 (UPD7) - Université Paris Descartes - Paris 5 (UPD5) - Université Paris 13 - Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) - Hôpital Robert Debré - Université Paris Diderot - Paris 7 (UPD7), Université Lille Nord de France, Hématologie pédiatrique, CHU Toulouse [Toulouse], Hôpital d'Enfants, CHU de Nancy, Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), and HAL AMU, Administrateur
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Male ,Adolescent ,Genotype ,Science ,CHILDREN ,[SDV.CAN]Life Sciences [q-bio]/Cancer ,VARIANTS ,Polymorphism, Single Nucleotide ,White People ,Ikaros Transcription Factor ,[SDV.CAN] Life Sciences [q-bio]/Cancer ,PESTICIDES ,Risk Factors ,Humans ,GENERAL-PRACTITIONER RECORDS ,Genetic Predisposition to Disease ,EXPOSURE ,Child ,Alleles ,RISK ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Infant, Newborn ,Infant ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,HEMATOPOIETIC MALIGNANCIES ,CANCER ,EPIGENETICS ,DNA-Binding Proteins ,INFECTIONS ,Case-Control Studies ,Child, Preschool ,Medicine ,Female ,Research Article ,Genome-Wide Association Study ,Transcription Factors - Abstract
International audience; Genome-wide association studies (GWAS) have identified that frequent polymorphisms in ARID5B and IKZF1, two genes involved in lymphoid differentiation, increase the risk of childhood acute lymphoblastic leukemia (ALL). These findings markedly modified the current field of research on the etiology of ALL. In this new context, the present exploratory study investigated the possible interactions between these at-risk alleles and the non-genetic suspected ALL risk factors that were of sufficient prevalence in the French ESCALE study: maternal use of home insecticides during pregnancy, preconception paternal smoking, and some proxies for early immune modulation, i.e. breastfeeding, history of common infections before age one year, and birth order. The analyses were based on 434 ALL cases and 442 controls of European origin, drawn from the nationwide population-based case-control study ESCALE. Information on non-genetic factors was obtained by standardized telephone interview. Interactions between rs10740055 in ARID5B or rs4132601 in IKZF1 and each of the suspected non-genetic factors were tested, with the SNPs coded as counts of minor alleles (trend variable). Statistical interactions were observed between rs4132601 and maternal insecticide use (p = 0.012), breastfeeding p = 0.017) and repeated early common infections (p = 0.0070), with allelic odds ratios (OR) which were only increased among the children not exposed to insecticides (OR = 1.8, 95% CI: 1.3, 2.4), those who had been breastfed (OR = 1.8, 95% CI: 1.3, 2.5) and those who had had repeated early common infections (OR = 2.4, 95% CI: 1.5, 3.8). The allelic ORs were close to one among children exposed to insecticides, who had not been breastfed and who had had no or few common infections. Repeated early common infections interacted with rs10740055 (p = 0.018) in the case-only design. Further studies are needed to evaluate whether these observations of a modification of the effect of the at-risk alleles by non-genetic factors are chance findings or reflect true underlying mechanisms.
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- 2015
11. Residential Exposure to Natural Background Radiation and Risk of Childhood Acute Leukemia in France, 1990-2009.
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Demoury, Claire, Marquant, Fabienne, Ielsch, Géraldine, Goujon, Stéphanie, Debayle, Christophe, Faure, Laure, Coste, Astrid, Laurent, Olivier, Guillevic, Jérôme, Laurier, Dominique, Hémon, Denis, and Clavel, Jacqueline
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LEUKEMIA risk factors ,CONFIDENCE intervals ,GAMMA rays ,INDOOR air pollution ,PROBABILITY theory ,RADIATION ,RADON ,REGRESSION analysis ,RESEARCH ,RESEARCH funding ,MATHEMATICAL variables ,ENVIRONMENTAL exposure ,RELATIVE medical risk ,RETROSPECTIVE studies ,DATA analysis software ,DESCRIPTIVE statistics ,ODDS ratio ,CHILDREN - Abstract
BACKGROUND: Exposures to high-dose ionizing radiation and high-dose rate ionizing radiation are established risk factors for childhood acute leukemia (AL). The risk of AL following exposure to lower doses due to natural background radiation (NBR) has yet to be conclusively determined. METHODS: AL cases diagnosed over 1990-2009 (9,056 cases) were identified and their municipality of residence at diagnosis collected by the National Registry of Childhood Cancers. The Geocap study, which included the 2,763 cases in 2002-2007 and 30,000 population controls, was used for complementary analyses. NBR exposures were modeled on a fine scale (36,326 municipalities) based on measurement campaigns and geological data. The power to detect an association between AL and dose to the red bone marrow (RBM) fitting UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) predictions was 92%, 45% and 99% for exposure to natural gamma radiation, radon and total radiation, respectively. RESULTS: AL risk, irrespective of subtype and age group, was not associated with the exposure of municipalities to radon or gamma radiation in terms of yearly exposure at age reached, cumulative exposure or RBM dose. There was no confounding effect of census-based socio-demographic indicators, or environmental factors (road traffic, high voltage power lines, vicinity of nuclear plants) related to AL in the Geocap study. CONCLUSIONS: Our findings do not support the hypothesis that residential exposure to NBR increases the risk of AL, despite the large size of the study, fine scale exposure estimates and wide range of exposures over France. However, our results at the time of diagnosis do not rule out a slight association with gamma radiation at the time of birth, which would be more in line with the recent findings in the UK and Switzerland. CITATION: Demoury C, Marquant F, Ielsch G, Goujon S, Debayle C, Faure L, Coste A, Laurent O, Guillevic J, Laurier D, Hémon D, Clavel J. 2017. Residential exposure to natural background radiation and risk of childhood acute leukemia in France, 1990-2009. Environ Health Perspect 125:714-720; http://dx.doi.org/10.1289/EHP296 [ABSTRACT FROM AUTHOR]
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- 2017
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12. Risk of Childhood Cancer and Socio-economic Disparities: Results of the French Nationwide Study Geocap 2002-2010.
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Marquant, Fabienne, Goujon, Stéphanie, Faure, Laure, Guissou, Sandra, Orsi, Laurent, Hémon, Denis, Lacour, Brigitte, and Clavel, Jacqueline
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CHILDHOOD cancer ,TUMORS in children ,SOCIAL status ,SOCIOECONOMIC factors ,HEMATOLOGIC malignancies ,CANCER risk factors ,COMPARATIVE studies ,DEMOGRAPHY ,LYMPHOBLASTIC leukemia ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH ,RURAL health ,TUMORS ,URBAN health ,RESIDENTIAL patterns ,EVALUATION research ,LIFESTYLES ,ACQUISITION of data ,CASE-control method - Abstract
Background: Socio-economic status is related to many life style and environmental factors, some of which have been suggested to influence the risk of childhood cancer. Studies requiring subject participation are usually hampered by selection of more educated parents. To prevent such bias, we used unselected nationwide Geographical Information System (GIS)-based registry data, to investigate the influence of socio-economic disparities on the risk of childhood cancer.Methods: The Geocap study included all French residents diagnosed with cancer aged up to 15 years over the period 2002-2010 (15 111 cases) and 45 000 contemporaneous controls representative of the childhood population. Area socio-economic characteristics used to calculate the European Deprivation Index (EDI) were based on census data collected on the fine scale of the Merged Islet for Statistical Information (IRIS).Results: Overall, the risk of acute lymphoblastic leukaemia (ALL) was lower in the most deprived quintile than in the other quintiles of EDI (ORQ5vsConclusion: Living in the most deprived areas was inversely associated with the risk of ALL in childhood. There was no indication that the risk of childhood cancer of any site could be increased by deprivation. Life style or environmental factors potentially underlying the association need further investigation. [ABSTRACT FROM AUTHOR] - Published
- 2016
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13. Épidémiologie des cancers de l'enfant
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SOMMELET Danièle, LACOUR Brigitte, CLAVEL Jacqueline, SOMMELET Danièle, LACOUR Brigitte, and CLAVEL Jacqueline
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- Children, Cancer in children--Epidemiology
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Cet ouvrage rassemble pour la première fois en France les données d'incidence (un enfant sur 500 est touché chaque année), de répartition par types histologiques et de survie (75,2% à 5 ans pour la période 1990-99) des cancers de l'enfant. Ces données proviennent des cinq registres régionaux de population dont le premier a été mis en place en Lorraine en 1983, et des deux registres nationaux (hémopathies et tumeurs solides) qui assurent désormais la surveillance sanitaire de la totalité du territoire français. Outils au service des recherches étiologiques, les registres, régulièrement évalués, éclairent sur les progrès thérapeutiques et la qualité de la prise en charge des patients dans des filières adaptées aux exigences de soins et d'une recherche clinico-biologique de qualité. Le recueil des données chez l'adulte guéri permet d'évaluer la réalité du suivi et le degré éventuel de complications tardives et de séquelles.
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- 2009
14. Residential Proximity to Heavy-Traffic Roads, Benzene Exposure, and Childhood Leukemia--The GEOCAP Study, 2002-2007.
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Houot, Jennifer, Marquant, Fabienne, Goujon, Stéphanie, Faure, Laure, Honoré, Cécile, Roth, Marie-Hélène, Hémon, Denis, and Clavel, Jacqueline
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LEUKEMIA risk factors ,CONFIDENCE intervals ,HOUSING ,LYMPHOBLASTIC leukemia ,RESEARCH funding ,TRANSPORTATION ,ENVIRONMENTAL exposure ,ACUTE myeloid leukemia ,CASE-control method ,DATA analysis software ,BENZENE derivatives ,DESCRIPTIVE statistics ,ODDS ratio ,CHILDREN - Abstract
Childhood leukemia may be associated with traffic-related environmental exposure to benzene, and additional data are needed. The Géolocalisation des Cancers Pédiatriques (GEOCAP) Study, a nationwide French case-control study, was designed to avoid selection bias due to differential participation and misclassification. The study compared the 2,760 childhood leukemia cases diagnosed in France between 2002 and 2007 (including 2,275 cases of acute lymphoblastic leukemia (ALL) and 418 cases of acute myeloblastic leukemia (AML)) with 30,000 contemporaneous child population controls. The residence addresses were precisely geocoded, and 3 indicators of residential proximity to traffic were considered. Estimates of benzene concentrations were also available for the Île-de-France region (including Paris). A 300-m increase in major road length within 150 m of the geocoded address was significantly associated with AML (odds ratio = 1.2, 95%confidence interval: 1.0, 1.4) but not with ALL (odds ratio = 1.0, 95% confidence interval: 0.9, 1.1), and the association was reinforced in the Île-de-France region when this indicator was combined with benzene estimates. These results, which were free from any participation bias and based on objectively determined indices of exposure, showed an increased incidence of AML associated with heavy-traffic road density near a child's home. The results support a role for traffic-related benzene exposure in the etiology of childhood AML. [ABSTRACT FROM AUTHOR]
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- 2015
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15. Road Traffic and Childhood Leukemia: The ESCALE Study (SFCE).
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Amigou, Alicia, Sermage-Faure, Claire, Orsi, Laurent, Leverger, Guy, Baruchel, André, Bertrand, Yves, Nelken, Brigitteÿ, Robert, Alain, Michel, Gérard, Margueritte, Geneviève, Perel, Yves, Mechinaud, Françoise, Bordigoni, Pierreÿ, Hémon, Denis, and Clavel, Jacqueline
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LEUKEMIA risk factors ,AIR pollution ,AUTOMOBILES ,BENZENE ,COMPUTER software ,EPIDEMIOLOGY ,MOTHERS ,NITROGEN oxides ,POPULATION geography ,REGRESSION analysis ,DATA analysis ,ENVIRONMENTAL exposure ,MAXIMUM likelihood statistics ,CASE-control method ,CHILDREN - Abstract
BACKGROUND: Traffic is a source of environmental exposures, including benzene, which may be related to childhood leukemia. OBJECTIVES: A national registry-based case-control study [ESCALE (Etude Sur les Cancers et les Leucémies de l'Enfant, Study on Environmental and Genetic Risk Factors of Childhood Cancers and Leukemia)] carried out in France was used to assess the effect of exposure to road traffic exhaust fumes on the risk of childhood leukemia. METHODS: Over the study period, 2003-2004, 763 cases and 1,681 controls < 15 years old were included, and the controls were frequency matched with the cases on age and sex. The ESCALE data were collected by a standardized telephone interview of the mothers. Various indicators of exposure to traffic and pollution were determined using the geocoded addresses at the time of diagnosis for the cases and of interview for the controls. Indicators of the distance from, and density of, main roads and traffic nitrogen dioxide (NO
2 ) concentrations derived from traffic emission data were used. Odds ratios (ORs) were estimated using unconditional regression models adjusted for potential confounders. RESULTS: Acute leukemia (AL) was significantly associated with estimates of traffic NO2 concentration at the place of residence > 27.7 µg/m3 compared with NO2 concentration < 21.9 µg/m3 [OR = 1.2; confidence interval (CI), 1.0-1.5] and with the presence of a heavy-traffic road within 500 m compared with the absence of a heavy-traffic road in the same area (OR = 2.0; 95% CI, 1.0-3.6). There was a significant association between AL and a high density of heavy-traffic roads within 500 m compared with the reference category with no heavy-traffic road within 500 m (OR = 2.2; 95% CI, 1.1-4.2), with a significant positive linear trend of the association of AL with the total length of heavy-traffic road within 500m. CONCLUSION: This study supports the hypothesis that living close to heavy-traffic roads may increase the risk of childhood leukemia. [ABSTRACT FROM AUTHOR]- Published
- 2011
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16. Childhood Acute Leukemia, Early Common Infections, and Allergy: The ESCALE Study.
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Rudant, Jérémie, Orsi, Laurent, Menegaux, Florence, Petit, Arnaud, Baruchel, André, Bertrand, Yves, Lambilliotte, Anne, Robert, Alain, Michel, Gérard, Margueritte, Geneviève, Tandonnet, Julie, Mechinaud, Françoise, Bordigoni, Pierre, Hémon, Denis, and Clavel, Jacqueline
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ALLERGIES ,ANALYSIS of variance ,ANIMALS ,ASTHMA ,BIRTH order ,BREASTFEEDING ,CHILD care ,COMMUNICABLE diseases ,COMPARATIVE studies ,CONFIDENCE intervals ,STATISTICAL correlation ,REPORTING of diseases ,EPIDEMIOLOGY ,IMMUNE system ,LYMPHOBLASTIC leukemia ,QUESTIONNAIRES ,REGRESSION analysis ,DATA analysis ,ACUTE myeloid leukemia ,CASE-control method ,CHILDREN ,LEUKEMIA etiology - Abstract
This study investigated the role of factors considered related to early stimulation of the immune system in the etiology of childhood acute leukemia. The national registry-based case-control study ESCALE was carried out in France in 2003–2004. Population controls were frequency matched to cases on age and gender. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios were estimated using unconditional regression models adjusted for potential confounders. Included were 634 acute lymphoblastic leukemia cases, 86 acute myeloblastic leukemia cases, and 1,494 controls aged ≥1 year. Negative associations were observed between acute lymphoblastic leukemia and birth order (P for trend < 0.0001), attendance at a day-care center before age 1 year (odds ratio (OR) = 0.8, 95% confidence interval (CI): 0.6, 1.1), prolonged breastfeeding (OR = 0.7, 95% CI: 0.5, 1.0), repeated early common infections (OR = 0.7, 95% CI: 0.6, 0.9), regular contact with farm animals (OR = 0.6, 95% CI: 0.5, 0.8), frequent farm visits in early life (OR = 0.4, 95% CI: 0.3, 0.6), and history of asthma (OR = 0.7, 95% CI: 0.4, 1.0) or eczema (OR = 0.7, 95% CI: 0.6, 0.9). Results support the hypothesis that repeated early infections and asthma may play a role against childhood acute leukemia. [ABSTRACT FROM PUBLISHER]
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- 2010
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17. Household Exposure to Pesticides and Risk of Childhood Hematopoietic Malignancies: The ESCALE Study (SFCE).
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Rudant, Jérémie, Menegaux, Florence, Leverger, Guy, Baruchel, André, Nelken, Brigitte, Bertrand, Yves, Patte, Catherine, Pacquement, Hélène, Vérité, Cécile, Robert, Alain, Michel, Gérard, Margueritte, Geneviève, Gandemer, Virginie, Hémon, Denis, and Clavel, Jacqueline
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PHYSIOLOGICAL effects of pesticides ,HEMATOPOIESIS ,PRENATAL influences ,PREGNANT women ,HOUSEHOLDS -- Environmental aspects ,ETIOLOGY of diseases - Abstract
OBJECTIVES: We investigated the role of household exposure to pesticides in the etiology of childhood hematopoietic malignancies. METHODS: The national registry-based case-control study ESCALE (Etude sur les cancers de l'enfant) was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and sex. Maternal household use of pesticides during pregnancy and paternal use during pregnancy or childhood were reported by the mothers in a structured telephone questionnaire. Insecticides (used at home, on pets, or for garden crops), herbicides, and fungicides were distinguished. We estimated odds ratios (ORs) using unconditional regression models closely adjusting for age, sex, degree of urbanization, and type of housing (flat or house). RESULTS: We included a total of 764 cases of acute leukemia (AL), 130 of Hodgkin lymphoma (HL), 166 of non-Hodgkin lymphoma (NHL), and 1,681 controls. Insecticide use during pregnancy was significantly associated with childhood AL [OR = 2.1; 95% confidence interval (CI), 1.7-2.5], both lymphoblastic and myeloblastic, NHL (OR = 1.8; 95% CI, 1.3-2.6), mainly for Burkitt lymphoma (OR = 2.7; 95% CI, 1.6-4.5), and mixed-cell HL (OR = 4.1; 95% CI, 1.4-11.8), but not nodular sclerosis HL (OR = 1.1; 95% CI, 0.6-1.9). Paternal household use of pesticides was also related to AL (OR = 1.5; 95% CI, 1.2-1.8) and NHL (OR = 1.7; 95% CI, 1.2-2.6); but for AL the relationships did not remain after adjustment for maternal pesticide use during pregnancy. CONCLUSION: The study findings strengthen the hypothesis that domestic use of pesticides may play a role in the etiology of childhood hematopoietic malignancies. The consistency of the findings with those of previous studies on AL raises the question of the advisability of preventing pesticide use by pregnant women. [ABSTRACT FROM AUTHOR]
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- 2007
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18. CHILDHOOD LEUKEMIA INCIDENCE AND EXPOSURE TO INDOOR RADON, TERRESTRIAL AND COSMIC GAMMA RADIATION.
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Evrard, Anne-Sophie, Hémon, Denis, Billon, Solenne, Laurier, Dominique, Jougla, Eric, Tirmarche, Margot, and Clavel, Jacqueline
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GAMMA rays ,IONIZING radiation ,RADON ,ACUTE myeloid leukemia ,LEUKEMIA in children ,COSMIC rays ,CANCER ,RADON measures ,LYMPHOMAS - Abstract
The article focuses on the evaluation of the ecological association between terrestrial and cosmic gamma radiation, indoor radon and acute leukemia among children in France. The cases of acute leukemia were recorded by the French National Registry of Childhood Leukemia and Lymphoma. Results of the study showed a retrained ecological association between childhood Acute Myelogenous Leukemia incidence and indoor radon. A case control study of residentially exposed children will have to make up of a large number of cases and controls with individual radon measurements and substantial contrasts in exposure.
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- 2006
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19. The Childhood Leukemia International Consortium.
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Metayer, Catherine, Milne, Elizabeth, Clavel, Jacqueline, Infante-Rivard, Claire, Petridou, Eleni, Taylor, Malcolm, Schüz, Joachim, Spector, Logan G., Dockerty, John D., Magnani, Corrado, Pombo-de-Oliveira, Maria S., Sinnett, Daniel, Murphy, Michael, Roman, Eve, Monge, Patricia, Ezzat, Sameera, Mueller, Beth A., Scheurer, Michael E., Armstrong, Bruce K., and Birch, Jill
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ASSOCIATIONS, institutions, etc. , *LEUKEMIA in children , *LYMPHOBLASTIC leukemia in children , *ACUTE myeloid leukemia , *CYTOGENETICS , *GENOTYPE-environment interaction - Abstract
Background: Acute leukemia is the most common cancer in children under 15 years of age; 80% are acute lymphoblastic leukemia (ALL) and 17% are acute myeloid leukemia (AML). Childhood leukemia shows further diversity based on cytogenetic and molecular characteristics, which may relate to distinct etiologies. Case--control studies conducted worldwide, particularly of ALL, have collected a wealth of data on potential risk factors and in some studies, biospecimens. There is growing evidence for the role of infectious/immunologic factors, fetal growth, and several environmental factors in the etiology of childhood ALL. The risk of childhood leukemia, like other complex diseases, is likely to be influenced both by independent and interactive effects of genes and environmental exposures. While some studies have analyzed the role of genetic variants, few have been sufficiently powered to investigate gene--environment interactions. Objectives: The Childhood Leukemia International Consortium (CLIC) was established in 2007 to promote investigations of rarer exposures, gene--environment interactions and subtype-specific associations through the pooling of data from independent studies. Methods: By September 2012, CLIC included 22 studies (recruitment period: 1962--present) from 12 countries, totaling approximately 31 000 cases and 50 000 controls. Of these, 19 case--control studies have collected detailed epidemiologic data, and DNA samples have been collected from children and child--parent trios in 15 and 13 of these studies, respectively. Two registry-based studies and one study comprising hospital records routinely obtained at birth and/or diagnosis have limited interview data or biospecimens. Conclusions: CLIC provides a unique opportunity to fill gaps in knowledge about the role of environmental and genetic risk factors, critical windows of exposure, the effects of gene--environment interactions and associations among specific leukemia subtypes in different ethnic groups. [ABSTRACT FROM AUTHOR]
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- 2013
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20. Age-, sex- and disease subtype–related foetal growth differentials in childhood acute myeloid leukaemia risk: A Childhood Leukemia International Consortium analysis.
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Karalexi, Maria A., Dessypris, Nick, Ma, Xiaomei, Spector, Logan G., Marcotte, Erin, Clavel, Jacqueline, Pombo-de-Oliveira, Maria S., Heck, Julia E., Roman, Eve, Mueller, Beth A., Hansen, Johnni, Auvinen, Anssi, Lee, Pei-Chen, Schüz, Joachim, Magnani, Corrado, Mora, Ana M., Dockerty, John D., Scheurer, Michael E., Wang, Rong, and Bonaventure, Audrey
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AGE distribution , *BIRTH weight , *CONFIDENCE intervals , *GESTATIONAL age , *SEX distribution , *TUMORS in children , *MYELOID leukemia , *FETAL development , *ACUTE diseases , *ODDS ratio , *DISEASE risk factors , *CHILDREN - Abstract
Evidence for an association of foetal growth with acute myeloid leukaemia (AML) is inconclusive. AML is a rare childhood cancer, relatively more frequent in girls, with distinct features in infancy. In the context of the Childhood Leukemia International Consortium (CLIC), we examined the hypothesis that the association may vary by age, sex and disease subtype using data from 22 studies and a total of 3564 AML cases. Pooled estimates by age, sex and overall for harmonised foetal growth markers in association with AML were calculated using the International Fetal and Newborn Growth Consortium for the 21st Century Project for 17 studies contributing individual-level data; meta-analyses were, thereafter, conducted with estimates provided ad hoc by five more studies because of administrative constraints. Subanalyses by AML subtype were also performed. A nearly 50% increased risk was observed among large-for-gestational-age infant boys (odds ratio [OR]: 1.49, 95% confidence interval [CI]: 1.03–2.14), reduced to 34% in boys aged <2 years (OR: 1.34, 95% CI: 1.05–1.71) and 25% in boys aged 0–14 years (OR: 1.25, 95% CI: 1.06–1.46). The association of large for gestational age became stronger in boys with M0/M1subtype (OR: 1.80, 95% CI: 1.15–2.83). Large birth length for gestational age was also positively associated with AML (OR: 1.38, 95% CI: 1.00–1.92) in boys. By contrast, there were null associations in girls, as well as with respect to associations of decelerated foetal growth markers. Accelerated foetal growth was associated with AML, especially in infant boys and those with minimally differentiated leukaemia. Further cytogenetic research would shed light into the underlying mechanisms. • Accelerated foetal growth was associated with childhood acute myeloid leukaemia. • The association was marked in large-for-gestational-age newborns. • The association was stronger in infant boys and minimally differentiated leukaemia. • Accelerated foetal growth age-, sex- and subtype- related differentials were showed. • These associations could shed light into the biology of AML and its subtypes. [ABSTRACT FROM AUTHOR]
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- 2020
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21. Risk of Central Nervous System Tumors in Children Related to Parental Occupational Pesticide Exposures in three European Case-Control Studies.
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Febvey, Olivia, Schüz, Joachim, Bailey, Helen D., Clavel, Jacqueline, Lacour, Brigitte, Orsi, Laurent, Lightfoot, Tracy, Roman, Eve, Vermeulen, Roel, Kromhout, Hans, and Olsson, Ann
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META-analysis , *PESTICIDES , *LOGISTIC regression analysis , *OCCUPATIONAL hazards , *ENVIRONMENTAL exposure , *CASE-control method , *ODDS ratio , *ADOLESCENCE , *CHILDREN , *TUMOR risk factors ,CENTRAL nervous system tumors - Abstract
Objective: The aim of this study was to assess the risk of childhood central nervous system (CNS) tumors associated with parental occupational pesticide exposure. Methods: We pooled three population-based case-control studies from France, Germany, and the United Kingdom. Cases were children below 15 years of age with CNS tumors; controls were matched by gender and age. A general population job-exposure matrix assessed parental occupational pesticide exposure. Logistic regressions estimated odds ratios (ORs) and 95% confidence intervals (CIs). Results: The study included 1361 cases and 5498 controls. Prevalence of maternal occupational pesticide exposure during pregnancy was low and no association with childhood CNS tumors was detected (OR 0.76, 95% Cl: 0.41 to 1.41). Around conception, OR for childhood CNS tumors associated with paternal occupational pesticide exposure was 0.71 (95% Cl: 0.53 to 0.95). Conclusion: Our results do not suggest a role of parental occupational pesticide exposure in the etiology of childhood CNS tumors. [ABSTRACT FROM AUTHOR]
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- 2016
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22. Childhood cancer survival in France, 1990–1999
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Desandes, Emmanuel, Berger, Claire, Tron, Isabelle, Demeocq, François, Bellec, Stéphanie, Blouin, Pascale, Casagranda, Léonie, De Lumley, Lionel, Freycon, Fernand, Goubin, Aurélie, Le Gall, Edouard, Sommelet, Danièle, Lacour, Brigitte, and Clavel, Jacqueline
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CANCER , *CHILD rearing , *CHILD care , *PEDIATRICS - Abstract
Abstract: The aim of this study was to describe the overall survival after childhood cancer in France using follow-up data from regional population-based registries. The survival of children (aged under 15 years) diagnosed with a cancer during 1990–1999 was analysed. For all cancers, the survivals were, respectively, 90.3% [89.4–91.3] at 1-year, 75.2% [73.8–76.6] at 5 years and 72.2% [70.7–73.7] at 10 years. During the 1990s, the average improvement in the 5-year survival was +1.2% per year. Adjusted for gender, age, area of residence and stage, children with cancer diagnosed between 1995 and 1999 had a 0.80 reduced risk of dying compared with those whose cancer had been diagnosed between 1990 and 1994. The increase of survival at the population level reflects a global improvement in childhood cancer care. The Paediatric Registries, in association with the French Society of Childhood Cancer, are now collecting data to quantify on a national basis the other events, at least relapse and second cancers. [Copyright &y& Elsevier]
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- 2008
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