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Introduction: Hypertension targets many organs. This study investigates left ventricular hypertrophy (LVH), which can lead to conduction disorders, arrhythmias, and heart failure. Endothelial dysfunction (ED) was assessed using serum asymmetric dimethyl-arginine (ADMA) levels. Methods: The study included a total of 90 voluntary participants: 30 patients with hypertension and left ventricular hypertrophy, 30 hypertensive patients without hypertrophy, and 30 normotensive healthy controls. Serum ADMA levels were used to detect endothelial dysfunction. Results: The results showed that serum ADMA levels were significantly higher in the patient group compared to the control group. However, there was no significant difference in serum ADMA levels between the two subgroups of patients, with or without left ventricular hypertrophy (LVH). A correlation analysis was performed, revealing no correlation between serum ADMA levels and the left ventricular mass index (LVMI). Discussion and Conclusion: There appears to be no direct relationship between LVH and endothelial dysfunction. Furthermore, inflammatory processes seem to contribute to the development of LVH rather than endothelial dysfunction. The duration of exposure to high blood pressure and the stage of hypertension are also believed to impact this process. [ABSTRACT FROM AUTHOR]

Pulse wave velocity (PWV), augmentation index (Aix), and central aortic pressure (CAP) are arterial stiffness markers of endothelial dysfunction (ED). We investigated the relationship between arterial stiffness parameters and asymmetric dimethylarginine (ADMA; a marker of ED), in newly diagnosed patients with hypertension (n = 101; 61 females). These patients were investigated in accordance with the recommendations of hypertension guidelines. Arterial stiffness was measured, and serum ADMA and C-reactive protein (CRP; a marker of inflammation) levels were determined. In both women and men, there was no difference in terms of age, body mass index, systolic and diastolic blood pressures, PWV, CAP and the levels of ADMA, while Aix and CRP levels were significantly higher in women (P = .004, P = .046, respectively). In the whole group, ADMA levels correlated with Aix (Pearson r = .237, P = .024). Our findings provide further evidence of a link between arterial stiffness and ED in newly diagnosed patients with hypertension. [ABSTRACT FROM AUTHOR]