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Investigation of the Relationship Between Left Ventricular Hypertrophy and Endothelial Dysfunction in Patients with Primary Hypertension by ADMA and hsCRP.
- Source :
- Lokman Hekim Health Sciences; 2024, Vol. 4 Issue 1, p44-49, 6p
- Publication Year :
- 2024
-
Abstract
- Introduction: Hypertension targets many organs. This study investigates left ventricular hypertrophy (LVH), which can lead to conduction disorders, arrhythmias, and heart failure. Endothelial dysfunction (ED) was assessed using serum asymmetric dimethyl-arginine (ADMA) levels. Methods: The study included a total of 90 voluntary participants: 30 patients with hypertension and left ventricular hypertrophy, 30 hypertensive patients without hypertrophy, and 30 normotensive healthy controls. Serum ADMA levels were used to detect endothelial dysfunction. Results: The results showed that serum ADMA levels were significantly higher in the patient group compared to the control group. However, there was no significant difference in serum ADMA levels between the two subgroups of patients, with or without left ventricular hypertrophy (LVH). A correlation analysis was performed, revealing no correlation between serum ADMA levels and the left ventricular mass index (LVMI). Discussion and Conclusion: There appears to be no direct relationship between LVH and endothelial dysfunction. Furthermore, inflammatory processes seem to contribute to the development of LVH rather than endothelial dysfunction. The duration of exposure to high blood pressure and the stage of hypertension are also believed to impact this process. [ABSTRACT FROM AUTHOR]
- Subjects :
- ARGININE
CROSS-sectional method
STATISTICAL correlation
BODY mass index
HYPERTENSION
SCIENTIFIC observation
KRUSKAL-Wallis Test
FISHER exact test
ENDOTHELIUM
DESCRIPTIVE statistics
MANN Whitney U Test
CHI-squared test
LEFT ventricular hypertrophy
RESEARCH
DATA analysis software
INFLAMMATION
C-reactive protein
Subjects
Details
- Language :
- English
- ISSN :
- 27917835
- Volume :
- 4
- Issue :
- 1
- Database :
- Complementary Index
- Journal :
- Lokman Hekim Health Sciences
- Publication Type :
- Academic Journal
- Accession number :
- 177669090
- Full Text :
- https://doi.org/10.14744/lhhs.2024.1202