1. Secondary metabolites from the stem bark of Stereospermum acuminatissimum and their antimicrobial activity.
- Author
-
Leutcha, Peron Bosco, Jouda, Jean-Bosco, Tsague Tankeu, Virginie Flaure, Magnibou, Larissa Mekontso, Atia-tul-Wahab, Choudhry, Muhammad Iqbal, and Lannang, Alain Meli
- Subjects
- *
METABOLITES , *ANTI-infective agents , *SHIGELLA flexneri , *CINNAMIC acid , *ANTIBACTERIAL agents , *ETHYL acetate , *PHYTOCHEMICALS - Abstract
Phytochemical investigation of the stem bark of Stereospermum acuminatissimum resulted in the isolation of seventeen compounds, including four tirucallanes (1 – 4), three hopanes (5 – 7), one oleanane (8), three sterols (9 – 11), three saponins (12 – 14), two cinnamic acids (15 – 16), and one iridoid (17). The dehydration of compound 5 led to compound 5a. The structures of all compounds were elucidated by analysis of spectroscopic and mass spectrometric data. Compounds 1 , 6 and 7 are reported from the Bignoniaceae family for the first time, while compounds 11 – 14 and 16 are reported from S. acuminatissimum for the first time. The in vitro antibacterial activities of some compounds (1 – 5 , 8 , 5a), the crude extract and the ethyl acetate fraction were assessed. The crude extract showed significant antibacterial activity against Staphylococcus aureus , Salmonea pneumonia and Klebsiella pneumoniae with MIC values of 62 μg/mL. Compound 1 revealed moderate antibacterial activities against K. pneumoniae , Shigella flexneri and Methycillin resistant S. aureus with MIC values of 62, 62 and 31 μg/mL respectively. [Display omitted] • Phytochemical investigation of Stereospermum acuminatissimum K. Schum. • Dehydration of one of the isolated compound. • Chemophenetic significance of the isolated compounds. • Antibacterial activities of crude extract, fractions and compounds. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF