1. Synthesis and Crystal Structure of Thiazolopyrimidine Derivatives: Insights into Weak Interactions
- Author
-
R. Shashi, Noor Shahina Begum, and N. L. Prasad
- Subjects
Crystal ,Crystallography ,chemistry.chemical_compound ,Ethanol ,chemistry ,Pyrimidine ,One-pot synthesis ,Fluorine ,chemistry.chemical_element ,General Materials Science ,General Chemistry ,Crystal structure ,Condensed Matter Physics - Abstract
Thiazolo[3,2-a]pyrimidines namely ethyl 2-acetyl-5-(2-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3a, ethyl 2-acetyl-5-(3-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3b, and ethyl 2-acetyl-5-(4-fluorophenyl)-3,7-dimethyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylate 3c were obtained by one pot synthesis using substituted 3,4 dihydropyrimidine2-thione (1a–1c) and 3-chloro-2,4-pentanedione in ethanol and characterized by single-crystal X-ray diffraction. The variation in the position of fluorine atom on pyrimidine nucleus and insight into the self-assembly of compounds with varied types of non-covalent interactions has great influence on crystal packing.
- Published
- 2020