83 results on '"Zhou Jin"'
Search Results
2. Simple and convenient two step synthesis of 5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone
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Qiu Yong-Fu, Lu Bin, Yan Yi-Yu, Zhou Jin, and Wang Jin
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coenzyme q ,1,4-benzoquinone ,bromination ,persulfate ,Chemistry ,QD1-999 - Abstract
5-bromo-2,3-dimethoxy-6-methyl-1,4-benzoquinone 3, a key intermediate for preparing coenzyme Q compounds, was readily synthesized in two steps by a reaction sequence starting from the commercially available 3,4,5-trimethoxytoluene 1 via bromination and oxidation reactions. Persulfate salts were first employed as oxidants to synthesize 1,4-benzoquinone, the overall yield of title compound 3 was 65%.
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- 2019
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3. Effects of chronic cadmium exposure on the structure and function of intestinal mucosal flora in mice
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Xiaoya Li, Yi Wu, Guozhen Xie, and Zhou-Jin Tan
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Pollutant ,CADMIUM EXPOSURE ,Human health ,Cadmium ,Flora ,Metabolic function ,chemistry ,chemistry.chemical_element ,Biology ,Toxicology ,Structure and function ,Microbiology - Abstract
Cadmium (Cd) is a serious environmental pollutant to human health. Intestinal flora is associated with human health. This study probed into the effects of Cd on the small intestinal mucosal flora i...
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- 2021
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4. lncRNA HOTAIR knockdown suppresses gastric cancer cell biological activities
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Ma Yong, Zhu Yu, Zhou Jin, Feng Yongheng, Pan Chao, Yang Kun-xing, and Yang Shi-yong
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0301 basic medicine ,lcsh:TX341-641 ,CCND2 ,Flow cytometry ,CCND1 ,03 medical and health sciences ,0302 clinical medicine ,Cyclin D1 ,HOTAIR ,medicine ,MTT assay ,Viability assay ,miRNA‐206 ,Original Research ,Gene knockdown ,medicine.diagnostic_test ,Chemistry ,gastric cancer ,Cancer ,medicine.disease ,030104 developmental biology ,Apoptosis ,030220 oncology & carcinogenesis ,Cancer research ,lcsh:Nutrition. Foods and food supply ,Food Science - Abstract
The aim of this study was to characterize the involvement of long noncoding RNA HOTAIR in gastric cancer development. Measurement of HOTAIR and miRNA‐206 expression by in situ hybridization (ISH) and analyzed for the correlation between HOTAIR and miRNA‐206 in gastric cancer tissues. To evaluate the effects of HOTAIR in gastric cancer, MTT assay, flow cytometry, transwell, and wound healing assays were applied. To explain the mechanism behind HOTAIR's involvement, the expression of proteins related to it was also measured by Western blotting. Finally, correlations among related factors were determined by a luciferase target experiment. HOTAIR expression significantly increased, and miRNA‐206 expression significantly decreased in cancer tissues (p, HOTAIR knockdown had antitumor effects by suppressing CCND1 and CCND2 expression by stimulating miRNA‐206 in gastric cancer in vitro study.
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- 2020
5. Extraction of Cr(VI) from chromite ore processing residue via hydrothermal-assisted phase transformation
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Zhang Lin, Mo Xiaofeng, Zhong Zuqi, Liu Xueming, Shaohua Yang, Zhou Jin, Dongye Zhao, Le Lin, and Zhenqing Shi
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Toxicity characteristic leaching procedure ,Extraction (chemistry) ,chemistry.chemical_element ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Hydrothermal circulation ,0104 chemical sciences ,Chromium ,chemistry.chemical_compound ,chemistry ,Hydroxide ,Leachate ,Chromite ,0210 nano-technology ,Mineral processing ,Nuclear chemistry - Abstract
The effective extracting Cr(VI) from chromite ore processing residue (COPR) is the key to achieve COPR detoxification and recovery. We developed an effective method to extract Cr(VI) from COPR via controlling the phase transformation of Cr(VI)-containing minerals. Characteristic analysis showed that Cr(VI) was mainly incorporated in the hydrocalumite (NaCa4Al2O6(SO4/CrO4)1.5⋅15H2O) in COPR, which was a layered-double hydroxide (LDH) with multilayer structure. In the hydrothermal treatment experiments, the Na2CO3 solution showed significant extraction effect of Cr(VI) and detoxification effect of COPR. After treatment, 95% of Cr(VI) was removed and the Cr(VI) concentration in the leachate was decreased to 1.6 mg/L by the toxicity characteristic leaching procedure (TCLP), within the regulatory limit disposal standard (HJ/T 301–2007, 3 mg/L). Further study revealed that, during the treatment, hydrocalumite transformed into calcite (CaCO3) under the effect of mineralizer, therefore, the layered structure collapsed and the incorporated Cr(VI) was released to the supernatant. Meanwhile, the Cr(VI) desorbed from calcite with the calcite particles grew into large size with smooth surface. Stir-flow experiment revealed that the amount of chromium released from CORP to the environment was significantly reduced after treatment, and it is safer for landfill disposal. This work will provide an instructive guidance for the detoxification and recovery of COPR.
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- 2020
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6. Decreased SIRT1 expression in the peripheral blood of patients with Graves’ disease
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Dongping Lin, Weiqing Wang, Yicheng Qi, Shu Wang, Yanqiu Wang, Liyun Shen, Ying Peng, Zhou Jin, Dalong Song, Qinglei Yin, Guang Ning, and Lei Ye
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0301 basic medicine ,medicine.medical_specialty ,endocrine system diseases ,Endocrinology, Diabetes and Metabolism ,Graves' disease ,Thyroid Gland ,030209 endocrinology & metabolism ,environment and public health ,NF-κB ,thyroid ,Pathogenesis ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Endocrinology ,SIRT1 ,Downregulation and upregulation ,Sirtuin 1 ,Internal medicine ,Medicine ,Humans ,Euthyroid ,biology ,business.industry ,Research ,Thyroid ,NF-kappa B ,medicine.disease ,Graves Disease ,enzymes and coenzymes (carbohydrates) ,030104 developmental biology ,Histone ,medicine.anatomical_structure ,chemistry ,biology.protein ,Protein deacetylase ,biological phenomena, cell phenomena, and immunity ,business ,Graves’ disease ,hormones, hormone substitutes, and hormone antagonists ,Signal Transduction - Abstract
SIRT1, a class III histone/protein deacetylase (HDAC), has been associated with autoimmune diseases. There is a paucity of data about the role of SIRT1 in Graves’ disease. The aim of this study was to investigate the role of SIRT1 in the pathogenesis of GD. Here, we showed that SIRT1 expression and activity were significantly decreased in GD patients compared with healthy controls. The NF-κB pathway was activated in the peripheral blood of GD patients. The reduced SIRT1 levels correlated strongly with clinical parameters. In euthyroid patients, SIRT1 expression was markedly upregulated and NF-κB downstream target gene expression was significantly reduced. SIRT1 inhibited the NF-κB pathway activity by deacetylating P65. These results demonstrate that reduced SIRT1 expression and activity contribute to the activation of the NF-κB pathway and may be involved in the pathogenesis of GD.
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- 2020
7. Cytochrome P450 Epoxygenase-Dependent Activation of TRPV4 Channel Participates in Enhanced Serotonin-Induced Pulmonary Vasoconstriction in Chronic Hypoxic Pulmonary Hypertension
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James S.K. Sham, Zhou Jin, Rui Jin, Lexin Xia, Omkar Paudel, and Yang Xia
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Male ,0301 basic medicine ,Epoxygenase ,Serotonin ,Cancer Research ,Contraction (grammar) ,Article Subject ,Hypertension, Pulmonary ,Morpholines ,TRPV Cation Channels ,Pulmonary Artery ,030204 cardiovascular system & hematology ,Pharmacology ,Epoxyeicosatrienoic acid ,Cytochrome P-450 CYP2J2 ,Pathology and Forensic Medicine ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Cytochrome P-450 Enzyme System ,Hypoxic pulmonary vasoconstriction ,medicine ,Animals ,Pyrroles ,Hypoxia ,RC254-282 ,QH573-671 ,biology ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,Cytochrome P450 ,Cell Biology ,General Medicine ,medicine.disease ,Amides ,Pulmonary hypertension ,Mice, Inbred C57BL ,030104 developmental biology ,chemistry ,Vasoconstriction ,Chronic Disease ,biology.protein ,Eicosanoids ,Molecular Medicine ,medicine.symptom ,Cytology ,Ion Channel Gating ,Endogenous agonist ,Research Article - Abstract
Transient receptor potential vanilloid 4 (TRPV4) is a multi-functional non-selective channel expressed in pulmonary vasculatures. TRPV4 contributes to serotonin- (5-HT-) induced pulmonary vasoconstriction and is responsible in part for the enhanced 5-HT response in pulmonary arteries (PAs) of chronic hypoxia mice. Epoxyeicosatrienoic acid (EET) is an endogenous agonist of TRPV4 and is known to regulate vasoreactivity. The levels of EETs, the expression of cytochrome P450 (CYP) epoxygenase for EET production, and epoxide hydrolase for EET degradation are altered by chronic hypoxia. Here, we examined the role of EET-dependent TRPV4 activation in the 5-HT-mediated PA contraction. In PAs of normoxic mice, inhibition of TRPV4 with a specific inhibitor HC-067047 caused a decrease in the sensitivity of 5-HT-induced PA contraction without affecting the maximal contractile response. Application of the cytochrome P450 epoxygenase inhibitor MS-PPOH had no effect on the vasoreactivity to 5-HT. In contrast, inhibition of CYP epoxygenase or TRPV4 both attenuated the 5-HT-elicited maximal contraction to a comparable level in PAs of chronic hypoxic mice. Moreover, the inhibitory effect of MS-PPOH on the 5-HT-induced contraction was obliterated in PAs of chronic hypoxic trpv4-/- mice. These results suggest that TRPV4 contributes to the enhanced 5-HT-induced vasoconstriction in chronic hypoxic PAs, in part via the CYP-EET-TRPV4 pathway. Our results further support the notion that manipulation of TRPV4 function may offer a novel therapeutic strategy for the treatment of hypoxia-related pulmonary hypertension.
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- 2020
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8. Simultaneous separation and immobilization of Cr(VI) from layered double hydroxide via reconstruction of the key phases
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Le Lin, Weizhen Liu, Li Li, Liu Xueming, Zhou Jin, Jiayi Zheng, and Zhang Lin
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Chromium ,Reaction mechanism ,Environmental Engineering ,Environmental remediation ,Health, Toxicology and Mutagenesis ,0211 other engineering and technologies ,02 engineering and technology ,Thermal treatment ,010501 environmental sciences ,01 natural sciences ,chemistry.chemical_compound ,Metals, Heavy ,Hydroxides ,Environmental Chemistry ,Waste Management and Disposal ,Mineral processing ,0105 earth and related environmental sciences ,021110 strategic, defence & security studies ,Volatilisation ,Extraction (chemistry) ,Pollution ,chemistry ,Hydroxide ,Leaching (metallurgy) ,Environmental Pollution ,Nuclear chemistry - Abstract
Layered double hydroxide (LDH) is one of the key host phases of Cr(VI) in the natural environment and chromite ore processing residue (COPR), causing serious pollution by Cr(VI). Therefore, efficient extraction or immobilization of the incorporated Cr(VI) in LDH is urgently needed. In this work, simultaneous separation and immobilization of Cr(VI) in LDH by using MgCl2·6H2O under thermal treatment is innovatively proposed. Cr was volatilized as CrCl3 and was immobilized as MgCr2O4 accounted for 62.2% and 37.8%, respectively, under the optimal condition (the mole ratio of Cl/Cr is 9, 700 °C and 120 min). The underlying reaction mechanisms are as follows: (i) HCl produced by MgCl2·6H2O accelerates the destruction of Cr(VI)-LDH layer structure, completely exposing the incorporated Cr(VI), (ii) Cr(VI) is reduced to Cr(III) by Cl-, part of which is directly immobilized as MgCr2O4, and the other part generates CrCl3, which is volatilized or further combined with Mg2+ to form MgCr2O4. The total Cr leaching concentration of the practical COPR sample treated by this method dramatically decreases from 421 to 0.7 mg/L, well below the landfill standard limit (4.5 mg/L). This work provides an attainable strategy for thorough remediation of COPR and inspires the treatment of heavy metal-containing LDH.
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- 2021
9. Effect of Gegenqinlian decoction on intestinal mucosal flora in mice with diarrhea induced by high temperature and humidity treatment
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Huaying Hui, Zhou-Jin Tan, Xiaoya Li, and Chenyang Zhang
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Lactobacillus crispatus ,biology ,Decoction ,Environmental Science (miscellaneous) ,Pharmacology ,biology.organism_classification ,medicine.disease_cause ,Agricultural and Biological Sciences (miscellaneous) ,Vascular endothelial growth factor ,Diarrhea ,chemistry.chemical_compound ,chemistry ,Intestinal mucosa ,medicine ,Tumor necrosis factor alpha ,Original Article ,medicine.symptom ,Neisseria mucosa ,Oxidative stress ,Biotechnology - Abstract
The objective of this study is to investigate the regulation effects of the active ingredients in Gegenqinlian Decoction (GD) on the intestinal mucosal flora of mice with diarrhea induced by high temperature and humidity based on systems pharmacology approach. Fifteen mice were randomly assigned to three equal groups of five mice, namely control (ctcm) group, model (ctmm) group and treatment (cttm) group. Mice in the cttm group were given 20 mL/kg of GD and sterile water was used as a placebo control twice a day for four consecutive days. We used the third-generation molecular high-throughput sequencing technology to measure the intestinal mucosal flora changes in mice. Combined with network pharmacology to predict the medicinal substances and action targets of GD against diarrhea. Results showed that Operational Taxonomic Unit (OTU) number and Alpha diversity in the intestinal mucosal flora of cttm group recovered and higher than that of the ctcm group. There were differences in the community structure between the ctmm and cttm groups in the Principal Coordinates Analysis (PCoA). The relative abundance results indicated dominant bacteria species (such as Lactobacillus crispatus, Muribaculum intestinal, Neisseria mucosa) in the intestinal mucosa of the three groups. Moreover, we screened out 146 active ingredients in GD corresponding to 252 component targets, and 328 disease targets in diarrhea to obtain 31 drug–disease common targets. Protein–protein interaction (PPI) networks mainly involved the core proteins such as Tumor necrosis factor (TNF) and Interleukin-6 (IL-6). Enrichment analyses showed that GD played a role in the treatment of diarrhea by regulating the hypoxia inducible factor-1 (HIF-1), vascular endothelial growth factor (VEGF) and adipocytokine signaling pathways and so on. In brief, the active ingredients of GD could intervene from oxidative stress and inflammatory response through multiple targets and multiple channels to adjust the balance of intestinal mucosa flora, thereby playing a role in the treatment of diarrhea. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s13205-020-02628-0.
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- 2021
10. Experimental Investigation of a Helium-Cooled Breeding Blanket First Wall under LOFA Conditions and Pre-Test and Post-Test Numerical Analysis
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Bradut-Eugen Ghidersa, Bruno Gonfiotti, André Kunze, Valentino Di Marcello, Mihaela Ionescu-Bujor, Xue Zhou Jin, and Robert Stieglitz
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Fluid Flow and Transfer Processes ,Technology ,QH301-705.5 ,Physics ,QC1-999 ,Process Chemistry and Technology ,General Engineering ,Engineering (General). Civil engineering (General) ,first wall ,Computer Science Applications ,Chemistry ,experimental investigation ,LOFA ,code validation ,DEMO ,General Materials Science ,TA1-2040 ,Biology (General) ,QD1-999 ,Instrumentation ,ddc:600 - Abstract
The experimental investigation of a prototypical set‐up simulating a loss of flow accident in a helium‐cooled breeding blanket first wall mock‐up under typical heat load conditions is presented. The experimental campaign reproduces the expected DEMO thermal‐hydraulics conditions during normal and off‐normal situations and aims at providing some insight into the fast transients associated with the loss of flow in the blanket first wall. The experimental set‐up and the definition of the experimental matrix are discussed, including pre‐test analysis performed in support of these activities. The major experimental results are discussed, and a procedure of using the acquired data for validating and calibrating the RELAP‐3D model of the mock‐up is introduced. All these activities contributed to the creation of a relevant theoretical and practical experience that can be used in further studies concerning incidental transients in real‐plant scenarios in the framework of DEMO plant fusion safety activities.
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- 2021
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11. Preliminary thermal-hydraulic analysis of the EU-DEMO Helium-Cooled Pebble Bed fusion reactor by using the RELAP5-3D system code
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Salvatore D’Amico, Francisco Alberto Hernandez Gonzalez, Xue Zhou Jin, I. Moscato, Guangming Zhou, Pietro Alessandro Di Maio, D'Amico S., Di Maio P.A., Jin X.Z., Hernandez Gonzalez F.A., Moscato I., and Zhou G.
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Technology ,Computer science ,020209 energy ,Nuclear engineering ,HCPB ,chemistry.chemical_element ,02 engineering and technology ,Blanket ,7. Clean energy ,01 natural sciences ,010305 fluids & plasmas ,Thermal hydraulics ,Reliability (semiconductor) ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,General Materials Science ,RELAP5-3D ,Safety and Environment ,Helium ,Settore ING-IND/19 - Impianti Nucleari ,Civil and Structural Engineering ,Steady state ,Finite volume method ,Mechanical Engineering ,Fusion power ,EU-DEMO ,Nuclear Energy and Engineering ,chemistry ,Thermal-hydraulics ,Heat transfer ,ddc:600 - Abstract
In the frame of the activities promoted and encouraged by the EUROfusion Consortium aimed at developing the EU-DEMO fusion reactor, great emphasis has been placed at a very early stage of the design to incorporate the provisions needed to improve the overall plant safety and reliability performances as well as to analyse possible mitigation actions. In this framework, the research activity has been focused on the representative and safety relevant cooling loop of the Helium Cooled Pebble Bed (HCPB) Breeding Blanket (BB) Primary Heat Transfer System (PHTS), purposely selected by the safety team, in order to assess its thermal-hydraulic behaviour during normal operational conditions (ramp up/down and steady state) and to preliminarily investigate the consequences of an ex-vessel LOCA accidental scenario ensuing a Double-Ended Guillotine (DEG) break in the hot leg. The research activity has been carried out following a theoretical-computational approach based on the finite volume method adopting the RELAP5−3D system code along with the ANSYS CFX computational fluid dynamic code, which were implicitly integrated to achieve a more detailed and realistic simulation of the EU-DEMO reactor thermal-hydraulics. Models, assumptions and outcomes of this preliminary study are herein presented and critically discussed.
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- 2021
12. The Mechanical Properties and Micro-Structure of Oil Well Cement Enhanced by Graphene Oxide
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Shuo Qiong Liu, Hui Ting Liu, Yong Jin Yu, and Jian Zhou Jin
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Cement ,Materials science ,Graphene ,Mechanical Engineering ,0211 other engineering and technologies ,Oxide ,02 engineering and technology ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,Micro structure ,law.invention ,chemistry.chemical_compound ,chemistry ,Mechanics of Materials ,Oil well ,law ,021105 building & construction ,General Materials Science ,Composite material ,0210 nano-technology - Abstract
The improvement of strength and ductility is a challenging task for application of oil well cement. As a 2D nanomaterial with high strength and toughness, graphene oxide (GO) was used as a reinforcing additive in oil well cement. The mechanical properties and micro-structure of oil well cement enhanced by GO were investigated. The compressive strength and flexrual strenghth of cement stone both showed a good enhancement effect when the content of GO was 0.02% -0.05%. The compressive strength and flexrual strength could increase by 15.8% and 33.5%, respectively. The results of SEM and MIP revealed that GO played a template role in promoting the formation of hydration products and further filled in the pores between the hydration products, which refined the micro-structure and improved mechanical properties of the cement consequently.
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- 2018
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13. Bis(phosphine imide)s: Easily tunable organic electron donors
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Guidi, Vanina V., Zhou Jin, Busse, Devin, Euler, William B., and Lucht, Brett L.
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Electron donor-acceptor complexes -- Research ,Oxidation-reduction reaction -- Research ,Biological sciences ,Chemistry - Abstract
The electrochemical, structural, and spectroscopic properties of bis(phosphine imide)s are investigated. p-Phenylenebis(phosphine imide)s Ar3PNC6H4NPAr3 have two reversible single-electron oxidations, in which electron-donating substituents lower the oxidation potential, while electron-withdrawing substituents increase the oxidation potentials.
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- 2005
14. Inhibition of cyclodextrins on the activity of α-amylase
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Cai Hongyan, Wang Zhan, Zhang Wei, Francisco J. Barba, Shen Wangyang, Sun Wei, Min Wang, Zhenzhou Zhu, Zhou Jin, Li Fang, Liu Lingyi, and Chen Xuan
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chemistry.chemical_classification ,Circular dichroism ,Chromatography ,Intrinsic factor ,biology ,Cyclodextrin ,Chemistry ,Starch ,04 agricultural and veterinary sciences ,General Chemistry ,010402 general chemistry ,Condensed Matter Physics ,040401 food science ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,carbohydrates (lipids) ,chemistry.chemical_compound ,0404 agricultural biotechnology ,biology.protein ,Fermentation ,Amylase ,Protein secondary structure ,Food Science - Abstract
α-amylase activity influences both flour fermentation process and the quality of the fermented products due to its ability of breaking starch into smaller units. The inhibition of cyclodextrins on α-amylase activity was investigated in this paper. Experiment results showed that hydrophobic cavity size was an intrinsic factor during the inhibition processing. Among three types of cyclodextrin (α-, β- and γ-), β-type exhibited the most significant inhibitory activity toward α-amylase. The optimal inhibitory parameters were indicated to be pH 5.9, concentration of β-cyclodextrins 1 mmol/L, reaction temperature 45 °C and reaction time 60 min. Results suggested that the endogenous fluorescence of α-amylase was inhibited by cyclodextrins. Circular dichroism spectrum indicated that the secondary structure of α-amylase, including α-helices, β-sheets and random coils, was changed by cyclodextrins. All the results in this paper aim to provide a further understanding for α-amylase in the industry application.
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- 2018
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15. Influences of Aflatoxin B1 on main intestinal bacteria communities and enzyme activities in mice
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Ya-Wei Liu, Nenqun Xiao, Zhou-Jin Tan, Lu He, and Yan-Fang Guo
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chemistry.chemical_classification ,021110 strategic, defence & security studies ,Aflatoxin ,Intestinal enzymes ,Host (biology) ,0211 other engineering and technologies ,02 engineering and technology ,010501 environmental sciences ,Biology ,Toxicology ,01 natural sciences ,Microbiology ,Enzyme ,chemistry ,Intestinal bacteria ,0105 earth and related environmental sciences - Abstract
Intestine microbiota and enzyme activities have crucial effects on host's health and behavior. In order to provide evidences for the toxicology of Aflatoxin B1 (AFB1) on human’s health objectively,...
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- 2018
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16. Bacterial Lactase Gene Characteristics in Intestinal Contents of Antibiotic-Associated Diarrhea Mice Treated with Debaryomyces hansenii
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Chun-Hui Wang, Zhou-Jin Tan, Yi Wu, Nen-Qun Xiao, and Yuan Tang
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Diarrhea ,Male ,medicine.drug_class ,medicine.medical_treatment ,Antibiotics ,030204 cardiovascular system & hematology ,Tubercidin ,Microbiology ,Mice ,03 medical and health sciences ,0302 clinical medicine ,Gene expression ,Debaryomyces hansenii ,medicine ,Animals ,Lactase ,chemistry.chemical_classification ,Bacteria ,Base Sequence ,biology ,Animal Study ,Testolactone ,Gastrula ,Biodiversity ,General Medicine ,biology.organism_classification ,Anti-Bacterial Agents ,Intestines ,Enzyme ,chemistry ,Genes, Bacterial ,030220 oncology & carcinogenesis ,Female ,Antibiotic-associated diarrhea ,medicine.symptom - Abstract
BACKGROUND Debaryomyces hansenii exhibits a therapeutic effect on antibiotic-associated diarrhea (AAD) by promoting the growth of beneficial intestinal bacteria. Previous research has reported that AAD involves not only dysbacteriosis but also dysfunction of the activity of intestinal enzymes (such as lactase). Enzyme activities can be influenced by many other factors, such as gene expression. The present study showed that D. hansenii has a curative effect on AAD at the lactase gene level. MATERIAL AND METHODS The effect of D. hansenii on the lactase gene from intestinal bacteria in AAD mice was investigated. The diarrhea model was established with a gentamycin sulfate and cefradine capsule mixture. The antibiotic mixture (23.33 mL·kg⁻¹·day⁻¹) was intragastrically administered for 5 days. Subsequently, half of the diarrhea mice were treated with D. hansenii twice a day for 3 days while the other mice were intragastrically administered with the same volume of distilled water. Next, the intestinal contents were collected, and metagenomic DNA was extracted for high-throughput sequencing analysis. RESULTS The Chao1 and Shannon indices decreased significantly following treatment with D. hansenii (P
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- 2020
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17. Connexin 43 contributes to temporomandibular joint inflammation induced-hypernociception via sodium channel 1.7 in trigeminal ganglion
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Ting Hao, Lu-Ming Wang, Mu-Di Guo, Yi-Zhou Jin, Ye-Hua Gan, and Peng Zhang
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0301 basic medicine ,Male ,Nociception ,medicine.medical_specialty ,Connexin ,Inflammation ,Rats, Sprague-Dawley ,03 medical and health sciences ,Trigeminal ganglion ,0302 clinical medicine ,stomatognathic system ,Downregulation and upregulation ,Internal medicine ,medicine ,Animals ,Glial fibrillary acidic protein ,biology ,Temporomandibular Joint ,Chemistry ,General Neuroscience ,NAV1.7 Voltage-Gated Sodium Channel ,Gap junction ,Temporomandibular joint ,stomatognathic diseases ,030104 developmental biology ,medicine.anatomical_structure ,Allodynia ,Endocrinology ,Trigeminal Ganglion ,Hyperalgesia ,Connexin 43 ,biology.protein ,medicine.symptom ,030217 neurology & neurosurgery - Abstract
We previously demonstrated that sodium channel 1.7 (Nav1.7) in trigeminal ganglion (TG) was a critical factor in temporomandibular joint (TMJ) inflammation-induced hypernociception, but the mechanism underlying inflammation-induced upregulation of Nav1.7 remained unclear. Glial-neuron interaction plays a critical role in pain process and connexin 43 (Cx43), a gap junction protein expressed in satellite glial cells (SGCs) has been shown to play an important role in several pain models. In the present study, we investigate the role of Cx43 in TMJ inflammation-induced hypernociception and its possible impact on neuronal Nav1.7. We induced TMJ inflammation in rats by injecting complete Freund’s adjuvant (CFA) into TMJ and observed a decrease in head withdraw threshold after 24 h. Electron microscopy showed morphological alterations of SGCs in TMJ-inflamed rats. The expression of Cx43, glial fibrillary acidic protein (GFAP), and Nav1.7 increased greatly compared with controls. In addition, pretreatment with Cx43 blockers in TMJ-inflamed rats could alleviate mechanical hypernociception, inhibit SGCs activation and IL-1βrelease, and thus block the upregulation of Nav1.7. These findings indicate that the propagation of SGCs activation via Cx43 plays a critical role in Nav1.7-involved mechanical hypernociception induced by TMJ inflammation.
- Published
- 2019
18. One-step extraction of high-purity CuCl2·2H2O from copper-containing electroplating sludge based on the directional phase conversion
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Yu Yao, Zhen Wu, Zhang Lin, Huang Qiuyun, Zhou Jin, Hong Deng, and Liu Xueming
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021110 strategic, defence & security studies ,Environmental Engineering ,Volatilisation ,Materials science ,Health, Toxicology and Mutagenesis ,Extraction (chemistry) ,Metallurgy ,0211 other engineering and technologies ,chemistry.chemical_element ,One-Step ,02 engineering and technology ,010501 environmental sciences ,01 natural sciences ,Pollution ,Copper ,Metal ,Copper extraction techniques ,chemistry ,Phase (matter) ,visual_art ,visual_art.visual_art_medium ,Environmental Chemistry ,Electroplating ,Waste Management and Disposal ,0105 earth and related environmental sciences - Abstract
The recovery of heavy metals is a vital way to turn electroplating sludge into resources and reduce its environmental hazards. However, the complex compositions of the polymetallic electroplating sludge severely limit the selective recovery of metal resources such as copper. In this study, we took a kind of copper-containing electroplating sludge (C-ES) as an example present and investigated the process of copper extraction. The copper and other metals were directional converted through an accurate phase transformation process carried out by chlorination combined with thermal regulation. Eventually, the copper was selectively recovered in the form of CuCl2·2H2O, while the rest of the metals were converted into stable metal salts or oxides. The HCl solution was the best regulator for selective copper recovery. Under the optimal conditions, the recovery of copper approached 97% and the purity of the CuCl2·2H2O product was about 95%. The kinetic reaction equation of the CuCl2 volatilization process can be described by Power Low, G(α) = α1/15. The economic estimate based on experimentation indicates the profit of recycling CuCl2·2H2O is about $23.2/kg. This work provides a novel, simple, and efficient approach to the selective recovery of heavy metal from polymetallic solid wastes.
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- 2021
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19. Ph2S/selectfluor-promoted deoxydifluorination of aldehydes
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Han-Zhou Jin, Jin-Hong Lin, Xuan Xiao, Xing Zheng, Tongsheng Zhong, Ji-Chang Xiao, and Guowen He
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chemistry.chemical_compound ,chemistry ,010405 organic chemistry ,Organic Chemistry ,Drug Discovery ,010402 general chemistry ,Selectfluor ,01 natural sciences ,Biochemistry ,Combinatorial chemistry ,0104 chemical sciences - Abstract
The installation of a HCF2 group is a research area that has received increasing attention, and deoxydifluorination of aldehydes have served as an attractive protocol due to the wide availability of aldehydes. Herein we describe a Ph2S/Selectfluor-promoted deoxydifluorination of aldehydes under mild conditions. Compared with previous deoxydifluorination methods, which usually use hazardous reagents such as SF4, DAST and Deoxo-Fluor, this protocol is quite attractive because of the safe and convenient operations, and the use of easily available reagents.
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- 2021
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20. A novel turn-on fluorescent sensor for highly selective detection of Al(<scp>iii</scp>) in an aqueous solution based on simple electrochemically synthesized carbon dots
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Ju Wu, Jun-Cheng Jin, Jiang-Zhou Jin, Xucheng Fu, and Cheng-Gen Xie
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Detection limit ,Aqueous solution ,Photoluminescence ,Quenching (fluorescence) ,integumentary system ,Chemistry ,General Chemical Engineering ,Metal ions in aqueous solution ,Inorganic chemistry ,General Engineering ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Photochemistry ,01 natural sciences ,Fluorescence ,0104 chemical sciences ,Analytical Chemistry ,Ion ,0210 nano-technology ,Luminescence - Abstract
In this study, a simple and sensitive turn on fluorescent sensor for the detection of Al3+ ion in an aqueous solution was developed based on carbon dots (C-dots) obtained via one-step electrolysis of graphite in sodium hydroxide aqueous solution. The as-prepared C-dots exhibit excellent photoluminescence and up-conversion photoluminescence properties and have an average size of 5.0 nm. The as-prepared C-dots showed a light green luminescence emission under 365 nm ultraviolet excitation and could be used as a novel label-free turn on fluorescent probe for the selective detection of Al3+; this is quite different from the case of usual quenching effects of metal ions on fluorescent C-dots. The fluorescence enhancement effect of Al3+ ion on the as-prepared C-dots could be attributed to the chelation-enhanced fluorescence (CHEF) mechanism. Abundant oxygen functional groups on the surface of C-dots have chelation interaction with Al3+ and increase the rigidity of the C-dots, leading to fluorescence enhancement. Moreover, the as-prepared C-dots are highly selective for Al3+ over other metal ions, with a detection limit of 0.05 μM, and the linear relationship between fluorescence intensity and concentration of Al3+ is in the range of 0.1–7.2 μM. In addition, the as-prepared novel fluorescent probe was successfully applied for the direct analysis of Al3+ in a real environmental water sample.
- Published
- 2017
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21. Fumaric Acid Production from Alkali-Pretreated Corncob by Fed-Batch Simultaneous Saccharification and Fermentation Combined with Separated Hydrolysis and Fermentation at High Solids Loading
- Author
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Zhou Jin, Shuiping Ouyang, Jia Ouyang, Qiang Yong, and Xin Li
- Subjects
0106 biological sciences ,Fumaric acid ,Rhizopus oryzae ,Industrial Waste ,Bioengineering ,Alkalies ,010501 environmental sciences ,Corncob ,Lignin ,Zea mays ,01 natural sciences ,Applied Microbiology and Biotechnology ,Biochemistry ,chemistry.chemical_compound ,Hydrolysis ,Bioreactors ,Fumarates ,010608 biotechnology ,Sodium Hydroxide ,Molecular Biology ,0105 earth and related environmental sciences ,Chromatography ,biology ,food and beverages ,General Medicine ,Plant Components, Aerial ,Alkali metal ,biology.organism_classification ,Glucose ,chemistry ,Batch Cell Culture Techniques ,Carbohydrate Metabolism ,Fermentation ,Rhizopus ,Biotechnology - Abstract
Production of fumaric acid from alkali-pretreated corncob (APC) at high solids loading was investigated using a combination of separated hydrolysis and fermentation (SHF) and fed-batch simultaneous saccharification and fermentation (SSF) by Rhizopus oryzae. Four different fermentation modes were tested to maximize fumaric acid concentration at high solids loading. The highest concentration of 41.32 g/L fumaric acid was obtained from 20 % (w/v) APC at 38 °C in the combined SHF and fed-batch SSF process, compared with 19.13 g/L fumaric acid in batch SSF alone. The results indicated that a combination of SHF and fed-batch SSF significantly improved production of fumaric acid from lignocellulose by R. oryzae than that achieved with batch SSF at high solids loading.
- Published
- 2016
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22. Research of Nanosilica Particles Grafted with Functional Polymer Used as Fluid Loss Additive for Cementing under Ultra-High Temperature
- Author
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Yakai Feng, Jin Tang Guo, Jian Zhou Jin, Yong Jin Yu, Shuo Qiong Liu, and Xiu Jian Xia
- Subjects
chemistry.chemical_classification ,Materials science ,Nanocomposite ,Mechanical Engineering ,Maleic anhydride ,Polymer ,Condensed Matter Physics ,Microstructure ,Silanol ,chemistry.chemical_compound ,Brine ,chemistry ,Mechanics of Materials ,Copolymer ,General Materials Science ,Thermal stability ,Composite material - Abstract
On account of that the domestic polymer fluid loss additive exists some severe problems, such as, inferior thermal resistance, poor salt tolerance, strong shear-and thermal thinning behavior, a novel polymer/silica nanocomposite PADMO-V@NS is used as ultra-high temperature fluid loss control additive for cementing. In the present study PADMO-V@NS was prepared through an in situ free radical copolymerization of 2-acrylamico-2-methylpropane sulfonic acid (AMPS), N,N-dimethylacryl amide (DMAM), maleic anhydride (MA), octadecyl dimethylallyl ammonium chloride (ODAAC) and triethoxyvinylsilane (VTS) modified nanosilica. The linear hydrophobic associated copolymer was regarded as the shell and the modified nanosilica as the core. The microstructure, compositions and thermal resistance of PADMO-V@NS were investigated through FTIR and TGA techniques. The results showed that the copolymer modified with nanosilica particles possessed more excellent thermal stability than that of PADMO, and the most rapid decomposing temperature of PADMO-V@NS was highly up to 396.9°C. The application performance of PADMO-V@NS in cement slurry exhibited that it had excellent fluid loss control capacity, good high temperature resistance, strong salt tolerance and mild shear-/ thermal thinning performance, and could be used in 220°C and saturated brine circumstances. Moreover, comparing to PADMO, the compressive strength of set cement containing the copolymer increased over 20 % at 80°C, atmosphere pressure and curing time of 1 day due to the reaction of residual silanol groups with Ca (OH)2. The laboratory research results indicated that the multi-functional fluid loss additive composed of hydrophobic associated polymer/silica nanocomposite had bestowed on the cement slurry systems good comprehensive properties, and may have extensive applications in deep & ultra-deep oil/gas wells cementing.
- Published
- 2016
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23. Research progress in the environmental application of magnesium hydroxide nanomaterials
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Le Lin, Gao Huiqin, Chengzhe Liao, Xueming Liu, Zhen Feng, Zhou Jin, and Zhang Lin
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Pollutant ,Materials science ,Waste management ,Magnesium ,Air pollution ,General Physics and Astronomy ,chemistry.chemical_element ,02 engineering and technology ,Surfaces and Interfaces ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Condensed Matter Physics ,medicine.disease_cause ,01 natural sciences ,0104 chemical sciences ,Surfaces, Coatings and Films ,Nanomaterials ,Preparation method ,chemistry ,medicine ,0210 nano-technology ,Water pollution ,Resource recovery ,Material recycling - Abstract
At present, multi-pollutant discharge from industrial sources prevails. Advanced synthetic nanomaterials can remove multiple types of pollutants, but they are costly and difficult to put into mass production. Therefore, it is necessary to explore a cost-effective material suitable for various pollutants. Magnesium hydroxide is a naturally-occurring material kinetically stabilized in nanoscale, characterized by its large specific area and considerable active reaction sites, which contributes to the viability of treatment for multiple pollutants. Moreover, its low-cost and eco-friendly properties also favor more extensive utilization in the environmental aspect. It has been proven to show excellent performance in water and air pollution control. Especially in water pollution treatment, it can not only efficiently remove a variety of low-concentration pollutants driven by diversified reaction mechanisms but also constitutes a resource recovery and material recycling route via simple regulation of structure and morphology. In this review, the preparation methods and morphological characteristics of magnesium hydroxide nanomaterials were introduced, and then its application in water pollution treatment, air pollution control was summarized. This review is of guiding significance to further promote the environmental application of magnesium hydroxide and provides a novel, efficient and easy way of managing multiple pollutants.
- Published
- 2020
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24. Development of Functional Polymer as Oil-Well Cement Retarder
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Yong Jin Yu, Jian Zhou Jin, Jin Tang Guo, Xiu Jian Xia, Shuo Qiong Liu, and Yakai Feng
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Cement ,chemistry.chemical_classification ,Materials science ,Mechanical Engineering ,Thermal treatment ,Polymer ,Condensed Matter Physics ,Retarder ,Cementation (geology) ,law.invention ,chemistry ,Mechanics of Materials ,Oil well ,law ,General Materials Science ,Thermal stability ,Cement slurry ,Composite material - Abstract
In this study, a novel polymer retarder DRH-200LG was synthesized to solve the problems of retarding failure, strong dispersivity under high temperature and adverse impact on the strength development of cement stone. The composition of the polymer was confirmed by IR, and its thermal stability was proved by DSC, TG analysis and thermal treatment at 200 °C. Furthermore, the stability and strength development of cement slurry was evaluated by the comparative consistency method and ultrasonic method, respectively. The results show that DRH-200LG has good high temperature-resistance and retarding performance, presenting favourable influence on the stability and strength development of cement slurry. DRH-200LG shows a good application prospect in the cementation of deep & ultra-deep wells. And it has some guiding significance in the research and innovation of a novel polymer used as oil well cement retarder.
- Published
- 2015
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25. Conceptual design of a helium heater for high temperature applications
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Yuming Chen, Bradut-Eugen Ghidersa, and Xue Zhou Jin
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Materials science ,Mechanical Engineering ,Nuclear engineering ,Divertor ,chemistry.chemical_element ,Fluid mechanics ,Pressure vessel ,Thermal hydraulics ,Nuclear Energy and Engineering ,Conceptual design ,Heat flux ,chemistry ,Heat transfer ,General Materials Science ,Helium ,Civil and Structural Engineering - Abstract
The Karlsruhe Advanced Technologies Helium Loop (KATHELO) has been designed for testing divertor modules as well as qualifying materials for high heat flux, high temperature (up to 800 °C) and high pressure (10 MPa) applications. The test section inlet temperature level is controlled using a process electrical heater. To cope with the extreme operating conditions, a special design of this unit has been proposed. In this paper the conceptual design of the unit will be presented and the impact of the coupling between the cold and hot helium gas on the overall efficiency of the loop will be investigated. The detailed thermal-hydraulic analysis of the feed through of the hot helium into the low temperature pressure vessel using ANSYS CFX will be presented. The impact of the design choices on the overall energy budget of the loop will be analyzed using RELAP5-3D.
- Published
- 2014
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26. Thermal–hydraulic system study of the HELOKA-LP helium loop using RELAP5-3D code
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Frederik Arbeiter, Yuming Chen, Markus Schlenker, Xue Zhou Jin, Bradut-Eugen Ghidersa, and Georg Schlindwein
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Materials science ,Mechanical Engineering ,Nuclear engineering ,Time constant ,chemistry.chemical_element ,International Fusion Materials Irradiation Facility ,Volumetric flow rate ,Thermal hydraulics ,Loop (topology) ,Nuclear Energy and Engineering ,chemistry ,Mass flow rate ,General Materials Science ,Body orifice ,Helium ,Civil and Structural Engineering - Abstract
The thermal–hydraulic system analyses for the HELOKA-LP (Helium Loop Karlsruhe – Low Pressure) facility are presented. Typical operation ranges for the test section are mass flow rate between 12 and 120 g/s, inlet temperature between 10 and 250 °C and pressure level between 0.3 and 0.6 MPa. An orifice is used for the loop testing, for which different experiments are validated with appropriate simulations. Afterwards instead of the orifice, two most heated compartments of IFMIF (International Fusion Materials Irradiation Facility) HFTM (high flux test module) are simulated in HELOKA-LP. Using the system code REALP5-3D components in the loop are modeled as well as the main control strategy. With this model the loop dynamics in conditions relevant for the HFTM operation are analyzed and the thermal time constant of the compartment is estimated.
- Published
- 2013
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27. KATHELO: A new high heat flux component testing facility
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M. Ionescu-Bujor, Xue Zhou Jin, Bradut-Eugen Ghidersa, and Michael Rieth
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Materials science ,Steady state ,Unit testing ,Mechanical Engineering ,Nuclear engineering ,Divertor ,Emphasis (telecommunications) ,Flux ,chemistry.chemical_element ,Loop (topology) ,Nuclear Energy and Engineering ,chemistry ,Heat flux ,General Materials Science ,Helium ,Civil and Structural Engineering - Abstract
In this article a new helium cooled test facility is presented. The loop, KATHELO, is designed to operate at pressures up to 10 MPa and temperatures up to 800 °C in order to be able to provide suitable testing conditions for the helium cooled divertor concept developed at KIT. The general layout of the loop is introduced and the some of the technological solutions adopted for the loop components are discussed. The thermal-dynamic behavior of the loop during start-up and steady state operation for two different scenarios is analyzed using a RELAP-3D model of the circuit. Based on these simulations the heating power needed for high temperature operation is estimated. A particular attention is given to the thermal coupling between the cold and hot leg of the loop with emphasis on overall loop efficiency.
- Published
- 2013
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28. Development of advanced high heat flux and plasma-facing materials
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Andrey Litnovsky, Takumi Chikada, M. Li, Robert Stieglitz, T. Shikama, Vladica Nikolić, A. von Müller, J. Reiser, Jeong-Ha You, Johann Riesch, S. Matsuo, Jan Hoffmann, T. Weber, Stefan Wurster, Anna Rebecca Hoffmann, Michael Rieth, A. Houben, Hiroaki Kurishita, Jarir Aktaa, Ch. Linsmeier, T. Palacios, D. Qu, Zhangjian Zhou, Reinhard Pippan, and Xue Zhou Jin
- Subjects
Nuclear and High Energy Physics ,Materials science ,Tokamak ,Nuclear engineering ,chemistry.chemical_element ,Tungsten ,01 natural sciences ,7. Clean energy ,composites ,010305 fluids & plasmas ,law.invention ,materials ,law ,high heat flux materials ,tritium permeation barriers ,0103 physical sciences ,plasma-facing materials ,ddc:530 ,functionally graded materials ,tungsten-based ,Engineering & allied operations ,010302 applied physics ,passive safety ,Divertor ,Radioactive waste ,Fusion power ,Condensed Matter Physics ,chemistry ,13. Climate action ,Transient (oscillation) ,ddc:620 ,Material properties ,Stellarator - Abstract
Plasma-facing materials and components in a fusion reactor are the interface between the plasma and the material part. The operational conditions in this environment are probably the most challenging parameters for any material: high power loads and large particle and neutron fluxes are simultaneously impinging at their surfaces. To realize fusion in a tokamak or stellarator reactor, given the proven geometries and technological solutions, requires an improvement of the thermo-mechanical capabilities of currently available materials. In its first part this article describes the requirements and needs for new, advanced materials for the plasma-facing components. Starting points are capabilities and limitations of tungsten-based alloys and structurally stabilized materials. Furthermore, material requirements from the fusion-specific loading scenarios of a divertor in a water-cooled configuration are described, defining directions for the material development. Finally, safety requirements for a fusion reactor with its specific accident scenarios and their potential environmental impact lead to the definition of inherently passive materials, avoiding release of radioactive material through intrinsic material properties. The second part of this article demonstrates current material development lines answering the fusion-specific requirements for high heat flux materials. New composite materials, in particular fiber-reinforced and laminated structures, as well as mechanically alloyed tungsten materials, allow the extension of the thermo-mechanical operation space towards regions of extreme steady-state and transient loads. Self-passivating tungsten alloys, demonstrating favorable tungsten-like plasma-wall interaction behavior under normal operation conditions, are an intrinsic solution to otherwise catastrophic consequences of loss-of-coolant and air ingress events in a fusion reactor. Permeation barrier layers avoid the escape of tritium into structural and cooling materials, thereby minimizing the release of tritium under normal operation conditions. Finally, solutions for the unique bonding requirements of dissimilar material used in a fusion reactor are demonstrated by describing the current status and prospects of functionally graded materials.
- Published
- 2017
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29. Research status of active cooling of endothermic hydrocarbon fueled scramjet engine
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Zhou Jin, Wang Ning, and Pan Yu
- Subjects
chemistry.chemical_classification ,Waste management ,Chemistry ,Mechanical Engineering ,Aerospace Engineering ,Combustion ,Endothermic process ,law.invention ,Ignition system ,Hydrocarbon ,law ,Active cooling ,Heat transfer ,Thermal protection ,Scramjet - Abstract
The active cooling with endothermic hydrocarbon fuel is proved to be a very effective approach for scramjet thermal protection. This article has summarized the research status of active cooling of ...
- Published
- 2012
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30. Thermal-hydraulic system study of a high pressure, high temperature helium loop using RELAP5-3D code
- Author
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Bradut-Eugen Ghidersa and Xue Zhou Jin
- Subjects
Nuclear and High Energy Physics ,Engineering ,System code ,business.industry ,Mechanical Engineering ,Nuclear engineering ,chemistry.chemical_element ,Blanket ,Loop (topology) ,System study ,Thermal hydraulics ,Nuclear Energy and Engineering ,chemistry ,Code (cryptography) ,General Materials Science ,Safety, Risk, Reliability and Quality ,business ,Waste Management and Disposal ,Simulation ,Helium - Abstract
The thermal-hydraulic system analysis for the Helium Loop Karlsruhe (HELOKA) facility, a high pressure, high temperature experimental helium loop having the European Helium Cooled Pebble Beds Test Blanket Module (HCPB TBM) as the test module, was investigated. Using the system code REALP5-3D, all components in the loop are modeled as well as the main control strategy. With this model, the loop dynamics in conditions relevant for blanket module operation are simulated and analyzed.
- Published
- 2012
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31. Study on Preparation and in Vitro Sustained Release of Bu-Yang-Huan-Wu Sustained-Release Tablet
- Author
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Yang Yantao, Liu Wen-long, Shi Jilian, Wu Chunying, Zhou Jin, and HE Fu-yuan
- Subjects
Osmotic pump ,Ingredient ,Chromatography ,In vitro dissolution ,Chemistry ,Sustained Release Tablet ,Synchronous control ,Pharmacology ,In vitro - Abstract
Aim of this study was to prepare Bu-Yang-Huan-Wu (BYHW) elementary osmotic pump sustained-release tablets and to investigate the situation of its main effective components of “synchronous control and sustained release.” The releasing similarity of chromatographic fingerprints of BYHW in vitro dissolution was evaluated. The results showed that BYHW elementary osmotic pump sustained-release tablet was prepared and the chromatographic fingerprints were extracted. And data of its release similarity was also obtained. It was concluded that BYHW elementary osmotic pump sustained-release tablet can achieve the synchronous control and sustained release of many ingredient. It is also fit for the characteristic of Chinese herbal medicine compound.
- Published
- 2012
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32. Synthesis and Biological Evaluation of 3-Substituted-indolin-2-one Derivatives Containing Chloropyrrole Moieties
- Author
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Zhan-Cheng Li, Yun-Zhou Jin, Nan Ma, Lin Xiao, Quan-Hai Liu, Rong-Hua Zhang, and Da-Xu Fu
- Subjects
Indoles ,synthesis ,Stereochemistry ,Substituent ,Pharmaceutical Science ,Antineoplastic Agents ,Indolin 2 one ,antitumor activities ,indolin-2-one ,chloropyrrole ,Ring (chemistry) ,Article ,Analytical Chemistry ,lcsh:QD241-441 ,chemistry.chemical_compound ,Mice ,lcsh:Organic chemistry ,Cell Line, Tumor ,Drug Discovery ,medicine ,Molecule ,Animals ,Humans ,Pyrroles ,Physical and Theoretical Chemistry ,Pyrrole ,Cardiotoxicity ,Molecular Structure ,Chemistry ,Melanoma ,Organic Chemistry ,medicine.disease ,Vascular Endothelial Growth Factor Receptor-2 ,respiratory tract diseases ,Chemistry (miscellaneous) ,Cell culture ,Molecular Medicine ,Intercellular Signaling Peptides and Proteins ,Chlorine ,Drug Screening Assays, Antitumor - Abstract
Eighteen novel 3-substituted-indolin-2-ones containing chloropyrroles were synthesized and their biological activities were evaluated. The presence of a chlorine atom on the pyrrole ring was crucial to reduce cardiotoxicity. The presence of a 2-(ethyl-amino)ethylcarbamoyl group as a substituent at the C-4' position of the pyrrole enhanced the antitumor activities notably. IC50 values as low as 0.32, 0.67, 1.19 and 1.22 μM were achieved against non-small cell lung cancer (A549), oral epithelial (KB), melanoma (K111) and large cell lung cancer cell lines (NCI-H460), respectively.
- Published
- 2011
33. Investigation of accident cases for high pressure, high temperature experimental helium loop using RELAP5-3D code
- Author
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Bradut-Eugen Ghidersa and Xue Zhou Jin
- Subjects
Materials science ,Steady state ,Mechanical Engineering ,Nuclear engineering ,Flow (psychology) ,chemistry.chemical_element ,Blanket ,Loop (topology) ,Nuclear Energy and Engineering ,chemistry ,Control system ,Code (cryptography) ,Water cooling ,General Materials Science ,Helium ,Civil and Structural Engineering - Abstract
Accident cases are investigated for the Helium Loop Karlsruhe (HELOKA) facility, a high pressure and high temperature experimental helium loop having the European Helium Cooled Pebble Beds (HCPB) Test Blanket Module (TBM) as test module. Two typical operation modes for the loop operation have been numerically modeled using RELAP5-3D code: a pulsed operation (ITER-like situation) and a steady state operation (very long pulse). In both situations a maximum heat load on the first wall of 500 kW/m 2 has been considered. Using the generated RELAP-model for these two operating modes three accident cases are studied: failure of helium pressure control system (PCS), loss of helium flow and loss of cooling water flow. Simulation results show that the most critical case is the loss of helium flow. In this case failure of the TBM box is possible. By the loss of cooling water the integrity of the TBM box could be assured, if actions are taken in time. By the failure of the PCS the integrity of pressure barriers are not affected.
- Published
- 2011
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34. Bagasse-based Nanoporous Carbon for Supercapacitor Application
- Author
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CI Wei-Jiang, Tun Xiao-Zhong, Geng Wei, Zhou Jin, and Zhuo Chu-Ping
- Subjects
Supercapacitor ,Materials science ,Scanning electron microscope ,Nanoporous ,Inorganic chemistry ,Electrolyte ,Dielectric spectroscopy ,Inorganic Chemistry ,chemistry.chemical_compound ,Adsorption ,chemistry ,Ionic liquid ,General Materials Science ,Cyclic voltammetry - Abstract
A kind of nanoporous carbon has been successfully prepared from sugarcane bagasse through a facile microwave-induced ZnCl2 activation and tested as electrode material in ionic liquid supercapacitor. The as-prepared nanoporous carbons are systematically characterized by a variety of means such as N2 adsorption, SEM (scanning electron microscope) and TEM (transmission electron microscope). Characterization results reveal that the pore size of nanoporous carbons can be tuned from 2.5 nm to 7 nm by simply adjusting the concentration of ZnCl2 solution from 20 wt% to 60 wt%. The nanoporous carbons are tested as electrode materials in ionic liquid using different electrochemical means such as cyclic voltammetry, constant current charge-discharge and electrochemical impedance spectroscopy. As evidenced by electrochemical measurements, the capacitive performances of the carbons are closely related to their pore sizes. It has been demonstrated that large pore size benefits the good capacitive performance of nanoporous carbon in ionic liquid electrolyte.
- Published
- 2011
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35. Preparation of Microporous Carbon Using a Zeolite HY Template and Its Capacitive Performance
- Author
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Li Wen, Lü Yi-Min, Zhou Jin, Xing Wei, and Zhuo Shu-Ping
- Subjects
Materials science ,Adsorption ,X-ray photoelectron spectroscopy ,Chemical engineering ,chemistry ,Desorption ,chemistry.chemical_element ,Chemical vapor deposition ,Microporous material ,Physical and Theoretical Chemistry ,Zeolite ,Carbon ,BET theory - Abstract
Several microporous carbons were prepared by polyfurfuryl alcohol-impregnation and impregnation-acetonitrile chemical vapor deposition (CVD) using zeolite HY as a template, denoted as PFA carbons and AN carbons, respectively. These were used as electrode materials for supercapacitors. X-ray diffraction (XRD) patterns show that the structural regularity of the zeolite was well-replicated by the carbon structures prepared by impregnation-CVD. X-ray photoelectron spectroscopy (XPS) confirmed that the AN carbons possess abundant nitrogen-containing groups because of the CVD of acetonitrile. The prepared carbons were typical microporous materials as determined by N2 adsorption/desorption test and they had a high BET surface area and narrow pore size distribution. Electrochemical tests showed that the AN carbons had higher capacitance because of their evident pseudo-capacitance from the nitrogencontaining groups. AN8 had a high capacitance up to 210 F·g-1. The capacitance retention ratio of the AN carbons were determined to its electric conductivity and mesoporosity.
- Published
- 2011
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36. Characterization of a fenpropathrin-degrading strain and construction of a genetically engineered microorganism for simultaneous degradation of methyl parathion and fenpropathrin
- Author
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Hong Qing, Jiang Jian-dong, Hong Yuanfan, Zhou Jin, Wang Qian, and Li Shunpeng
- Subjects
Insecticides ,Environmental Engineering ,Hydrolases ,Industrial Waste ,Methyl Parathion ,Management, Monitoring, Policy and Law ,Chromosomes ,chemistry.chemical_compound ,Bioremediation ,hemic and lymphatic diseases ,Pyrethrins ,Parathion methyl ,Soil Pollutants ,Waste Management and Disposal ,Pyrethroid ,Bacteria ,Sewage ,biology ,Pesticide residue ,Strain (chemistry) ,business.industry ,General Medicine ,Hydrolase Gene ,Biodegradation ,biology.organism_classification ,Biotechnology ,Biodegradation, Environmental ,Biochemistry ,chemistry ,Genetic Engineering ,business - Abstract
A gram-negative fenpropathrin-degrading bacterial strain Sphingobium sp. JQL4-5 was isolated from the wastewater treatment sludge of an insecticide factory. Strain JQL4-5 showed the ability to degrade other pyrethroid insecticides, but it was not able to degrade methyl parathion. To enhance its degrading range of substrate, a methyl parathion hydrolase gene (mpd) was successfully introduced into the chromosome of strain JQL4-5 with a mini-Tn-transposon system. A genetically engineered microorganism (GEM) named JQL4-5-mpd resulted, which was capable of simultaneously degrading methyl parathion and fenpropathrin. Soil treatment results indicated that JQL4-5-mpd is a promising multifunctional bacterium in the bioremediation of multiple pesticide-contaminated environments.
- Published
- 2010
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37. Catalytic Regioselective Synthesis of Structurally Diverse Indene Derivatives from N-Benzylic Sulfonamides and Disubstituted Alkynes
- Author
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Nan Li, Xian-Tao Ma, Yi-Zhou Jin, Fu-Lai Yang, Dao-Juan Cheng, Shi-Kai Tian, and Congrong Liu
- Subjects
chemistry.chemical_compound ,Chemistry ,Organic Chemistry ,Organic chemistry ,Regioselectivity ,Physical and Theoretical Chemistry ,Indene ,Cleavage (embryo) ,Biochemistry ,Combinatorial chemistry ,Catalysis - Abstract
An unprecedented protocol has been developed for the regioselective synthesis of structurally diverse indene derivatives from readily accessible N-benzylic sulfonamides and disubstituted alkynes through FeCl(3)-catalyzed cleavage of sp(3) carbon-nitrogen bonds to generate benzyl cation intermediates. In the presence of 10 mol % of FeCl(3), a broad range of N-benzylic sulfonamides smoothly react with internal alkynes, alkynylcarbonyl compounds, alkynyl chalcogenides, or alkynyl halides to afford various functionalized indene derivatives with extremely high regioselectivity.
- Published
- 2010
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38. Effect of incorporation of Astragalus sinicus on microbe and enzyme dynamics in tobacco cultivated soils
- Author
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Zhuang Cheng, Xiang-Dan Liu, Qiao-Zhen Tong, Yang-Zhu Zhang, Nen-Qun Xiao, Zhou-Jin Tan, and Hong-Xia Zhang
- Subjects
chemistry.chemical_classification ,Enzyme ,Ecology ,Agronomy ,chemistry ,Botany ,Soil water ,Soil Science ,Astragalus sinicus ,Plant Science ,Biology ,Agronomy and Crop Science ,Ecology, Evolution, Behavior and Systematics - Published
- 2010
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39. Facile synthesis of bagasse waste derived carbon dots for trace mercury detection
- Author
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Gan Wei, Li Xuan-Hua, Jiang-Zhou Jin, Jian Zhang, and Fu Xu-Cheng
- Subjects
Detection limit ,Photoluminescence ,Materials science ,Polymers and Plastics ,Metals and Alloys ,chemistry.chemical_element ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Fluorescence ,Fluorescence spectroscopy ,0104 chemical sciences ,Surfaces, Coatings and Films ,Electronic, Optical and Magnetic Materials ,Mercury (element) ,Biomaterials ,chemistry.chemical_compound ,X-ray photoelectron spectroscopy ,chemistry ,Urea ,Fourier transform infrared spectroscopy ,0210 nano-technology ,Nuclear chemistry - Abstract
In this paper, water-soluble nitrogen doped fluorescent carbon dots (N-CDs) have been prepared by a facile hydrothermal treatment of bagasse waste and urea. The prepared N-CDs were characterized by high resolution TEM, fluorescence spectroscopy, FTIR and x-ray photoelectron spectroscopy. The results revealed that the prepared N-CDs were mainly composed of hydroxyl, carboxyl and amino groups with an average size of ca. 5.0 nm. The prepared N-CDs exhibited excellent photoluminescence and emitted light blue fluorescence under a 365 nm UV light. Owing to the selective fluorescent quenching response of Hg2+, the prepared N-CDs have been used as a fluorescent probe for sensitive detection of Hg2+ in water. The fluorescent quenching mechanism could be due to the special coordination interaction between Hg2+ and the surface functional groups of the fluorescent N-CDs. Meanwhile, the fluorescence quenching efficiency decreased linearly with Hg2+ in the concentration range of 0.005–0.8 μM. The detection limit is low to 0.002 μM. The synthesized N-CDs were further applied to the detection of Hg2+ in real water samples.
- Published
- 2018
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40. W/O Nano‐Emulsions with Olive Leaf Phenolics Improved Oxidative Stability of Sacha Inchi Oil
- Author
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Zhenzhou Zhu, Lianliang Liu, Zhou Jin, Min Wang, Liu Lingyi, Wang Zhan, and Shen Wangyang
- Subjects
chemistry.chemical_classification ,Chemistry ,010401 analytical chemistry ,Nano emulsion ,Induction time ,04 agricultural and veterinary sciences ,General Chemistry ,Oxidative phosphorylation ,Limiting ,040401 food science ,01 natural sciences ,Industrial and Manufacturing Engineering ,0104 chemical sciences ,stomatognathic diseases ,0404 agricultural biotechnology ,Olive leaf ,Edible oil ,Food science ,Droplet size ,Food Science ,Biotechnology ,Polyunsaturated fatty acid - Abstract
Natural phenolic compounds have been drawn a wide attention to replace the synthesis antioxidants due to the food safety issues, while, natural phenolic compounds are usually polyhydroxy derivatives which exhibit hydrophilic capacity, limiting their applications directly in lipid systems. In this work, olive leaf phenolics (OLP) are extracted by ultrasound from five cultivars and the optimal cultivar is chosen to prepare W/O nano‐emulsions of Sacha Inchi oil (SIO, containing more than 90% polyunsaturated fatty acids). The droplet size could reach 2.15 ± 0.13 nm and remaines stable without phase separation during 30‐day storage. Oxidative stabilities of SIO containing 0.02%, 0.05%, and 0.1% OLP (w/w) are evaluated by Rancimat test and accelerated storage test. The release of OLP by preparation of W/O nano‐emulsions is capable of controlling the oxidative progress of SIO, by prolonging the induction time, preventing the production of primary and secondary oxidative products and also the deterioration of polyunsaturated fatty acids and tocopherols. Practical Applications: Sacha Inchi oil (SIO) contains approximately 90% of polyunsaturated fatty acids (PUFAs) associated with poor oxidative stability. Olive leaf phenolics (OLP) are considered as a great and cheap source of natural phenolic compounds. This study aimes to select the optimum source of OLP from five cultivars and to prepare a W/O nano‐emulsion of OLP. By diluting the W/O nano‐emulsion of OLP into SIO, effect of different concentrations OLP on the oxidative stability of SIO is evaluated through thermal oxidative stability and storage oxidative stability in an accelerated storage test. Results indicate that the capacity of OLP to retard the SIO oxidation depends on the incorporated concentration, which means that it is doable to adopt OLP, an abundant and cheap material, to improve the stability of edible oil with high PUFAs in the industry. Olive leaf phenolics are extracted and detected to prepare an efficient and stable W/O nano‐emulsion; By diluting W/O nano‐emulsion into Sacha Inchi oil, oxidative stability of the high content PUFAs oil is improved.
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- 2018
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41. Poly-p-phenylene phosphine/polyaniline alternating copolymers: Electronic delocalization through phosphorus
- Author
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Zhou Jin and Lucht, Brett L.
- Subjects
Nitrogen compounds -- Electric properties ,Nitrogen compounds -- Spectra ,Chemistry - Abstract
Phosphorus-containing poly(N-arylaniline)s and related model compounds are prepared, and their spectroscopic and electronic properties are investigated. Copolymers containing -(-C6H4-P-C6H4-P-C6H4-)- linkages between nitrogen centers show evidence for weak electronic delocalization along the polymer chain.
- Published
- 2005
42. Synaptophysin Expression in Rat Retina Following Acute High Intraocular Pressure
- Author
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Zeng Le-ping, Chen Dan, Huang Jufang, Luo Xue-gang, Wang Hui, Zhou Jin, and Tong Jianbin
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Pathology ,medicine.medical_specialty ,acute high intraocular pressure ,Histology ,Physiology ,Synaptogenesis ,synaptophysin ,degeneration ,Biochemistry ,Pathology and Forensic Medicine ,Synapse ,chemistry.chemical_compound ,synapse ,medicine ,Outer nuclear layer ,Retina ,biology ,Retinal ,Regular Article ,Cell Biology ,Cell biology ,medicine.anatomical_structure ,chemistry ,Retinal ganglion cell ,nervous system ,plasticity ,Synaptic plasticity ,Synaptophysin ,biology.protein ,sense organs - Abstract
In response to injury, synapse alteration may occur earlier than the changes in the cell body of neurons. Although retinal ganglion cell death and thinning of the inner part of retina were found after acute high intraocular pressure (HIOP), the structural and functional changes of synapses in the retina remain unknown. In the present study, we investigated the protein and mRNA expression of synaptophysin (SYN), an important molecule closely related to synaptic activities, synaptogenesis and synaptic plasticity. In addition, we also studied the ultrastructural changes of the retinal synapses. We found that (1) synaptophysin was upregulated transiently at both protein and mRNA level following HIOP; (2) broadened distribution of synaptophysin protein was present within the outer nuclear layer at the early stage following HIOP; (3) in the outer nuclear layer bouton-like vesicle-containing structures were observed by electron microscopy. This data suggested that, besides degeneration, synapses in rat retina may undergo regenerative events following HIOP.
- Published
- 2008
43. Improved Method of Ink-Gelatin Perfusion for Visualising Rat Retinal Microvessels
- Author
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Chen Dan, Wang Hui, Tong Jianbin, Huang Liang, Luo Xue-gang, Zhou Jin, Zeng Le-ping, and Huang Jufang
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retina ,Pathology ,medicine.medical_specialty ,Mean arterial pressure ,Histology ,food.ingredient ,Physiology ,von Willebrand factor ,Biochemistry ,Gelatin ,Pathology and Forensic Medicine ,chemistry.chemical_compound ,food ,Von Willebrand factor ,Medicine ,rat ,Microvessel ,Retina ,biology ,business.industry ,ink perfusion ,Regular Article ,Retinal ,Cell Biology ,body regions ,medicine.anatomical_structure ,chemistry ,microvessel ,biology.protein ,business ,Perfusion ,Immunostaining ,circulatory and respiratory physiology - Abstract
To visualize completely rat retinal microvessels, the gelatin-ink perfusion condition was systematically optimized using von Willebrand factor (vWf) immunostaining as control. Whether the vessel showed by the new perfusion condition can be used for double label with neurons or glial cells in the same retina was also tested. Our results showed that infusing rats first with 20 ml of 37 degrees C ink plus 3% gelatin at 140% rat mean arterial pressure (MAP), and subsequently with 20 ml of 37 degrees C ink plus 5% gelatin at 180% rat MAP allowed the ink to completely fill the rat retinal microvessels. Rat retinal microvessels labeled by the perfusion method were more in number than that by vWf immunostaining. Moreover, our data, for the first time, displayed that the improved gelatin-ink perfusion had no effect on and caused no contamination to the following fluorogold labeling or immunostaining of retinal neurons or glial cells in the same tissue. These data suggest that the improved gelatin-ink perfusion technique is a superior method for morphological characterization of rat retinal microvessels, compatible to the double labeling of glial cells and neurons, and it extends the practical scale of the classic method.
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- 2008
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44. DNA methylation among firefighters.
- Author
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Zhou, Jin, Jenkins, Timothy G., Jung, Alesia M., Jeong, Kyoung Sook, Zhai, Jing, Jacobs, Elizabeth T., Griffin, Stephanie C., Dearmon-Moore, Devi, Littau, Sally R., Peate, Wayne F., Ellis, Nathan A., Lance, Peter, Chen, Yin, and Burgess, Jefferey L.
- Subjects
- *
DNA methylation , *FIRE fighters , *PROTEIN kinases , *BONFERRONI correction , *GENE regulatory networks , *COMPUTATIONAL biology - Abstract
Firefighters are exposed to carcinogens and have elevated cancer rates. We hypothesized that occupational exposures in firefighters would lead to DNA methylation changes associated with activation of cancer pathways and increased cancer risk. To address this hypothesis, we collected peripheral blood samples from 45 incumbent and 41 new recruit non-smoking male firefighters and analyzed the samples for DNA methylation using an Illumina Methylation EPIC 850k chip. Adjusting for age and ethnicity, we performed: 1) genome-wide differential methylation analysis; 2) genome-wide prediction for firefighter status (incumbent or new recruit) and years of service; and 3) Ingenuity Pathway Analysis (IPA). Four CpGs, including three in the YIPF6, MPST, and PCED1B genes, demonstrated above 1.5-fold statistically significant differential methylation after Bonferroni correction. Genome-wide methylation predicted with high accuracy incumbent and new recruit status as well as years of service among incumbent firefighters. Using IPA, the top pathways with more than 5 gene members annotated from differentially methylated probes included Sirtuin signaling pathway, p53 signaling, and 5' AMP-activated protein kinase (AMPK) signaling. These DNA methylation findings suggest potential cellular mechanisms associated with increased cancer risk in firefighters. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
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45. Poly-p-phenylene Phosphine/Polyaniline Alternating Copolymers: Electronic Delocalization through Phosphorus
- Author
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Brett L. Lucht and Zhou Jin
- Subjects
Diphenylphosphine ,General Chemistry ,Electronic structure ,Biochemistry ,Catalysis ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Poly(p-phenylene) ,Diamine ,Polyaniline ,Polymer chemistry ,Copolymer ,Cyclic voltammetry ,Phosphine - Abstract
Phosphorus-containing poly(N-arylaniline)s and related polymer model compounds have been prepared. The spectroscopic and electronic properties of the materials were investigated via UV-vis-NIR spectroscopy and cyclic voltammetry. PPPP-PANI copolymers containing p-phenylene diamine units in the polymer backbone have electronic and spectroscopic properties characteristic of aromatic substituted p-phenylene diamines. Copolymers containing -(-C(6)H(4)-P-C(6)H(4)-P-C(6)H(4)-)- linkages between nitrogen centers show evidence for weak electronic delocalization along the polymer chain. The electrochemical and spectroscopic properties support strong electronic delocalization in copolymers containing -(-P-C(6)H(4)-N-C(6)H(4)-)- repeat units. The presence of a single diphenylphosphine bridge between nitrogen centers provides an efficient mode of electronic delocalization between nitrogen centers. PPPP oxide-PANI copolymers and related polymer model compounds were also prepared and investigated. The resemblance of PPPP oxide-PANI copolymers to isolated p-phenylene diamines or triarylamines suggests electronic isolation of the amine fragments in the polymer. The conversion of phosphorus(III) phosphines to phosphorus(V) phosphine oxides inhibits electronic delocalization through phosphorus, further supporting delocalization of the lone pair of electrons on phosphorus in PPPP-PANI copolymers. PPPP-PANI copolymers are a new type of pi-conjugated polymer with low oxidation potentials and electronic delocalization through phosphorus along the polymer chain.
- Published
- 2005
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46. A Novel Positive Type Photosensitive Polyimide Based on Soluble Block Copolyimide with Alicyclic Dianhydride
- Author
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Xing Zhou Jin, Shigemasa Segawa, and Hiroyuki Ishii
- Subjects
chemistry.chemical_classification ,Tetramethylammonium hydroxide ,Materials science ,Condensation polymer ,Aqueous solution ,Polymers and Plastics ,Base (chemistry) ,Organic Chemistry ,Solvent ,Alicyclic compound ,chemistry.chemical_compound ,chemistry ,Pyridine ,Polymer chemistry ,Materials Chemistry ,Polyimide - Abstract
A novel positive type photosensitive polyimide based on soluble block copolyimide (Bco-PI) with alicyclic dianhydride has been developed. The base Bco-PI was prepared by a direct one-pot polycondensation of cyclohexanetetracarboxylic dianhydride (H-PMDA), 2, 2-Bis (3-amino-4-hydroxyphenyl)hexafluoropropane (Bis-AP-AF) and bis(4-(3-aminophenoxy)phenyl)sulfone (m-BAPS) in the presence of a γ-valerolactone and pyridine catalyst system and N-methyl-2-pyrrolidone(NMP) was used as solvent. The resulting film was transparent and colorless. It exhibited the cutoff at 290nm, and the refractive index was 1.55. The Tg and CTE were 278°C and 39 ppm/°C. As alicyclic dianhydride, H-PMDA, contributed to the resulting Bco-PI film with good thermal properties and excellent optical properties.By the addition of 20wt% 1,2-Naphthoqiunonediazide-5-sulfonic acid p-cresol ester (PC5) to the Bco-PI, It was found to be a positive type photosensitive polyimide. It showed a sensitivity of 350mJ/cm2 and a contrast of 2.42 when it was exposed to UV light, followed by development with 5% tetramethylammonium hydroxide (TMAH) aqueous solution at room temperature.
- Published
- 2005
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47. Novel positive-type photosensitive polyimide with low dielectric constant
- Author
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Hiroyuki Ishii and Xing Zhou Jin
- Subjects
Tetramethylammonium hydroxide ,Materials science ,Aqueous solution ,Polymers and Plastics ,General Chemistry ,Dielectric ,Surfaces, Coatings and Films ,Kapton ,Solvent ,chemistry.chemical_compound ,Diazonaphthoquinone ,chemistry ,Photosensitivity ,Polymer chemistry ,Materials Chemistry ,Polyimide - Abstract
A novel positive-type photosensitive polyimide (PSPI) with a low dielectric constant was developed. The PSPI system was composed of soluble block PI (Bco-PI) with a hydroxy group and diazonaphthoquinone as a photoreactive compound. The base Bco-PI was prepared by a direct one-pot polycondensation of 2,2-bis(3-amino-4-hydroxy-phenylhexafluoropropane), 2,2-bis[4-(4-aminophenoxy)phenyl]hexafluoropropane, and cyclohexanetetracarboxylic dianhydride in the presence of a γ-valerolactone and pyridine catalyst system using N-methyl-2-pyrrolidone as the solvent. The film of Bco-PI was colorless and transparent, both important factors for a PSPI. Photosensitive soluble block PI (Bco-PI), containing 20 wt % ester of 2,3,4-trihydroxybenzophenone with 1,2-naphthoquinone-(2)-diazide-5-sulfonic acid (NT200), showed a sensitivity of 350 mJ/cm2 and a contrast of 1.20 when it was exposed to UV light, followed by development with 5% tetramethylammonium hydroxide aqueous solution at room temperature. The estimated optical dielectric constants of the PIs with and without NT200 were 2.68 and 2.75, respectively. These values were significantly lower than those of conventional aromatic PIs, such as Kapton film (50EN). © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 15–21, 2005
- Published
- 2005
- Full Text
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48. Asymmetric synthesis of (1S,6R,7S,9R)-7,9-bis(tert-butyldiphenylsilyloxy)-3-oxabicyclo[4,3,0]nonan-2-one
- Author
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Xiao-Xin Shi, Qing-Quan Wu, Wei He, Xiao-Zhou Jin, Jie Yin, and Feng Ni
- Subjects
chemistry.chemical_classification ,Bicyclic molecule ,Organic Chemistry ,Enantioselective synthesis ,chemistry.chemical_element ,Catalysis ,Inorganic Chemistry ,chemistry.chemical_compound ,chemistry ,Organic chemistry ,Malic acid ,Physical and Theoretical Chemistry ,Lactone ,Palladium - Abstract
The asymmetric synthesis of (1 S ,6 R ,7 S ,9 R )-7,9-bis( tert -butyldiphenylsilyloxy)-3-oxabicyclo[4,3,0]nonan-2-one 1 from (4 S )-4-acetoxy-2-methoxycarbonyl-3-methoxycarbonylmethyl-2-cyclopenten-1-one 2 is described in eight steps. Compound 2 was readily prepared from l -malic acid according to a known procedure. The key step of this synthesis is a palladium on charcoal catalyzed hydrogenation of olefinic bicyclic lactone 9 .
- Published
- 2004
- Full Text
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49. Positive-type Photosensitive Polyimide with Low Modulus based on Soluble Block Copoly(imide-siloxane)
- Author
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Hiroyuki Ishii and Xing Zhou Jin
- Subjects
chemistry.chemical_classification ,Tetramethylammonium hydroxide ,Materials science ,Aqueous solution ,Condensation polymer ,Polymers and Plastics ,Base (chemistry) ,Organic Chemistry ,BPDA ,chemistry.chemical_compound ,Diazonaphthoquinone ,chemistry ,Siloxane ,Polymer chemistry ,Materials Chemistry ,Polyimide - Abstract
A novel positive-type photosensitive polyimide with low modulus based on soluble block copoly(imide-siloxane) with hydroxyl group and diazonaphthoquinone as a photoreactive compound has been developed. The base block copoly(imide-siloxane) was prepared by a direct one-pot polycondensation of biphenyltetracarboxylic dianhydride(BPDA) 2,2-Bis(3-amino-4-methyl)phenylhexafluoropropane(Bis-AP-AF) and diamino(poly)siloxane in the presence of a γ-valerolactone and pyridine catalyst system using dipolar aprotic solvent such as N-methyl-2-pyrrolidone(NMP). The base block copoly(imide-siloxane) consists of aromatic polyimide unit as a hard segment, and polysiloxane unit as a soft segment.The polysiloxane unit contributed to the resulting poly(imide-siloxane) film with not only colorlessness and transparency which are the important factors for a photosensitive polyimide but also low modulus. Due to the low modulus, it can reduce the residual wafer stress caused by the CTE (coefficient of thermal expand) mismatch between silicon wafer (3ppm/K) and polyimide (30∼60ppm/K), and prevent semiconductor devices from physical and electric damage. Photosensitive block copoly(imide-siloxane) containing 20wt% Ester of 2,3,4,4'-trihydrobenzophenone with 1,2-naphthoquinone-(2)-diazide-5-sulfonic acid (4NT-300) showed a sensitivity of 350mj/cm2 and a contrast of 1.95 when it was exposed to UV light, followed by development with 2.38% tetramethylammonium hydroxide (TMAH) aqueous solution containing 10wt% isopropyl alcohol (IPA) at room temperature.
- Published
- 2004
- Full Text
- View/download PDF
50. Biotransformation of glycosides in herbal medicine by gut microbiota
- Author
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Zhou-Jin Tan, Mai-Jiao Peng, Hua-Ying Hui, and Guozhen Xie
- Subjects
chemistry.chemical_classification ,03 medical and health sciences ,0302 clinical medicine ,Biotransformation ,chemistry ,030220 oncology & carcinogenesis ,Glycoside ,030211 gastroenterology & hepatology ,Biology ,Gut flora ,biology.organism_classification ,Microbiology - Published
- 2018
- Full Text
- View/download PDF
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