1. π‐Extended Donor–Acceptor Porphyrins and Metalloporphyrins for Antimicrobial Photodynamic Inactivation
- Author
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Tadeusz Lis, Yi Lin Wu, Anzhela Galstyan, Yogesh Kumar Maurya, Youn Jue Bae, Halina Zhylitskaya, Ulrich Dobrindt, Michael R. Wasielewski, and Marcin Stępień
- Subjects
inorganic chemicals ,Porphyrins ,Metalloporphyrins ,medicine.medical_treatment ,Chemie ,chemistry.chemical_element ,triplet state ,Photodynamic therapy ,Zinc ,010402 general chemistry ,Photochemistry ,Gram-Positive Bacteria ,01 natural sciences ,Catalysis ,singlet oxygen ,Metal ,π-extended porphyrins ,chemistry.chemical_compound ,medicine ,Humans ,Triplet state ,Photosensitizing Agents ,Full Paper ,010405 organic chemistry ,Singlet oxygen ,Organic Chemistry ,Free base ,General Chemistry ,photosensitizers ,Full Papers ,Antimicrobial ,Porphyrins | Hot Paper ,0104 chemical sciences ,Anti-Bacterial Agents ,chemistry ,Photochemotherapy ,visual_art ,visual_art.visual_art_medium ,antimicrobial ,Palladium - Abstract
Free base, zinc and palladium π‐extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in antimicrobial photodynamic therapy (aPDT). Their efficacy, assessed by photophysical and in vitro photobiological studies on Gram‐positive bacteria, was found to depend on metal coordination, showing a dramatic enhancement of photosensitizing activity for the palladium complex., Photo finish it: Antimicrobial photodynamic therapy (aPDT) has been proposed as an alternative approach for the treatment of bacterial infections. Here, free base, zinc and palladium π‐extended porphyrins containing fused naphthalenediamide units were employed as photosensitizers in aPDT, assessed by photophysical and in vitro photobiological studies.
- Published
- 2020