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6 results on '"Ouahiba Hocine"'

1. Nanodiamond–PMO for two-photon PDT and drug delivery

Author

Rabah Boukherroub, Vanja Stojanovic, Yolanda Galàn Rubio, Ouahiba Hocine, Marcel Garcia, Dina Aggad, J.O. Durand, Nikola Knezevic, Chiara Mauriello Jimenez, Magali Gary-Bobo, Florina Teodorescu, Marie Maynadier, Laurence Raehm, Martina Seric, Sabine Szunerits, Jonas G. Croissant, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Institut supérieur de l'électronique et du numérique (ISEN)-Université de Valenciennes et du Hainaut-Cambrésis (UVHC)-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), NanoMedSyn, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM), and NanoMedSyn (NMS)

Subjects
Materials science, Biomedical Engineering, Nanoparticle, Nanotechnology, 02 engineering and technology, 010402 general chemistry, Photochemistry, 01 natural sciences, Two-photon excitation microscopy, medicine, General Materials Science, Doxorubicin, Nanodiamond, ComputingMilieux_MISCELLANEOUS, chemistry.chemical_classification, Reactive oxygen species, [CHIM.ORGA]Chemical Sciences/Organic chemistry, General Chemistry, General Medicine, 021001 nanoscience & nanotechnology, 0104 chemical sciences, 3. Good health, Mesoporous organosilica, chemistry, Drug delivery, Cancer cell, 0210 nano-technology, medicine.drug
Abstract

In this article, we highlight the properties of nanodiamonds (ND), which were encapsulated in periodic mesoporous organosilica nanoparticles (PMO) and were able to generate reactive oxygen species for photodynamic applications upon two-photon excitation (TPE). The ND@PMO nanoparticles were characterized by various techniques and were then loaded with the anti-cancer drug doxorubicin. The release of the drug was pH sensitive and a synergistic cancer cell killing effect was observed when cancer cells were incubated with doxorubicin-loaded ND@PMO and irradiated with two-photon excitation at 800 nm.

Published
2016

2. Improved gene transfer with histidine-functionalized mesoporous silica nanoparticles

Author

David Brevet, Jean-Olivier Durand, Ouahiba Hocine, Anthony Delalande, Chantal Pichon, Laurence Raehm, Patrick Midoux, Clarence Charnay, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre de biophysique moléculaire (CBM), and Université d'Orléans (UO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)

Subjects
animal structures, media_common.quotation_subject, Genetic Vectors, Pharmaceutical Science, Nanoparticle, Cytomegalovirus, Transfection, Achilles Tendon, Mice, In vivo, Luciferases, Firefly, Animals, Humans, Electrophoretic mobility shift assay, Histidine, Internalization, ComputingMilieux_MISCELLANEOUS, media_common, Drug Carriers, Propylamines, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Chemistry, Gene Transfer Techniques, DNA, Mesoporous silica, Silanes, Silicon Dioxide, 3. Good health, HEK293 Cells, Biochemistry, Biophysics, Degradation (geology), Nanoparticles, sense organs, Plasmids
Abstract

Mesoporous silica nanoparticles (MSN) were functionalized with aminopropyltriethoxysilane (MSN-NH2) then L-histidine (MSN-His) for pDNA delivery in cells and in vivo. The complexation of pDNA with MSN-NH2 and MSN-His was first studied with gel shift assay. pDNA complexed with MSN-His was better protected from DNase degradation than with MSN-NH2. An improvement of the transfection efficiency in cells was observed with MSN-His/pDNA compared to MSN-NH2/pDNA, which could be explained by a better internalization of MSN-His. The improvement of the transfection efficiency with MSN-His was also observed for gene transfer in Achilles tendons in vivo.

Published
2014

3. Cancer Therapy Improvement with Mesoporous Silica Nanoparticles Combining Targeting, Drug Delivery and PDT

Author

Magali Gary-Bobo, Virginie Charasson, Jean-Olivier Durand, Philippe Maillard, David Brevet, Sébastien Richeter, Marcel Garcia, Bernard Loock, Ouahiba Hocine, Alain Morère, Marie Maynadier, Laurence Raehm, Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), and Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)

Subjects
animal structures, Time Factors, medicine.medical_treatment, Chemistry, Pharmaceutical, Drug Compounding, Pharmaceutical Science, Photodynamic therapy, Receptors, Cell Surface, 02 engineering and technology, Endosomes, 010402 general chemistry, 01 natural sciences, law.invention, Confocal microscopy, law, Neoplasms, medicine, Humans, Nanotechnology, Technology, Pharmaceutical, Photosensitizer, ComputingMilieux_MISCELLANEOUS, Drug Carriers, Microscopy, Confocal, Photosensitizing Agents, Cell Death, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Galactose, Mesoporous silica, 021001 nanoscience & nanotechnology, HCT116 Cells, Silicon Dioxide, 0104 chemical sciences, 3. Good health, Biochemistry, Photochemotherapy, Cancer cell, Drug delivery, Biophysics, Nanoparticles, Fluorescein, sense organs, 0210 nano-technology, Drug carrier, Lysosomes, Porosity, Camptothecin, medicine.drug
Abstract

The synthesis of mesoporous silica nanoparticles (MSN) covalently encapsulating fluoresceine or a photosensitizer, functionalized with galactose on the surface is described. Confocal microscopy experiments demonstrated that the uptake of galactose-functionalized MSN by colorectal cancer cells was mediated by galactose receptors leading to the accumulation of the nanoparticles in the endosomal and lysosomal compartments. The MSN functionalized with a photosensitizer and galactose were loaded with the anti-cancer drug camptothecin. Those MSN combining drug delivery and photodynamic therapy were tested on three cancer cell lines and showed a dramatic enhancement of cancer cell death compared to separate treatments.

Published
2012

4. Multifunctionalized mesoporous silica nanoparticles for the in vitro treatment of retinoblastoma: Drug delivery, one and two-photon photodynamic therapy

Author

Audrey Gallud, Marie Maynadier, David Brevet, Alain Morère, Youssef Mir, Cédric Rouxel, Ouahiba Hocine, Magali Gary-Bobo, Olivier Mongin, Afitz Da Silva, Jean-Olivier Durand, Mireille Blanchard-Desce, Philippe Maillard, Bernard Loock, Laurence Raehm, Marcel Garcia, Sébastien Richeter, Laboratoire d'Aquaculture tropicale, Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER), Chimie et Photonique Moléculaires (CPM), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS), Conception, synthèse et vectorisation de biomolécules. (CSVB), Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Institut de Recherche pour le Développement (IRD [France-Sud])-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université Paul-Valéry - Montpellier 3 (UM3), Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Université de Rennes (UR)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Université Paul-Valéry - Montpellier 3 (UPVM)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)

Subjects
animal structures, Retinal Neoplasms, medicine.medical_treatment, Pharmaceutical Science, Nanoparticle, Photodynamic therapy, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Cell Line, Tumor, medicine, Humans, ComputingMilieux_MISCELLANEOUS, Drug Carriers, Retinoblastoma, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Galactose, Mesoporous silica, Silicon Dioxide, 021001 nanoscience & nanotechnology, medicine.disease, Antineoplastic Agents, Phytogenic, Molecular biology, Endocytosis, eye diseases, In vitro, 0104 chemical sciences, 3. Good health, Photochemotherapy, Cancer cell, Drug delivery, Cancer research, Nanoparticles, Camptothecin, 0210 nano-technology, Mannose, medicine.drug
Abstract

In this work, we focused on mesoporous silica nanoparticles (MSN) for one photon excitated photodynamic therapy (OPE-PDT) combined with drug delivery and carbohydrate targeting applied on retinoblastoma, a rare disease of childhood. We demonstrate that bitherapy (camptothecin delivery and photodynamic therapy) performed with MSN on retinoblastoma cancer cells was efficient in inducing cancer cell death. Alternatively MSN designed for two-photon excited photodynamic therapy (TPE-PDT) were also studied and irradiation at low fluence efficiently killed retinoblastoma cancer cells.

Published
2012

5. Silicalites and Mesoporous Silica Nanoparticles for photodynamic therapy

Author

Pierre Couleaud, Sébastien Richeter, Alain Morère, Magali Gary-Bobo, Ouahiba Hocine, Monique Smaïhi, Simon Fontanel, Bernard Loock, Marie Maynadier, Laurence Raehm, Gaelle Derrien, Philippe Maillard, Céline Frochot, Jean-Olivier Durand, Clarence Charnay, Amar Sahmoune, David Brevet, Marcel Garcia, Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), CRLCC Val d'Aurelle - Paul Lamarque-Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Montpellier 1 (UM1), Médicaments Photoactivables - Photochimiothérapie (PHOTOMED), Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Réactions et Génie des Procédés (LRGP), Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Institut Européen des membranes (IEM), Centre National de la Recherche Scientifique (CNRS)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), Marie, Nathalie, Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS), and Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_treatment, Pharmaceutical Science, Nanoparticle, Mannose, Photodynamic therapy, Nanotechnology, Breast Neoplasms, Receptors, Cell Surface, 02 engineering and technology, 010402 general chemistry, Endocytosis, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Cell Line, Tumor, medicine, Humans, Lectins, C-Type, Microparticle, ComputingMilieux_MISCELLANEOUS, Fluorescent Dyes, Microscopy, Confocal, Singlet Oxygen, Chemistry, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Silicates, [CHIM.MATE]Chemical Sciences/Material chemistry, Mesoporous silica, 021001 nanoscience & nanotechnology, Silicon Dioxide, [CHIM.ORGA] Chemical Sciences/Organic chemistry, 3. Good health, 0104 chemical sciences, Mannose-Binding Lectins, Photochemotherapy, Biophysics, Surface modification, Nanoparticles, Female, Fluorescein, 0210 nano-technology, Mesoporous material, Lysosomes, Mannose Receptor
Abstract

International audience; The synthesis of silicalites and Mesoporous Silica Nanoparticles (MSN), which covalently incorporate original water-soluble photosensitizers for PDT applications is described. PDT was performed on MDA-MB-231 breast cancer cells. All the nanoparticles showed significant cell death after irradiation, which was not correlated with 1O2 quantum yield of the nanoparticles. Other parameters are involved and in particular the surface and shape of the nanoparticles which influence the pathway of endocytosis. Functionalization with mannose was necessary to obtain the best results with PDT due to an active endocytosis of mannose-functionalized nanoparticles. The quantity of mannose on the surface should be carefully adjusted as a too high amount of mannose impairs the phototoxicity of the nanoparticles. Fluorescein was also encapsulated in MCM-41 type MSN in order to localize the nanoparticles in the organelles of the cells by confocal microscopy. The MSN were localized in lysosomes after active endocytosis by mannose receptors.

Published
2010

6. Mannose-targeted mesoporous silica nanoparticles for photodynamic therapy

Author

Laurence Raehm, Jean-Olivier Durand, David Brevet, Alain Morère, Kassem Amro, Pierre Couleaud, Sébastien Richeter, Céline Frochot, Magali Gary-Bobo, Philippe Maillard, Marcel Garcia, Bernard Loock, Ouahiba Hocine, Le Ster, Yves, Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier (ICGM ICMMM), Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Conception, synthèse et vectorisation de biomolécules. (CSVB), Université Paris Descartes - Paris 5 (UPD5)-Institut Curie [Paris]-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Département de Chimie Physique des Réactions (DCPR), Institut National Polytechnique de Lorraine (INPL)-Centre National de la Recherche Scientifique (CNRS), Institut des Biomolécules Max Mousseron [Pôle Chimie Balard] (IBMM), Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Financial support by ANR PNANO. 07-102, Université Paris Descartes - Paris 5 (UPD5)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris], Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut de Chimie du CNRS (INC), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Montpellier (UM)-Ecole Nationale Supérieure de Chimie de Montpellier (ENSCM), and Institut Curie-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)

Subjects
[SDV.BIO]Life Sciences [q-bio]/Biotechnology, medicine.medical_treatment, Nanoparticle, Mannose, Apoptosis, Photodynamic therapy, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Drug Delivery Systems, Materials Chemistry, polycyclic compounds, [INFO.INFO-BT]Computer Science [cs]/Biotechnology, Receptor, ComputingMilieux_MISCELLANEOUS, MESH: Receptors, Cell Surface, [SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases, [SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases, Molecular Structure, [CHIM.ORGA]Chemical Sciences/Organic chemistry, Metals and Alloys, Silicon Dioxide, 021001 nanoscience & nanotechnology, 3. Good health, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, MESH: Mannose, 0210 nano-technology, therapeutics, Mannose Receptor, animal structures, MESH: Cell Line, Tumor, education, MESH: Drug Delivery Systems, MESH: Molecular Structure, Receptors, Cell Surface, [SDV.CAN]Life Sciences [q-bio]/Cancer, 010402 general chemistry, Catalysis, MESH: Silicon Dioxide, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, MESH: Mannose-Binding Lectins, medicine, Humans, Lectins, C-Type, MESH: Photochemotherapy, MESH: Humans, MESH: Apoptosis, General Chemistry, Mesoporous silica, eye diseases, 0104 chemical sciences, [SDV.BIO] Life Sciences [q-bio]/Biotechnology, Mannose-Binding Lectins, [INFO.INFO-BT] Computer Science [cs]/Biotechnology, Photochemotherapy, chemistry, Cell culture, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, MESH: HeLa Cells, Ceramics and Composites, Cancer research, Nanoparticles, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, sense organs, Breast cancer cells, MESH: Lectins, C-Type, MESH: Nanoparticles, HeLa Cells
Abstract

International audience; Functionalisation of MSN with mannose for PDT applications dramatically improved the efficiency of PDT on breast cancer cells.

Published
2009

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