1,093 results on '"Kaveh, A."'
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2. Sampling and Analysis for Lead in Water and Soil Samples on a University Campus: A Student Research Project.
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Butala, Steven J. and Zarrabi, Kaveh
- Abstract
Describes a student research project that determined concentrations of lead in water drawn from selected drinking fountains and in selected soil samples on the campus of the University of Nevada, Las Vegas. (18 references) (DDR)
- Published
- 1995
3. Hyaluronic Acid-Targeted Niosomes for Effective Breast Cancer Chemostarvation Therapy
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Masoumeh Kaveh Zenjanab, Elaheh Dalir Abdolahinia, Effat Alizadeh, Hamed Hamishehkar, Rasoul Shahbazi, Zahra Ranjbar-Navazi, Rana Jahanban-Esfahlan, Marziyeh Fathi, and Seyed Abolghasem Mohammadi
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Chemistry ,QD1-999 - Published
- 2024
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4. VIS/NIR Spectroscopy as a Non-Destructive Method for Evaluation of Quality Parameters of Three Bell Pepper Varieties Based on Soft Computing Methods
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Meysam Latifi Amoghin, Yousef Abbaspour-Gilandeh, Mohammad Tahmasebi, Mohammad Kaveh, Hany S. El-Mesery, Mariusz Szymanek, and Maciej Sprawka
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non-destructive evaluation ,spectroscopy ,bell pepper ,quality parameter ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Spectroscopic analysis was employed to evaluate the quality of three bell pepper varieties within the 350–1150 nm wavelength range. Quality parameters such as firmness, pH, soluble solids content, titratable acids, vitamin C, total phenols, and anthocyanins were measured. To enhance data reliability, principal component analysis (PCA) was used to identify and remove outliers. Raw spectral data were initially modeled using partial least squares regression (PLSR). To optimize wavelength selection, support vector machines (SVMs) were combined with genetic algorithms (GAs), particle swarm optimization (PSO), ant colony optimization (ACO), and imperial competitive algorithm (ICA). The most effective wavelength selection method was subsequently used for further analysis. Three modeling techniques—PLSR, multiple linear regression (MLR), and artificial neural networks (ANNs)—were applied to the selected wavelengths. PLSR analysis of raw data yielded a maximum R2 value of 0.98 for red pepper pH, while the lowest R2 (0.58) was observed for total phenols in yellow peppers. SVM-PSO was determined to be the optimal wavelength selection algorithm based on ratio of performance to deviation (RPD), root mean square error (RMSE), and correlation values. An average of 15 effective wavelengths were identified using this combined approach. Model performance was evaluated using root mean square error of cross-validation and coefficient of determination (R2). ANN consistently outperformed MLR and PLSR in predicting firmness, pH, soluble solids content, titratable acids, vitamin C, total phenols, and anthocyanins for all three varieties. R2 values for the ANN model ranged from 0.94 to 1.00, demonstrating its superior predictive capability. Based on these results, ANN is recommended as the most suitable method for evaluating the quality parameters of bell peppers using spectroscopic data.
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- 2024
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5. The Dynamics of Per- and Polyfluoroalkyl Substances (PFAS) at Interfaces in Porous Media: A Computational Roadmap from Nanoscale Molecular Dynamics Simulation to Macroscale Modeling
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Kaveh Sookhak Lari, Greg B. Davis, Anand Kumar, John L. Rayner, Xiang-Zhao Kong, and Martin O. Saar
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Chemistry ,QD1-999 - Published
- 2024
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6. Kinetics of N2 Release from Diazo Compounds: A Combined Machine Learning-Density Functional Theory Study
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Kaveh Farshadfar, Arsalan Hashemi, Reza Khakpour, and Kari Laasonen
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Chemistry ,QD1-999 - Published
- 2023
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7. Investigation of ultrasound-assisted starch acetylation by single- and dual- frequency ultrasound based on rheology modelling, non-isothermal reaction kinetics, and flow/acoustic simulation
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Elahe Abedi, Reza Roohi, Seyed Mohammad Bagher Hashemi, and Shima Kaveh
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Ultrasound-assisted acetylation ,Rheology modeling ,Non-isothermal reaction kinetics ,CFD ,Dual frequency ultrasonic ,Chemistry ,QD1-999 ,Acoustics. Sound ,QC221-246 - Abstract
To achieve wheat starch acetylation (AC) with a high degree of substitution (DS), the acetylation process was carried out using various ultrasonication frequencies, including 25 kHz, 40 kHz, and 25 + 40 kHz. In the second step, wheat starch's ultrasound-assisted acetylation (UAA) is simulated using various approaches including the rheology models, non-isothermal reaction kinetics, and flow/acoustic modelling. The computational fluid dynamics (CFD) simulation solves the non-linear acoustic governing equation to determine the flow field and the amount of delivered ultrasound energy. The acetylated starch increased peak and final viscosity, with the highest values observed for the 25 + 40 kHz frequency than other single frequencies (25 kHz and 40 kHz). The viscosity of the starch is specified based on the experimental data using Herschel–Bulkley, power law, and Casson rheology models. According to differential scanning calorimetry (DSC) analysis, the gelatinization parameters and enthalpy of gelatinization (ΔHgel), were found to be lower in acetylated starches at the frequency of 25 + 40 kHz compared to those at frequencies of 25 kHz and 40 kHz, as well as native starches (NS). Moreover, the gelatinization process is examined by implementing the non-isothermal reaction kinetics to obtain the activation energy and reaction order. Based on the results obtained, implementing sonication at 25 kHz reduces the activation energy by 70.3 % compared to native starch. However, the same parameter is obtained to be 69.9 % and 67.1 % for the application of 40 and 25 + 40 kHz transducers, respectively. Additionally, during the sonication treatment, the yield shear stress increases between 24.1 and 31.8 %, based on the applied frequency. Morphology analysis determined by scanning electron microscopy (SEM) revealed that the surfaces and small granules underwent more damage in acetylated starches at frequencies of 25 kHz and 40 kHz. However, in acetylated starches at 25 + 40 kHz, the larger granules were more affected than the smaller ones.
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- 2024
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8. Microfluidic integrated gas sensors for smart analyte detection: a comprehensive review
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Arian Yeganegi, Kaveh Yazdani, Nishat Tasnim, Somayeh Fardindoost, and Mina Hoorfar
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microfluidic ,gas sensors ,miniaturization ,selectivity ,sensitivity ,Chemistry ,QD1-999 - Abstract
The utilization of gas sensors has the potential to enhance worker safety, mitigate environmental issues, and enable early diagnosis of chronic diseases. However, traditional sensors designed for such applications are often bulky, expensive, difficult to operate, and require large sample volumes. By employing microfluidic technology to miniaturize gas sensors, we can address these challenges and usher in a new era of gas sensors suitable for point-of-care and point-of-use applications. In this review paper, we systematically categorize microfluidic gas sensors according to their applications in safety, biomedical, and environmental contexts. Furthermore, we delve into the integration of various types of gas sensors, such as optical, chemical, and physical sensors, within microfluidic platforms, highlighting the resultant enhancements in performance within these domains.
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- 2023
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9. Recent Advances in the Application of Agricultural Waste in Construction
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Esmail Khalife, Maryam Sabouri, Mohammad Kaveh, and Mariusz Szymanek
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agro-waste ,additive ,concrete ,compressive strength ,insulation ,sustainable solutions ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
On a global scale, millions of tons of diverse agricultural residues are generated annually. Most of these wastes are burned or dumped in landfills, which causes environmental pollution. Addressing environmental issues arising from agricultural waste materials, in addition to mitigating heating and cooling expenses in the construction sector, is an interesting challenge for researchers. The utilization of agricultural wastes in different parts of construction is producing positive findings day by day, and investigating research in this field is a curiosity for researchers. This short study reviewed the most recent achievements in using agricultural wastes as a substitute or additive material for construction. Using these wastes as aggregate, ash (as a supplementary for cement), or fibers for foam concrete, insulation materials, etc. has been reviewed. This review has focused on very recent published papers. Several studies have demonstrated the effective influences of agro-waste materials in construction, like retaining the compressive strength (155 MPa) of concrete at standard levels and reducing heat losses in buildings (69% energy savings for brick insulated using wheat straw), as well as sound insulation. The use of agro-waste materials for insulation positively improved thermal conductivity, costs, and energy savings. However, some wastes did not provide a high added value, which shows that more investigations still need be performed to fill this gap in the research. Considering the global scale of agricultural waste generation and the potential benefits to both the environment and construction industry, continued research in this area is essential.
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- 2024
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10. Identifying lipid particle sub-types in live Caenorhabditis elegans with two-photon fluorescence lifetime imaging
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Wei-Wen Chen, Wenyu Tang, Emily K. Hamerton, Penelope X. Kuo, George A. Lemieux, Kaveh Ashrafi, and Marcus T. Cicerone
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C. elegans ,lipid metabolism ,aging ,yolk lipoprotein ,two-photon excitation fluorescence (TPEF) imaging ,coherent Raman imaging ,Chemistry ,QD1-999 - Abstract
Fat metabolism is an important modifier of aging and longevity in Caenorhabditis elegans. Given the anatomy and hermaphroditic nature of C. elegans, a major challenge is to distinguish fats that serve the energetic needs of the parent from those that are allocated to the progeny. Broadband coherent anti-Stokes Raman scattering (BCARS) microscopy has revealed that the composition and dynamics of lipid particles are heterogeneous both within and between different tissues of this organism. Using BCARS, we have previously succeeded in distinguishing lipid-rich particles that serve as energetic reservoirs of the parent from those that are destined for the progeny. While BCARS microscopy produces high-resolution images with very high information content, it is not yet a widely available platform. Here we report a new approach combining the lipophilic vital dye Nile Red and two-photon fluorescence lifetime imaging microscopy (2p-FLIM) for the in vivo discrimination of lipid particle sub-types. While it is widely accepted that Nile Red staining yields unreliable results for detecting lipid structures in live C. elegans due to strong interference of autofluorescence and non-specific staining signals, our results show that simple FLIM phasor analysis can effectively separate those signals and is capable of differentiating the non-polar lipid-dominant (lipid-storage), polar lipid-dominant (yolk lipoprotein) particles, and the intermediates that have been observed using BCARS microscopy. An advantage of this approach is that images can be acquired using common, commercially available 2p-FLIM systems within about 10% of the time required to generate a BCARS image. Our work provides a novel, broadly accessible approach for analyzing lipid-containing structures in a complex, live whole organism context.
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- 2023
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11. Quantifying of the Best Model for Prediction of Greenhouse Gas Emission, Quality, and Thermal Property Values during Drying Using RSM (Case Study: Carrot)
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Ebrahim Taghinezhad, Mohammad Kaveh, Antoni Szumny, and Adam Figiel
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greenhouse gas emission ,microwave power ,drying time ,specific energy consumption ,RSM ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The aim of this study is to use the response surface methodology (RSM) to mathematically model the response parameters and emission of greenhouse gases (GHG) and optimize the drying variables for a carrot dried with the microwave method using various pretreatments. To this end, the influence of the drying parameters (independent), such as microwave power and slice thickness dried by two pretreatments of ultrasonication at 30 °C for 10 min and blanching at 70 ℃ for 2 min, was explored on the dependent (response) parameters including the thermal properties (drying time, effective moisture diffusion coefficient (Deff), specific energy consumption, energy efficiency, quality features (color changes and shrinkage), and GHG emission (including CO2 and NOx). It should be mentioned that the emission of GHG was determined based on the energy consumption of various types of power plants such as the gas turbine steam power turbine, and combined cycle turbines using various fuels such as natural gas, heavy oil, and gas oil. The results indicated that the ultrasonication and blanching pretreatments can decrement the drying time (linearly), energy consumption (linearly or quadratically), shrinkage(quadratically), and color changes(quadratically) and enhance the Deff (linearly) and energy efficiency (linearly or quadratically) in all samples with R2 > 0.86. Moreover, the shortest drying time (42 min), lowest SEC (9.51 MJ/kg), and GHG emission ((4279.74 g CO2 in the combined cycle turbines plant, and 18.16 g NOX in the gas turbine plant) with natural gas for both plants) were recorded for the samples pretreated with blanching while the lowest color changes (13.69) and shrinkage (21.29) were observed in the ultrasonicated samples. Based on the optimization results, a microwave power of 300 W and steam power turbine of 2 mm were the best variables with a desirability of about 80% which resulted in the highest-quality products at the lowest GHG emission.
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- 2023
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12. CpACpP: In Silico Cell-Penetrating Anticancer Peptide Prediction Using a Novel Bioinformatics Framework
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Farid Nasiri, Fereshteh Fallah Atanaki, Saman Behrouzi, Kaveh Kavousi, and Mojtaba Bagheri
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Chemistry ,QD1-999 - Published
- 2021
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13. Enhanced gas permeation performance of mixed matrix membranes containing polysulfone and modified mesoporous MCM-41
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Abbasi Kololi Kaveh, Tabatabaei Qomsheh Seyed Mostafa, Noei Maziar, and Saberi Masoud
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psf ,mcm-41 ,surface modification ,silane coupling agent ,gas separation ,Chemistry ,QD1-999 - Abstract
The aim of this study was the development of mixed matrix membranes (MMMs) based on silica MCM-41 dispersed in polysulfone (PSf) for the separation of carbon dioxide from methane. For this purpose, MCM-41 was synthesized by a hydrothermal method and was modified with 3-aminopropyltrietoxysilane (APTES). SEM, FTIR, BET and XRD analyses were used for characterization of the modified and unmodified particles. Then, various MMMs containing PSf at different weight percents (5, 10, 15 and 20) of modified and unmodified particles were prepared and the morphology and structure of the prepared membranes were studied using SEM and XRD analyses. Regardless of the particle type, the addition of MCM-41 to PSf caused an increase in gas permeability compared to a neat PSf membrane. Adding unmodified particles to PSf matrix resulted in undesirable effects, including particle agglomeration and/or the formation of interfacial voids. The MMMs with modified MCM-41 showed relatively better separation performance compared to MMMs with unmodified MCM-41. As a result, the MMM of PSf with 20 wt. % modified MCM-41 showed a significant increase in selectivity of carbon dioxide/methane and the value of selectivity reached 25.24.
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- 2021
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14. A Novel method for Synthesis of Modified Nanofiber with Functionalized Mesopouros by Electrospinning for Removal of Dye(Direct Yellow 12 (D.Y.12))
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saeid masoudnia, Mohammad habibi joybari, ramin ZafarMehrabian, mehdi ebadi, and fariborz kaveh
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modified nanofibers ,functionalized mesoporous ,electrospinning ,dye ,removal ,Chemistry ,QD1-999 - Abstract
The purpose of this study is to consider and compare applicability of modified chitosan nano fibers with functionalized mesoporous silica in Elecrtrospinning method for Direct Yellow 12 (D.Y.12) removal from aqueous solutions. Provided nano fibers were monitored and detected by TEM, Fe-SEM, XRD, FT-IR devices and Tensile testing. Subsequently, the effect of different operating parameters was achieving optimum condition for performing the adsorption process: such as nano adsorbent types, adsorbent dose, pH, initial dye concentration, contact time. And ultimately, finding suitable isotherms for adsorption of D.Y.12 was performed. Desirable conditions for removing by mesoporous silica chitosan nano fibers with SBA-15-NH2 adsorbent in 40 minutes contact, pH=2, the amount of adsorbent was 0.05 gr with 20 mg/l initial concentration. Also, the results have shown that D.Y.12 removal is following Langmuir and Freundlich isotherm model. The conclusions of this investigation have shown that CTS/SBA-15-NH2 nano fibers adsorb the D.Y.12 effectively and has great potential for purification of infected waste water with dyes.
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- 2020
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15. BIPEP: Sequence-based Prediction of Biofilm Inhibitory Peptides Using a Combination of NMR and Physicochemical Descriptors
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Fereshteh Fallah Atanaki, Saman Behrouzi, Shohreh Ariaeenejad, Amin Boroomand, and Kaveh Kavousi
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Chemistry ,QD1-999 - Published
- 2020
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16. The State of the Art of Artificial Intelligence Approaches and New Technologies in Structural Health Monitoring of Bridges
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Raffaele Zinno, Sina Shaffiee Haghshenas, Giuseppe Guido, Kaveh Rashvand, Alessandro Vitale, and Ali Sarhadi
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smart cities ,SHM ,bridge ,IoT ,AI ,drone technology ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The challenges of urban administration are growing, as the population, automobiles, and cities rise. Making cities smarter is thus one of the most effective solutions to urban issues. A key feature of the “smart cities” of today is that they use cutting-edge technology in their infrastructure and services. With strategic planning, the smart city utilizes its resources in the most efficient manner. With reduced expenses and enhanced infrastructure, smart cities provide their residents with more and better services. One of these important urban services that can be very helpful in managing cities is structural health monitoring (SHM). By combining leading new technologies like the Internet of Things (IoT) with structural health monitoring, important urban infrastructure can last longer and work better. A thorough examination of recent advances in SHM for infrastructure is thus warranted. Bridges are one of the most important parts of a city’s infrastructure, and their building, development, and proper maintenance are some of the most important aspects of managing a city. The main goal of this study is to look at how artificial intelligence (AI) and some technologies, like drone technology and 3D printers, could be used to improve the current state of the art in SHM systems for bridges, including conceptual frameworks, benefits and problems, and existing methods. An outline of the role AI and other technologies will play in SHM systems of bridges in the future was provided in this study. Some novel technology-aided research opportunities are also highlighted, explained, and discussed.
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- 2022
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17. Carbon-dots conductometric sensor for high performance gas sensing
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Shadi Sawalha, Kaveh Moulaee, Giuseppe Nocito, Alessandro Silvestri, Salvatore Petralia, Maurizio Prato, Simona Bettini, Ludovico Valli, Sabrina Conoci, and Giovanni Neri
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Carbon dots ,Conductometric sensors ,NO2 ,Chemistry ,QD1-999 - Abstract
In this paper the first example of using C-dots (CDs) as sensing nanomaterial for monitoring low concentrations of NO2 in ambient air is reported. In the logic to support a green circular economy, CDs were prepared from a natural low cost precursor consisting in olive solid waste (OSW) by a simple pyrolysis process combined with chemical oxidation. Characterization data showed the formation of spherical CDs with dimensions in the narrow size range from 0.5 to 5 nm and charged with functional groups (COO- (carboxylate), C-O-C (epoxide) and C-OH (hydroxyl) imprinting excellent water colloidal dispersion. The nanomaterial was used to fabricate and test a conductometric gas sensor (CDs-sensor) that was found to exhibit excellent performances in terms of high and selective response to sub-ppm concentration of NO2 at low temperature (150 °C), low limit of detection (LOD) of 50 ppb, good reproducibility and stability over use and aging. To the best of our knowledge, this is the first example reported in the literature of CDs high performances gas sensing material. Results here presented pave the way for a new class of a carbon nanomaterial for gas sensing to be applied in the field of environmental monitoring.
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- 2021
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18. Synthesis and Study of Catalytic, Anti–Bacterial, Anti–Oxidant, and DNA Cleavage Properties of Ag–Co and Ag–Ni Magnetic Nanoparticles
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Kaveh Parvanak Boroujeni, Mansooreh Shahrokh, Jamshid Karvani, Niloofar Moradi, Ahmad Farokhnia, and Mohsen Mobini
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Nanoalloys ,Magnetism and magnetic properties ,1,8–Dioxooctahydroxanthenes ,Anti-bacterial activity ,Anti-oxidant activity ,DNA cleavage properties ,Chemistry ,QD1-999 - Abstract
Magnetic Ag–Co and Ag–Ni alloy nanoparticles were prepared through a chemical reduction method using their corresponding [Co(NH3)6]Cl3 and [Ni(C2O4)2]K2 complexes, and AgNO3. In this reaction, hydrazine monohydrate was used as reducing agent. The obtained nanoparticles were characterized by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). Ag–Co and Ag–Ni nanoalloys exhibited excellent catalytic performance in the preparation of 1,8–dioxooctahydroxanthenes from the reaction of 5,5-dimethyl-1,3-cycloheanedione (dimedone) with aromatic aldehydes. Catalysts were separated by an external permanent magnet and reused. Both, Ag–Co and Ag–Ni nanoalloys posess antibacterial and antioxidant properties and have no significant effect on DNA cleavage.
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- 2019
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19. Modeling and Optimization of Hybrid HIR Drying Variables for Processing of Parboiled Paddy Using Response Surface Methodology
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Ebrahim Taghinezhad, Vali Rasooli Sharabiani, and Mohammad Kaveh
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hybrid drying ,parboiling ,quality ,rice ,rsm ,Chemical engineering ,TP155-156 ,Chemistry ,QD1-999 - Abstract
The effects of hot air temperature (40, 50 and 60 oC) and Radiation Intensity (RI) (0.21, 0.31 and 0.41 w/cm2) on the response variables (drying time, Head Parboiled Rice Yield (HPRY), color value and hardness)) of parboiled rice were investigated. The drying was performed using hybrid hot air–infrared drying. The optimization of drying variables and the relationship between response variables and the influence factors were analyzed using response surface methodology (RSM). Based on RSM results, the best mathematical model for prediction of HPRY, hardness and color value and drying time of samples was linear(R2= 0.96), quadratic(R2= 0.99), linear(R2= 0.93) and linear(R2= 0.99) equation, respectively. The HPRY (62.13- 68.13%) and hardness (130.27- 247.3 N) increased with increasing drying temperature and RI, while the color value (19.77- 18.03) and drying time (59.72- 34.41 min) decreased. The optimized parameters of drying were obtained 55 oC drying temperature and 0.41 w/ cm2 RI.
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- 2019
20. Application of Artificial Neural Networks, Support Vector, Adaptive Neuro-Fuzzy Inference Systems for the Moisture Ratio of Parboiled Hulls
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Vali Rasooli Sharabiani, Mohammad Kaveh, Ebrahim Taghinezhad, Rouzbeh Abbaszadeh, Esmail Khalife, Mariusz Szymanek, and Agata Dziwulska-Hunek
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drying ,parboiled hulls ,artificial neural networks ,neuro-fuzzy inference ,support vector regression ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Drying as an effective method for preservation of crop products is affected by various conditions and to obtain optimum drying conditions it is needed to be evaluated using modeling techniques. In this study, an adaptive neuro-fuzzy inference system (ANFIS), artificial neural network (ANN), and support vector regression (SVR) was used for modeling the infrared-hot air (IR-HA) drying kinetics of parboiled hull. The ANFIS, ANN, and SVR were fed with 3 inputs of drying time (0–80 min), drying temperature (40, 50, and 60 °C), and two levels of IR power (0.32 and 0.49 W/cm2) for the prediction of moisture ratio (MR). After applying different models, several performance prediction indices, i.e., correlation coefficient (R2), mean square error index (MSE), and mean absolute error (MAE) were examined to select the best prediction and evaluation model. The results disclosed that higher inlet air temperature and IR power reduced the drying time. MSE values for the ANN, ANFIS tests, and SVR training were 0.0059, 0.0036, and 0.0004, respectively. These results indicate the high-performance capacity of machine learning methods and artificial intelligence to predict the MR in the drying process. According to the results obtained from the comparison of the three models, the SVR method showed better performance than the ANN and ANFIS methods due to its higher R2 and lower MSE.
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- 2022
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21. Prediction of Almond Nut Yield and Its Greenhouse Gases Emission Using Different Methodologies
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Mohsen Beigi, Mehdi Torki, Hossein Safarinia, Mohammad Kaveh, Mariusz Szymanek, Esmail Khalife, and Agata Dziwulska-Hunek
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almond ,greenhouse gas emission ,artificial intelligent ,yield prediction ,ANFIS ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The evaluation of a production system to analyze greenhouse gases is one of the most interesting challenges for researchers. The aim of the present study is to model almond nut production based on inputs by employing artificial neural networks (ANNs) and adaptive neuro-fuzzy inference systems (ANFIS) procedures. To predict the almond nut yield with respect to the energy inputs, several ANN and ANFIS models were developed, evaluated, and compared. Among the several developed ANNs, a network with an architecture of 8-12-1 and a log-sigmoid, and a linear transfer function in the hidden and output layers, respectively, is found to be the best model. In general, both approaches had a good capability for predicting the nut yield. The comparison results revealed that the ANN procedure could predict the nut yield more precisely than the ANFIS models. Furthermore, greenhouse gas (GHG) emissions in almond orchards are determined where the total GHG emission is estimated to be about 2348.85 kg CO2eq ha−1. Among the inputs, electricity had the largest contribution to GHG emissions, with a share of 72.32%.
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- 2022
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22. Hybrid Noble-Metals/Metal-Oxide Bifunctional Nano-Heterostructure Displaying Outperforming Gas-Sensing and Photochromic Performances
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David Maria Tobaldi, Salvatore Gianluca Leonardi, Kaveh Movlaee, Luc Lajaunie, Maria Paula Seabra, Raul Arenal, Giovanni Neri, and João António Labrincha
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Chemistry ,QD1-999 - Published
- 2018
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23. Analyzing Dynamic Operational Conditions of Limb Prosthetic Sockets with a Mechatronics-Twin Framework
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Dejiu Chen, Peng Su, Suranjan Ottikkutti, Panagiotis Vartholomeos, Kaveh Nazem Tahmasebi, and Michalis Karamousadakis
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prosthetic socket ,mechatronics-twin ,biomechanical modeling and simulation ,Stewart manipulator ,stochastic dynamic process ,wearable sensor ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
Lower limb prostheses offer a solution to restore the ambulation and self-esteem of amputees. One key component is the prosthetic socket that serves as the interface between prosthetic device and amputee stump and thereby has a wide range of impacts on efficient fitting, appropriate load transmission, operational stability, and control. For the design and optimization of a prosthetic socket, an understanding of the actual intra-socket operational conditions becomes therefore necessary. This is however a difficult task due to the inherent complexity and restricted observability of socket operation. In this study, an innovative mechatronics-twin framework that integrates advanced biomechanical models and simulations with physical prototyping and dynamic operation testing for effective exploration of operational behaviors of prosthetic sockets with amputees is proposed. Within this framework, a specific Stewart manipulator is developed to enable dynamic operation testing, in particular for a well-managed generation of dynamic intra-socket loads and behaviors that are otherwise difficult to observe or realize with the real amputees. A combination of deep learning and Bayesian Inference algorithms is then employed for analyzing the intra-socket load conditions and revealing possible anomalous.
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- 2022
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24. Active Terahertz Modulator and Slow Light Metamaterial Devices with Hybrid Graphene–Superconductor Photonic Integrated Circuits
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Samane Kalhor, Stephen J. Kindness, Robert Wallis, Harvey E. Beere, Majid Ghanaatshoar, Riccardo Degl’Innocenti, Michael J. Kelly, Stephan Hofmann, Hannah J. Joyce, David A. Ritchie, and Kaveh Delfanazari
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hybrid photonic integrated circuits ,graphene ,superconductors ,terahertz photonics ,terahertz electronics ,electromagnetic induced transparency ,Chemistry ,QD1-999 - Abstract
Metamaterial photonic integrated circuits with arrays of hybrid graphene–superconductor coupled split-ring resonators (SRR) capable of modulating and slowing down terahertz (THz) light are introduced and proposed. The hybrid device’s optical responses, such as electromagnetic-induced transparency (EIT) and group delay, can be modulated in several ways. First, it is modulated electrically by changing the conductivity and carrier concentrations in graphene. Alternatively, the optical response can be modified by acting on the device temperature sensitivity by switching Nb from a lossy normal phase to a low-loss quantum mechanical phase below the transition temperature (Tc) of Nb. Maximum modulation depths of 57.3% and 97.61% are achieved for EIT and group delay at the THz transmission window, respectively. A comparison is carried out between the Nb-graphene-Nb coupled SRR-based devices with those of Au-graphene-Au SRRs, and significant enhancements of the THz transmission, group delay, and EIT responses are observed when Nb is in the quantum mechanical phase. Such hybrid devices with their reasonably large and tunable slow light bandwidth pave the way for the realization of active optoelectronic modulators, filters, phase shifters, and slow light devices for applications in chip-scale future communication and computation systems.
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- 2021
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25. Effect of Pretreatments on Convective and Infrared Drying Kinetics, Energy Consumption and Quality of Terebinth
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Yousef Abbaspour-Gilandeh, Mohammad Kaveh, Hamideh Fatemi, Esmail Khalife, Dorota Witrowa-Rajchert, and Małgorzata Nowacka
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terebinth ,drying ,pretreatment ,energy consumption ,color ,bioactive compounds ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This study is focused on the influence of convective drying (50, 60, and 70 °C) and infrared (IR) power (250, 500, and 750 W) on the drying kinetics, the specific energy consumption of terebinth drying as well as quality and bioactive compounds upon various pretreatments such as ultrasound (US), blanching (BL), and microwave (MW). Compared to convective drying, IR drying decreased more the drying time and energy consumption (SEC). Application of higher IR powers and air temperatures accelerated the drying process at lower energy consumption (SEC) and higher energy efficiency and moisture diffusion. Terebinth dried by a convective dryer at 60 °C with US pretreatment showed a better color compared to other samples. It also exhibited the polyphenol and flavonoid content of 145.35 mg GAE/g d.m. and 49.24 mg QE/g d.m., respectively, with color variations of 14.25 and a rehydration rate of 3.17. The proposed pretreatment methods significantly reduced the drying time and energy consumption, and from the other side it increased energy efficiency, bioactive compounds, and quality of the dried samples (p < 0.01). Among the different pretreatments used, microwave pretreatment led to the best results in terms of the drying time and SEC, and energy efficiency. US pretreatment showed the best results in terms of preserving the bioactive compounds and the general appearance of the terebinth.
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- 2021
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26. Magnetite-Containing Sulfonated Polyacrylamide as a Nanocatalyst for the Preparation of Biscoumarins
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Kaveh Parvanak Boroujeni, Shahla Hadizadeh, Sodabeh Hasani, Abdulhamid Fadavi, and Mansooreh Shahrokh
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Nanoparticles ,Radical polymerization ,Magnetism and magnetic properties ,Catalysts ,Biscoumarins ,Chemistry ,QD1-999 - Abstract
Magnetite-containing sulfonated polyacrylamide was easily prepared through polymerization of the corresponding monomers followed by the reaction with Fe3O4 nanoparticles. The characterization of the obtained catalyst was performed by Fourier transform infrared spectroscopy (FT-IR), thermal gravimetric analysis (TGA), scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), X-ray diffraction (XRD), and vibrating sample magnetometer (VSM). The acidic SO3H moiety was found to be 1.1 mmol per gram of the obtained polymer. The catalytic activity of the polymer was examined for the synthesis of biscoumarin derivatives by two-component one-pot domino Knoevenagel-type condensation/Michael reaction between aldehydes and 4-hydroxycoumarin. Biscoumarins were obtained in high to excellent yields in short time. The work-up procedure of this reaction was very simple. The catalyst is stable (as a bench top catalyst) with easy-handling and it can be used again.
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- 2017
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27. Study on TiO2 Nanoparticles Distribution in Electrospun Polysulfone/TiO2 Composite Nanofiber
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Davood Almasi, Kaveh Abbasi, Naznin Sultana, and Woei Jye Lau
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electrospinning ,nanofiber ,polysulfone ,tio2 ,interfacial tension ,radial distribution ,Chemical engineering ,TP155-156 ,Chemistry ,QD1-999 - Abstract
Composite nanofibers composed of an organic polymer and inorganic nanomaterials have huge potential to be used in different industrial applications. However, the main concern on the use of composite nanofibers is the distribution properties of nanomaterials in the polymeric matrix. The effect of the capillary tip charge on the additive distribution in the electrospun nanofiber has been previously studied and can be found in the literature. In this study, focus is placed on the investigation of TiO2 nanoparticles (TiO2 NPs) distribution in the polysulfone (PSF) nanofiber. X-ray Photoelectron Spectroscopy (XPS) was conducted to measure the percentage of TiO2 on the surface of the prepared PSF/TiO2 composite nanofiber. The results showed that there was no TiO2 NPs on the surface of the nanofiber for up to 10 nm in depth. TiO2 nanoparticles were mainly found in the center of the nanofiber due to the accumulation of the hydrophobic PSF at the surface of the composite nanofiber. The findings of this work can provide better interpretation of the impact of the interfacial tension on the distribution of the inorganic nanomaterials in the electrospun nanofiber.
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- 2017
28. Study on the Performance of Optical Lenses under High Fluxes of Solar Radiation
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Luís Guerra Rosa, José Carlos Garcia Pereira, Kaveh Rahmani, Guilherme De Almeida, and Luís F. Santos
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concentrated solar radiation ,optical lenses ,borosilicate glass ,silica glass ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
This work compares the performance of optical lenses made of silica glass or borosilicate glass (BK-7) when submitted to high-flux radiation emitted by a xenon arc lamp or provided by a high-concentration solar tower. Each irradiation test lasted for 60 min, with continuous monitoring of the radiation-flux incident on the lenses and the temperature generated in their vicinity. All silica glass lenses showed a good performance with both irradiation sources, xenon arc lamp and natural solar radiation, contrary to what was observed with the lenses made of borosilicate glass which fractured when irradiated with a xenon arc lamp. The negative behavior observed with the borosilicate lenses is attributed to the fact that the radiation spectrum of a xenon arc lamp contains certain wavelengths, in the near ultraviolet (UV) region, that are not present in the natural solar radiation spectrum at sea level.
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- 2021
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29. Thermodynamic and Quality Performance Studies for Drying Kiwi in Hybrid Hot Air-Infrared Drying with Ultrasound Pretreatment
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Ebrahim Taghinezhad, Mohammad Kaveh, and Antoni Szumny
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dry ,efficiency ,energy ,kiwifruit ,quality ,ultrasound ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
The present study examined the effect of ultrasonic pretreatment at three time the levels of 10, 20 and 30 min on some thermodynamic (effective moisture diffusivity coefficient(Deff), drying time, specific energy consumption (SEC), energy efficiency, drying efficiency, and thermal efficiency) and physical (color and shrinkage) properties of kiwifruit under hybrid hot air-infrared(HAI) dryer at different temperatures (50, 60 and 70 °C) and different thicknesses (4, 6 and 8 mm). A total of 11 mathematical models were applied to represent the moisture ratio (MR) during the drying of kiwifruit. The fitting of MR mathematical models to experimental data demonstrated that the logistic model can satisfactorily describe the MR curve of dried kiwifruit with a correlation coefficient (R2) of 0.9997, root mean square error (RMSE) of 0.0177 and chi-square (χ2) of 0.0007. The observed Deff of dried samples ranged from 3.09 × 10−10 to 2.26 × 10−9 m2/s. The lowest SEC, color changes and shrinkage were obtained as 36.57 kWh/kg, 13.29 and 25.25%, respectively. The highest drying efficiency, energy efficiency, and thermal efficiency were determined as 11.09%, 7.69% and 10.58%, respectively. The results revealed that increasing the temperature and ultrasonic pretreatment time and decreasing the sample thickness led to a significant increase (p < 0.05) in drying efficiency, thermal efficiency, and energy efficiency, while drying time, SEC and shrinkage significantly decreased (p < 0.05).
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- 2021
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30. Carbon Nanotube-Supported Butyl 1-Sulfonic Acid Groups as a Novel and Environmentally Compatible Catalyst for the Synthesis of 1,8-Dioxo-octahydroxanthenes
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Kaveh Parvanak Boroujeni, Zahra Heidari, and Reza Khalifeh
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Nanocatalyst ,Heterogeneous catalysis ,1,8-Dioxo-octahydroxanthene ,Aldehyde ,5,5-Dimethyl-1,3-cyclohexanedione ,Chemistry ,QD1-999 - Abstract
A novel multiwalled carbon nanotube catalyst with –SO3H functional groups was easily prepared from its starting materials and used as an efficient heterogeneous catalyst for one-pot Knoevenagel condensation, Michael addition, and cyclodehydration of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with various aromatic aldehydes. Using this method 1,8-dioxo-octahydroxanthenes were obtained in excellent yields at room temperature. The present method is superior in terms of reaction temperature, reaction time, easy work-up, high yields, and ease of recovery of catalyst.
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- 2016
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31. Novel Pt-Ag3PO4/CdS/Chitosan Nanocomposite with Enhanced Photocatalytic and Biological Activities
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Mahsa Kiani, Mojtaba Bagherzadeh, Reyhaneh Kaveh, Navid Rabiee, Yousef Fatahi, Rassoul Dinarvand, Ho Won Jang, Mohammadreza Shokouhimehr, and Rajender S. Varma
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Pt-Ag3PO4/CdS/chitosan ,photocatalytic activity ,antibacterial activity ,cytotoxicity ,visible light ,Chemistry ,QD1-999 - Abstract
Decorating photocatalysts with noble metal nanoparticles (e.g., Pt) often increases the catalysts’ photocatalytic activity and biomedical properties. Here, a simple and inexpensive method has been developed to prepare a Pt-Ag3PO4/CdS/chitosan composite, which was characterized and used for the visible light-induced photocatalytic and antibacterial studies. This synthesized composite showed superior photocatalytic activity for methylene blue degradation as a hazardous pollutant (the maximum dye degradation was observed in 90 min of treatment) and killing of Gram positive bacterial (Staphylococcus aureus and Bacillus cereus) as well as Gram negative bacteria (Klebsiella pneumoniae, Salmonella typhimurium, Escherichia coli, and Pseudomonas aeruginosa) under visible light irradiation. The antibacterial activity of CdS, CdS/Ag3PO4, and Pt-Ag3PO4/CdS/chitosan against E. coli, Pseudomonas aeruginosa, Salmonella typhimurium, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus cereus showed the zone of inhibition (mm) under visible light and under dark conditions at a concentration of 20 µg mL−1. Furthermore, the cell viability of the CdS/chitosan, Ag3PO4, Ag3PO4/CdS/chitosan, and Pt-Ag3PO4/CdS/chitosan were investigated on the human embryonic kidney 293 cells (HEK-293), Henrietta Lacks (HeLa), human liver cancer cell line (HepG2), and pheochromocytoma (PC12) cell lines. In addition, the results indicated that the photodegradation rate for Pt-Ag3PO4/CdS/chitosan is 3.53 times higher than that of CdS and 1.73 times higher than that of the CdS/Ag3PO4 composite. Moreover, Pt-Ag3PO4/CdS/chitosan with an optimal amount of CdS killed large areas of different bacteria and different cells separately in a shorter time period under visible-light irradiation, which shows significantly higher efficiency than pure CdS and other CdS/Ag3PO4 composites. The superb performances of this composite are attributed to its privileged properties, such as retarded recombination of photoinduced electron/hole pairs and a large specific surface area, making Pt-Ag3PO4/CdS/chitosan a valuable composite that can be deployed for a range of important applications, such as visible light-induced photocatalysis and antibacterial activity.
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- 2020
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32. Ultrasonic-Microwave and Infrared Assisted Convective Drying of Carrot: Drying Kinetic, Quality and Energy Consumption
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Yousef Abbaspour-Gilandeh, Mohammad Kaveh, and Muhammad Aziz
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mathematical modeling ,color ,moisture diffusivity ,shrinkage ,rehydration ratio ,Technology ,Engineering (General). Civil engineering (General) ,TA1-2040 ,Biology (General) ,QH301-705.5 ,Physics ,QC1-999 ,Chemistry ,QD1-999 - Abstract
In this study, the drying time, effective moisture diffusivity (Deff), specific energy consumption (SEC), and quality (color, shrinkage, and rehydration) of the ultrasound-pretreated (US) carrot slices were compared when dried by hot air drying (HD), microwave drying (MWD), infrared drying (INFD), and hybrid methods of MW–HD and INF–HD. Five mathematical models were considered to describe the drying kinetics in the carrots. The results show that US+MW–HD and INFD were the fastest and the slowest drying techniques compared to the HD technique with a 73% and 23% drying time reduction, respectively. The Deff ranged from 7.12 × 10−9 to 2.78 × 10−8 m2/s. The highest and lowest SECs were 297.29 ± 11.21 and 23.75 ± 2.22 MJ/kg which were observed in the HD and US+MWD, respectively. The color variation indices indicated that the best sample in terms of color stability was the one dried by US+MW–HD with the color variation of 11.02 ± 0.27. The lowest and highest shrinkage values were also observed in the samples dried by US+MWD and HD (31.8 ± 1.1% and 62.23 ± 1.77%), respectively. Samples dried by US+MWD and HD possessed the highest and lowest rehydration, respectively. Although the carrot slices dried at a higher pace by US+MW–HD (compared to US+MWD), the shrinkage and SEC of the samples dried by US+MWD were significantly lower than the US+MW–HD (p < 0.05). Therefore, it can be concluded that the application of the US+MWD method can be considered as a proper alternative for drying the carrot slices when compared to the HD, MWD, INFD, and hybrid methods.
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- 2020
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33. Synthesis and preliminary evaluation of octreotate conjugates of bioactive synthetic amatoxins for targeting somatostatin receptor (sstr2) expressing cells
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Alla Pryyma, David M. Perrin, Yong Jia Bu, Helen Merkens, Francois Benard, Zhengxing Zhang, and Kaveh Matinkhoo
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chemistry.chemical_classification ,Octreotate ,010405 organic chemistry ,Somatostatin receptor ,medicine.medical_treatment ,Peptide ,010402 general chemistry ,01 natural sciences ,Biochemistry, Genetics and Molecular Biology (miscellaneous) ,Biochemistry ,0104 chemical sciences ,3. Good health ,Targeted therapy ,Chemistry ,chemistry.chemical_compound ,chemistry ,Chemistry (miscellaneous) ,medicine ,Somatostatin receptor 2 ,Molecular Biology ,Linker ,Conjugate ,Amanitin - Abstract
Targeted cancer therapy represents a paradigm-shifting approach that aims to deliver a toxic payload selectively to target-expressing cells thereby sparing normal tissues the off-target effects associated with traditional chemotherapeutics. Since most targeted constructs rely on standard microtubule inhibitors or DNA-reactive molecules as payloads, new toxins that inhibit other intracellular targets are needed to realize the full potential of targeted therapy. Among these new payloads, α-amanitin has gained attraction as a payload in targeted therapy. Here, we conjugate two synthetic amanitins at different sites to demonstrate their utility as payloads in peptide drug conjugates (PDCs). As an exemplary targeting agent, we chose octreotate, a well-studied somatostatin receptor (sstr2) peptide agonist for the conjugation to synthetic amatoxins via three tailor-built linkers. The linker chemistry permitted the evaluation of one non-cleavable and two cleavable self-immolative conjugates. The immolating linkers were chosen to take advantage of either the reducing potential of the intracellular environment or the high levels of lysosomal proteases in tumor cells to trigger toxin release. Cell-based assays on target-positive Ar42J cells revealed target-specific reduction in viability with up to 1000-fold enhancement in bioactivity compared to the untargeted amatoxins. Altogether, this preliminary study enabled the development of a highly modular synthetic platform for the construction of amanitin-based conjugates that can be readily extended to various targeting moieties., Synthetic amanitin is conjugated to octreotate as a targeting agent: three different linkers and two sites of attachment highlight a robust chemical approach leading to targeted cytotoxicity.
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- 2022
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34. Electroactive Self-Healing Shape Memory Polymer Composites Based on Diels–Alder Chemistry
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Yutao Pei, Rodrigo Araya-Hermosilla, Francesco Picchioni, Ignacio Moreno-Villoslada, Felipe Orozco, Guilherme Macedo R. Lima, Dian Sukmayanda Santosa, Diego Ribas Gomes, Ranjita K. Bose, Mahsa Kaveh, Product Technology, and Advanced Production Engineering
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chemistry.chemical_classification ,Polymers and Plastics ,polymer composites ,shape memory ,Process Chemistry and Technology ,Organic Chemistry ,Diels-Alder ,Nanotechnology ,Shape-memory alloy ,Polymer ,electroactive polymer ,Shape-memory polymer ,self-healing polymers ,chemistry ,Self-healing ,Diels alder ,Polymer composites ,Electroactive polymers ,Self-healing material - Abstract
Both shape memory and self-healing polymers have received significant attention from the materials science community. The former, for their application as actuators, self-deployable structures, and medical devices; and the latter, for extending the lifetime of polymeric products. Both effects can be stimulated by heat, which makes resistive heating a practical approach to trigger these effects. Here we show a conductive polyketone polymer and carbon nanotube composite with cross-links based on the thermo-reversible furan/maleimide Diels–Alder chemistry. This approach resulted in products with efficient electroactive shape memory effect, shape reprogrammability, and self-healing. They exhibit electroactive shape memory behavior with recovery ratios of about 0.9; requiring less than a minute for shape recovery; electroactive self-healing behavior able to repair microcracks and almost fully recover their mechanical properties; requiring a voltage in the order of tens of volts for both shape memory and self-healing effects. To the best of our knowledge, this is the first report of electroactive self-healing shape memory polymer composites that use covalent reversible Diels–Alder linkages, which yield robust solvent-resistant polymer networks without jeopardizing their reprocessability. These responsive polymers may be ideal for soft robotics and actuators. They are also a step toward sustainable materials by allowing an increased lifetime of use and reprocessability.
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- 2021
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35. Fabrication and in vitro study of <scp>3D</scp> novel porous hydroxyapatite/polyether ether ketone surface nanocomposite
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Sajad Rasaee, Davood Almasi, Woei Jye Lau, and Kaveh Abbasi
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Nanocomposite ,Materials science ,Biocompatibility ,Polymers ,Surface Properties ,Simulated body fluid ,technology, industry, and agriculture ,Biomedical Engineering ,Ketones ,Osseointegration ,Nanocomposites ,Polyethylene Glycols ,Biomaterials ,Contact angle ,Benzophenones ,Polyether ether ketone ,chemistry.chemical_compound ,Durapatite ,chemistry ,Peek ,Surface modification ,Composite material ,Porosity ,Ethers - Abstract
The unique characteristics of polyether ether ketone (PEEK) including low elastic modulus, high mechanical strength, and biocompatibility have made it an attractive alternative for the metallic biomaterials. However, its bioinert property is always the main concern, which could lead to poor osseointegration and subsequent clinical failure of the implant. Changing the surface structure to porous structure and mixing it with bioactive hydroxyapatite (HA) are the common methods, which could be used to enhance the properties of the PEEK-based implants. In this study, friction stir processing was utilized for the fabrication of porous HA/PEEK surface nanocomposite. Scanning electron microscopic image of the nanocomposite surface showed nano-scale roughness of the porous structure. Water contact angle test confirmed the increase in the wettability of the treated specimens. In vitro bioactivity test via simulated body fluid solution, initial cell adhesion, cell proliferation, and cell differentiation assay also confirmed the enhancement in bioactivity of the treated surface in comparison to the bare PEEK. This surface modification method requires no special equipment and would not damage the heat-sensitive PEEK substrate due to the low temperature used during the fabrication process.
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- 2021
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36. Cardiovascular events in patients treated with chimeric antigen receptor T-cell therapy for aggressive B-cell lymphoma
- Author
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Efstratios Koutroumpakis, Raphael E Steiner, Sairah Ahmed, Michael Wang, Loretta J. Nastoupil, Nicolas Palaskas, Catherine M. Claussen, Jason R. Westin, Paolo Strati, Anita Deswal, Chelsea C. Pinnix, Jose Banchs, Lei Feng, Elizabeth J. Shpall, Francisco Vega, Cristina Gutierrez, Kaveh Karimzad, Sattva S. Neelapu, Gabriela Rondon, and Melody R. Becnel
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Adult ,medicine.medical_specialty ,Antigens, CD19 ,Cell- and Tissue-Based Therapy ,Receptors, Antigen, T-Cell ,Cardiomyopathy ,Immunotherapy, Adoptive ,chemistry.chemical_compound ,Tocilizumab ,Internal medicine ,medicine ,Humans ,Prospective cohort study ,Aged ,Retrospective Studies ,Receptors, Chimeric Antigen ,Performance status ,business.industry ,Organ dysfunction ,Hematology ,Middle Aged ,medicine.disease ,Clinical trial ,Cytokine release syndrome ,chemistry ,Cardiovascular Diseases ,Lymphoma, Large B-Cell, Diffuse ,medicine.symptom ,business ,Mace - Abstract
Standard of care (SOC) chimeric antigen receptor (CAR) T-cell therapies such as axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are associated with multisystem toxicities. There is limited information available about cardiovascular (CV) events associated with SOC axi-cel or tisa-cel. Patients with CV comorbidities, organ dysfunction, or lower performance status were often excluded in the clinical trials leading to their Food and Drug Adminsitration approval. An improved understanding of CV toxicities in the real-world setting will better inform therapy selection and management of patients receiving these cellular therapies. Here, we retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with SOC axi-cel or tisa-cel. Among the 165 patients evaluated, 27 (16%) developed at least one 30-day (30-d) major adverse CV event (MACE). Cumulatively, these patients experienced 21 arrhythmias, four exacerbations of heart failure/cardiomyopathy, four cerebrovascular accidents, three myocardial infarctions, and one patient died due to myocardial infaction. Factors significantly associated with an increased risk of 30-d MACE included age ≥60 years, an earlier start of cytokine release syndrome (CRS), CRS ≥ grade 3, long duration of CRS, and use of tocilizumab. After a median follow-up time of 16.2 months (range, 14.3-19.1), the occurrence of 30-d MACE was not significantly associated with progression-free survival or with overall survival. Our results suggest that the occurrence of 30-d MACE is more frequent among patients who are elderly, with early, severe, and prolonged CRS. However, with limited follow-up, larger prospective studies are needed, and multidisciplinary management of these patients is recommended.
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- 2021
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37. Recent research progress in friction stir welding of aluminium and copper dissimilar joint: a review
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Mohd Sayuti Ab Karim, Nukman Yusoff, Farazila Yusof, Sufian Raja, Kaveh Moghadasi, Mohammad Ashraf Ariffin, Mohd Fadzil Jamaludin, Mohd Ridha Muhamad, and Mohammad Syahid Mohd Isa
- Subjects
Electrical property ,Materials science ,Mining engineering. Metallurgy ,Friction stir welding ,Metallurgy ,Metals and Alloys ,TN1-997 ,chemistry.chemical_element ,Microstructure ,Copper ,Surfaces, Coatings and Films ,Biomaterials ,Welding process ,chemistry ,Aluminium ,Intermetallic compound ,Ceramics and Composites ,Dissimilar joint ,Joint (geology) ,Mechanical property - Abstract
Aluminium and copper are employed in various industrial applications due to their high plasticity, thermal conductivity, electrical conductivity and characteristics. By effectively joining dissimilar aluminium and copper, the unique properties of composite formed by these metals can be adequately addressed. Friction stir welding (FSW), an energy-efficient solid-state welding process is capable of joining dissimilar metals, has enormous potential in the future of various industries. This present work comprehensively summarises all pertinent topics related to aluminium to copper FSW, such as FSW process parameters, microstructural characterisation, mechanical properties, and electrical characteristics of aluminium–copper joints produced by FSW. In addition, the current report also discusses several applications of additives used in dissimilar FSW of Al–Cu and new FSW techniques, which generally aim to enhance Al–Cu joint properties. Moreover, numerical modelling of Al–Cu FSW is discussed profoundly to understand the effects of alterations in different process parameters on temperature gradients and microstructure evolution, which would be time-consuming or prohibitively expensive in practice by physical testing. Additionally, several recommendations for future research are proposed to facilitate the advancement and success of Al–Cu FSW studies.
- Published
- 2021
38. The effect of vitamin D, magnesium and zinc supplements on interferon signaling pathways and their relationship to control SARS-CoV-2 infection
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Elham Bahreini, Mohsen Nabi-Afjadi, Kaveh Goudarzi, Iraj Alipourfard, and Hadis Karami
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Vitamin ,medicine.medical_treatment ,Immunology ,Review ,chemistry.chemical_compound ,Immune system ,Interferon ,medicine ,Vitamin D and neurology ,Immunology and Allergy ,Magnesium ,Vitamin D ,Molecular Biology ,business.industry ,COVID-19 ,RC581-607 ,medicine.disease ,Zinc ,Cytokine ,chemistry ,Signal transduction ,Immunologic diseases. Allergy ,business ,Cytokine storm ,Adjuvant ,medicine.drug - Abstract
The concern of today's communities is to find a way to prevent or treat COVID-19 and reduce its symptoms in the patients. However, the genetic mutations and more resistant strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge; the designed vaccines and adjuvant therapies would potentially control the symptoms and severity of COVID-19. The most important complication of this viral infection is acute respiratory distress syndrome, which occurs due to the infiltration of leukocytes into the alveoli and the raised cytokine storm. Interferons, as a cytokine family in the host, play an important role in the immune-related antiviral defense and have been considered in the treatment protocols of COVID-19. In addition, it has been indicated that some nutrients, including vitamin D, magnesium and zinc are essential in the modulation of the immune system and interferon (IFN) signaling pathway. Several recent studies have investigated the treatment effect of vitamin D on COVID-19 and reported the association between optimal levels of this vitamin and reduced disease risk. In the present study, the synergistic action of vitamin D, magnesium and zinc in IFN signaling is discussed as a treatment option for COVID-19 involvement.
- Published
- 2021
39. New Cu (I) complexes as catalyst for 'click' reaction: An experimental and computational study
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Khodayar Gholivand, Mohammad Faraghi, Rahime Eshagi Malekshah, Mohammadreza Jafari, Ali Reza Akbarzadeh, Reza Latifi, Farzaneh Fadaei‐Tirani, Nasrin Fallah, and Kaveh Farshadfar
- Subjects
schiff-bases ,catalytic activity ,quantum calculations ,General Chemistry ,chemistry ,efficient ,Inorganic Chemistry ,green ,recyclable catalyst ,copper ,cu (i) complex ,click reaction ,1,4-disubstituted 1,2,3-triazoles ,cycloaddition - Abstract
In this work, two novel well-defined Cu (I) complexes of a Schiff base ligand are described. For this purpose, N, N '-bis (trans-cinnamaldehyde) ethylenediimine [C20H20N2] (L) and Cu (I) complex of the type [CuC20H20N2)PPh3Cl] (C1) and [Cu(C20H20N2)PPh3Br] (C2) were synthesised. IR, NMR, XRD and TGA analyses were used to characterise these compounds and single-crystal X-ray crystallography confirmed the structure of the compounds. The catalytic activity of the synthesised complexes was studied in azide-alkyne click reaction (AAC) and the best reaction condition was 15 mol% catalyst, 30 min and 45 degrees C in water, which can be considered moderate catalytic activity for the complexes. Material Studio 2017 software was used to obtain the geometry, energy, HOMO and LUMO of all structures by the quantum calculations (module DMol(3) and LDA/PWC). The computational results showed catalyst C2 has more reactivity than catalyst C1, and the C1-catalysed products form faster than the C2-catalysed products exceptions 4a and 4b. Product 4b (resulting catalyst C2) is formed faster than product (4a).
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- 2023
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40. Selenium nanoparticles are more efficient than sodium selenite in reducing the toxicity of aflatoxin B 1 in Japanese quail
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Sayed Ali Tabeidian, Mahmood Habibian, and Seyed Kaveh Khazraei
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Aflatoxin ,Aflatoxin B1 ,Antioxidant ,Veterinary medicine ,medicine.medical_treatment ,chemistry.chemical_element ,Blood lipids ,Coturnix ,antioxidant status ,Feed conversion ratio ,immune response ,Selenium ,Sodium Selenite ,Animal science ,SF600-1100 ,broiler quail ,medicine ,Animals ,chemistry.chemical_classification ,Sheep ,General Veterinary ,Glutathione peroxidase ,Broiler ,Original Articles ,Animal Feed ,chemistry ,selenium source ,Toxicity ,Nanoparticles ,Original Article ,POULTRY ,Chickens ,performance - Abstract
Background Dietary selenium (Se), as an antioxidant element, plays a protective role in aflatoxin B1 (AFB1) toxicosis in poultry. Objectives To compare the effects of sodium selenite (SS) and Se nanoparticles (SeNPs) against AFB1‐induced toxicity on growth performance, carcass traits, immune response, antioxidant status and serum lipid concentrations in Japanese broiler quails. Methods A total of 540 quails were divided into six treatments, each with six replicates and 15 birds per replicate at 24 days of age and reared for 21 days. Treatments included: (1) a basal diet without Se and AFB1 (negative control; NC); (2) NC + 1.0 mg/kg AFB1 (positive control; PC); (3) PC + 0.2 mg/kg Se as SS; (4) PC + 0.5 mg/kg Se as SS; (5) PC + 0.2 mg/kg Se as SeNPs; and (6) PC + 0.5 mg/kg Se as SeNPs. Results Treatment with PC diet decreased feed intake and body weight gain and increased feed conversion ratio than the NC diet. The PC diet also atrophied the lymphoid organs and depressed antibody responses against Newcastle disease and avian influenza viruses and sheep red blood cell. Moreover, quails treated with PC diet appeared to have lower serum glutathione peroxidase and thioredoxin reductase activities and disturbed serum lipids than those receiving the NC diet. Dietary Se attenuated these detrimental effects, but failed to completely eliminate them. Additionally, SeNPs performed better than SS in improving thioredoxin reductase activity and antibody titer against sheep red blood cell. Conclusions Diet supplementation with SeNPs to provide 0.5 mg/kg of Se is recommended to reduce the AFB1 toxicosis in broiler quails., This study compared the effects of sodium selenite (SS) and selenium (Se) nanoparticles (SeNPs) against aflatoxin B1 (AFB1) toxicosis in broiler quails. Both SS and SeNPs, especially at 0.5 mg/kg of diet, improved growth performance, immune responses, and serum lipids through antioxidant enzymes induction. Moreover, SeNPs showed more favorable effects on enhancing TrxR activity, serum MDA content, and antibody titers against SRBC.
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- 2021
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41. Antioxidant and antibacterial evaluation of Manuka leaves (Leptospermum scoparium) extracted by hydrophobic deep eutectic solvent
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Mohammed Farid, Kaveh Shahbaz, and Noor Alsaud
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Antioxidant ,food.ingredient ,biology ,General Chemical Engineering ,medicine.medical_treatment ,Extraction (chemistry) ,food and beverages ,General Chemistry ,biology.organism_classification ,Lactic acid ,law.invention ,Deep eutectic solvent ,Leptospermum scoparium ,chemistry.chemical_compound ,food ,chemistry ,law ,medicine ,Manuka Oil ,Agar ,Food science ,Essential oil - Abstract
Manuka (Leptospermum scoparium) has been studied as a valuable shrub as its leaves are rich in bioactive components such as β-caryophyllene. This study investigated the extractability of hydrophobic deep eutectic solvent (HDES) namely menthol:lactic acid HDES for the total phenolic content (TPC) and antioxidant activity from β-caryophyllene-rich Manuka leaves. Results were also compared with ethanol and n-hexane extracts. The ethanolic extract possessed the highest amount of TPC (86.08 ± 6.22 mg GAE/g DW) among tested extracts. The extraction of TPC using HDES was at a sufficient level (79.82 ± 0.75 mg GAE/g DW), while n-hexane presented poor yield (2.74 ± 0.70 mg GAE/g DW). Higher 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power were found to be in ethanolic extract. The antibacterial effects of Manuka extract obtained by HDES was also assessed and the results were compared with the antibacterial effect of HDES, lactic acid, commercial Manuka essential oil, steam distilled Manuka oil, and β-caryophyllene pure oil. E. coli, Pseudomonas aeruginosa and Staphylococcus epidermidis were tested using agar disc diffusion method. Results revealed that lactic acid, HDES, and Manuka-HDES extract showed toxicity towards the tested bacteria indicating that the bactericidal effect of the Manuka extract was due to the lactic acid as a forming compound. This study verified the possibility of extracting and characterising different bioactive compounds from Manuka leaves using menthol:lactic acid HDES in a single step and thus it could be explored for broader industrial applications.
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- 2021
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42. Effect of boiling in salt solution and drying on the quality of farmed Pacific white shrimp (Litopenaeus vannamei)
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Mehdi Nikoo, Kaveh Rahmanifarah, and Hossein Zarei
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Salt solution ,biology ,Chemistry ,Boiling ,Litopenaeus ,Food science ,biology.organism_classification ,Food Science ,Shrimp - Published
- 2021
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43. A comparative study of 3D printing and heat-compressing methods for manufacturing the thermoplastic composite bone fixation plate: Design, characterization, and in vitro biomechanical experimentation
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Gholamhossein Liaghat, Fatemeh Alavi, Ali Kabiri, Seyyed Kaveh Hedayati, and Mohamed Nainar Mohamed Ansari
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Hot Temperature ,Materials science ,Bone fixation ,0206 medical engineering ,Glass fiber ,3D printing ,Rigidity (psychology) ,02 engineering and technology ,Fracture Fixation, Internal ,chemistry.chemical_compound ,Animals ,Composite material ,Thermoplastic composites ,Polypropylene ,business.industry ,Mechanical Engineering ,General Medicine ,021001 nanoscience & nanotechnology ,020601 biomedical engineering ,Biomechanical Phenomena ,Characterization (materials science) ,chemistry ,Printing, Three-Dimensional ,Cattle ,0210 nano-technology ,business ,Bone Plates - Abstract
Metallic bone fixations, due to their high rigidity, can cause long-term complications. To alleviate metallic biomaterials’ drawbacks, in this research new Glass Fiber/Polypropylene (GF/PP) composite internal fixations were developed, and an investigation of their mechanical behavior was performed through in vitro biomechanical experiments. Short randomly oriented, long unidirectional prepreg, and long unidirectional fiber yarn were considered as reinforcements, and the effects on their mechanical properties of different manufacturing processes, that is, 3D printing and heat-compressing, were investigated. The constructed fixation plates were tested in the transversely fractured diaphysis of bovine tibia under axial compression loading. The overall stiffness and the Von Mises strain field of the fixation plates were obtained within stable and unstable fracture conditions. The samples were loaded until failure to determine their failure loads, strains, and mechanisms. Based on the results, the GF/PP composite fixation plates can provide adequate interfragmentary movement to amplify bone ossification, so they can provide proper support for bone healing. Moreover, their potential for stress shielding reduction and their load-bearing capacity suggest their merits in replacing traditional metallic plates.
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- 2021
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44. Expanded Spectrum of Optical Coherence Tomography Findings in Patients with Ocular Toxoplasmosis
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Masoud Soheilian, Alireza Hedayatfar, Seyedeh Maryam Hosseini, Mohammad Zarei, Nazanin Ebrahimiadib, and Kaveh Fadakar
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medicine.medical_specialty ,Choroidal granuloma ,genetic structures ,Visual Acuity ,Serous Retinal Detachment ,Lesion ,chemistry.chemical_compound ,Optical coherence tomography ,Ophthalmology ,medicine ,Humans ,Immunology and Allergy ,In patient ,Toxoplasmosis, Ocular ,medicine.diagnostic_test ,Choroid ,business.industry ,Retinal Detachment ,Retinal ,medicine.disease ,eye diseases ,Toxoplasmosis ,chemistry ,sense organs ,Epiretinal membrane ,medicine.symptom ,business ,Tomography, Optical Coherence - Abstract
Purpose: To describe the optical coherence tomography (OCT) findings of toxoplasmic retinochoroiditis at different stages of activity.Methods: Observational case series.Results: A total of 32 eyes of 31 patients were included; 43 sets of OCT were reviewed. A total of 14 lesions were classified as active, 13 as partially active, and 16 as inactive. All active lesions demonstrated increased retinal thickness and reflectivity with blurring of details of retinal layers. Choroidal granuloma was detected in eight (61.5%) and serous retinal detachment in nine (64%). In partially active lesions, sustained thickening and/or attachment of posterior hyaloid face with fine epiretinal membrane was the hallmark. Scarified lesions showed decreased retinal and choroidal thickness starting from the periphery. Characteristic signs for decreased activity of a lesion seen in majority of both partially active and inactive lesions were RPE changes and retina-RPE approximation. We called this unique feature 'hourglass configuration'.Conclusion: Features in OCT are helpful to specify and monitor the activity of toxoplasmic retinochoroiditis.
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- 2021
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45. Design, Synthesis, and Biochemical Evaluation of Alpha‐Amanitin Derivatives Containing Analogs of the trans ‐Hydroxyproline Residue for Potential Use in Antibody‐Drug Conjugates
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Torsten Hechler, Andreas Pahl, Alexandra Braun, Kaveh Matinkhoo, Brandon Kato, Christoph Müller, Francesca Gallo, Antonio A. W. L. Wong, Charlie Wei, Chido M. Hambira, and David M. Perrin
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Immunoconjugates ,Amanita ,Allosteric regulation ,RNA polymerase II ,alpha-Amanitin ,010402 general chemistry ,medicine.disease_cause ,01 natural sciences ,Catalysis ,chemistry.chemical_compound ,medicine ,Structure–activity relationship ,Amanita phalloides ,Alpha-Amanitin ,Amanitin ,biology ,Bicyclic molecule ,010405 organic chemistry ,Toxin ,Chemistry ,Organic Chemistry ,General Chemistry ,biology.organism_classification ,0104 chemical sciences ,Hydroxyproline ,Biochemistry ,biology.protein - Abstract
Alpha-amanitin, an extremely toxic bicyclic octapeptide extracted from the death-cap mushroom, Amanita phalloides, is a highly selective allosteric inhibitor of RNA polymerase II. Following on growing interest in using this toxin as a payload in antibody-drug conjugates, herein we report the synthesis and biochemical evaluation of several new derivatives of this toxin to probe the role of the trans-hydroxyproline (Hyp), which is known to be critical for toxicity. This structure activity relationship (SAR) study represents the first of its kind to use various Hyp-analogs to alter the conformational and H-bonding properties of Hyp in amanitin.
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- 2021
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46. A highly carbon‐efficient and techno‐economically optimized process for the renewable‐assisted synthesis of gas to liquid fuels, ammonia, and urea products
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Mehdi Panahi, Mohammad Ziaei, Mohammad Ali Fanaei, Kaveh Rajab Khalilpour, and Ahmad Rafiee
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Waste management ,Renewable Energy, Sustainability and the Environment ,business.industry ,Energy Engineering and Power Technology ,chemistry.chemical_element ,Renewable energy ,chemistry.chemical_compound ,Gas to liquids ,Ammonia ,Fuel Technology ,Nuclear Energy and Engineering ,chemistry ,Scientific method ,Urea ,Environmental science ,business ,Carbon - Published
- 2021
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47. Optical Coherence Tomography Angiography and Structural Analyses of the Pale Optic Discs: Is It Possible to Differentiate the Cause?
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Mostafa Soltan Sanjari, Kaveh Abri Aghdam, Ali Aghajani, Khalil Ghasemi Falavarjani, Marjan Razi-Khosroshahi, and Samira Chaibakhsh
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Adult ,Male ,Retinal Ganglion Cells ,medicine.medical_specialty ,genetic structures ,Optic Disk ,Nerve fiber layer ,Optic neuropathy ,Cellular and Molecular Neuroscience ,chemistry.chemical_compound ,Nerve Fibers ,Atrophy ,Optical coherence tomography ,Ophthalmology ,Optic Nerve Diseases ,Humans ,Medicine ,Fluorescein Angiography ,medicine.diagnostic_test ,business.industry ,Optic disc pallor ,Retinal ,Middle Aged ,medicine.disease ,eye diseases ,Sensory Systems ,Cross-Sectional Studies ,medicine.anatomical_structure ,chemistry ,Microvessels ,Optic nerve ,Anterior ischemic optic neuropathy ,Female ,sense organs ,business ,Tomography, Optical Coherence - Abstract
Introduction: To compare the optic nerve head (ONH) structure and microvasculature in patients with optic atrophy due to non-arteritic anterior ischemic optic neuropathy (NAION), compressive optic neuropathy (CON), methanol-induced optic neuropathy (MION), and traumatic optic neuropathy (TON) using optical coherence tomography angiography.Methods: In this comparative, cross-sectional study, 32 eyes with NAION, 18 eyes with CON, 32 eyes with MION, 23 eyes with TON, and 55 normal eyes were enrolled. Radial peripapillary capillary (RPC) vessel density, peripapillary retinal nerve fiber layer (RNFL) thickness, disc area, cup volume, and cup/disc area ratio were obtained using the RTVue XR Avanti system (Optovue Inc., Fremont, CA, USA).Results: RPC vessel density and peripapillary RNFL thickness in all patients were significantly lower than normal subjects. A positive correlation was found between the RPC vessel density and peripapillary RNFL thickness in normal subjects and all study groups. The positive correlation between the inside and outside disc RPC vessel density was only found in the NAION (r = 0.36, P = .042) and MION (r = 0.42, P = .018) groups. No significant difference was found among the groups in terms of peripapillary and inside disc vascular densities (all P > .05). Disc area and cup volume in patients with MION was larger than the values in patients with NAION (P = .018) and TON (P = .044) and normal subjects (P = .015). The discriminating features among the study groups were the larger cup volume and cup/disc area ratio in patients with MION, and lower RNFL thickness in patients with TON.Conclusions: There was a positive correlation between the RNFL thickness and peripapillary RPC vessel density regardless of the cause of optic disc pallor. Structural evaluation of the ONH seems to be a better way to differentiate the cause of optic nerve head atrophy than the microangiographic changes.
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- 2021
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48. Intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevents the H-89-induced spatial learning deficits in Morris water maze
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Iraj Sharamian, Hanieh Rezaei, Mehdi Sanati, Ali Bazi, Jafar Shahraki, Sahar Fanoudi, Kaveh Tabrizian, Maryam Belaran, Ramin Rezaee, Mahmoud Hashemzaei, and Najmeh Baratzadeh
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Nicotine ,medicine.medical_treatment ,Spatial Learning ,Morris water navigation task ,Pharmacology ,Hippocampus ,030226 pharmacology & pharmacy ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Morris Water Maze Test ,medicine ,Animals ,Memory impairment ,Dimethyl Sulfoxide ,Rats, Wistar ,Maze Learning ,Protein kinase A ,Acetylcarnitine ,Saline ,Sulfonamides ,Chemistry ,Dimethyl sulfoxide ,Isoquinolines ,H-89 ,Rats ,Complementary and alternative medicine ,Protein Kinases ,030217 neurology & neurosurgery ,medicine.drug - Abstract
Objectives H-89 (a protein kinase AII [PKA II] inhibitor) impairs the spatial memory in the Morris water maze task in rats. In the present study, we aimed to study the protective effects of nicotine and O-acetyl-L-carnitine against H-89-induced spatial memory deficits. Methods Spatial memory impairment was induced by the bilateral intrahippocampal administration of 10 µM H-89 (dissolved in dimethyl sulfoxide, DMSO) to rats. The rats then received bilateral administrations of either nicotine (1 μg/μL, dissolved in saline) or O-acetyl-L-carnitine (100 μM/side, dissolved in deionized water) alone and in combination. Control groups received either saline, deionized water, or DMSO. Results The H-89-treated animals showed significant increases in the time and distance travelled to find hidden platforms, and there was also a significant decrease in the time spent in the target quadrant compared to DMSO-treated animals. Nicotine and O-acetyl-L-carnitine had no significant effects on H-89-induced spatial learning impairments alone, but the bilateral intrahippocampal co-administration of nicotine and O-acetyl-L-carnitine prevented H-89-induced spatial learning deficits and increased the time spent in the target quadrant in comparison with H-89-treated animals. Conclusions Our results indicated the potential synergistic effects of nicotine and O-acetyl-L-carnitine in preventing protein kinase AII inhibitor (H-89)-induced spatial learning impairments.
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- 2021
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49. Magnetic Separation of Antibodies with High Binding Capacity by Site-Directed Immobilization of Protein A-Domains to Bare Iron Oxide Nanoparticles
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Paula Fraga-García, Raphaela Allgayer, Sebastian P. Schwaminger, Yasmin Kaveh-Baghbaderani, and Sonja Berensmeier
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chemistry.chemical_compound ,Chemical engineering ,biology ,Chemistry ,biology.protein ,Magnetic separation ,Nanoparticle ,General Materials Science ,Char ,Antibody ,Protein A ,Iron oxide nanoparticles ,Immunoglobulin G - Abstract
The demand for purified antibodies is ever-rising. This study presents a nanoparticle-based material for efficient magnetic separation of immunoglobulin G (IgG) with high binding capacity. The char...
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- 2021
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50. Active terahertz modulator and slow light metamaterial devices with hybrid graphene–superconductor photonic integrated circuits
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Harvey E. Beere, Kaveh Delfanazari, Majid Ghanaatshoar, Hannah J. Joyce, R. Wallis, Stephen J. Kindness, Michael Kelly, Stephan Hofmann, Samane Kalhor, Riccardo Degl'Innocenti, David A. Ritchie, Hofmann, Stephan [0000-0001-6375-1459], Joyce, Hannah [0000-0002-9737-680X], Delfanazari, Kaveh [0000-0002-1386-3855], Apollo - University of Cambridge Repository, Ghanaatshoar, Majid [0000-0003-4614-1549], Joyce, Hannah J. [0000-0002-9737-680X], Degl'Innocenti, Riccardo [0000-0003-2655-1997], and Joyce, Hannah J [0000-0002-9737-680X]
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Materials science ,business.industry ,Terahertz radiation ,Electromagnetically induced transparency ,General Chemical Engineering ,Photonic integrated circuit ,graphene ,Metamaterial ,Physics::Optics ,Slow light ,superconductors ,Article ,Chemistry ,Resonator ,Modulation ,electromagnetic induced transparency ,Optoelectronics ,General Materials Science ,hybrid photonic integrated circuits ,terahertz electronics ,business ,terahertz photonics ,slow light devices ,QD1-999 ,Group delay and phase delay - Abstract
Metamaterial photonic integrated circuits with arrays of hybrid graphene–superconductor coupled split-ring resonators (SRR) capable of modulating and slowing down terahertz (THz) light are introduced and proposed. The hybrid device’s optical responses, such as electromagnetic-induced transparency (EIT) and group delay, can be modulated in several ways. First, it is modulated electrically by changing the conductivity and carrier concentrations in graphene. Alternatively, the optical response can be modified by acting on the device temperature sensitivity by switching Nb from a lossy normal phase to a low-loss quantum mechanical phase below the transition temperature (Tc) of Nb. Maximum modulation depths of 57.3% and 97.61% are achieved for EIT and group delay at the THz transmission window, respectively. A comparison is carried out between the Nb-graphene-Nb coupled SRR-based devices with those of Au-graphene-Au SRRs, and significant enhancements of the THz transmission, group delay, and EIT responses are observed when Nb is in the quantum mechanical phase. Such hybrid devices with their reasonably large and tunable slow light bandwidth pave the way for the realization of active optoelectronic modulators, filters, phase shifters, and slow light devices for applications in chip-scale future communication and computation systems.
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- 2021
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