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230 results on '"Costas Ioannides"'

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1. Neuroprotective Effects of 7-Geranyloxycinnamic Acid from Melicope lunu ankenda Leaves

2. Induction of Apoptosis by Gluconasturtiin-Isothiocyanate (GNST-ITC) in Human Hepatocarcinoma HepG2 Cells and Human Breast Adenocarcinoma MCF-7 Cells

3. Synergistic and antagonistic interactions of binary mixtures of polycyclic aromatic hydrocarbons in the upregulation of CYP1 activity and mRNA levels in precision-cut rat liver slices

4. Effects of nicotine and E-cigarette fluids on cytochromes P450 in hCMEC/D3 blood-brain barrier cell line

5. Induction of Apoptosis and Cytotoxicity by Isothiocyanate Sulforaphene in Human Hepatocarcinoma HepG2 Cells

6. SHORT COMMUNICATION: The in vitro metabolic activation of the 11-trifluoromethyl analogue of the potent carcinogen 15, 16-dihydro-11-methyl-cyclopenta[a]-phenanthren-17-one to mutagens

7. Up-regulation of CYP1A1 and phase II enzymes by 5-ring isomeric polycyclic aromatic hydrocarbons in precision-cut rat hepatic slices: Importance of molecular shape

8. Phenethyl isothiocyanate, a naturally occurring phytochemical, is an antagonist of the aryl hydrocarbon receptor

9. Debrisoquine Metabolism and CYP2D Expression in Marmoset Liver Microsomes

10. Up-regulation of cytochrome P450 and phase II enzyme systems in rat precision-cut rat lung slices by the intact glucosinolates, glucoraphanin and glucoerucin

11. Exposure to Isothiocyanates Suppresses Urinary Mutagenicity in Rats Treated With Heterocyclic Amine IQ: Lack of Association With CYP1 Activity

12. The natural chemopreventive phytochemical R-sulforaphane is a far more potent inducer of the carcinogen-detoxifying enzyme systems in rat liver and lung than the S-isomer

13. Differential response of four human livers to modulation of phase II enzyme systems by the chemopreventive phytochemical phenethyl isothiocyanate

14. Isothiocyanates and Xenobiotic Detoxification

15. Isothiocyanates: A Chemical Class of Potential Nutraceuticals

16. Repeated oral administration modulates the pharmacokinetic behavior of the chemopreventive agent phenethyl isothiocyanate in rats

17. Repeated intake of broccoli does not lead to higher plasma levels of sulforaphane in human volunteers

18. Effect of 2-amino-9H-pyrido[2,3-b]indole (AαC), a carcinogenic heterocyclic amine present in food, on atherosclerotic plaque development in apoE deficient mice

19. Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane

20. Tissue differences in the modulation of rat cytochromes P450 and phase II conjugation systems by dietary doses of phenethyl isothiocyanate

21. Modulation of Rat Hepatic and Pulmonary Cytochromes P450 and Phase II Enzyme Systems by Erucin, an Isothiocyanate Structurally Related to Sulforaphane

22. Interactions between polycyclic aromatic hydrocarbons in binary mixtures: Effects on gene expression and DNA adduct formation in precision-cut rat liver slices

23. Absolute bioavailability and dose-dependent pharmacokinetic behaviour of dietary doses of the chemopreventive isothiocyanate sulforaphane in rat

24. Up-regulation of CYP1A/B in rat lung and liver, and human liver precision-cut slices by a series of polycyclic aromatic hydrocarbons; association with the Ah locus and importance of molecular size

25. Evaluation of the precision-cut liver and lung slice systems for the study of induction of CYP1, epoxide hydrolase and glutathione S-transferase activities

26. A principal mechanism for the cancer chemopreventive activity of phenethyl isothiocyanate is modulation of carcinogen metabolism

27. Inhibitory effect of phenethyl isothiocyanate against benzo[a] pyrene-induced rise in CYP1A1 mRNA and apoprotein levels as its chemopreventive properties

28. Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity

29. An improved method for the extraction of mutagens from human urine and cooked meat using blue rayon

30. Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins

31. Cytochrome P450 expression and testosterone metabolism in the liver of deer

32. A quantitative structure-activity relationship (QSAR) study of mutagenicity in several series of organic chemicals likely to be activated by cytochrome P450 enzymes

33. Xenobiotic conjugation systems in deer compared with cattle and rat

34. Pharmacokinetic interactions between herbal remedies and medicinal drugs

35. Contribution of CYP1A2 in the hepatic metabolism of melatonin: studies with isolated microsomal preparations and liver slices

36. Evidence for the presence of a microsomal NADH-dependent enzyme system that can bioactivate aromatic amines in the liver of rats and mice

37. Consumption of tea modulates the urinary excretion of mutagens in rats treated with IQ. Role of caffeine

38. Structural and functional integrity of precision-cut liver slices in xenobiotic metabolism: a comparison of the dynamic organ and multiwell plate culture procedures

39. Contribution of Caffeine and Flavanols in the Induction of Hepatic Phase II Activities by Green Tea

40. An examination of DNA strand breakage in the comet assay and antioxidant capacity in diabetic patients

41. Further evaluation of COMPACT, the molecular orbital approach for the prospective safety evaluation of chemicals

42. Fractionation of green tea extracts: correlation of antimutagenic effect with flavanol content

43. Bioactivation of mushroom hydrazines to mutagenic products by mammalian and fungal enzymes

44. Diaminonaphthalenes and related aminocompounds: Mutagenicity, CYP1A induction and interaction with the Ah receptor

45. COMPACT and molecular structure in toxicity assessment: a prospective evaluation of 30 chemicals currently being tested for rodent carcinogenicity by the NCI/NTP

46. Mutagenicity of white grape juice in the ames test

47. Computer graphics analysis of the interaction of alkoxy methylenedioxybenzenes with cytochromes P4501

48. The influence of dihydrodiol conformation on the metabolic activation of cyclopenta[a]phenanthrenes

49. CYP1 induction, binding to the hepatic aromatic hydrocarbon receptor and mutagenicity of a series of 11-alkoxy cyclopenta[a]phenanthren-17-ones: a structure activity relationship

50. Precision-Cut Tissue Slices: A SuitableIn VitroSystem for the Study of the Induction of Drug-Metabolizing Enzyme Systems

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